Cardiac Ionic Currents and Acute Ischemia: From Channels to Arrhythmias

The Structure of the Potassium Channel: Molecular Basis of K ⁺ Conduction and Selectivity

1998 • 6,595 citations

Inositol trisphosphate and calcium signalling

1993 • 6,546 citations

Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly

1996 • 5,498 citations

The mitochondrial permeability transition

1995 • 2,412 citations

A mechanistic link between an inherited and an acquird cardiac arrthytmia: HERG encodes the IKr potassium channel

1995 • 2,391 citations

Currents carried by sodium and potassium ions through the membrane of the giant axon of Loligo

1952 • 2,384 citations

ATP-regulated K+ channels in cardiac muscle

1983 • 2,350 citations

Coassembly of KVLQT1 and minK (IsK) proteins to form cardiac IKS potassium channel

1996 • 1,741 citations

Reconstitution of I _KATP : An Inward Rectifier Subunit Plus the Sulfonylurea Receptor

1995 • 1,703 citations

Bell-shaped calcium-response curves of lns(l,4,5)P3- and calcium-gated channels from endoplasmic reticulum of cerebellum

1991 • 1,699 citations

Excitation-Contraction Coupling and Cardiac Contractile Force

2010 • 1,661 citations

KvLQT1 and IsK (minK) proteins associate to form the IKS cardiac potassium current

1996 • 1,585 citations

Two components of cardiac delayed rectifier K+ current. Differential sensitivity to block by class III antiarrhythmic agents.

1990 • 1,467 citations

Cloning of the β Cell High-Affinity Sulfonylurea Receptor: a Regulator of Insulin Secretion

1995 • 1,310 citations

Different modes of Ca channel gating behaviour favoured by dihydropyridine Ca agonists and antagonists

1984 • 1,292 citations

Stationary and drifting spiral waves of excitation in isolated cardiac muscle

1992 • 1,221 citations

Type-Specific Regulation of Adenylyl Cyclase by G Protein βγ Subunits

1991 • 1,076 citations

A new class of ligand-gated ion channel defined by P2X receptor for extracellular ATP

1994 • 1,039 citations

Cardioprotective Effect of Diazoxide and Its Interaction With Mitochondrial ATP-Sensitive K ⁺ Channels

1997 • 1,032 citations

Primary structure and functional expression of a mouse inward rectifier potassium channel

1993 • 1,004 citations

Regulation and modulation of calcium channels in cardiac, skeletal, and smooth muscle cells

1994 • 998 citations

Electrophysiological mechanisms of ventricular arrhythmias resulting from myocardial ischemia and infarction

1989 • 995 citations

A family of hyperpolarization-activated mammalian cation channels

1998 • 945 citations

Ryanodine Receptor/Ca2+ Release Channels and Their Regulation by Endogenous Effectors

1994 • 908 citations

Time and calcium dependence of activation and inactivation of calcium-induced release of calcium from the sarcoplasmic reticulum of a skinned canine cardiac Purkinje cell.

1985 • 904 citations

Direct activation of inward rectifier potassium channels by PIP2 and its stabilization by Gβγ

1998 • 886 citations

THE CELLULAR AND MOLECULAR RESPONSE OF CARDIAC MYOCYTES TO MECHANICAL STRESS

1997 • 876 citations

Potassium channel block by cytoplasmic polyamines as the mechanism of intrinsic rectification

1994 • 847 citations

Direct activation of cardiac pacemaker channels by intracellular cyclic AMP

1991 • 832 citations

The G-protein-gated atrial K+ channel IKAch is a heteromultimer of two inwardly rectifying K+-channel proteins

1995 • 830 citations

Mitochondrial non-specific pores remain closed during cardiac ischaemia, but open upon reperfusion

1995 • 830 citations

Ionic Remodeling Underlying Action Potential Changes in a Canine Model of Atrial Fibrillation

1997 • 809 citations

Contribution of two types of calcium currents to the pacemaker potentials of rabbit sino‐atrial node cells.

1988 • 780 citations

Role of intracellular Na+ in Ca2+ overload and depressed recovery of ventricular function of reperfused ischemic rat hearts. Possible involvement of H+-Na+ and Na+-Ca2+ exchange.

1989 • 755 citations

Defective Excitation-Contraction Coupling in Experimental Cardiac Hypertrophy and Heart Failure

1997 • 754 citations

ATP-sensitive K+ channel in the mitochondrial inner membrane

1991 • 746 citations

A novel type of cardiac calcium channel in ventricular cells

1985 • 745 citations

Mitochondria Are Excitable Organelles Capable of Generating and Conveying Electrical and Calcium Signals

1997 • 739 citations

Heterogeneity within the ventricular wall. Electrophysiology and pharmacology of epicardial, endocardial, and M cells.

1991 • 731 citations

Molecular characterization of a neuronal low-voltage-activated T-type calcium channel

1998 • 722 citations

Alterations of K+ currents in isolated human ventricular myocytes from patients with terminal heart failure.

1993 • 717 citations

Two kinds of calcium channels in canine atrial cells. Differences in kinetics, selectivity, and pharmacology.

1985 • 715 citations

Inward current channels activated by intracellular Ca in cultured cardiac cells

1981 • 687 citations

Mechanical stretch rapidly activates multiple signal transduction pathways in cardiac myocytes: potential involvement of an autocrine/paracrine mechanism.

1993 • 678 citations

Early afterdepolarizations: mechanism of induction and block. A role for L-type Ca2+ current.

1989 • 675 citations

Cardiac pacemaking in the sinoatrial node

1993 • 665 citations

Ionic Mechanisms of Propagation in Cardiac Tissue

1997 • 659 citations

Regulation of Cardiac Na ⁺ ,Ca ²⁺ Exchange and K _ATP Potassium Channels by PIP ₂

1996 • 655 citations

Identification of sodium‐calcium exchange current in single ventricular cells of guinea‐pig.

1987 • 625 citations

Characteristics of the Delayed Rectifier Current (I_Krand I_Ks) in Canine Ventricular Epicardial, Midmyocardial, and Endocardial Myocytes

1995 • 605 citations

Flow of "injury" current and patterns of excitation during early ventricular arrhythmias in acute regional myocardial ischemia in isolated porcine and canine hearts. Evidence for two different arrhythmogenic mechanisms.

1980 • 604 citations

Ohmic conductance through the inwardly rectifying K channel and blocking by internal Mg2+

1987 • 597 citations

Reperfusion-induced arrhythmias: Mechanisms and prevention

1984 • 574 citations

Membrane Phospholipid Control of Nucleotide Sensitivity of K _ATP Channels

1998 • 569 citations

Sustained depolarization-induced outward current in human atrial myocytes. Evidence for a novel delayed rectifier K+ current similar to Kv1.5 cloned channel currents.

1993 • 568 citations

How does adrenaline accelerate the heart?

1979 • 563 citations

Conductance properties of single inwardly rectifying potassium channels in ventricular cells from guinea‐pig heart.

1984 • 560 citations

Sodium Current-Induced Release of Calcium from Cardiac Sarcoplasmic Reticulum

1990 • 559 citations

Ryanodine modifies conductance and gating behavior of single Ca2+ release channel

1987 • 548 citations

The control of calcium release in heart muscle

1995 • 547 citations

Fractional SR Ca release is regulated by trigger Ca and SR Ca content in cardiac myocytes

1995 • 545 citations

CALCIUM CHANNELS: Mechanisms of Selectivity, Permeation, and Block

1987 • 528 citations

PIP ₂ and PIP as Determinants for ATP Inhibition of K _ATP Channels

1998 • 517 citations

Cloning of a Membrane Protein That Induces a Slow Voltage-Gated Potassium Current

1988 • 511 citations

α ₁ -Adrenergic Receptor Subtypes

1996 • 509 citations

Fatty acid homeostasis in the normoxic and ischemic heart

1992 • 506 citations

Inward rectification of a potassium channel in cardiac ventricular cells depends on internal magnesium ions.

1987 • 495 citations

Rapid calcium release from cardiac sarcoplasmic reticulum vesicles is dependent on Ca2+ and is modulated by Mg2+, adenine nucleotide, and calmodulin.

1987 • 489 citations

Ca2+ current is regulated by cyclic GMP-dependent protein kinase in mammalian cardiac myocytes.

1991 • 475 citations

Nitric oxide regulates cardiac Ca2+ current. Involvement of cGMP-inhibited and cGMP-stimulated phosphodiesterases through guanylyl cyclase activation.

1993 • 473 citations

Activation of the cloned muscarinic potassium channel by G protein βγ subunits

1994 • 472 citations

Acetylcholine activation of single muscarinic K+ channels in isolated pacemaker cells of the mammalian heart

1983 • 471 citations

The steady state TTX-sensitive (?window?) sodium current in cardiac Purkinje fibres

1979 • 468 citations

Molecular identification of a hyperpolarization-activated channel in sea urchin sperm

1998 • 464 citations

Effects of Atrial Dilatation on Refractory Period and Vulnerability to Atrial Fibrillation in the Isolated Langendorff-Perfused Rabbit Heart

1997 • 461 citations

Regional Differences in Current Density and Rate-Dependent Properties of the Transient Outward Current in Subepicardial and Subendocardial Myocytes of Human Left Ventricle

1996 • 459 citations

Regulation of fast inactivation of cloned mammalian IK(A) channels by cysteine oxidation

1991 • 454 citations

A neuronal two P domain K+ channel stimulated by arachidonic acid and polyunsaturated fatty acids

1998 • 453 citations

Regulation of Calcium Release Is Gated by Calcium Current, Not Gating Charge, in Cardiac Myocytes

1989 • 451 citations

Redox modulation of L-type calcium channels in ferret ventricular myocytes. Dual mechanism regulation by nitric oxide and S-nitrosothiols.

1996 • 444 citations

Molecular identification of a volume-regulated chloride channel

1997 • 443 citations

Extracellular Potassium Modulation of Drug Block of I _Kr

1996 • 437 citations

Mode of regulation of the ACh-sensitive K-channel by the muscarinic receptor in rabbit atrial cells

1984 • 436 citations

Role of the Kv4.3 K ⁺ Channel in Ventricular Muscle

1996 • 434 citations

Electrophysiological effects of myocardial stretch and mechanical determinants of stretch-activated arrhythmias.

1992 • 418 citations

Protective effects of HOE642, a selective sodium-hydrogen exchange subtype 1 inhibitor, on cardiac ischaemia and reperfusion

1995 • 413 citations

Coupling of ATP-sensitive K+ channels to A1 receptors by G proteins in rat ventricular myocytes

1990 • 409 citations

Ion channel regulation by G proteins

1995 • 408 citations

Resting membrane potential, extracellular potassium activity, and intracellular sodium activity during acute global ischemia in isolated perfused guinea pig hearts.

