VEGF Receptor Subtypes KDR and FLT1 Show Different Sensitivities to Heparin and Placenta Growth Factor

THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS

1949 • 19,979 citations

Vascular Endothelial Growth Factor Is a Secreted Angiogenic Mitogen

1989 • 4,988 citations

Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis

1992 • 4,631 citations

Tumor Cells Secrete a Vascular Permeability Factor That Promotes Accumulation of Ascites Fluid

1983 • 3,942 citations

Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo

1992 • 2,293 citations

Vascular Permeability Factor, an Endothelial Cell Mitogen Related to PDGF

1989 • 2,090 citations

The fms -Like Tyrosine Kinase, a Receptor for Vascular Endothelial Growth Factor

1992 • 2,042 citations

The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing

1991 • 1,991 citations

High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis

1993 • 1,961 citations

Molecular and Biological Properties of the Vascular Endothelial Growth Factor Family of Proteins

1992 • 1,612 citations

Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor

1992 • 1,528 citations

Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor.

1993 • 1,391 citations

The Vascular Endothelial Growth Factor Family: Identification of a Fourth Molecular Species and Characterization of Alternative Splicing of RNA

1991 • 1,375 citations

Isolation of a human placenta cDNA coding for a protein related to the vascular permeability factor.

1991 • 999 citations

Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family.

1990 • 982 citations

Fetal liver kinase 1 is a receptor for vascular endothelial growth factor and is selectively expressed in vascular endothelium.

1993 • 764 citations

Heparin is required for cell-free binding of basic fibroblast growth factor to a soluble receptor and for mitogenesis in whole cells.

1992 • 634 citations

Isolation of brain fibroblast growth factor by heparin-Sepharose affinity chromatography: identity with pituitary fibroblast growth factor.

1984 • 624 citations

Isolation and characterization of a vascular endothelial cell mitogen produced by pituitary-derived folliculo stellate cells.

1989 • 568 citations

Selective proliferation of normal human melanocytes in vitro in the presence of phorbol ester and cholera toxin.

1982 • 552 citations

Identification of a new endothelial cell growth factor receptor tyrosine kinase

1991 • 529 citations

A receptor tyrosine kinase cDNA isolated from a population of enriched primitive hematopoietic cells and exhibiting close genetic linkage to c-kit.

1991 • 516 citations

The binding of vascular endothelial growth factor to its receptors is dependent on cell surface-associated heparin-like molecules.

1992 • 495 citations

Binding sites for vascular endothelial growth factor are localized on endothelial cells in adult rat tissues.

1992 • 443 citations

Two alternative mRNAs coding for the angiogenic factor, placenta growth factor (PlGF), are transcribed from a single gene of chromosome 14.

1993 • 317 citations

Characterization of the receptors for vascular endothelial growth factor.

1990 • 310 citations

FLT4 receptor tyrosine kinase contains seven immunoglobulin-like loops and is expressed in multiple human tissues and cell lines.

1992 • 285 citations

The related FLT4, FLT1, and KDR receptor tyrosine kinases show distinct expression patterns in human fetal endothelial cells.

1993 • 263 citations

Human Melanoma Cells but Not Normal Melanocytes Express Vascular Endothelial Growth Factor Receptors

1993 • 141 citations

Characterization of the receptor to vasculotropin on bovine adrenal cortex-derived capillary endothelial cells.

1990 • 120 citations

NYK/FLK-1: a putative receptor protein tyrosine kinase isolated from E10 embryonic neuroepithelium is expressed in endothelial cells of the developing embryo.

1993 • 90 citations

Platelet-Derived Growth Factor Receptor: Current Views of the Two-Subunit Model

1990 • 58 citations