Expression cloning of a diphtheria toxin receptor: Identity with a heparin-binding EGF-like growth factor precursor

A comprehensive set of sequence analysis programs for the VAX

1984 • 14,824 citations

A general method applicable to the search for similarities in the amino acid sequence of two proteins

1970 • 11,049 citations

An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs

1987 • 5,139 citations

A new method for predicting signal sequence cleavage sites

1986 • 4,629 citations

SV40-transformed simian cells support the replication of early SV40 mutants

1981 • 2,564 citations

A Heparin-Binding Growth Factor Secreted by Macrophage-Like Cells That Is Related to EGF

1991 • 1,135 citations

NPXY, a sequence often found in cytoplasmic tails, is required for coated pit-mediated internalization of the low density lipoprotein receptor.

1990 • 944 citations

Human transforming growth factor-α: Precursor structure and expression in E. coli

1984 • 888 citations

Mechanisms for the incorporation of proteins in membranes and organelles.

1982 • 875 citations

trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor

1991 • 830 citations

Diphtheria Toxin

1977 • 780 citations

Expression cloning of an activin receptor, a predicted transmembrane serine kinase

1991 • 760 citations

THE LDL RECEPTOR LOCUS IN FAMILIAL HYPERCHOLESTEROLEMIA: Mutational Analysis of a Membrane Protein

1990 • 684 citations

The biochemistry of glycoproteins and proteoglycans

1980 • 651 citations

trkB, a novel tyrosine protein kinase receptor expressed during mouse neural development.

1989 • 604 citations

Structure and Function of Human Amphiregulin: A Member of the Epidermal Growth Factor Family

1989 • 586 citations

Diphtheria toxin: mode of action and structure

1975 • 552 citations

The TGF-α precursor expressed on the cell surface binds to the EGF receptor on adjacent cells, leading to signal transduction

1989 • 482 citations

Diphtheria toxin entry into cells is facilitated by low pH.

1980 • 467 citations

Transmembrane TGF-α precursors activate EGF/TGF-α receptors

1989 • 432 citations

Transforming growth factor-alpha. A model for membrane-anchored growth factors.

1990 • 430 citations

The entry of diphtheria toxin into the mammalian cell cytoplasm: evidence for lysosomal involvement.

1980 • 372 citations

Expression cloning of a receptor for murine granulocyte colony-stimulating factor

1990 • 362 citations

The Amphiregulin Gene Encodes a Novel Epidermal Growth Factor-Related Protein with Tumor-Inhibitory Activity

1990 • 359 citations

The low density lipoprotein receptor. Identification of amino acids in cytoplasmic domain required for rapid endocytosis.

1987 • 355 citations

Structure of heparin-binding EGF-like growth factor. Multiple forms, primary structure, and glycosylation of the mature protein.

1992 • 346 citations

Bacterial toxins: cellular mechanisms of action

1984 • 322 citations

Human epidermal growth factor precursor: cDNA sequence, expressionin vitroand gene organization

1986 • 321 citations

Role of the human transferrin receptor cytoplasmic domain in endocytosis: localization of a specific signal sequence for internalization.

1990 • 312 citations

Molecular Cloning of the Zeta Chain of the T Cell Antigen Receptor

1988 • 275 citations

Mutations in the cytoplasmic domain of the 275 kd mannose 6-phosphate receptor differentially alter lysosomal enzyme sorting and endocytosis

1989 • 272 citations

The NPXY internalization signal of the LDL receptor adopts a reverse-turn conformation

1991 • 246 citations

Structure of Glycoproteins and Their Oligosaccharide Units

1980 • 243 citations

Diphtheria toxin: mode of action and structure.

1975 • 242 citations

The amphiregulin gene encodes a novel epidermal growth factor-related protein with tumor-inhibitory activity.

1990 • 241 citations

Expression of Multiple Forms of the Prolactin Receptor in Mouse Liver

1989 • 237 citations

Genes expressed in the brain define three distinct neuronal nicotinic acetylcholine receptors.

1988 • 232 citations

Membrane receptors for bacterial toxins

1983 • 222 citations

Cleavage of the membrane precursor for transforming growth factor alpha is a regulated process.