1983 • 407 citations

The oxygen free radical system: from equations through membrane-protein interactions to cardiovascular injury and protection

1992 • 400 citations

A Cellular Mechanism for the Generation of Ventricular Arrhythmias by Acetylstrophanthidin

1973 • 393 citations

Glycolysis Preferentially Inhibits ATP-Sensitive K ⁺ Channels in Isolated Guinea Pig Cardiac Myocytes

1987 • 391 citations

Ionic basis of transient inward current induced by strophanthidin in cardiac Purkinje fibres.

1978 • 389 citations

Suppression of voltage-gated L-type Ca ²⁺ currents by polyunsaturated fatty acids in adult and neonatal rat ventricular myocytes

1997 • 384 citations

Alpha adrenergic contributions to dysrhythmia during myocardial ischemia and reperfusion in cats.

1980 • 377 citations

cAMP increases junctional conductance and stimulates phosphorylation of the 27-kDa principal gap junction polypeptide.

1986 • 374 citations

Na-Ca exchange current in mammalian heart cells

1986 • 370 citations

Adenosine: electrophysiologic effects and therapeutic use for terminating paroxysmal supraventricular tachycardia.

1983 • 370 citations

Modulation of Mitochondrial ATP-Dependent K ⁺ Channels by Protein Kinase C

1998 • 368 citations

Intracellular Na+ activates a K+ channel in mammalian cardiac cells

1984 • 358 citations

Electrical uncoupling and increase of extracellular resistance after induction of ischemia in isolated, arterially perfused rabbit papillary muscle.

1987 • 357 citations

Opposite voltage gating polarities of two closely related onnexins

1994 • 353 citations

Rapid Adaptation of Cardiac Ryanodine Receptors: Modulation by Mg ²⁺ and Phosphorylation

1995 • 349 citations

Primary structure and functional expression from cDN A of the cardiac ryanodine receptor/calcium release channel

1990 • 347 citations

Identity of a novel delayed rectifier current from human heart with a cloned K+ channel current.

1993 • 345 citations

Properties of adenosine‐triphosphate‐regulated potassium channels in guinea‐pig ventricular cells.

1985 • 344 citations

Protons in ischemia: Where do they come from; Where do they go to?

1991 • 343 citations

VDAC channels mediate and gate the flow of ATP: implications for the regulation of mitochondrial function

1997 • 337 citations

Conductance and kinetics of delayed rectifier potassium channels in nodal cells of the rabbit heart.

1987 • 334 citations

Inward-rectifying channels in isolated patches of the heart cell membrane: ATP-dependence and comparison with cell-attached patches

1984 • 333 citations

Volume-sensitive anion channels mediate swelling-activated inositol and taurine efflux

1993 • 331 citations

Potassium Channels in Cardiac Cells Activated by Arachidonic Acid and Phospholipids

1989 • 329 citations

Ryanodine Receptor Adaptation: Control Mechanism of Ca ²⁺ -Induced Ca ²⁺ Release in Heart

1993 • 328 citations

Blocking effects of polyunsaturated fatty acids on Na+ channels of neonatal rat ventricular myocytes.

1995 • 327 citations

Mechanisms underlying early and delayed afterdepolarizations induced by catecholamines

1990 • 323 citations

Regulation of a Heart Potassium Channel by Protein Kinase A and C

1988 • 317 citations

Voltage- and time-dependent block of the delayed K+ current in cardiac myocytes by dofetilide.

1992 • 316 citations

Dependence of junctional conductance on proton, calcium and magnesium ions in cardiac paired cells of guinea‐pig.

1987 • 316 citations

Direct measurement of changes in intracellular calcium transients during hypoxia, ischemia, and reperfusion of the intact mammalian heart.

1989 • 316 citations

Structure-activity relations of the cardiac gap junction channel

1990 • 312 citations

The regulation of the intracellular pH in cells from vertebrates

1988 • 311 citations

Long-chain fatty acids activate calcium channels in ventricular myocytes.

1992 • 310 citations

Cardiac ATP-sensitive K+ channels: regulation by intracellular nucleotides and K+ channel-opening drugs

1995 • 309 citations

Effect of intracellular injection of calcium and strontium on cell communication in heart.

1975 • 307 citations

Beta-adrenergic stimulation of calcium channels occurs by potentiation of high-activity gating modes.

1990 • 307 citations

Rapid β-Adrenergic Modulation of Cardiac Calcium Channel Currents by a Fast G Protein Pathway

1989 • 307 citations

Adrenaline and the plateau phase of the cardiac action potential

1969 • 306 citations

Slow ventricular conduction in mice heterozygous for a connexin43 null mutation.

1997 • 305 citations

Control of rectification and permeation by residues in two distinct domains in an inward rectifier K+ channel

1995 • 304 citations

Protein kinase A‐dependent and ‐independent stimulation of exocytosis by cAMP in mouse pancreatic B‐cells

1997 • 302 citations

Arachidonic acid metabolites as intracellular modulators of the G protein-gated cardiac K+ channel

1989 • 299 citations

Nucleotide modulation of the activity of rat heart ATP‐sensitive K+ channels in isolated membrane patches.

1989 • 297 citations

On the involvement of a cyclosporin A sensitive mitochondrial pore in myocardial reperfusion injury

1993 • 295 citations

Characterization of two distinct depolarization-activated K+ currents in isolated adult rat ventricular myocytes.

1991 • 295 citations

Structure and function of voltage-dependent sodium channels: comparison of brain II and cardiac isoforms

1996 • 292 citations

Myocardial extracellular K+ and H+ increase and noradrenaline release as possible cause of early arrhythmias following acute coronary artery occlusion in pigs

1980 • 291 citations

Single cardiac sarcoplasmic reticulum Ca2+-release channel: activation by caffeine

1989 • 288 citations

Class III Antiarrhythmic Drugs Block HERG, a Human Cardiac Delayed Rectifier K ⁺ Channel

1996 • 288 citations

Phosphorylation Modulates the Function of the Calcium Release Channel of Sarcoplasmic Reticulum from Cardiac Muscle

1995 • 286 citations

Hypoxia increases persistent sodium current in rat ventricular myocytes.

1996 • 283 citations

On the mechanism of muscarinic inhibition of the cardiac Ca current

1986 • 283 citations

Lysophospholipids modulate channel function by altering the mechanical properties of lipid bilayers.

1994 • 282 citations

Mitochondrial membrane potential in single living adult rat cardiac myocytes exposed to anoxia or metabolic inhibition.

1995 • 281 citations

Paradoxical Improvement of Impulse Conduction in Cardiac Tissue by Partial Cellular Uncoupling

1997 • 279 citations

Calcium-activated chloride current in rabbit ventricular myocytes.

1991 • 279 citations

Essential Ca ²⁺ -Binding Motif for Ca ²⁺ -Sensitive Inactivation of L-Type Ca ²⁺ Channels

1995 • 278 citations

Ionic basis of the electrophysiological actions of adenosine on cardiomyocytes

1995 • 278 citations

Isolated atrial myocytes: adenosine and acetylcholine increase potassium conductance

1983 • 277 citations

Muscarinic Modulation of Cardiac Rate at Low Acetylcholine Concentrations

1989 • 277 citations

Stretch-induced arrhythmias in the isolated canine ventricle. Evidence for the importance of mechanoelectrical feedback.

1990 • 276 citations

Two periods of early ventricular arrhythmia in the canine acute myocardial infarction model.

1979 • 276 citations

Chloride conductance regulated by cyclic AMP-dependent protein kinase in cardiac myocytes

1989 • 271 citations

Voltage‐dependent inactivation of inward‐rectifying single‐channel currents in the guinea‐pig heart cell membrane.

1984 • 271 citations

A rapidly activating and slowly inactivating potassium channel cloned from human heart. Functional analysis after stable mammalian cell culture expression.

1993 • 265 citations

Tissue osmolality, cell swelling, and reperfusion in acute regional myocardial ischemia in the isolated porcine heart.

1981 • 264 citations

Effects of protein kinase C activators on cardiac Ca2+ channels

1988 • 264 citations

A nuclear magnetic resonance study of metabolism in the ferret heart during hypoxia and inhibition of glycolysis.

1985 • 264 citations

Intramolecular interactions mediate pH regulation of connexin43 channels

1996 • 263 citations

Regulation of the gating of cystic fibrosis transmembrane conductance regulator C1 channels by phosphorylation and ATP hydrolysis.

1994 • 262 citations

Characterization of single pacemaker channels in cardiac sino-atrial node cells

1986 • 262 citations

The mitochondrial megachannel is the permeability transition pore

1992 • 262 citations

Regional variations in action potentials and transient outward current in myocytes isolated from rabbit left ventricle.

1991 • 261 citations

Changes in conduction velocity during acute ischemia in ventricular myocardium of the isolated porcine heart.

1986 • 258 citations

Hypoxia-Induced Inhibition of Adenosine Kinase Potentiates Cardiac Adenosine Release

1997 • 257 citations

Characterization of a transient outward K⁺ current with inward rectification in canine ventricular myocytes

1998 • 256 citations

An imbalance between glycolysis and glucose oxidation is a possible explanation for the detrimental effects of high levels of fatty acids during aerobic reperfusion of ischemic hearts.

1993 • 256 citations

[Na] and [K] dependence of the Na/K pump current-voltage relationship in guinea pig ventricular myocytes.

1989 • 254 citations

ATP-sensitive potassium channel modulation of the guinea pig ventricular action potential and contraction.

1991 • 254 citations

Gating of inwardly rectifying K+ channels localized to a single negatively charged residue

1994 • 253 citations

Inward sodium current at resting potentials in single cardiac myocytes induced by the ischemic metabolite lysophosphatidylcholine.

1992 • 247 citations

Phorbol ester increases calcium current and simulates the effects of angiotensin II on cultured neonatal rat heart myocytes.

1988 • 245 citations

Mechanism of Ca2+-sensitive inactivation of L-type Ca2+ channels

1994 • 245 citations

Electrogenic Suppression of Automaticity in Sheep and Dog Purkinje Fibers

1970 • 244 citations

Slow currents through single sodium channels of the adult rat heart.

1985 • 242 citations

Effects of pH on Na+-Ca2+ exchange in canine cardiac sarcolemmal vesicles.

1982 • 242 citations

Redox modification of sodium-calcium exchange activity in cardiac sarcolemmal vesicles.

