Multidrug-Resistance Transporters

ABC Transporters: From Microorganisms to Man

1992 • 3,956 citations

BIOCHEMISTRY OF MULTIDRUG RESISTANCE MEDIATED BY THE MULTIDRUG TRANSPORTER

1993 • 3,515 citations

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

1976 • 3,228 citations

Overexpression of a Transporter Gene in a Multidrug-Resistant Human Lung Cancer Cell Line

1992 • 3,039 citations

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues.

1987 • 2,788 citations

Goodman and Gilman's The Pharmacological Basis of Therapeutics

1996 • 2,325 citations

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

1994 • 2,255 citations

Characterization of the Human Colon Carcinoma Cell Line (Caco-2) as a Model System for Intestinal Epithelial Permeability

1989 • 2,127 citations

THE BIOCHEMISTRY OF P-GLYCOPROTEIN-MEDIATED MULTIDRUG RESISTANCE

1989 • 2,060 citations

Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells

1991 • 1,787 citations

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites.

1989 • 1,744 citations

Expression of a multidrug-resistance gene in human tumors and tissues.

1987 • 1,547 citations

Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil.

1981 • 1,463 citations

Homozygous disruption of the murine MDR2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease

1993 • 1,437 citations

Expression of Multidrug Resistance Gene in Human Cancers

1989 • 1,305 citations

P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs.

1996 • 1,268 citations

Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

1995 • 1,109 citations

Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine.

1987 • 1,080 citations

Mammalian multidrug resistance gene: Complete cDNA sequence indicates strong homology to bacterial transport proteins

1986 • 1,058 citations

Cell Surface P-Glycoprotein Associated with Multidrug Resistance in Mammalian Cell Lines

1983 • 1,001 citations

Pharmacology of drugs that alter multidrug resistance in cancer.

1990 • 970 citations

Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells

1991 • 962 citations

Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins

1997 • 934 citations

Detection of P-glycoprotein in multidrug-resistant cell lines by monoclonal antibodies

1985 • 927 citations

Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines.

1997 • 889 citations

Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine

1997 • 871 citations

Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P‐glycoprotein: Implications for drug delivery and activity in cancer chemotherapy

1995 • 856 citations

Amplification of P-glycoprotein genes in multidrug-resistant mammalian cell lines

1985 • 843 citations

Congenital Jaundice in Rats with a Mutation in a Multidrug Resistance-Associated Protein Gene

1996 • 827 citations

Epithelial Transport Of Drugs In Cell Culture. I: A Model For Studying The Passive Diffusion Of Drugs Over Intestinal Absorbtive (Caco-2) Cells

1990 • 820 citations

Isolation and expression of a complementary DNA that confers multidrug resistance

1986 • 808 citations

Cellular resistance to actinomycin D in Chinese hamster cells in vitro: cross-resistance, radioautographic, and cytogenetic studies.

1970 • 752 citations

Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells.

1986 • 688 citations

The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pump.

1994 • 685 citations

Human P-glycoprotein transports cyclosporin A and FK506.

1993 • 676 citations

Overexpression of multidrug resistance-associated protein (MRP) increases resistance to natural product drugs.

1994 • 635 citations

The drug resistance-related protein LRP is the human major vault protein

1995 • 621 citations

Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport.

1994 • 621 citations

Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein P170: evidence for localization in brain capillaries and crossreactivity of one antibody with a muscle protein.

1989 • 606 citations

Phosphatidylcholine translocase: A physiological role for the mdr2 gene

1994 • 600 citations

In vitro and in vivo reversal of multidrug resistance by GF120918, an acridonecarboxamide derivative.

1993 • 526 citations

P‐glycoprotein: multidrug‐resistance and a superfamily of membrane‐associated transport proteins

1989 • 512 citations

Overexpression of a M(r) 110,000 vesicular protein in non-P-glycoprotein-mediated multidrug resistance.

1993 • 508 citations

Role of glutathione in the export of compounds from cells by the multidrug-resistance-associated protein.

1995 • 501 citations

A retrovirus carrying an MDR1 cDNA confers multidrug resistance and polarized expression of P-glycoprotein in MDCK cells.

