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“Western Blotting”: Electrophoretic transfer of proteins from sodium dodecyl sulfate-polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A

1981 • 8,657 citations

Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold.

1982 • 5,284 citations

THE BIOCHEMISTRY OF P-GLYCOPROTEIN-MEDIATED MULTIDRUG RESISTANCE

1989 • 2,060 citations

Reversible binding of Pi by beef heart mitochondrial adenosine triphosphatase.

1977 • 1,579 citations

The principles and practice of oncology

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Detection of P-glycoprotein in multidrug-resistant cell lines by monoclonal antibodies

1985 • 927 citations

The multidrug transporter, a double-edged sword.

1988 • 763 citations

Inorganic and organic phosphate measurements in the nanomolar range

1987 • 726 citations

Mechanism of multidrug resistance

1988 • 630 citations

Expression of the human multidrug resistance cDNA in insect cells generates a high activity drug-stimulated membrane ATPase.

1992 • 629 citations

Structure and function of vacuolar class of ATP-driven proton pumps

1989 • 600 citations

A characterization of vanadate interactions with the (Na,K)-ATPase. Mechanistic and regulatory implications.

1978 • 520 citations

P‐glycoprotein: multidrug‐resistance and a superfamily of membrane‐associated transport proteins

1989 • 512 citations

ATP-dependent transport of vinblastine in vesicles from human multidrug-resistant cells.

1988 • 480 citations

Mechanism of Calcium Transport

1985 • 453 citations

Genetic and biochemical characterization of multidrug resistance

1985 • 405 citations

Purification of P-glycoprotein from plasma membrane vesicles of Chinese hamster ovary cell mutants with reduced colchicine permeability.

1979 • 368 citations

Binding of Adenosine Triphosphate to Sodium and Potassium Ion-stimulated Adenosine Triphosphatase

1971 • 349 citations

Purification of the 170- to 180-kilodalton membrane glycoprotein associated with multidrug resistance. 170- to 180-kilodalton membrane glycoprotein is an ATPase.

1988 • 340 citations

The function of Gp170, the multidrug resistance gene product, in rat liver canalicular membrane vesicles

1989 • 329 citations

Pleiotropic phenotype of colchicine‐resistant CHO cells: Cross‐resistance and collateral sensitivity

1976 • 314 citations

Discrete mutations introduced in the predicted nucleotide-binding sites of the mdr1 gene abolish its ability to confer multidrug resistance.

1989 • 303 citations

Adenine nucleotide binding sites on beef heart F1-ATPase. Evidence for three exchangeable sites that are distinct from three noncatalytic sites.

1982 • 282 citations

Isolation and biochemical characterization of folate deficient mutants of chinese hamster cells

1974 • 277 citations

[59] Inhibitors of the ATP synthetase systems

1979 • 256 citations

Stimulation of rat liver mitochondrial adenosine triphosphatase by anions.

1975 • 253 citations

Cloning and Expression of a cDNA Coding for a Rat Liver Plasma Membrane Ecto-ATPase

1989 • 240 citations

Vanadate inhibition of sarcoplasmic reticulum Ca2+-ATPase and other ATPases

1979 • 216 citations

The Mitochondrial ATPase

1975 • 215 citations

ATP‐binding properties of P glycoprotein from multidrug‐resistant KB cells

1987 • 207 citations

Interaction of calcium and magnesium in activating and inhibiting the nucleoside triphosphatase of sarcoplasmic reticulum vesicles

1975 • 189 citations

P-glycoprotein and resistance to anticancer drugs

1992 • 182 citations

The reactivity of SH groups with a fluorogenic reagent

1970 • 177 citations

Characterization of the ATPase activity of the Mr 170,000 to 180,000 membrane glycoprotein (P-glycoprotein) associated with multidrug resistance in K562/ADM cells.

1988 • 176 citations

Pyridoxal phosphate. An anionic probe for protein amino groups exposed on the outer and inner surfaces of intact human red blood cells.

1975 • 149 citations

Formation and Decomposition of a Phosphorylated Intermediate in the Reaction of Na+-K+ Dependent ATPase*

1970 • 148 citations

Role of water in the energy of hydrolysis of phosphate compounds — energy transduction in biological membranes

1989 • 148 citations

The Mitochondrial ATPase. Selective Modification of a Nitrogen Residue in the beta Subunit

1975 • 138 citations

Adenine nucleotide binding sites on beef heart F1 ATPase: photoaffinity labeling of beta-subunit Tyr-368 at a noncatalytic site and beta Tyr-345 at a catalytic site.