1986 • 242 citations

Effect of tetrodotoxin on action potentials of the conducting system in the dog heart

1979 • 241 citations

Alterations in canine myocardial excitability during ischemia.

1977 • 241 citations

Voltage dependence of Na/K pump current in isolated heart cells

1985 • 240 citations

Effect of some free radical scavengers on reperfusion induced arrhythmias in the isolated rat heart

1985 • 240 citations

Open‐state substructure of inwardly rectifying potassium channels revealed by magnesium block in guinea‐pig heart cells.

1988 • 239 citations

The Ib Phase of Ventricular Arrhythmias in Ischemic In Situ Porcine Heart Is Related to Changes in Cell-to-Cell Electrical Coupling

1995 • 239 citations

Cardiac Na currents and the inactivating, reopening, and waiting properties of single cardiac Na channels.

1985 • 239 citations

Cloning and functional expression in yeast of two human isoforms of the outer mitochondrial membrane channel, the voltage-dependent anion channel.

1993 • 239 citations

Rapid and slow components of delayed rectifier current in human atrial myocytes

1994 • 236 citations

Role of bicarbonate in pH recovery from intracellular acidosis in the guinea‐pig ventricular myocyte.

1992 • 236 citations

Using gadolinium to identify stretch-activated channels: technical considerations

1998 • 236 citations

Intracellular calcium-release channels: regulators of cell life and death

1997 • 236 citations

Extracellular K+ specifically modulates a rat brain K+ channel.

1992 • 235 citations

Characteristics of transient outward current in human ventricular myocytes from patients with terminal heart failure.

1993 • 233 citations

Modulation of the mitochondrial megachannel by divalent cations and protons.

1992 • 232 citations

Low-Flow Ischemia Leads to Translocation of Canine Heart GLUT-4 and GLUT-1 Glucose Transporters to the Sarcolemma In Vivo

1997 • 232 citations

Heterogeneity of action potential waveforms and potassium currents in rat ventricle

1993 • 232 citations

Patch-clamping of the inner mitochondrial membrane reveals a voltage-dependent ion channel

1987 • 232 citations

Differences between outward currents of human atrial and subepicardial ventricular myocytes.

1996 • 231 citations

Relation Between the Sarcolemmal Ca ²⁺ Current and Ca ²⁺ Sparks and Local Control Theories for Cardiac Excitation-Contraction Coupling

1996 • 231 citations

Ionic selectivity, saturation, and block in a K+-selective channel from sarcoplasmic reticulum.

1980 • 230 citations

Cytosolic Free Magnesium Levels in Ischemic Rat Heart

1989 • 230 citations

Voltage dependence of Na translocation by the Na/K pump

1986 • 230 citations

Cardiac ATP-sensitive K+ channels. Evidence for preferential regulation by glycolysis.

1989 • 230 citations

Potassium accumulation in the globally ischemic mammalian heart. A role for the ATP-sensitive potassium channel.

1990 • 228 citations

Developmental Changes in the Delayed Rectifier K ⁺ Channels in Mouse Heart

1996 • 227 citations

Reentrant and nonreentrant mechanisms contribute to arrhythmogenesis during early myocardial ischemia: results using three-dimensional mapping.

1987 • 226 citations

Ca-dependent facilitation of cardiac Ca current is due to Ca-calmodulin-dependent protein kinase

1994 • 225 citations

Ionic basis of the different action potential configurations of single guinea‐pig atrial and ventricular myocytes.

1985 • 223 citations

Reduction of ischemic K+ loss and arrhythmias in rat hearts. Effect of glibenclamide, a sulfonylurea.

1990 • 222 citations

Charge movement during Na+ translocation by native and cloned cardiac Na+/Ca2+ exchanger

1991 • 221 citations

Myocardial Architecture and Ventricular Arrhythmogenesis

1998 • 220 citations

Effects of Intracellular Free Magnesium on Calcium Current in Isolated Cardiac Myocytes

1988 • 218 citations

Nitric oxide donor SIN-1 inhibits mammalian cardiac calcium current through cGMP-dependent protein kinase

1995 • 218 citations

Studies of the unitary properties of adenosine‐5'‐triphosphate‐regulated potassium channels of frog skeletal muscle.

1987 • 218 citations

Cardiac Efficiency Is Improved After Ischemia by Altering Both the Source and Fate of Protons

1996 • 217 citations

Quantification of [Ca2+]i in perfused hearts. Critical evaluation of the 5F-BAPTA and nuclear magnetic resonance method as applied to the study of ischemia and reperfusion.

1990 • 217 citations

Sodium-calcium exchange current. Dependence on internal Ca and Na and competitive binding of external Na and Ca.

1989 • 215 citations

Multifunctional Ca2+/calmodulin-dependent protein kinase mediates Ca(2+)-induced enhancement of the L-type Ca2+ current in rabbit ventricular myocytes.

1994 • 215 citations

Two components of transient outward current in canine ventricular myocytes.

1989 • 215 citations

Mechanism of action of acetylcholine on calcium current in single cells from frog ventricle.

1986 • 214 citations

Mechanosensitive gating of atrial ATP-sensitive potassium channels.

1993 • 213 citations

Alpha 1-adrenergic agonists selectively suppress voltage-dependent K+ current in rat ventricular myocytes.

1988 • 213 citations

Phase 2 reentry as a mechanism of initiation of circus movement reentry in canine epicardium exposed to simulated ischemia

1996 • 212 citations

Protein tyrosine phosphorylation is involved in osmoregulation of ionic conductances.

1993 • 211 citations

Repolarizing K ⁺ Currents I _TO1 and I _Ks Are Larger in Right Than Left Canine Ventricular Midmyocardium

1999 • 211 citations

Localization of the Kv1.5 K+ channel protein in explanted cardiac tissue.

1995 • 211 citations

Effects of [Ca2+]i, SR Ca2+ load, and rest on Ca2+ spark frequency in ventricular myocytes

1997 • 210 citations

Flux of Ca2+ across the sarcoplasmic reticulum of guinea‐pig cardiac cells during excitation‐contraction coupling.

1991 • 209 citations

Stretch‐activated anion currents of rabbit cardiac myocytes.

1992 • 208 citations

Prophylaxis of early ventricular fibrillation by inhibition of acylcarnitine accumulation.

1989 • 207 citations

Single channel and 45Ca2+ flux measurements of the cardiac sarcoplasmic reticulum calcium channel

1986 • 206 citations

An estimate of the calcium content of the sarcoplasmic reticulum in rat ventricular myocytes

1993 • 205 citations

Regulation of calcium release by calcium inside the sarcoplasmic reticulum in ventricular myocytes

1996 • 204 citations

Voltage‐dependent activation of the inward‐rectifier potassium channel in the ventricular cell membrane of guinea‐pig heart.

1985 • 202 citations

Modulation by intracellular Ca2+ of the hyperpolarization‐activated inward current in rabbit single sino‐atrial node cells.

1989 • 202 citations

NADH regulates the gating of VDAC, the mitochondrial outer membrane channel.

1994 • 200 citations

Relaxation of the ACh-induced potassium current in the rabbit sinoatrial node cell

1978 • 200 citations

Effects of Overexpression of the Na ⁺ -Ca ²⁺ Exchanger on [Ca ²⁺ ] _i Transients in Murine Ventricular Myocytes

1998 • 200 citations

Single-channel events and gating behavior of the cardiac gap junction channel.

1988 • 200 citations

Sodium channel blockade reduces hypoxic sodium loading and sodium-dependent calcium loading.

1994 • 200 citations

Distribution of the Na(+)-Ca2+ exchange protein in mammalian cardiac myocytes: an immunofluorescence and immunocolloidal gold-labeling study

1992 • 199 citations

Novel mechanism of voltage-dependent gating in L-type calcium channels

1990 • 199 citations

A persistent sodium current in rat ventricular myocytes.

1992 • 199 citations

Properties of cloned ATP‐sensitive K+ currents expressed in Xenopus oocytes.

1997 • 198 citations

Channel-Like Function of the Na,K Pump Probed at Microsecond Resolution in Giant Membrane Patches

1994 • 197 citations

Ionic mechanism of the effects of hydrogen peroxide in rat ventricular myocytes.

1997 • 197 citations

Activation of a High Affinity Gi Protein-coupled Plasma Membrane Receptor by Sphingosine-1-phosphate

1996 • 197 citations

Regulation of Cardiac Ca ²⁺ Release Channel (Ryanodine Receptor) by Ca ²⁺ , H ⁺ , Mg ²⁺ , and Adenine Nucleotides Under Normal and Simulated Ischemic Conditions

1996 • 196 citations

The Stochastic Nature of Cardiac Propagation at a Microscopic Level

1995 • 196 citations

Modulation of single hyperpolarization‐activated channels (i(f)) by cAMP in the rabbit sino‐atrial node.

1994 • 196 citations

The effects of metabolic inhibition on intracellular calcium and pH in isolated rat ventricular cells.

1989 • 195 citations

Low Efficiency of Ca ²⁺ Entry Through the Na ⁺ -Ca ²⁺ Exchanger as Trigger for Ca ²⁺ Release From the Sarcoplasmic Reticulum

1997 • 194 citations

Calcium‐activated non‐selective cation channel in ventricular cells isolated from adult guinea‐pig hearts.

1988 • 194 citations

Calcium handling proteins in the failing human heart

1997 • 190 citations

Molecular physiology of cardiac potassium channels

1996 • 188 citations

Nitric Oxide Can Increase Heart Rate by Stimulating the Hyperpolarization-Activated Inward Current, I _f

1997 • 187 citations

Electrophysiologic mechanisms underlying arrhythmias due to reperfusion of ischemic myocardium.

1987 • 185 citations

Swelling-induced chloride-sensitive current in canine atrial cells revealed by whole-cell patch-clamp method.

1992 • 184 citations

Stretch activated ion channels in ventricular myocytes

1988 • 184 citations

O2 free radicals: cause of ischemia-reperfusion injury to cardiac Na+-K+-ATPase

1987 • 183 citations

Expression of Multiple Connexins in Cultured Neonatal Rat Ventricular Myocytes

1995 • 183 citations

Fatty acids suppress voltage-gated Na ⁺ currents in HEK293t cells transfected with the α-subunit of the human cardiac Na ⁺ channel

1998 • 182 citations

Extracellular Access to the Na,K Pump: Pathway Similar to Ion Channel

1993 • 182 citations

Nonexocytotic release of endogenous noradrenaline in the ischemic and anoxic rat heart: mechanism and metabolic requirements.