1988 • 489 citations

Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells.

1996 • 487 citations

Tissue distribution of the multidrug resistance protein.

1996 • 473 citations

Multiple drug-resistant human KB carcinoma cells independently selected for high-level resistance to colchicine, adriamycin, or vinblastine show changes in expression of specific proteins.

1986 • 461 citations

ATP-dependent transport of glutathione S-conjugates by the multidrug resistance-associated protein.

1994 • 435 citations

Two members of the mouse mdr gene family confer multidrug resistance with overlapping but distinct drug specificities.

1990 • 420 citations

P-glycoprotein—A mediator of multidrug resistance in tumour cells

1996 • 406 citations

Heat shock and arsenite increase expression of the multidrug resistance (MDR1) gene in human renal carcinoma cells.

1990 • 396 citations

Partial purification and reconstitution of the human multidrug-resistance pump: characterization of the drug-stimulatable ATP hydrolysis.

1992 • 395 citations

The human multidrug resistance (mdr1) gene. cDNA cloning and transcription initiation.

1987 • 384 citations

Biology of the multidrug resistance-associated protein, MRP

1996 • 367 citations

Expression and activity of the multidrug resistance P-glycoprotein in human peripheral blood lymphocytes [see comments]

1992 • 347 citations

Mice with homozygous disruption of the mdr2 P-glycoprotein gene. A novel animal model for studies of nonsuppurative inflammatory cholangitis and hepatocarcinogenesis.

1994 • 346 citations

Structure of the Multidrug Resistance P-glycoprotein to 2.5 nm Resolution Determined by Electron Microscopy and Image Analysis

1997 • 341 citations

Purification of the 170- to 180-kilodalton membrane glycoprotein associated with multidrug resistance. 170- to 180-kilodalton membrane glycoprotein is an ATPase.

1988 • 340 citations

Transport of digoxin by human P-glycoprotein expressed in a porcine kidney epithelial cell line (LLC-PK1).

1992 • 335 citations

Reversal of P-glycoprotein-mediated multidrug resistance by a potent cyclopropyldibenzosuberane modulator, LY335979.

1996 • 329 citations

Analysis of the expression of MRP, the gene for a new putative transmembrane drug transporter, in human multidrug resistant lung cancer cell lines

1994 • 315 citations

Active secretion and enterocytic drug metabolism barriers to drug absorption

1996 • 310 citations

Discrete mutations introduced in the predicted nucleotide-binding sites of the mdr1 gene abolish its ability to confer multidrug resistance.

1989 • 303 citations

Alteration of etoposide pharmacokinetics and pharmacodynamics by cyclosporine in a phase I trial to modulate multidrug resistance.

1992 • 298 citations

The MRP gene associated with a non-P-glycoprotein multidrug resistance encodes a 190-kDa membrane bound glycoprotein.

1993 • 297 citations

Structure and expression of the human MDR (P-glycoprotein) gene family.

1989 • 296 citations

Molecular cloning of canalicular multispecific organic anion transporter defective in EHBR

1997 • 294 citations

Sequence of mdr3 cDNA encoding a human P-glycoprotein

1988 • 292 citations

The use of surfactants to enhance the permeability of peptides through Caco-2 cells by inhibition of an apically polarized efflux system.

1996 • 285 citations

The human mdr3 gene encodes a novel P-glycoprotein homologue and gives rise to alternatively spliced mRNAs in liver.

1987 • 283 citations

The human MDR3 P‐glycoprotein promotes translocation of phosphatidylcholine through the plasma membrane of fibroblasts from transgenic mice

1994 • 278 citations

Substantial excretion of digoxin via the intestinal mucosa and prevention of long‐term digoxin accumulation in the brain by the mdrla P‐glycoprotein

1996 • 278 citations

Expression of the Multidrug-Resistant Gene in Hepatocarcinogenesis and Regenerating Rat Liver

1987 • 274 citations

The use of cultured epithelial and endothelial cells for drug transport and metabolism studies.

1990 • 272 citations

Cloning and characterization of a second member of the mouse mdr gene family.

1988 • 268 citations

P-glycoprotein: a major determinant of rifampicin-inducible expression of cytochrome P4503A in mice and humans.