1991 • 209 citations

Association of diphtheria toxin with Vero cells. Demonstration of a receptor.

1978 • 195 citations

Cysteines in the transmembrane region of major histocompatibility complex antigens are fatty acylated via thioester bonds.

1984 • 189 citations

Molecular cloning and chromosomal localization of the human T-cell receptor zeta chain: distinction from the molecular CD3 complex.

1988 • 180 citations

The genealogy of some recently evolved vertebrate proteins

1985 • 179 citations

The essential tyrosine of the internalization signal in lysosomal acid phosphatase is part of a β turn

1991 • 165 citations

Epstein-Barr virus shuttle vector for stable episomal replication of cDNA expression libraries in human cells.

1988 • 154 citations

Response of cultured mammalian cells to the exotoxins of Pseudomonas aeruginosa and Corynebacterium diphtheriae: differential cytotoxicity

1977 • 149 citations

Bacterial toxins: cellular mechanisms of action.

1984 • 135 citations

Recombinant Human Epidermal Growth Factor Precursor Is a Glycosylated Membrane Protein with Biological Activity

1989 • 111 citations

Membrane receptors for bacterial toxins.

1983 • 107 citations

Deletions in the cytoplasmic domain of the polymeric immunoglobulin receptor differentially affect endocytotic rate and postendocytotic traffic.

1990 • 100 citations

Cell surface sulfhydryls are required for the cytotoxicity of diphtheria toxin but not of ricin in Chinese hamster ovary cells.

1991 • 86 citations

Cell-mediated reduction of the interfragment disulfide in nicked diphtheria toxin. A new system to study toxin entry at low pH.

1987 • 75 citations

Somatic cell cloning in polyester stacks.

1982 • 66 citations

Recombinant human epidermal growth factor precursor is a glycosylated membrane protein with biological activity.

1989 • 63 citations

Characterization and affinity labeling of the cationic phosphate-binding (nucleotide-binding) peptide located in the receptor-binding region of the B-fragment of diphtheria toxin.

1980 • 60 citations

An antibody that inhibits the binding of diphtheria toxin to cells revealed the association of a 27-kDa membrane protein with the diphtheria toxin receptor.

1991 • 57 citations

Binding properties of diphtheria toxin to cells are altered by mutation in the fragment A domain.

1985 • 57 citations

Localization of the diphtheria toxin receptor-binding domain to the carboxyl-terminal Mr approximately 6000 region of the toxin.

1990 • 56 citations

Diphtheria toxin receptor. Identification of specific diphtheria toxin-binding proteins on the surface of Vero and BS-C-1 cells.

1987 • 55 citations

Genetic distinction between sterol-mediated transcriptional and posttranscriptional control of 3-hydroxy-3-methylglutaryl-coenzyme A reductase

1991 • 49 citations

Requirement of specific receptors for efficient translocation of diphtheria toxin A fragment across the plasma membrane.

1988 • 45 citations

Diphtheria toxin:receptor interaction. Characterization of the receptor interaction with the nucleotide-free toxin, the nucleotide-bound toxin, and the B-fragment of the toxin.

1981 • 39 citations

Purification of diphtheria toxin receptor from Vero cells.

1991 • 35 citations

Expression of functional diphtheria toxin receptors on highly toxin-sensitive mouse cells that specifically bind radioiodinated toxin.

1992 • 27 citations

A functional role for cysteine disulfides in the transmembrane transport of diphtheria toxin.

1984 • 23 citations

Effect of polymers of L-lysine on the cytotoxic action of diphtheria toxin

1982 • 21 citations

Enzyme treatment of KB cells: The altered effect of diphtheria toxin

1974 • 21 citations

Isolation of diphtheria toxin-sensitive mouse cells from a toxin-resistant population transfected with monkey DNA.

1990 • 17 citations

[37] Isolation of mutant chinese hamster ovary cells defective in endocytosis

1987 • 16 citations

Anti-idiotypic antibodies that protect cells against the action of diphtheria toxin.

1989 • 10 citations