1987 • 182 citations

Macroscopic and unitary properties of physiological ion flux through T‐type Ca2+ channels in guinea‐pig heart cells.

1992 • 182 citations

Cell swelling increases membrane conductance of canine cardiac cells: evidence for a volume-sensitive Cl channel

1992 • 181 citations

Ionic mechanisms of adenosine actions in pacemaker cells from rabbit heart.

1988 • 180 citations

NMR measurements of Na+ and cellular energy in ischemic rat heart: role of Na(+)-H+ exchange

1993 • 180 citations

Block and activation of the pace‐maker channel in calf Purkinje fibres: effects of potassium, caesium and rubidium

1982 • 179 citations

Relation of mitochondrial and cytosolic free calcium to cardiac myocyte recovery after exposure to anoxia.

1992 • 177 citations

Calcium‐sensitive and insensitive transient outward current in rabbit ventricular myocytes.

1989 • 176 citations

Regulation of the Cardiac Na+-Ca2+ Exchanger by the Endogenous XIP Region

1997 • 175 citations

Synergistic Modulation of ATP-Sensitive K ⁺ Currents by Protein Kinase C and Adenosine

1996 • 175 citations

Tissue and Species Distribution of mRNA for the i _kr -like K ⁺ Channel, ERG

1997 • 174 citations

New Na(+)-H+ exchange inhibitor HOE 694 improves postischemic function and high-energy phosphate resynthesis and reduces Ca2+ overload in isolated perfused rabbit heart.

1994 • 173 citations

Effects of flecainide, quinidine, and 4-aminopyridine on transient outward and ultrarapid delayed rectifier currents in human atrial myocytes.

1995 • 171 citations

The protein kinase A-regulated cardiac CI− channel resembles the cystic fibrosis transmembrane conductance regulator

1992 • 170 citations

Regulation of the gating of the sheep cardiac sarcoplasmic reticulum ca2+-release channel by luminal Ca2+

1994 • 170 citations

Is a High Glycogen Content Beneficial or Detrimental to the Ischemic Rat Heart?

1996 • 170 citations

Alpha 1-adrenoceptors in myocardium: functional aspects and transmembrane signaling mechanisms.

1993 • 169 citations

The Ventricular Arrhythmias of Ischemia and Infarction: Electrophysiological Mechanisms

1993 • 168 citations

Cytoplasmic Ca2+ inhibits the ryanodine receptor from cardiac muscle

1995 • 168 citations

Inward Rectification and Implications for Cardiac Excitability

1996 • 168 citations

Regional differences in the role of the Ca2+ and Na+ currents in pacemaker activity in the sinoatrial node

1997 • 168 citations

Mechanism of receptor‐mediated modulation of the delayed outward potassium current in guinea‐pig ventricular myocytes.

1990 • 167 citations

Voltage-dependent gating of single sodium channels from mammalian neuroblastoma cells

1987 • 167 citations

Potentiation by cyclic GMP of beta‐adrenergic effect on Ca2+ current in guinea‐pig ventricular cells.

1991 • 167 citations

Gap junction channels: distinct voltage-sensitive and -insensitive conductance states

1994 • 167 citations

CYTOPLASMIC ATP-DEPENDENT REGULATION OF ION TRANSPORTERS AND CHANNELS: Mechanisms and Messengers

1997 • 165 citations

Mechanisms of pHi recovery after global ischemia in the perfused heart.

1993 • 165 citations

Intracellular calcium activates a chloride current in canine ventricular myocytes

1994 • 165 citations

Rapid Inactivation Determines the Rectification and [K ⁺ ] _o Dependence of the Rapid Component of the Delayed Rectifier K ⁺ Current in Cardiac Cells

1997 • 164 citations

Role of an inwardly rectifying potassium current in rabbit ventricular action potential.

1992 • 164 citations

Functional Consequences of Sulfhydryl Modification in the Pore-Forming Subunits of Cardiovascular Ca ²⁺ and Na ⁺ Channels

1995 • 164 citations

Phosphorylation shifts unitary conductance and modifies voltage dependent kinetics of human connexin43 gap junction channels

1992 • 164 citations

Externalization of beta-adrenergic receptors promoted by myocardial ischemia

1985 • 164 citations

Background current in sino‐atrial node cells of the rabbit heart.

1992 • 164 citations

Different electrophysiological responses of canine endocardium and epicardium to combined hyperkalemia, hypoxia, and acidosis.

1980 • 164 citations

Sodium‐calcium exchange during the action potential in guinea‐pig ventricular cells.

1989 • 163 citations

Ca ²⁺ Flux Through Promiscuous Cardiac Na ⁺ Channels: Slip-Mode Conductance

1998 • 163 citations

Protein Kinase C Activates ATP-Sensitive K ⁺ Current in Human and Rabbit Ventricular Myocytes

1996 • 162 citations

Contribution of Sialic Acid to the Voltage Dependence of Sodium Channel Gating

1997 • 161 citations

Cloning, expression, pharmacology and regulation of a delayed rectifier K+ channel in mouse heart.

1991 • 158 citations

The Mg2+ block and intrinsic gating underlying inward rectification of the K+ current in guinea‐pig cardiac myocytes.

1989 • 158 citations

Depression of membrane-bound Na+-K+-ATPase activity induced by free radicals and by ischemia of kidney

1988 • 158 citations

Transgenic A ₁ adenosine receptor overexpression increases myocardial resistance to ischemia

1997 • 158 citations

Stretch-activated ion channels in tissue-cultured chick heart

1993 • 158 citations

Influence of Extracellular K ⁺ Concentration on Cable Properties and Excitability of Sheep Cardiac Purkinje Fibers

1970 • 158 citations

High Frequency–Induced Upregulation of Human Cardiac Calcium Currents

1996 • 157 citations

Transient outward and delayed rectifier currents in canine atrium: properties and role of isolation methods

1996 • 154 citations

Free radicals enhance Na+/Ca2+ exchange in ventricular myocytes

1996 • 153 citations

Contributions of a transient outward current to repolarization in human atrium

1989 • 153 citations

Measurement of Single Channel Currents from Cardiac Gap Junctions

1986 • 152 citations

Protective effect of vagal stimulation on reperfusion arrhythmias in cats.

1987 • 152 citations

MODULATION OF CARDIAC ION CHANNELS BY MAGNESIUM

1991 • 152 citations

Regulation of intracellular free Mg2+ and contraction in single adult mammalian cardiac myocytes

1994 • 152 citations

Regulation of Cardiac Muscle Ca2+ Release Channel by Sarcoplasmic Reticulum Lumenal Ca2+

1998 • 149 citations

Modulation of CFTR chloride channels by calyculin A and genistein

1997 • 149 citations

Protein Kinase C–Induced Changes in the Stoichiometry of ATP Binding Activate Cardiac ATP-Sensitive K ⁺ Channels

1996 • 148 citations

Effects of Development and Thyroid Hormone on K⁺ Currents and K⁺ Channel Gene Expression in Rat Ventricle

1997 • 147 citations

Evidence for proton countertransport by the sarcoplasmic reticulum Ca2(+)-ATPase during calcium transport in reconstituted proteoliposomes with low ionic permeability.

1990 • 147 citations

Chloride current in mammalian cardiac myocytes. Novel mechanism for autonomic regulation of action potential duration and resting membrane potential.

1990 • 146 citations

A fuzzy subsarcolemmal space for intracellular Na+ in cardiac cells?

1992 • 146 citations

Inhibition and Rapid Recovery of Ca ²⁺ Current During Ca ²⁺ Release From Sarcoplasmic Reticulum in Guinea Pig Ventricular Myocytes

1995 • 145 citations

Mechanism of potassium efflux and action potential shortening during ischaemia in isolated mammalian cardiac muscle.

1990 • 145 citations

Inactivation of Voltage-Gated Cardiac K ⁺ Channels

1998 • 145 citations

The ionic basis of concentration‐related effects of noradrenaline on the action potential of calf cardiac purkinje fibres.

1982 • 144 citations

A cellular mechanism for nitric oxide-mediated cholinergic control of mammalian heart rate.

1995 • 144 citations

Na(+)‐HCO3‐ symport in the sheep cardiac Purkinje fibre.

1992 • 143 citations

Steady-state and dynamic properties of cardiac sodium-calcium exchange. Ion and voltage dependencies of the transport cycle.

1992 • 142 citations

Heterogeneity of the early outward current in ventricular cells isolated from normal and hypertrophied rat hearts.

1993 • 141 citations

Gap junctional conductance between pairs of ventricular myocytes is modulated synergistically by H+ and Ca++.

1990 • 141 citations

The CFTR Chloride Channel of Mammalian Heart

1995 • 140 citations

Changes in extracellular and intracellular pH in ischemic rabbit papillary muscle.

1992 • 140 citations

Slow inactivation of the sodium current in rabbit cardiac Purkinje fibres

1987 • 140 citations

Intracellular Ca2+ and protein kinase C modulate K+ current in guinea pig heart cells

1987 • 139 citations

Two Components of Delayed Rectifier Current in Canine Atrium and Ventricle

1996 • 139 citations

Functional linkage of the cardiac ATP-sensitive K+ channel to the actin cytoskeleton

1996 • 138 citations

Multiple types of Ca2+ currents in single canine Purkinje cells.

1989 • 138 citations

Fast and slow gating behaviour of single calcium channels in cardiac cells

1986 • 136 citations

Superoxide Anion Radical-Triggered Ca²⁺Release from Cardiac Sarcoplasmic Reticulum through Ryanodine Receptor Ca²⁺Channel

1998 • 136 citations

Measurement of reversal potential of Na+‐Ca2+ exchange current in single guinea‐pig ventricular cells.

1989 • 136 citations

Novel cation-selective mechanosensitive ion channel in the atrial cell membrane.

1993 • 136 citations

Neurotensin Inhibition of the Hyperpolarization‐Activated Cation Current (I_h) in the Rat Substantia Nigra Pars Compacta Implicates the Protein Kinase C Pathway

1997 • 135 citations

The change of the free energy of ATP hydrolysis during global ischemia and anoxia in the rat heartIts possible role in the regulation of transsarcolemmal sodium and potassium gradients

1984 • 135 citations

A sustained inward current activated at the diastolic potential range in rabbit sino‐atrial node cells.

1995 • 135 citations

Ca2+ and voltage inactivate Ca2+ channels in guinea‐pig ventricular myocytes through independent mechanisms.

1991 • 135 citations

Effects of extracellular potassium on ventricular automaticity and evidence for a pacemaker current in mammalian ventricular myocardium.

