Differential transport properties of two mdr gene products are distinguished by progesterone.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues.

1987 • 2,788 citations

THE BIOCHEMISTRY OF P-GLYCOPROTEIN-MEDIATED MULTIDRUG RESISTANCE

1989 • 2,060 citations

Expression of a multidrug-resistance gene in human tumors and tissues.

1987 • 1,547 citations

Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil.

1981 • 1,463 citations

The three mouse multidrug resistance (mdr) genes are expressed in a tissue-specific manner in normal mouse tissues.

1989 • 467 citations

Tissue distribution of P-glycoprotein encoded by a multidrug-resistant gene as revealed by a monoclonal antibody, MRK 16.

1988 • 443 citations

An altered pattern of cross-resistance in multidrug-resistant human cells results from spontaneous mutations in the mdr1 (P-glycoprotein) gene

1988 • 430 citations

Reversal of Adriamycin Resistance by Verapamil in Human Ovarian Cancer

1984 • 398 citations

PROGESTERONE AND MAINTENANCE OF PREGNANCY: IS PROGESTERONE NATURE'S IMMUNOSUPPRESSANT?^*

1977 • 350 citations

Identification of the multidrug resistance-related membrane glycoprotein as an acceptor for calcium channel blockers.

1987 • 333 citations

Cyclosporin A reverses vincristine and daunorubicin resistance in acute lymphatic leukemia in vitro.

1986 • 321 citations

Single cell analysis of daunomycin uptake and efflux in multidrug-resistant and -sensitive KB cells: effects of verapamil and other drugs.

1986 • 312 citations

Structure and expression of the human MDR (P-glycoprotein) gene family.

1989 • 296 citations

Progesterone Interacts with P-Glycoprotein in Multidrug-resistant Cells and in the Endometrium of Gravid Uterus

1989 • 290 citations

The gene encoding multidrug resistance is induced and expressed at high levels during pregnancy in the secretory epithelium of the uterus.

1988 • 270 citations

Increased vinblastine binding to membrane vesicles from multidrug-resistant KB cells.

1986 • 255 citations

Potentiation of vincristine and Adriamycin effects in human hemopoietic tumor cell lines by calcium antagonists and calmodulin inhibitors.

1983 • 250 citations

Differential overexpression of three mdr gene family members in multidrug-resistant J774.2 mouse cells

1989 • 241 citations

Structural features determining activity of phenothiazines and related drugs for inhibition of cell growth and reversal of multidrug resistance.

1989 • 217 citations

Most drugs that reverse multidrug resistance also inhibit photoaffinity labeling of P-glycoprotein by a vinblastine analog.

1988 • 211 citations

Two different regions of Phosphoglycoprotein are photoaffinity-labeled by azidopine

1989 • 196 citations

Identification of members of the P-glycoprotein multigene family.

1989 • 195 citations

Transepithelial Transport of Drugs by the Multidrug Transporter in Cultured Madin-Darby Canine Kidney Cell Epithelia

1989 • 191 citations

Reversal of acquired resistance to doxorubicin in P388 murine leukemia cells by tamoxifen and other triparanol analogues.

1984 • 182 citations

Multidrug Resistance

1989 • 166 citations

A phosphoglycoprotein associated with taxol resistance in J774.2 cells.

1985 • 158 citations

Anthracycline resistance in P388 murine leukemia and its circumvention by calcium antagonists.

1985 • 149 citations

Action of calcium antagonists on multidrug resistant cells

1987 • 144 citations

Competitive inhibition by verapamil of ATP-dependent high affinity vincristine binding to the plasma membrane of multidrug-resistant K562 cells without calcium ion involvement.

1989 • 138 citations

Cytoplasmic Orientation and Two-domain Structure of the Multidrug Transporter, P-glycoprotein, Demonstrated with Sequence-specific Antibodies

1989 • 135 citations

Active amino acid transport in plasma membrane vesicles from Simian virus 40-transformed mouse fibroblasts. Characteristics of electrochemical Na+ gradient-stimulated uptake.

1977 • 132 citations

Effects of indole alkaloids on multidrug resistance and labeling of P-glycoprotein by a photoaffinity analog of vinblastine

1988 • 110 citations

Biosynthesis of heterogeneous forms of multidrug resistance-associated glycoproteins.

1987 • 110 citations

Photoaffinity probes for the alpha 1-adrenergic receptor and the calcium channel bind to a common domain in P-glycoprotein.

1990 • 108 citations

Distinct P-glycoprotein precursors are overproduced in independently isolated drug-resistant cell lines.

1988 • 99 citations

Reversal of Vinca alkaloid resistance but not multiple drug resistance in human leukemic cells by verapamil.

1986 • 96 citations

Azidopine photoaffinity labeling of multidrug resistance-associated glycoproteins

1988 • 86 citations

Reversal of acquired resistance to doxorubicin in P388 murine leukemia cells by perhexiline maleate.

1984 • 79 citations

Lysosomotropic agents reverse multiple drug resistance in human cancer cells

1986 • 70 citations

The effect of lysosomotropic agents and secretory inhibitors on anthracycline retention and activity in multiple drug-resistant cells.

1988 • 66 citations

Correlation between reversing of multidrug resistance and inhibiting of [3H]azidopine photolabeling of P-glycoprotein by newly synthesized dihydropyridine analogues in a human cell line.

1989 • 56 citations

Identification of a multidrug resistance associated antigen (P-glycoprotein) in normal human tissues

1988 • 43 citations

Alternate Overexpression of Two Phosphoglycoprotein Genes Is Associated with Changes in Multidrug Resistance in a J774.2 Cell Line

1989 • 42 citations

Use of antibodies to probe membrane glycoproteins associated with drug-resistant J774.2 cells

1987 • 31 citations

Activity of Cyclosporin A and a Non-Immunosuppressive Cyclosporin Against Multidrug Resistant Leukemic Cell Lines

1989 • 27 citations

The products of the la and lb genes from multidrug resistant murine cells have similar degradation rates

1990 • 25 citations

P‐glycoproteins encoded by mdr 1b in murine gravid uterus and multidrug resistant tumor cell lines are differentially glycosylated

1989 • 16 citations

Potentiation of vincristine by vitamin A against drug-resistant mouse leukaemia cells

1987 • 14 citations