Structure of the Multidrug Resistance P-glycoprotein to 2.5 nm Resolution Determined by Electron Microscopy and Image Analysis

ABC Transporters: From Microorganisms to Man

1992 • 3,956 citations

BIOCHEMISTRY OF MULTIDRUG RESISTANCE MEDIATED BY THE MULTIDRUG TRANSPORTER

1993 • 3,515 citations

Structure of the protein subunits in the photosynthetic reaction centre of Rhodopseudomonas viridis at 3Å resolution

1985 • 3,049 citations

Crystal structure of an integral membrane light-harvesting complex from photosynthetic bacteria

1995 • 2,683 citations

AREAS, VOLUMES, PACKING, AND PROTEIN STRUCTURE

1977 • 2,631 citations

Structure at 2.8 Å resolution of cytochrome c oxidase from Paracoccus denitrificans

1995 • 1,991 citations

Small-volume extrusion apparatus for preparation of large, unilamellar vesicles

1991 • 1,461 citations

Structural model of ATP-binding proteing associated with cystic fibrosis, multidrug resistance and bacterial transport

1990 • 1,149 citations

Static and dynamic lipid asymmetry in cell membranes

1991 • 796 citations

Is the multidrug transporter a flippase?

1992 • 720 citations

Use of multivariate statistics in analysing the images of biological macromolecules

1981 • 579 citations

Three‐dimensional reconstruction from a single‐exposure, random conical tilt series applied to the 50S ribosomal subunit of Escherichia coli

1987 • 500 citations

Three‐Dimensional reconstruction of single particles from random and nonrandom tilt series

1988 • 497 citations

Fluorescent cellular indicators are extruded by the multidrug resistance protein.

1993 • 496 citations

A method for the determination of inorganic phosphate in the presence of labile organic phosphate and high concentrations of protein: Application to lens ATPases

1988 • 480 citations

Three-dimensional reconstruction of single particles embedded in ice

1992 • 463 citations

An altered pattern of cross-resistance in multidrug-resistant human cells results from spontaneous mutations in the mdr1 (P-glycoprotein) gene

1988 • 430 citations

Computer Averaging of Electron Micrographs of 40 S Ribosomal Subunits

1981 • 377 citations

CRISP: crystallographic image processing on a personal computer

1992 • 375 citations

Location of a folding protein and shape changes in GroEL–GroES complexes imaged by cryo-electron microscopy

1994 • 334 citations

SPIDER—A modular software system for electron image processing

1981 • 287 citations

Membrane Topology of a Cysteine-less Mutant of Human P-glycoprotein

1995 • 252 citations

Mechanisms of membrane protein insertion into liposomes during reconstitution procedures involving the use of detergents. 2. Incorporation of the light-driven proton pump bacteriorhodopsin

1988 • 250 citations

ATPase activity of purified and reconstituted P-glycoprotein from Chinese hamster ovary cells.

1994 • 235 citations

Characterization of the ATPase activity of P-glycoprotein from multidrug-resistant Chinese hamster ovary cells

1995 • 215 citations

Detergent structure in crystals of a bacterial photosynthetic reaction centre

1989 • 212 citations

Major photoaffinity drug labeling sites for iodoaryl azidoprazosin in P-glycoprotein are within, or immediately C-terminal to, transmembrane domains 6 and 12

1993 • 194 citations

Structural model of the nucleotide-binding conserved component of periplasmic permeases.

1991 • 183 citations

Characteristic views of E. coli and B. stearothermophilus 30S ribosomal subunits in the electron microscope.

1985 • 177 citations

Motif detection in quantum noise-limited electron micrographs by cross-correlation

1976 • 175 citations

Spider—A modular software system for electron image processing

1981 • 174 citations

Three-dimensional reconstruction of the 70S Escherichia coli ribosome in ice: the distribution of ribosomal RNA.

1991 • 171 citations

ATPase activity of partially purified P-glycoprotein from multidrug-resistant Chinese hamster ovary cells

1992 • 147 citations

Molecular basis of preferential resistance to colchicine in multidrug-resistant human cells conferred by Gly-185----Val-185 substitution in P-glycoprotein.

1990 • 143 citations

Synthetic and natural opiates interact with P-glycoprotein in multidrug-resistant cells

1993 • 142 citations

Secondary and Tertiary Structure Changes of Reconstituted P-glycoprotein

1996 • 141 citations

Active amino acid transport in plasma membrane vesicles from Simian virus 40-transformed mouse fibroblasts. Characteristics of electrochemical Na+ gradient-stimulated uptake.

1977 • 132 citations

Crystal structure of the annexin XII hexamer and implications for bilayer insertion

1995 • 128 citations

Stoichiometry of recombinant cystic fibrosis transmembrane conductance regulator in epithelial cells and its functional reconstitution into cells in vitro.

1994 • 122 citations

P-glycoprotein possesses A 1,4-dihydropyridine-selective drug acceptor site which is alloserically coupled to a vinca-alkaloid-selective binding site

1992 • 121 citations

Three-dimensional structure of photosystem II

1993 • 118 citations

Classification of macromolecular assemblies studied as ‘single particles’

1990 • 113 citations

Interaction of tamoxifen with the multidrug resistance P-glycoprotein

1995 • 110 citations

[2] Statistical image analysis of electron micrographs of ribosomal subunits

1988 • 94 citations

Membrane Topology of P-Glycoprotein As Determined by Epitope Insertion: Transmembrane Organization of the N-Terminal Domain of mdr3

1995 • 86 citations

Membrane solubilization by detergent: use of brominated phospholipids to evaluate the detergent-induced changes in calcium-ATPase/lipid interaction

1989 • 82 citations

The ATP-binding component of a prokaryotic traffic ATPase is exposed to the periplasmic (external) surface.

1993 • 69 citations

Dimerization of the P-glycoprotein in membranes

1990 • 57 citations

The Minimum Functional Unit of Human P-glycoprotein Appears to be a Monomer

1996 • 55 citations

Ion channels: a practical approach

1997 • 55 citations

Detection of Oligomeric and Monomeric Forms of P-glycoprotein in Multidrug Resistant Cells

1994 • 49 citations

[1] Studying ribosome structure by electron microscopy and computer-image processing

1988 • 48 citations

Photosystem II 3-D structure and the role of the extrinsic subunits in photosynthetic oxygen evolution

1995 • 42 citations

Ion Channels, a Practical Approach

1996 • 37 citations

Functionally active homodimer of P-glycoprotein in multidrug-resistant tumor cells

1992 • 35 citations

The MalK protein of the ATP-binding cassette transporter for maltose of Escherichia coli is accessible to protease digestion from the periplasmic side of the membrane

1995 • 29 citations

Three-dimensional structure of 50 S Escherichia coli ribosomal subunits depleted of proteins L7/L12

1988 • 23 citations