1977 • 135 citations

A structural determinant of differential sensitivity of cloned inward rectifier K⁺ channels to intracellular spermine

1994 • 135 citations

The mechanism by which cytoplasmic protons inhibit the sodium‐calcium exchanger in guinea‐pig heart cells.

1993 • 134 citations

Cardiac transmembrane potentials and metabolism.

1978 • 134 citations

Inositol 1,4,5-trisphosphate receptor expression in cardiac myocytes.

1993 • 133 citations

Transient outward current in human and rat ventricular myocytes

1993 • 133 citations

An analysis of the delayed outward current in single ventricular cells of the guinea-pig

1987 • 133 citations

Swelling-activated and isoprenaline-activated chloride currents in guinea pig cardiac myocytes have distinct electrophysiology and pharmacology.

1994 • 133 citations

Catecholamine release and arrhythmias in acute myocardial ischaemia

1991 • 133 citations

Characterization of the hyperpolarization‐activated current, I(f), in ventricular myocytes isolated from hypertensive rats.

1994 • 133 citations

The inositol 1,4,5-trisphosphate (InsP3) receptor

1995 • 132 citations

A rapidly activating sustained K⁺ current modulates repolarization and excitation–contraction coupling in adult mouse ventricle

1997 • 132 citations

Automatie-f�rdernde Dehnungseffekte an Purkinje-F�den, Papillarmuskeln und Vorhoftrabekeln von Rhesus-Affen

1967 • 131 citations

IK of rabbit ventricle is composed of two currents: evidence for IKs

1996 • 131 citations

Effects of Delayed Rectifier Current Blockade by E-4031 on Impulse Generation in Single Sinoatrial Nodal Myocytes of the Rabbit

1995 • 131 citations

Automatic activity in depolarized guinea pig ventricular myocardium. Characteristics and mechanisms.

1976 • 131 citations

Fluorescence measurements of cytoplasmic and mitochondrial sodium concentration in rat ventricular myocytes.

1992 • 131 citations

A mechanosensitive K+ channel in heart cells. Activation by arachidonic acid.

1992 • 131 citations

ATP-sensitive K+ channels in rat ventricular myocytes are blocked and inactivated by internal divalent cations

1987 • 131 citations

Inositol phosphate production following α₁‐adrenergic, muscarinic or electrical stimulation in isolated rat heart

1986 • 129 citations

Activation of β-Adrenergic Receptor Kinase During Myocardial Ischemia

1996 • 128 citations

Reperfusion ventricular tachyarrhythmias: Correlation with antecedent coronary artery occlusion tachyarrhythmias and duration of myocardial ischemia

1981 • 128 citations

Cloning and Functional Expression of a Novel Cardiac Two-Pore Background K ⁺ Channel (cTBAK-1)

1998 • 127 citations

A novel cardiac potassium channel that is active and conductive at depolarized potentials

1988 • 127 citations

The shortening of the action potential by DNP in guinea-pig ventricular myocytes is mediated by an increase of a time-independent K conductance

1983 • 127 citations

Slow inactivation of a tetrodotoxin-sensitive current in canine cardiac Purkinje fibers

1984 • 126 citations

Characteristics of calcium-current in isolated human ventricular myocytes from patients with terminal heart failure

1991 • 126 citations

Permeation in the dihydropyridine-sensitive calcium channel. Multi-ion occupancy but no anomalous mole-fraction effect between Ba2+ and Ca2+.

1990 • 126 citations

Streptomycin reverses a large stretch induced increase in [Ca2+]i in isolated guinea pig ventricular myocytes

1994 • 125 citations

Effects of α‐adrenoceptor stimulation with phenylephrine in the presence of propranolol on force of contraction, slow inward current and cyclic AMP content in the bovine heart

1984 • 125 citations

Na+ activation of the muscarinic K+ channel by a G-protein-independent mechanism.

1996 • 125 citations

Potential electrophysiologic mechanisms responsible for dysrhythmias associated with reperfusion of ischemic myocardium.

1983 • 125 citations

Myocardial Protection by Na ⁺ -H ⁺ Exchange Inhibition in Ischemic, Reperfused Porcine Hearts

1995 • 125 citations

Phosphorylation-Independent Modulation of L-Type Calcium Channels by Magnesium-Nucleotide Complexes

1992 • 125 citations

Thermodynamic and kinetic studies of the gating behavior of a K+-selective channel from the sarcoplasmic reticulum membrane.

1980 • 124 citations

Glutathione peroxidase knockout mice are susceptible to myocardial ischemia reperfusion injury.

1997 • 124 citations

Adrenergic Modulation of Ultrarapid Delayed Rectifier K+ Current in Human Atrial Myocytes

1996 • 124 citations

Mechanism of cAMP-dependent modulation of cardiac sodium channel current kinetics.

1993 • 124 citations

cGMP-Dependent Protein Kinase Regulation of the L-Type Ca ²⁺ Current in Rat Ventricular Myocytes

1995 • 123 citations

Cytoskeleton modulates gating of voltage-dependent sodium channel in heart

1995 • 123 citations

Intracellular calcium transients and arrhythmia in isolated heart cells.

1991 • 122 citations

Spontaneous calcium release from the sarcoplasmic reticulum in myocardial cells: mechanisms and consequences

1988 • 122 citations

Mechanism of gating of T-type calcium channels.

1990 • 122 citations

Differential Expression of Gap Junction Proteins in the Canine Sinus Node

1998 • 121 citations

Chloride‐sensitive nature of the adrenaline‐induced current in guinea‐pig cardiac myocytes.

1990 • 121 citations

C-terminus determinants for Mg2+ and polyamine block of the inward rectifier K+ channel IRK1.

1995 • 121 citations

Two ATP-activated conductances in bullfrog atrial cells.

1988 • 120 citations

Sodium current in voltage clamped internally perfused canine cardiac Purkinje cells

1987 • 120 citations

Ion-dependent Inactivation of Barium Current through L-type Calcium Channels

1997 • 120 citations

T‐type Ca²⁺ current as a trigger for Ca²⁺ release from the sarcoplasmic reticulum in guinea‐pig ventricular myocytes

1998 • 119 citations

Immunofluorescence localization of the Na-Ca exchanger in heart cells

1992 • 119 citations

Calcium current restitution in mammalian ventricular myocytes is modulated by intracellular calcium.

1988 • 118 citations

Characterization of an ultrarapid delayed rectifier potassium channel involved in canine atrial repolarization.

1996 • 118 citations

Regulation of K+ channels in cardiac myocytes by free fatty acids.

1990 • 118 citations

Catalase-overexpressing transgenic mouse heart is resistant to ischemia-reperfusion injury

1997 • 117 citations

Pacemaker current i(f) in adult canine cardiac ventricular myocytes.

1995 • 117 citations

Effect of serial brief ischemic episodes on extracellular K+, pH, and activation in the pig.

1985 • 117 citations

Protection of reoxygenated cardiomyocytes against hypercontracture by inhibition of Na+/H+ exchange

1995 • 117 citations

The min K channel underlies the cardiac potassium current IKs and mediates species-specific responses to protein kinase C.

1993 • 117 citations

Extracellular K+ accumulation during myocardial ischemia in isolated rabbit heart

1982 • 117 citations

Single cardiac Purkinje cells: general electrophysiology and voltage‐clamp analysis of the pace‐maker current.

1984 • 117 citations

Enhanced Ca ²⁺ Current and Decreased Ca ²⁺ Efflux Restore Sarcoplasmic Reticulum Ca ²⁺ Content After Depletion

1997 • 115 citations

Chloride conductance pathways in heart

1991 • 115 citations

Age-related appearance of outward currents may contribute to developmental differences in ventricular repolarization.

1992 • 115 citations

Two distinct gating mechanisms in gap junction channels: CO2-sensitive and voltage-sensitive

1997 • 115 citations

Background potassium current active during the plateau of the action potential in guinea pig ventricular myocytes.

1993 • 114 citations

Effects of Mechanical Stretch on Membrane Currents of Single Ventricular Myocytes of Guinea-Pig Heart.

1992 • 114 citations

Cellular Magnesium and Na/Mg Exchange in Heart Cells

1991 • 114 citations

A mutation in segment I-S6 alters slow inactivation of sodium channels

1997 • 114 citations

Assessment of intra-SR free [Ca] and buffering in rat heart

1997 • 113 citations

Membrane currents underlying delayed rectification and pace‐maker activity in frog atrial muscle

1969 • 113 citations

Cardiac calcium channels in planar lipid bilayers. L-type channels and calcium-permeable channels open at negative membrane potentials.

1988 • 113 citations

Functionally distinct phospho-forms underlie incremental activation of protein kinase-regulated Cl- conductance in mammalian heart.

1993 • 113 citations

Inactivation of L-type Ca channels in embryonic chick ventricle cells: dependence on the cytoskeletal agents colchicine and taxol

1994 • 113 citations

The gating of the sheep skeletal sarcoplasmic reticulum Ca2+-release channel is regulated by luminal Ca2+

1995 • 112 citations

Species differences in the activity of the Na(+)‐Ca2+ exchanger in mammalian cardiac myocytes.

1995 • 112 citations

Abnormal electrical activity induced by free radical generating systems in isolated cardiocytes

1988 • 112 citations

Different intracellular localization of inositol 1,4,5-trisphosphate and ryanodine receptors in cardiomyocytes.

1993 • 111 citations

The calcium-independent transient outward potassium current in isolated ferret right ventricular myocytes. I. Basic characterization and kinetic analysis.

1993 • 111 citations

Differences in rate dependence of transient outward current in rabbit and human atrium

1992 • 111 citations

Control of channel activity through a unique amino acid residue of a G protein-gated inwardly rectifying K ⁺ channel subunit

1996 • 111 citations

Microheterogeneity of subsarcolemmal sodium gradients. Electron probe microanalysis in guinea‐pig ventricular myocytes.

1993 • 111 citations

Influence of global ischemia on intracellular sodium in the perfused rat heart

1990 • 111 citations

Block of intercellular communication: interaction of intracellular H+ and Ca2+

1987 • 110 citations

Effects of fatty acids on Na+-Ca2+ exchange and Ca2+ permeability of cardiac sarcolemmal vesicles.

1985 • 110 citations

Dependence of cardiac mitochondrial pyruvate dehydrogenase activity on intramitochondrial free Ca2+ concentration

1988 • 110 citations

Potassium rectifier currents differ in myocytes of endocardial and epicardial origin.

1992 • 110 citations

Extracellular H+ inactivation of Na(+)-H+ exchange in the sheep cardiac Purkinje fibre.

