The gene structure of the insulin-like growth factor family

Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs

1984 • 3,334 citations

The amino acid sequence of human insulin-like growth factor I and its structural homology with proinsulin.

1978 • 1,530 citations

Tissue concentrations of somatomedin C: further evidence for multiple sites of synthesis and paracrine or autocrine mechanisms of action.

1984 • 1,171 citations

Primary structure of human insulin‐like growth factor II

1978 • 776 citations

Cellular Localization of Somatomedin (Insulin-Like Growth Factor) Messenger RNA in the Human Fetus

1987 • 663 citations

Regulation of insulin-like growth factor I gene expression by growth hormone.

1986 • 558 citations

Somatomedin-C/insulin-like growth factor-I and insulin-like growth factor-II mRNAs in rat fetal and adult tissues.

1986 • 531 citations

Differential expression of insulin-like growth factor genes in rat central nervous system.

1988 • 477 citations

Insulin-like growth factor-II gene expression in Wilms' tumour and embryonic tissues

1985 • 413 citations

Sequence of cDNA encoding human insulin-like growth factor I precursor

1983 • 401 citations

Expression of Somatomedin/Insulin-Like Growth Factor Messenger Ribonucleic Acids in the Human Fetus: Identification, Characterization, and Tissue Distribution*

1988 • 375 citations

Organization and sequence of the human insulin-like growth factor I gene. Alternative RNA processing produces two insulin-like growth factor I precursor peptides.

1986 • 371 citations

Expression of insulin-like growth factor-II transcripts in Wilms' tumour

1985 • 352 citations

Sequence of a cDNA clone encoding human preproinsulin-like growth factor II

1984 • 326 citations

Developmental regulation of insulin-like growth factor II mRNA in different rat tissues.

1986 • 322 citations

Secretion of an insulin-like growth factor-I-related protein by human breast cancer cells.

1986 • 310 citations

Enhanced levels of insulin-like growth factor messenger RNA in human colon carcinomas and liposarcomas.

1986 • 293 citations

Differential expression of alternative 5' untranslated regions in mRNAs encoding rat insulin-like growth factor I.

1987 • 292 citations

Insulin-like growth factor II precursor gene organization in relation to insulin gene family

1984 • 281 citations

1 Biological and immunological properties of insulin-like growth factors (IGF) I and II

1984 • 279 citations

Mosaic evolution of the insulin-like growth factors. Organization, sequence, and expression of the rat insulin-like growth factor I gene.

1987 • 279 citations

Molecular Cloning of Rat Insulin-Like Growth Factor I Complementary Deoxyribonucleic Acids: Differential Messenger Ribonucleic Acid Processing and Regulation by Growth Hormone in Extrahepatic Tissues

1987 • 275 citations

Human chromosomal mapping of genes for insulin-like growth factors I and II and epidermal growth factor

1984 • 267 citations

Expression of the insulin-like growth factor II gene in the choroid plexus and the leptomeninges of the adult rat central nervous system.

1988 • 262 citations

Two insulin-like growth factor I messenger RNAs are expressed in human liver.

1986 • 260 citations

Identification, Characterization, and Regulation of a Rat Complementary Deoxyribonucleic Acid which Encodes Insulin-Like Growth Factor-I*

1987 • 241 citations

Distribution and Regulation of Rat Insulin-Like Growth Factor I Messenger Ribonucleic Acids Encoding Alternative Carboxyterminal E-Peptides: Evidence for Differential Processing and Regulation in Liver

1988 • 224 citations

Sequences of liver cDNAs encoding two different mouse insulin-like growth factor I precursors

1986 • 215 citations

Isolation of the human insulin-like growth factor genes: insulin-like growth factor II and insulin genes are contiguous.

1985 • 212 citations

Pattern of the insulin-like growth factor II gene expression during rat embryogenesis

1988 • 199 citations

Rat insulin-like growth factor II gene

1986 • 192 citations

Insulin-like growth factor II in human adrenal pheochromocytomas and Wilms tumors: expression at the mRNA and protein level.

1987 • 191 citations

Localization of insulin-like growth factor genes to human chromosomes 11 and 12

1984 • 180 citations

Isolation of the human insulin-like growth factor I gene using a single synthetic DNA probe.

1984 • 177 citations

Growth hormone regulates the abundance of insulin-like growth factor I RNA in adult rat liver.