1996 • 266 citations

ATP-dependent 17β-Estradiol 17-(β-D-Glucuronide) Transport by Multidrug Resistance Protein (MRP)

1996 • 265 citations

Functional reconstitution of drug transport and ATPase activity in proteoliposomes containing partially purified P-glycoprotein.

1993 • 257 citations

Membrane Topology of a Cysteine-less Mutant of Human P-glycoprotein

1995 • 252 citations

ATPase activity of purified and reconstituted P-glycoprotein from Chinese hamster ovary cells.

1994 • 235 citations

Isolation and characterization of DNA sequences amplified in multidrug-resistant hamster cells.

1986 • 226 citations

The direct activation of human multidrug resistance gene (MDR1) by anticancer agents

1989 • 223 citations

Characterization of the adenosine triphosphatase activity of Chinese hamster P-glycoprotein.

1993 • 220 citations

Functional consequences of proline mutations in the predicted transmembrane domain of P-glycoprotein.

1993 • 218 citations

Drug absorption limited by P-glycoprotein-mediated secretory drug transport in human intestinal epithelial Caco-2 cell layers.

1993 • 217 citations

Characterization of the ATPase activity of P-glycoprotein from multidrug-resistant Chinese hamster ovary cells

1995 • 215 citations

Characterization of the human MDR3 P-glycoprotein and its recognition by P-glycoprotein-specific monoclonal antibodies.

1991 • 212 citations

Most drugs that reverse multidrug resistance also inhibit photoaffinity labeling of P-glycoprotein by a vinblastine analog.

1988 • 211 citations

Clinical trials of p-glycoprotein reversal in solid tumours

1996 • 210 citations

ATP‐binding properties of P glycoprotein from multidrug‐resistant KB cells

1987 • 207 citations

Cyclosporins as drug resistance modifiers

1992 • 205 citations

Enhanced oral bioavailability of paclitaxel in mice treated with the P-glycoprotein blocker SDZ PSC 833

1997 • 201 citations

Identification of members of the P-glycoprotein multigene family.

1989 • 195 citations

Major photoaffinity drug labeling sites for iodoaryl azidoprazosin in P-glycoprotein are within, or immediately C-terminal to, transmembrane domains 6 and 12

1993 • 194 citations

Broad distribution of the multidrug resistance-related vault lung resistance protein in normal human tissues and tumors.

1996 • 193 citations

The effects of lipids and detergents on ATPase-active P-glycoprotein

1993 • 186 citations

MDR1 Gene Expression in Lung Cancer

1989 • 182 citations

Transport of celiprolol across human intestinal epithelial (Caco‐2) cells: mediation of secretion by multiple transporters including P‐glycoprotein

1993 • 178 citations

Altered Pharmacokinetics of Vinblastine in Mdr1a P-glycoprotein-Deficient Mice

1996 • 175 citations

Classical and novel forms of multidrug resistance and the physiological functions of P-glycoproteins in mammals

1993 • 171 citations

The MDR1 gene product, P-glycoprotein, mediates the transport of the cardiac glycoside, digoxin

1992 • 171 citations

Evidence for a Polarized Efflux System in Caco-2 Cells Capable of Modulating Cyclosporine A Transport

1993 • 167 citations

Kinetics of Steady-state Currents and Charge Movements Associated with the Rat Na+/Glucose Cotransporter

1995 • 166 citations

Experimental reversal of P-glycoprotein-mediated multidrug resistance by pharmacological chemosensitisers

1996 • 165 citations

Reconstitution of ATP-dependent Leukotriene C4 Transport by Co-expression of Both Half-molecules of Human Multidrug Resistance Protein in Insect Cells

1996 • 162 citations

Models for Assessing Drug Absorption and Metabolism

1996 • 150 citations

MDR1 gene expression in solid tumours

1996 • 148 citations

ATPase activity of partially purified P-glycoprotein from multidrug-resistant Chinese hamster ovary cells

1992 • 147 citations

CYP3A-like cytochrome P450-mediated metabolism and polarized efflux of cyclosporin A in Caco-2 cells.