1990 • 110 citations

Lactate activates ATP-sensitive potassium channels in guinea pig ventricular myocytes.

1991 • 110 citations

Cyclic AMP‐dependent phosphorylation and regulation of the cardiac dihydropyridine‐sensitive Ca channel

1992 • 109 citations

Single channel analysis of the inward rectifier K current in the rabbit ventricular cells.

1983 • 109 citations

Proarrhythmic effects of an oxygen-derived free radical generating system on action potentials recorded from guinea pig ventricular myocardium: a possible cause of reperfusion-induced arrhythmias.

1987 • 109 citations

Time-dependent outward current in guinea pig ventricular myocytes. Gating kinetics of the delayed rectifier.

1990 • 108 citations

Regulation of mitochondrial respiration by controlling the permeability of the outer membrane through the mitochondrial channel, VDAC

1992 • 108 citations

The Molecular Basis of Anisotropy: Role of Gap Junctions

1995 • 108 citations

[Ca2+]i transients and [Ca2+]i‐dependent chloride current in single Purkinje cells from rabbit heart.

1993 • 108 citations

Measurement of Na(+)-K+ pump current in isolated rabbit ventricular myocytes using the whole-cell voltage-clamp technique. Inhibition of the pump by oxidant stress.

1993 • 108 citations

Ca2+ load of guinea‐pig ventricular myocytes determines efficacy of brief Ca2+ currents as trigger for Ca2+ release.

1994 • 108 citations

Effects of ADP upon the ATP-sensitive K+ channel in rat ventricular myocytes

1988 • 107 citations

Role of rapidly activating delayed rectifier K+ current in sinoatrial node pacemaker activity

1995 • 107 citations

ATP-Activated Channels in Excitable Cells

1990 • 107 citations

The role of Na(+)‐Ca2+ exchange in activation of excitation‐contraction coupling in rat ventricular myocytes.

1996 • 107 citations

The Role of the Na+Channel in the Accumulation of Intracellular Na+During Myocardial Ischemia: Consequences for Post-ischemic Recovery

1997 • 107 citations

Nonlinear charge movement in mammalian cardiac ventricular cells. Components from Na and Ca channel gating.

1989 • 107 citations

Cytoplasmic Ca2+ does not inhibit the cardiac muscle sarcoplasmic reticulum ryanodine receptor Ca2+ channel, although Ca2+-induced Ca2+ inactivation of Ca2+ release is observed in native vesicles

1993 • 107 citations

Functional Effects of Protein Kinase C Activation on the Human Cardiac Na sup + Channel

1997 • 106 citations

Cellular uncoupling induced by accumulation of long-chain acylcarnitine during ischemia.

1994 • 106 citations

Interactions of protons with single open L-type calcium channels. Location of protonation site and dependence of proton-induced current fluctuations on concentration and species of permeant ion.

1989 • 106 citations

Evidence for physiological functions of protein phosphatases in the heart: evaluation with okadaic acid

1993 • 106 citations

Mitochondrial function in the oxygen depleted and reoxygenated myocardial cell

1994 • 105 citations

Membrane currents in the rabbit atrioventricular node cell

1982 • 104 citations

Actin microfilament disrupters enhance K(ATP) channel opening in patches from guinea‐pig cardiomyocytes.

1996 • 104 citations

Properties of human atrial ICa at physiological temperatures and relevance to action potential

1997 • 104 citations

Intracellular sodium during ischemia and calcium-free perfusion: A Na NMR study

1991 • 104 citations

On the mechanism of lysophosphatidylcholine-induced depolarization of cat ventricular myocardium.

1983 • 104 citations

The mechanism of the inactivation of the inward-rectifying K current during hyperpolarizing steps in guinea-pig ventricular myocytes

1987 • 103 citations

Divalent cation conduction in the ryanodine receptor channel of sheep cardiac muscle sarcoplasmic reticulum.

1992 • 103 citations

Excitation‐contraction coupling in single guinea‐pig ventricular myocytes exposed to hydrogen peroxide.

1994 • 103 citations

Pacemaker current exists in ventricular myocytes.

1993 • 103 citations

Reperfusion arrhythmias: dose-related protection by anti-free radical interventions

1989 • 102 citations

Passive electrical properties, mechanical activity, and extracellular potassium in arterially perfused and ischemic rabbit ventricular muscle. Effects of calcium entry blockade or hypocalcemia.

1990 • 102 citations

The inotropic effect of endothelin‐1 on rat atria involves hydrolysis of phosphatidylinositol

1989 • 102 citations

Effects of cGMP-dependent phosphorylation on rat and human connexin43 gap junction channels

1995 • 102 citations

Unitary Cl ⁻ Channels Activated by Cytoplasmic Ca ²⁺ in Canine Ventricular Myocytes

1996 • 102 citations

Developmental change in the voltage-dependence of the pacemaker current, i f , in rat ventricle cells

1997 • 102 citations

Alpha‐adrenergic modulation of the transient outward current in rabbit atrial myocytes.

1990 • 102 citations

Regional expression of sodium pump subunits isoforms and Na+-Ca++ exchanger in the human heart.

1996 • 102 citations

The subendocardial border zone during acute ischemia of the rabbit heart: an electrophysiologic, metabolic, and morphologic correlative study.

1986 • 102 citations

Mechanism of cardiac Na(+)‐Ca2+ exchange current stimulation by MgATP: possible involvement of aminophospholipid translocase.

1992 • 101 citations

The ‘ins’ and ‘outs’ of mitochondrial membrane channels

1992 • 101 citations

Intracellular calcium and ventricular fibrillation. Studies in the aequorin-loaded isovolumic ferret heart.

1991 • 101 citations

Adenosine-sensitive afterdepolarizations and triggered activity in guinea pig ventricular myocytes.

1992 • 101 citations

Stretch-induced depolarizations as a trigger of arrhythmias in isolated canine left ventricles

1992 • 101 citations

Reactive oxygen species modify the structure and function of the cardiac sarcoplasmic reticulum calcium-release channel.

1991 • 101 citations

Slow Inactivation in Human Cardiac Sodium Channels

1998 • 100 citations

Cardiac gap junctions: three distinct single channel conductances and their modulation by phosphorylating treatments

1992 • 100 citations

Enhancement of the L-Type Ca ²⁺ Current by Mechanical Stimulation in Single Rabbit Cardiac Myocytes

1996 • 100 citations

Short-term desensitization of muscarinic K+ channel current in isolated atrial myocytes and possible role of GTP-binding proteins

1987 • 100 citations

Ca(2+)-dependent inactivation of a cloned cardiac Ca2+ channel alpha 1 subunit (alpha 1C) expressed in Xenopus oocytes

1994 • 99 citations

Mitochondrial free calcium transients during excitation‐contraction coupling in rabbit cardiac myocytes

1996 • 99 citations

Stimulation of cardiac alpha receptors increases Na/K pump current and decreases gK via a pertussis toxin-sensitive pathway

1988 • 99 citations

Locating the Anion-selectivity Filter of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Chloride Channel

1997 • 99 citations

The Sensor Regions of VDAC Are Translocated from within the Membrane to the Surface during the Gating Processes

1998 • 99 citations

Alterations in electrical and contractile behavior of isolated cardiomyocytes by hydrogen peroxide: Possible ionic mechanisms

1991 • 98 citations

Basal responses of the L‐type Ca2+ and hyperpolarization‐activated currents to autonomic agonists in the rabbit sino‐atrial node.

1996 • 98 citations

Modulation of the delayed rectifier potassium current in frog cardiomyocytes by beta‐adrenergic agonists and magnesium.

1989 • 98 citations

Myocardial potassium loss and cell depolarisation in ischaemia and hypoxia

1995 • 98 citations

Modification of the cardiac action potential by intracellular injection of adenosine triphosphate and related substances in guinea pig single ventricular cells.

1983 • 98 citations

A chloride current associated with swelling of cultured chick heart cells.

1993 • 97 citations

Na+-activated K+ current in cardiac cells: rectification, open probability, block and role in digitalis toxicity

1990 • 97 citations

Regional Localization of ERG , the Channel Protein Responsible for the Rapid Component of the Delayed Rectifier, K ⁺ Current in the Ferret Heart

1997 • 97 citations

Experimental models of ventricular tachycardia and fibrillation caused by ischemia and infarction.

1992 • 97 citations

Modulation of inner mitochondrial membrane channel activity

1992 • 97 citations

Oxidative stress alters specific membrane currents in isolated cardiac myocytes.

1990 • 97 citations

Axoplasmic free magnesium levels and magnesium extrusion from squid giant axons.

1976 • 96 citations

Measurement of mitochondrial calcium in single living cardiomyocytes by selective removal of cytosolic indo 1

1997 • 96 citations

Inhibitory Effects of Glibenclamide on Cystic Fibrosis Transmembrane Regulator, Swelling-Activated, and Ca ²⁺ -Activated Cl ⁻ Channels in Mammalian Cardiac Myocytes

1997 • 95 citations

Glibenclamide, an ATP-Sensitive K ⁺ Channel Blocker, Inhibits Cardiac cAMP-Activated Cl ⁻ Conductance

1995 • 95 citations

Two Kinds of Calcium-Induced Release of Calcium from the Sarcoplasmic Reticulum of Skinned Cardiac Cells

1992 • 95 citations

Total and free myoplasmic calcium during a contraction cycle: x‐ray microanalysis in guinea‐pig ventricular myocytes.

1991 • 94 citations

Changes in mitochondrial calcium concentration during the cardiac contraction cycle

1993 • 94 citations

Uncoupling of cardiac cells by fatty acids: structure-activity relationships

1991 • 94 citations

Characterization of a Slowly Inactivating Outward Current in Adult Mouse Ventricular Myocytes

1998 • 94 citations

Modulation of Kv4 channels, key components of rat ventricular transient outward K⁺ current, by PKC

1997 • 94 citations

Palmitoyl carnitine modifies sodium currents and induces transient inward current in ventricular myocytes

1994 • 93 citations

Influence of sodium‐hydrogen exchange on intracellular pH, sodium and tension in sheep cardiac Purkinje fibres.

1987 • 93 citations

The beta subunit increases Ca2+ currents and gating charge movements of human cardiac L-type Ca2+ channels

1996 • 92 citations

Age-related changes of action potential plateau shape in isolated human atrial fibers

1985 • 92 citations

α-Adrenergic Control of Volume-Regulated Cl ⁻ Currents in Rabbit Atrial Myocytes

1995 • 92 citations

A model of calcium dynamics in cardiac myocytes based on the kinetics of ryanodine-sensitive calcium channels

1994 • 91 citations

Extracellular potassium activity changes in the canine myocardium after acute coronary occlusion and the influence of beta-blockade

1979 • 91 citations

Adrenoceptor‐mediated changes of excitation and contraction in ventricular heart muscle from guinea‐pigs and rabbits.