1986 • 174 citations

The human insulin‐like growth factor II gene contains two development‐specific promoters

1987 • 170 citations

Identification of Somatomedin/Insulin-Like Growth Factor Immunoreactive Cells in the Human Fetus

1987 • 165 citations

Nucleotide sequences of cDNAs encoding precursors of human insulin‐like growth factor II (IGF‐II) and an IGF‐II variant

1985 • 164 citations

Tissue-Specific and Developmentally Regulated Transcription of the Insulin-Like Growth Factor 2 Gene

1987 • 161 citations

Developmental and tissue-specific expression of a family of transcripts related to rat insulin-like growth factor II mRNA

1985 • 155 citations

Differential expression of the human insulin-like growth factor II gene Characterization of the IGF-II mRNAs and an mRNA encoding a putative IGF-II-associated protein

1988 • 146 citations

Insulin-Like Growth Factor II Messenger Ribonucleic Acids are Synthesized in the Choroid Plexus of the Rat Brain

1988 • 127 citations

The expression of insulin-like growth factor I and insulin-like growth factor II genes in the human fetal and adult brain and in glioma

1988 • 123 citations

Structure and expression of the rat insulin-like growth factor II (rIGF-II) gene. rIGF-II RNAs are transcribed from two promoters.

1986 • 122 citations

Expression of insulin-like growth factor-I and -II genes in human smooth muscle tumours.

1988 • 121 citations

Insulin-Like Growth Factor Gene Expression during Rat Embryonic Development*

1987 • 118 citations

Amino acid sequence of a variant pro-form of insulin-like growth factor II.

1985 • 106 citations

Isolation of Rat Testis cDNAs Encoding an Insulin-Like Growth Factor I Precursor

1987 • 105 citations

Tissue-specific expression of insulin-like growth factor II mRNAs with distinct 5' untranslated regions.

1987 • 95 citations

Sequence of a Placental cDNA Encoding the Mouse Insulin-Like Growth Factor II Precursor

1986 • 93 citations

Linkage map of the short arm of human chromosome 11: location of the genes for catalase, calcitonin, and insulin-like growth factor II.

1985 • 92 citations

Organization of the human genes for insulin‐like growth factors I and II

1986 • 88 citations

A promoter of the rat insulin-like growth factor II gene consists of minimal control elements

1988 • 88 citations

Sequence of two rat insulin-like growth factor I mRNAs differing within the 5' untranslated region

1987 • 85 citations

Coordinate developmental regulation of high and low molecular weight mRNAs for rat insulin-like growth factor II.

1986 • 77 citations

Rat IGF-I cDNA's contain multiple 5′-untranslated regions

1987 • 76 citations

Complete characterization of the human IGF‐I nucleotide sequence isolated from a newly constructed adult liver cDNA library

1986 • 72 citations

The human gene encoding insulin-like growth factor I is located on chromosome 12

1985 • 71 citations

Biosynthesis of human insulin-like growth factor I (IGF-I). The primary translation product of IGF-I mRNA contains an unusual 48-amino acid signal peptide.

1987 • 65 citations

Regulation of human IGF-II transcription in fetal and adult tissues

1987 • 50 citations

Synthesis of Insulin-Like Growth Factor II (IGF-II) in Fetal Rat Tissues: Translation of IGF-II Ribonucleic Acid and Processing of Pre-Pro-IGF-II*

1988 • 46 citations

A new leader exon identified in the rat insulin-like growth factor II gene

1987 • 44 citations

Isolation of an insulin-like growth factor II cDNA with a unique 5' untranslated region from human placenta.

1988 • 41 citations

Basic and Clinical Aspects of Growth Hormone

1988 • 38 citations

Transcriptional deviation of the rat insulin-like growth factor II gene initiated at three alternative leader-exons between neonatal tissues and ascites hepatomas

1988 • 36 citations

Chromosomal localization and preliminary characterization of the human gene encoding insulin-like growth factor II

1985 • 34 citations

A new 5′‐non‐coding region for human placental insulin‐like growth factor II mRNA expression

1987 • 32 citations

Expression of insulin‐like growth factor‐I and ‐II genes in rat medullary thyroid carcinoma

1987 • 26 citations

Morphological characterization of transformed colonies in rat tracheal epithelial cell cultures exposed to carcinogen.

1986 • 20 citations

Tissue-specific expression of insulin-like growth factor II mRNAs with distinct 5′ untranslated regions

1988 • 15 citations

Somatomedin gene structure and expression

1989 • 5 citations

Organization and Expression of the Genes Encoding the Human Somatomedins

1988 • 3 citations