Purification of the 170- to 180-kilodalton membrane glycoprotein associated with multidrug resistance. 170- to 180-kilodalton membrane glycoprotein is an ATPase.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Measurement of protein using bicinchoninic acid

1985 • 17,516 citations

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

1976 • 3,228 citations

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells

1986 • 1,903 citations

Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil.

1981 • 1,463 citations

Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine.

1987 • 1,080 citations

Mammalian multidrug resistance gene: Complete cDNA sequence indicates strong homology to bacterial transport proteins

1986 • 1,058 citations

Cell Surface P-Glycoprotein Associated with Multidrug Resistance in Mammalian Cell Lines

1983 • 1,001 citations

Monoclonal Antibodies: Principles and Practice

1996 • 928 citations

Detection of P-glycoprotein in multidrug-resistant cell lines by monoclonal antibodies

1985 • 927 citations

Isolation and expression of a complementary DNA that confers multidrug resistance

1986 • 808 citations

Homology between P-glycoprotein and a bacterial haemolysin transport protein suggests a model for multidrug resistance

1986 • 680 citations

Increased accumulation of vincristine and adriamycin in drug-resistant P388 tumor cells following incubation with calcium antagonists and calmodulin inhibitors.

1982 • 667 citations

Monoclonal Antibodies: Principles and Practice

1985 • 648 citations

Functional role for the 170- to 180-kDa glycoprotein specific to drug-resistant tumor cells as revealed by monoclonal antibodies.

1986 • 561 citations

Certain calcium channel blockers bind specifically to multidrug-resistant human KB carcinoma membrane vesicles and inhibit drug binding to P-glycoprotein.

1987 • 538 citations

Altered surface membrane glycoproteins in Vinca alkaloid-resistant human leukemic lymphoblasts.

1979 • 478 citations

Active efflux of daunorubicin and adriamycin in sensitive and resistant sublines of P388 leukemia.

1979 • 454 citations

Genetic and biochemical characterization of multidrug resistance

1985 • 405 citations

Purification of P-glycoprotein from plasma membrane vesicles of Chinese hamster ovary cell mutants with reduced colchicine permeability.

1979 • 368 citations

Membrane vesicles from multidrug-resistant human cancer cells contain a specific 150- to 170-kDa protein detected by photoaffinity labeling.

1986 • 342 citations

Vinblastine photoaffinity labeling of a high molecular weight surface membrane glycoprotein specific for multidrug-resistant cells.

1986 • 290 citations

Molecular and Cellular Biology of Multidrug Resistance in Tumor Cells

1991 • 281 citations

[16] Solubilization of functional membrane proteins

1984 • 272 citations

Characteristics of resistance to adriamycin in human myelogenous leukemia K562 resistant to adriamycin and in isolated clones.

1986 • 231 citations

Mechanism of cross-resistance between vincristine and daunorubicin in Ehrlich ascites tumor cells.

1978 • 231 citations

DNA-mediated transfer of multiple drug resistance and plasma membrane glycoprotein expression.

1982 • 201 citations

Phosphorylation of the Mr 170,000 to 180,000 glycoprotein specific to multidrug-resistant tumor cells: effects of verapamil, trifluoperazine, and phorbol esters.

1987 • 198 citations

Multidrug Resistance of DNA-Mediated Transformants is Linked to Transfer of the Human mdr1 Gene

1986 • 161 citations

Activities of lectins and their immobilized derivatives in detergent solutions. Implications on the use of lectin affinity chromatography for the purification of membrane glycoproteins

1977 • 160 citations

A 22-kd protein (sorcin/V19) encoded by an amplified gene in multidrug-resistant cells, is homologous to the calcium-binding light chain of calpain.

1986 • 137 citations

A method for the direct demonstration of the lectin-binding components of the human erythrocyte membrane

1976 • 126 citations

Alterations in cell surface membranes in chinese hamster lung cells resistant to adriamycin

1982 • 84 citations

[18] Purification of integral membrane proteins

1984 • 61 citations

Determination of membrane antigens by a covalent crosslinking method with monoclonal antibodies

1987 • 28 citations