1988 • 91 citations

Stimulation-dependent facilitation of the high threshold calcium current in guinea-pig ventricular myocytes.

1990 • 90 citations

Inhibition of the cardiac protein kinase A-dependent chloride conductance by endothelin-1

1994 • 90 citations

Action potential transfer in cell pairs isolated from adult rat and guinea pig ventricles.

1988 • 89 citations

Novel chloride‐dependent acid loader in the guinea‐pig ventricular myocyte: part of a dual acid‐loading mechanism.

1996 • 89 citations

The onset and autonomic regulation of cardiac pacemaker activity: relevance of the f current

1995 • 89 citations

Effects of ischemia and hypercarbic acidosis on myocyte calcium transients, contraction, and pHi in perfused rabbit hearts.

1991 • 89 citations

Ca2+ activation and Ca2+ inactivation of canine reconstituted cardiac sarcoplasmic reticulum Ca(2+)‐release channels.

1995 • 89 citations

Direct measurement of L-type Ca2+ window current in heart cells.

1992 • 88 citations

Guanylate-cyclase-mediated inhibition of cardiac I Ca by carbachol and sodium nitroprusside

1994 • 88 citations

G proteins activate ATP-sensitive K+ channels by antagonizing ATP-dependent gating

1994 • 88 citations

Tetradotoxin-sensitive and tetrodotoxin-resistant Na+ channels differ in their sensitivity to Cd2+ and Zn2+

1986 • 88 citations

Different effects of intracellular Ca and protein kinase C on cardiac T and L Ca currents

1991 • 88 citations

The Vulnerable Window for Unidirectional Block in Cardiac Tissue:

1995 • 88 citations

Protein kinase C-mediated preconditioning of cardiac myocytes: role of adenosine receptor and KATP channel

1997 • 88 citations

Inhibition by external Cd2+ of Na/Ca exchange and L-type Ca channel in rabbit ventricular myocytes

1997 • 88 citations

Cellular electrophysiological basis for oxygen radical-induced arrhythmias. A patch-clamp study in guinea pig ventricular myocytes.

1991 • 88 citations

A model for anomalous rectification: Electrochemical-potential-dependent gating of membrane channels

1978 • 88 citations

Chloride channel and chloride conductance regulator domains of CFTR, the cystic fibrosis transmembrane conductance regulator

1998 • 87 citations

Cloning and Functional Expression of an Inwardly Rectifying K ⁺ Channel From Human Atrium

1995 • 87 citations

Channel-mediated monovalent cation fluxes in isolated sarcoplasmic reticulum vesicles.

1984 • 87 citations

Adrenergic modulation of the transient outward current in isolated canine Purkinje cells.

1988 • 87 citations

Expression of cystic fibrosis transmembrane regulator Cl- channels in heart.

1992 • 87 citations

Calcium release from cardiac sarcoplasmic reticulum induced by photorelease of calcium or Ins(1,4,5)P3

1990 • 86 citations

Dissociation between cellular K+ loss, reduction in repolarization time, and tissue ATP levels during myocardial hypoxia and ischemia.

1993 • 86 citations

On the involvement of a mitochondrial pore in reperfusion injury

1993 • 86 citations

Increase of the delayed rectifier K+ and Na(+)-K+ pump currents by hypotonic solutions in guinea pig cardiac myocytes.

1994 • 86 citations

The mitochondrial outer membrane channel, VDAC, is modulated by a soluble protein

1988 • 85 citations

Na+/H+ exchange and its inhibition in cardiac ischemia and reperfusion

1993 • 85 citations

Regulation of spontaneous opening of muscarinic K+ channels in rabbit atrium.

1991 • 85 citations

Triple‐barrel structure of inwardly rectifying K+ channels revealed by Cs+ and Rb+ block in guinea‐pig heart cells.

1989 • 85 citations

The sulphonylurea receptor SUR1 regulates ATP‐sensitive mouse Kir6.2 K⁺ channels linked to the green fluorescent protein in human embryonic kidney cells (HEK 293)

1998 • 85 citations

Termination of Ca²⁺ release during Ca²⁺ sparks in rat ventricular myocytes

1998 • 85 citations

Blockade of multiple human cardiac potassium currents by the antihistamine terfenadine: possible mechanism for terfenadine-associated cardiotoxicity.

1995 • 85 citations

Na+/Ca2+ exchange current density in cardiac myocytes from rabbits and guinea pigs during postnatal development

1995 • 85 citations

A TTX‐sensitive inward sodium current contributes to spontaneous activity in newborn rabbit sino‐atrial node cells.

1996 • 84 citations

Intracellular pH regulation in cultured embryonic chick heart cells. Na(+)-dependent Cl-/HCO3- exchange.

1990 • 84 citations

Arachidonic acid and endothelin potentiate Ca2+ transients in rat cardiac myocytes via inhibition of distinct K+ channels.

1993 • 84 citations

Effects of protein kinase inhibitors on canine Purkinje fibre pacemaker depolarization and the pacemaker current i(f).

1991 • 84 citations

Intracellular magnesium during myocardial ischemia and reperfusion: Possible consequences for postischemic recovery

1989 • 84 citations

Developmental increases in the inwardly rectifying potassium current of rat ventricular myocytes

1992 • 83 citations

Properties of the transient outward current in rabbit atrial cells.

1988 • 83 citations

Inhibition of gap junctional conductance by long-chain acylcarnitines and their preferential accumulation in junctional sarcolemma during hypoxia.

1993 • 83 citations

Inositol 1,4,5-trisphosphate receptor in heart: evidence for its concentration in Purkinje myocytes of the conduction system.

1993 • 83 citations

Cardiac ventricular automaticity induced by current of injury

1975 • 83 citations

Two mechanisms by which ATP depletion potentiates induction of the mitochondrial permeability transition

1997 • 83 citations

Transient depolarisation and action potential alterations following mechanical changes in isolated myocardium

1980 • 83 citations

Alpha adrenoceptor stimulation reduces outward currents in rat ventricular myocytes.

1989 • 82 citations

Suppression of Ventricular Arrhythmias During Ischemia-Reperfusion by Agents Inhibiting Ins(1,4,5)P₃Release

1995 • 82 citations

Cardiac α₁‐adrenoceptor densities in different mammalian species

1992 • 82 citations

Two functionally distinct 4-aminopyridine-sensitive outward K+ currents in rat atrial myocytes.

1992 • 82 citations

Effects of sarcoplasmic reticulum Ca2+ load on the gain function of Ca2+ release by Ca2+ current in cardiac cells

1995 • 82 citations

Attempts to define functional domains of gap junction proteins with synthetic peptides

1994 • 81 citations

Kinetic analysis of single sodium channels from canine cardiac Purkinje cells.

1990 • 81 citations

Inactivation of outward Na(+)‐Ca2+ exchange current in guinea‐pig ventricular myocytes.

1994 • 81 citations

Injury current and gradients of diastolic stimulation threshold, TQ potential, and extracellular potassium concentration during acute regional ischemia in the isolated perfused pig heart.

1991 • 81 citations

Cardiac T‐Type Calcium Current:

1994 • 80 citations

DEVELOPMENTS IN CARDIOVASCULAR MEDICINE

1980 • 80 citations

Propagation of excitation-contraction coupling into ventricular myocytes

1994 • 80 citations

Characterization of the inward-rectifying potassium current in cat ventricular myocytes.

1988 • 80 citations

Metabolic regulation of cardiac ATP-sensitive K+ channels

1993 • 80 citations

Functional properties of cardiac L-type calcium channels transiently expressed in HEK293 cells. Roles of alpha 1 and beta subunits.

1995 • 80 citations

Age-related appearance of outward currents may contribute to developmental differences in ventricular repolarization.

1992 • 80 citations

Modulation of electrical heterogeneity by compensated hypertrophy in rat left ventricle

1997 • 79 citations

Effects of lysophosphatidylcholine on resting potassium conductance of isolated guinea pig ventricular cells

1986 • 79 citations

Cryo-EM of the native structure of the calcium release channel/ryanodine receptor from sarcoplasmic reticulum

1992 • 79 citations

Both Na+-K+ATPase and Na+-H+Exchanger are Immediately Active upon Post-ischemic Reperfusion in Isolated Rat Hearts

1998 • 78 citations

Isoproterenol directly stimulates the Na+-K+ pump in isolated cardiac myocytes

1986 • 78 citations

Oxidant Stress Enhances Adenylyl Cyclase Activation

1995 • 78 citations

Alpha 1-adrenoceptor stimulation enhances the delayed rectifier K+ current of guinea pig ventricular cells through the activation of protein kinase C.

1992 • 77 citations

Cardiac gap junction channel activity in embryonic chick ventricle cells

1988 • 77 citations

Evidence That Outwardly Rectifying Cl ⁻ Channels Underlie Volume-Regulated Cl ⁻ Currents in Heart

1997 • 77 citations

Electrophysiological derangements induced by lipid peroxidation in cardiac tissue

1987 • 77 citations

The arrhythmogenic current ITI in the absence of electrogenic sodium‐calcium exchange in sheep cardiac Purkinje fibres.

1986 • 77 citations

Mechanisms of extracellular divalent and trivalent cation block of the sodium current in canine cardiac Purkinje cells.

1992 • 76 citations

Two phosphatase sites on the Ca2+ channel affecting different kinetic functions.

1993 • 76 citations

Subcellular mechanism for Ca(2+)-dependent enhancement of delayed rectifier K+ current in isolated membrane patches of guinea pig ventricular myocytes.

1994 • 76 citations

Induction of delayed afterdepolarizations and triggered activity in canine Purkinje fibers by lysophosphoglycerides.

1986 • 76 citations

Delayed K+ current and external K+ in single cardiac Purkinje cells

1989 • 76 citations

Spermine Gates Inward-rectifying Muscarinic but Not ATP-sensitive K+ Channels in Rabbit Atrial Myocytes

1995 • 76 citations

α1-Adrenoceptor stimulation increases intracellular pH and Ca2+ in cardiomyocytes through Na+/H+ and Na+/Ca2+ exchange

1990 • 76 citations

One hour of myocardial ischemia in conscious dogs increases β-adrenergic receptors, but decreases adenylate cyclase activity

1988 • 75 citations

Regulation of Ca2+ current in frog ventricular myocytes by the holding potential, c-AMP and frequency

1989 • 75 citations

Regulation of calcium slow channels of cardiac muscle by cyclic nucleotides and phosphorylation

1988 • 75 citations

The negative inotropic effect of acetylcholine on ferret ventricular myocardium.