1987 • 137 citations

Cytoplasmic Orientation and Two-domain Structure of the Multidrug Transporter, P-glycoprotein, Demonstrated with Sequence-specific Antibodies

1989 • 135 citations

Photosensitization of mitochondrial cytochrome c oxidase by hematoporphyrin derivative and related porphyrins in vitro and in vivo.

1983 • 131 citations

Cysteine 254 of the 73-kDa A subunit is responsible for inhibition of the coated vesicle (H+)-ATPase upon modification by sulfhydryl reagents.

1992 • 124 citations

Expression of the human multidrug transporter in insect cells by a recombinant baculovirus

1990 • 119 citations

Multidrug Resistance and Chemosensitization: Therapeutic Implications for Cancer Chemotherapy

1990 • 116 citations

Unique Enzymes of Purified Microsomes From Pig Fundic Mucosa

1975 • 111 citations

Biosynthesis of heterogeneous forms of multidrug resistance-associated glycoproteins.

1987 • 110 citations

Omeprazole, a specific inhibitor of gastric (H+-K+)-ATPase, is a H+-activated oxidizing agent of sulfhydryl groups.

1985 • 104 citations

Tautomerism of 2-azidoadenine nucleotides Effects on enzyme kinetics and photoaffinity labeling

1984 • 90 citations

Reaction of (sodium(1+)-potassium(1+) ion)-activated ATPase with 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole: evidence for an essential tyrosine at the active site

1978 • 85 citations

Nucleotide and divalent cation interactions with the ()-dependent ATPase

1974 • 78 citations

Steady state kinetics of soluble and membrane-bound mitochondrial ATPase

1971 • 78 citations

Functional reconstitution of prokaryote and eukaryote membrane proteins

1989 • 76 citations

Studies on the phosphorylated intermediates of a K+-stimulated ATPase from rabbit gastric mucosa

1976 • 73 citations

P-glycoprotein. ATP hydrolysis by the N-terminal nucleotide-binding domain.

1992 • 69 citations

Functional reassembly of the coated vesicle proton pump.

1990 • 68 citations

Inhibition of proton-translocating ATPases of Streptococcus mutans and Lactobacillus casei by fluoride and aluminum

1990 • 68 citations

Specific Alkylation of the Sarcoplasmic Reticulum ATPase by N‐Ethyl‐[1‐¹⁴C]maleimide and Identification of the Labeled Protein in Acrylamide Gel‐Electrophoresis

1970 • 66 citations

Complete cDNA sequences encoding the Chinese hamster P-glycoprotein gene family

1991 • 57 citations

Electrophoretic Analysis of P-glycoproteins Produced by Mouse J774.2 and Chinese Hamster Ovary Multidrug-Resistant Cells

1988 • 56 citations

Functional effects and cross-reactivity of antibody to purified subunit b (uncF protein) of Escherichia coli proton-ATPase

1985 • 47 citations

Equilibrium, kinetic and photoaffinity labeling studies of daunomycin binding to P‐glycoprotein‐containing membranes of multidrug‐resistant Chinese hamster ovary cells

1989 • 39 citations

Inhibition of sarcoplasmic reticulum Ca2+-ATPase by Mg2+ at high pH.

1988 • 36 citations

ATP and GTP as alternative energy sources for vinblastine transport by P‐170 in KB‐V1 plasma membrane vesicles

1992 • 36 citations

Effect of temperature on phosphorylation and ouabain binding to N-ethylmaleimide-treated (Na+, K+)-ATPase.

1978 • 34 citations

Effects of dimethyl sulfoxide on catalysis in Escherichia coli F1-ATPase

1992 • 34 citations

Directed mutagenesis of the strongly conserved aspartate 242 in the beta-subunit of Escherichia coli proton-ATPase.

1988 • 32 citations

ATPase and phosphatase activities from human red cell membranes: I. The effects of N-ethylmaleimide

1977 • 31 citations

Some properties of a Ca²⁺- and (or) Mg²⁺-requiring nucleoside di- and tri-phosphatase(s) associated with the membranes of rat pancreatic zymogen granules

1978 • 28 citations

Studies on the phosphorylated intermediates of A K+-stimulated ATPase from rabbit gastric mucosa

1976 • 25 citations

[9] Drug-resistant mutants: Selection and dominance analysis

1987 • 11 citations

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