1996 • 143 citations

Synthetic and natural opiates interact with P-glycoprotein in multidrug-resistant cells

1993 • 142 citations

Clinical trials of modulation of multidrug resistance pharmacokinetic and pharmacodynamic considerations

1993 • 139 citations

Pharmacological considerations in the modulation of multidrug resistance

1996 • 139 citations

Covalent inhibitors of P-glycoprotein ATPase activity.

1994 • 139 citations

Inhibition of intestinal P-glycoprotein and effects on etoposide absorption

1995 • 138 citations

Multidrug resistance gene (P-glycoprotein) expression in the human fetus.

1992 • 138 citations

Cytoplasmic Orientation and Two-domain Structure of the Multidrug Transporter, P-glycoprotein, Demonstrated with Sequence-specific Antibodies

1989 • 135 citations

Chemosensitization and drug accumulation effects of VX-710, verapamil, cyclosporin A, MS-209 and GF120918 in multidrug resistant HL60/ADR cells expressing the multidrug resistance-associated protein MRP

1997 • 134 citations

Study of membrane orientation and glycosylated extracellular loops of mouse P-glycoprotein by in vitro translation.

1991 • 132 citations

Cellular and biochemical characterization of VX-710 as a chemosensitizer

1997 • 131 citations

Unlocking vaults: organelles in search of a function

1991 • 128 citations

Functional consequences of phenylalanine mutations in the predicted transmembrane domain of P-glycoprotein.

1993 • 126 citations

Regulation of 2‐acetylaminofluorene‐and 3‐methylcholanthrene‐mediated induction of multidrug resistance and cytochrome P450IA gene family expression in primary hepatocyte cultures and rat liver

1991 • 125 citations

Topology of P-glycoprotein as determined by epitope mapping of MRK-16 monoclonal antibody.

1993 • 125 citations

Evidence for P‐glycoprotein‐modulated penetration of morphine‐6‐glucuronide into brain capillary endothelium

1996 • 125 citations

Expression complementary DNA library transfer establishes mrp as a multidrug resistance gene.

1994 • 124 citations

Transport and epithelial secretion of the cardiac glycoside, digoxin, by human intestinal epithelial (Caco‐2) cells

1996 • 124 citations

Transport properties of P-glycoprotein in plasma membrane vesicles from multidrug-resistant Chinese hamster ovary cells

1992 • 114 citations

MDR1 RNA Levels in Human Renal Cell Carcinomas: Correlation With Grade and Prediction of Reversal of Doxorubicin Resistance by Quinidine in Tumor Explants

1989 • 114 citations

SDZ PSC 833, A non‐immunosuppressive cyclosporine: Its potency in overcoming P‐glycoprotein‐mediated multidrug resistance of murine leukemia

1992 • 112 citations

Retroviral transfer of a murine cDNA for multidrug resistance confers pleiotropic drug resistance to cells without prior drug selection.

1988 • 107 citations

Photoaffinity substrates for P-glycoprotein

1992 • 105 citations

Cloning and characterization of a member of the rat multidrug resistance (mdr) gene family

1991 • 104 citations

Differential transport properties of two mdr gene products are distinguished by progesterone.

1990 • 103 citations

Role of P‐Glycoprotein in the Blood‐Brain Transport of Colchicine and Vinblastine

1996 • 101 citations

Induction of multidrug resistance gene expression during cholestasis in rats and nonhuman primates

1993 • 101 citations

Interaction of drugs with P-glycoprotein in brain capillaries

1995 • 100 citations

Major vault protein LRP-related multidrug resistance

1996 • 99 citations

Quantitative expression patterns of multidrug‐resistance P‐glycoprotein (MDR1) and differentially spliced cystic‐fibrosis transmembrane‐conductance regulator mRNA transcripts in human epithelia

1992 • 97 citations

Active intestinal secretion of the fluoroquinolone antibacterials ciprofloxacin, norfloxacin and pefloxacin; a common secretory pathway?

1994 • 94 citations

Intronic Enhancer Activity of the Eosinophil-derived Neurotoxin (RNS2) and Eosinophil Cationic Protein (RNS3) Genes Is Mediated by an NFAT-1 Consensus Binding Sequence

1997 • 90 citations

RETRACTED: ATP-dependent uptake of natural product cytotoxic drugs by membrane vesicles establishes MRP as a broad specificity transporter.

