Perlecan, basal lamina proteoglycan, promotes basic fibroblast growth factor-receptor binding, mitogenesis, and angiogenesis

Angiogenic Factors

1987 • 3,702 citations

Improved quantitation and discrimination of sulphated glycosaminoglycans by use of dimethylmethylene blue

1986 • 3,282 citations

Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor

1991 • 2,437 citations

Proteoglycans: Structures And Interactions

1991 • 1,596 citations

Requirement of Heparan Sulfate for bFGF-Mediated Fibroblast Growth and Myoblast Differentiation

1991 • 1,507 citations

Proteoglycans as modulators of growth factor activities

1991 • 1,338 citations

Recent developments in the cell biology of basic fibroblast growth factor.

1989 • 1,049 citations

Endothelial cell-derived basic fibroblast growth factor: synthesis and deposition into subendothelial extracellular matrix.

1987 • 1,045 citations

A heparin-binding angiogenic protein--basic fibroblast growth factor--is stored within basement membrane.

1988 • 892 citations

Heparin is required for cell-free binding of basic fibroblast growth factor to a soluble receptor and for mitogenesis in whole cells.

1992 • 634 citations

Activating and inhibitory heparin sequences for FGF-2 (basic FGF). Distinct requirements for FGF-1, FGF-2, and FGF-4.

1993 • 542 citations

Neovascularization is associated with a switch to the export of bFGF in the multistep development of fibrosarcoma

1991 • 523 citations

An Essential Heparin-Binding Domain in the Fibroblast Growth Factor Receptor Kinase

1993 • 520 citations

Identification of the basic fibroblast growth factor binding sequence in fibroblast heparan sulfate.

1992 • 511 citations

Cell surface heparan sulfate proteoglycans.

1992 • 476 citations

Developmental changes in heparan sulfate expression: in situ detection with mAbs.

1992 • 464 citations

Minimal sequence in heparin/heparan sulfate required for binding of basic fibroblast growth factor.

1993 • 449 citations

The complete sequence of perlecan, a basement membrane heparan sulfate proteoglycan, reveals extensive similarity with laminin A chain, low density lipoprotein-receptor, and the neural cell adhesion molecule.

1991 • 446 citations

Developmental Regulation of Neural Response to FGF-1 and FGF-2 by Heparan Sulfate Proteoglycan

1993 • 420 citations

Controlled and modulated release of basic fibroblast growth factor

1991 • 361 citations

Extension and structural variability of the antithrombin-binding sequence in heparin.

1984 • 340 citations

Differential structural requirements of heparin and heparan sulfate proteoglycans that promote binding of basic fibroblast growth factor to its receptor.

1994 • 254 citations

Cell surface heparan sulfate proteoglycans from human vascular endothelial cells. Core protein characterization and antithrombin III binding properties.

1992 • 245 citations

Specific heparan sulfate saccharides mediate the activity of basic fibroblast growth factor.

1994 • 202 citations

Structure of a heparan sulphate oligosaccharide that binds to basic fibroblast growth factor

1992 • 173 citations

A confined variable region confers ligand specificity on fibroblast growth factor receptors: implications for the origin of the immunoglobulin fold.

1992 • 165 citations

Heparin sequences in the heparan sulfate chains of an endothelial cell proteoglycan.

1987 • 161 citations

A cell-type-specific abnormality of cell proliferation in mutant (curly tail) mouse embryos developing spinal neural tube defects

1988 • 139 citations

Heparan Sulfate Proteoglycan (Perlecan) Expression by Mouse Embryos during Acquisition of Attachment Competence

1993 • 134 citations

Patterns of sulphation in heparan sulphate: Polymorphism based on a common structural theme

1992 • 133 citations

Inhibition of basic fibroblast growth factor-induced growth promotion by overexpression of syndecan-1.

1993 • 129 citations

Multifactorial inheritance of neural tube defects: localization of the major gene and recognition of modifiers in ct mutant mice

1994 • 118 citations

Expression of two different forms of fibroblast growth factor receptor 1 in different mouse tissues and cell lines.

1991 • 75 citations

Myoepithelial and basement membrane antigens in benign and malignant human breast tumors

1993 • 71 citations

Distribution and origin of the basement membrane component perlecan in rat liver and primary hepatocyte culture.

1993 • 69 citations

Self-association of heparan sulfate. Demonstration of binding by affinity chromatography of free chains on heparan sulfate-substituted agarose gels.

1981 • 63 citations

Accumulation of basement membrane-associated hyaluronate is reduced in the posterior neuropore region of mutant (curly tail) mouse embryos developing spinal neural tube defects

1988 • 61 citations

The use of an improved rabbit ear chamber technique for the study of dental materials

1980 • 11 citations