1996 • 87 citations

Analysis of structural features of dihydropyridine analogs needed to reverse multidrug resistance and to inhibit photoaffinity labeling of P-glycoprotein

1989 • 86 citations

Epithelial secretion of vinblastine by human intestinal adenocarcinoma cell (HCT-8 and T84) layers expressing P-glycoprotein

1991 • 85 citations

Enhancement of Mdr2-mediated Phosphatidylcholine Translocation by the Bile Salt Taurocholate

1995 • 85 citations

Inhibition of the intestinal digoxin absorption and exsorption by quinidine.

1996 • 84 citations

Secretion of Organic Anions by Hepatocytes: Involvement of Homologues of the Multidrug Resistance Protein

1996 • 79 citations

Cloning and regulation of the ratmdr2gene

1993 • 79 citations

Multidrug resistance after retroviral transfer of the human MDR1 gene correlates with P-glycoprotein density in the plasma membrane and is not affected by cytotoxic selection.

1991 • 78 citations

Functional analysis of chimeric genes obtained by exchanging homologous domains of the mouse mdr1 and mdr2 genes.

1991 • 77 citations

Transepithelial transport of vinblastine by kidney-derived cell lines. Application of a new kinetic model to estimate in situ Km of the pump

1990 • 77 citations

Drug resistance: genotype versus phenotype--thirty-second G. H. A. Clowes Memorial Award Lecture.

1994 • 75 citations

Expression of the multidrug resistance genes in the liver

1997 • 73 citations

Modulation of ATP and drug binding by monoclonal antibodies against P‐glycoprotein

1991 • 72 citations

Expression of multidrug resistance genes in rat liver during regeneration and after carbon tetrachloride intoxication

1993 • 71 citations

Reduction of expression of the multidrug resistance protein (MRP) in human tumor cells by antisense phosphorothioate oligonucleotides

1996 • 66 citations

Are the Major Effects of P-Glycoprotein Modulators Due to Altered Pharmacokinetics of Anticancer Drugs?

1996 • 61 citations

Reversible transcriptional activation of mdr1 by sodium butyrate treatment of human colon cancer cells.

1994 • 55 citations

Role of multidrug resistance protein (MRP) in glutathione S-conjugate transport in mammalian cells.

1996 • 47 citations

Inhibition of P-glycoprotein-mediated vinblastine transport across HCT-8 intestinal carcinoma monolayers by verapamil, cyclosporine A and SDZ PSC 833 in dependence on extracellular pH

1994 • 44 citations

Experimental modulation of MRP (multidrug resistanceassociated protein)-mediated resistance

1996 • 43 citations

Identification of distinct P-glycoprotein gene sequences in rat

1992 • 42 citations

Intestinal elimination of ofloxacin enantiomers in the rat: evidence of a carrier-mediated process

1996 • 42 citations

Functional Expression of the Multidrug Resistance-associated Protein in the Yeast Saccharomyces cerevisiae

1996 • 36 citations

Regulation of mdrlb gene expression in Fischer, Wistar and Sprague-Dawley rats in vivo and in vitro

1996 • 33 citations

The role of mdr2 P-glycoprotein in biliary lipid secretion. Cross-talk between cancer research and biliary physiology

1995 • 32 citations

Relationship between expression level of p-glycoprotein and daunorubicin transport in LLC-PK1 cells transfected with human MDR1 gene

1997 • 28 citations

In vitro and in vivo chemosensitizing effect of cyclosporin A on an intrinsic multidrug-resistant rat colon tumour

1993 • 19 citations

Effect of the multidrug inhibitor GG918 on drug sensitivity of human leukemic cells

1997 • 18 citations

The chemosensitizer cyclosporin A enhances the toxic side-effects of doxorubicin in the rat

1994 • 13 citations

Expression of multidrug resistance genes in rat liver during regeneration and after carbon tetrachloride intoxication

1993 • 7 citations

Induction of multidrug resistance gene expression during cholestasis in rats and nonhuman primates

1993 • 5 citations