1988 • 74 citations

Direct regulation of cardiac Ca2+ channels by G proteins: neither proven nor necessary?

1992 • 74 citations

Forskolin Stimulates Swelling-Induced Chloride Current, Not Cardiac Cystic Fibrosis Transmembrane-Conductance Regulator Current, in Human Cardiac Myocytes

1995 • 74 citations

The effect of exchanger inhibitory peptide (XIP) on sodium-calcium exchange current in guinea pig ventricular cells.

1993 • 74 citations

Contribution of a swelling-activated chloride current to changes in the cardiac action potential

1997 • 74 citations

On the mechanism of basal and agonist-induced activation of the G protein-gated muscarinic K+ channel in atrial myocytes of guinea pig heart.

1991 • 74 citations

Measurement of matrix free Mg2+ concentration in rat heart mitochondria by using entrapped fluorescent probes

1990 • 74 citations

Delayed Rectifier Channels in Human Ventricular Myocytes

1995 • 74 citations

Alternative splicing of CFTR Cl- channels in heart

1993 • 74 citations

Modification of gap junction conductance by divalent cations and protons in neonatal rat heart cells

1995 • 73 citations

Mechanisms of inactivation of L-type calcium channels in human atrial myocytes

1997 • 73 citations

Interaction of the Na⁺‐K⁺ pump and Na⁺‐Ca²⁺ exchange via [Na⁺]_i in a restricted space of guinea‐pig ventricular cells

1998 • 73 citations

Contribution of Na+/Ca2+ exchange to action potential of human atrial myocytes

1996 • 73 citations

The pacemaker current (If) plays an important role in regulating SA node pacemaker activity

1995 • 73 citations

Direct Activation of the ATP-sensitive Potassium Channel by Oxygen Free Radicals in Guinea-pig Ventricular Cells:its Potentiation by MgADP

1996 • 73 citations

Molecular and Functional Identification of m ₁ Muscarinic Acetylcholine Receptors in Rat Ventricular Myocytes

1996 • 72 citations

Ca2+ cycling between sarcoplasmic reticulum and mitochondria in rabbit cardiac myocytes.

1993 • 72 citations

Sinus slowing and pacemaker shift caused by adenosine in rabbit SA node

1985 • 72 citations

Alterations in electrical activity and membrane currents induced by intracellular oxygen-derived free radical stress in guinea pig ventricular myocytes.

1993 • 72 citations

Mechanism of modulation of the voltage-gated skeletal and cardiac muscle sodium channels by fatty acids

1997 • 72 citations

Modulation of the delayed rectifier, IK, by cadmium in cat ventricular myocytes

1992 • 72 citations

Effect of ischemia and reperfusion on sarcoplasmic reticulum calcium uptake.

1992 • 72 citations

?-Subunit expression is required for cAMP-dependent increase of cloned cardiac and vascular calcium channel currents

1992 • 72 citations

Repolarizing K ⁺ Currents in Nonfailing Human Hearts

1995 • 71 citations

Sodium conductance in calcium channels of guinea-pig ventricular cells induced by removal of external calcium ions

1986 • 71 citations

Role of GTP-binding proteins in the regulation of mammalian cardiac chloride conductance.

1992 • 70 citations

Activation mechanism of Ca(2+)‐sensitive transient outward current in rabbit ventricular myocytes.

1995 • 70 citations

Gradation of Ca(2+)‐induced Ca2+ release by voltage‐clamp pulse duration in potentiated guinea‐pig ventricular myocytes.

1994 • 70 citations

Early afterdepolarizations induced in vivo by reperfusion of ischemic myocardium. A possible mechanism for reperfusion arrhythmias.

1990 • 70 citations

Activation and inactivation kinetics of an E-4031-sensitive current from single ferret atrial myocytes

1996 • 70 citations

Ionic basis of the chronotropic effect of acetylcholine on the rabbit sinoatrial node

1995 • 70 citations

Alpha-subunit of Gs directly activates cardiac calcium channels in lipid bilayers

1988 • 70 citations

Tetrodotoxin‐blockable calcium currents in rat ventricular myocytes; a third type of cardiac cell sodium current

1997 • 69 citations

Two distinct functional effects of protein phosphatase inhibitors on guinea‐pig cardiac L‐type Ca2+ channels.

1995 • 69 citations

Inositol Phosphate Release and Metabolism During Myocardial Ischemia and Reperfusion in Rat Heart

1995 • 69 citations

Acetylcholine-sensitive muscarinic K+ channels in mammalian ventricular myocytes

1994 • 69 citations

The pacemaker current I_f in single human atrial myocytes and the effect of β‐adrenoceptor and A₁‐adenosine receptor stimulation

1997 • 69 citations

Effects of metabolic blockade on intracellular calcium concentration in isolated ferret ventricular muscle.

1988 • 69 citations

Desensitization of the acetylcholine‐induced increase of potassium conductance in rabbit cardiac Purkinje fibres.

1986 • 69 citations

Reperfusion induced arrhythmias following ischaemia in intact rat heart: role of intracellular calcium

1995 • 68 citations

ATP‐sensitive K channels in heart muscle Spare channels

1991 • 68 citations

Effect of Sustained Load on Dispersion of Ventricular Repolarization and Conduction Time in the Isolated Intact Rabbit Heart

1996 • 68 citations

Catecholamines modulate the delayed rectifying potassium current (IK) in guinea pig ventricular myocytes

1987 • 67 citations

Effect of lidocaine on contracture, intracellular sodium, and pH in ischemic rat hearts

1993 • 67 citations

Single sodium channels from canine ventricular myocytes: voltage dependence and relative rates of activation and inactivation.

1989 • 67 citations

External K+ increases Na+ conductance of the hyperpolarization-activated current in rabbit cardiac pacemaker cells

1992 • 67 citations

Recovery of anoxic-reoxygenated cardiomyocytes from severe Ca2+ overload

1992 • 67 citations

Function, Regulation, Pharmacology, and Molecular Structure of ATP‐Sensitive K⁺ Channels in the Cardiovascular System

1997 • 67 citations

L-palmitylcarnitine and calcium ions act similarly on excitatory ionic currents in avian ventricular muscle.

1983 • 66 citations

Arrhythmias and cellular electrophysiological changes during myocardial "ischaemia" and reperfusion

1983 • 66 citations

ATP‐regulated K+ channels are modulated by intracellular H+ in guinea‐pig ventricular cells.

1993 • 66 citations

Reperfusion arrhythmias in isolated perfused pig hearts. Inhomogeneities in extracellular potassium, ST and TQ potentials, and transmembrane action potentials.

1992 • 66 citations

The sustained inward current in sino-atrial node cells of guinea-pig heart

1997 • 66 citations

[Autonomously promoted extension effect in Purkinje fibers, papillary muscles and trabeculae carneae of rhesus monkeys].

1967 • 66 citations

Activation of chloride current by purinergic stimulation in guinea pig heart cells.

1992 • 65 citations

Gating kinetics of ATP-sensitive single potassium channels in myocardial cells depends on electromotive force

1988 • 65 citations

Molecular Cloning of Two Human Cardiac Gap Junction Proteins, Connexin40 and Connexin45

1994 • 65 citations

Lanthanum blocks a specific component of IK and screens membrane surface change in cardiac cells

1990 • 65 citations

Surface topography and molecular stoichiometry of the mitochondrial channel, VDAC, in crystalline arrays*1

1991 • 65 citations

Arachidonic acid and lipoxygenase metabolites uncouple neonatal rat cardiac myocyte pairs

1992 • 64 citations

Cardiac swelling-induced chloride current depolarizes canine atrial myocytes

1997 • 64 citations

”Voltage-activated Ca release" in rabbit, rat and guinea-pig cardiac myocytes, and modulation by internal cAMP

1997 • 64 citations

Single delayed rectifier channels in the membrane of rabbit ventricular myocytes.

1993 • 64 citations

Lipid Peroxidation‐Derived Free Radical Production and Postischemic Myocardial Reperfusion Injury_a

1994 • 64 citations

Beta-2 adrenergic activation of L-type Ca++ current in cardiac myocytes.

1997 • 64 citations

Single channel characteristics of a high conductance anion channel in "sarcoballs".

1989 • 64 citations

Sodium‐‐potassium pump current in rabbit sino‐atrial node cells.

1996 • 64 citations

Properties and modulation of If in newborn versus adult cardiac SA node

1997 • 63 citations

Evidence for an electrogenic Na⁺‐HCO₃⁻ symport in rat cardiac myocytes

1998 • 63 citations

Cystic fibrosis gene encodes a cAMP-dependent chloride channel in heart.

1996 • 63 citations

Effects of arachidonic acid on the gap junctions of neonatal rat heart cells

1990 • 63 citations

Antiarrhythmic effects of HOE642, a novel Na+-H+ exchange inhibitor, on ventricular arrhythmias in animal hearts

1996 • 63 citations

Coexpression of beta 1 with cardiac sodium channel alpha subunits in oocytes decreases lidocaine block.

1996 • 63 citations

Activation and inhibition of K-ATP currents by guanine nucleotides is mediated by different channel subunits

1997 • 63 citations

Rectification of muscarinic K+ current by magnesium ion in guinea pig atrial cells

1987 • 62 citations

Delayed rectification in single cells isolated from guinea pig sinoatrial node

1992 • 62 citations

Simulated ischaemia and reperfusion in isolated guinea pig ventricular myocytes

1994 • 62 citations

Effect of serial brief ischemic episodes on extracellular K+, pH, and activation in the pig.

1985 • 61 citations

Targeting Peptides Transiently Block a Mitochondrial Channel

1995 • 61 citations

P2-purinoceptor activation stimulates phosphoinositide hydrolysis and inhibits accumulation of cAMP in cultured ventricular myocytes.

1992 • 61 citations

Extracellular volume and transsarcolemmal proton movement during ischemia and reperfusion: A ³¹P NMR spectroscopic study of the isovolumic rat heart

1993 • 61 citations

Effects of hydrogen peroxide on action potentials and intracellular Ca2+ concentration of guinea pig heart

1989 • 61 citations

Initiation of ventricular extrasystoles by myocardial stretch in chronically dilated and failing canine left ventricle.

1994 • 61 citations

Changes in Mitochondrial Matrix Free Calcium in Perfused Rat Hearts Subjected to Hypoxia-Reoxygenation

1993 • 61 citations

Modulation of the transient outward current in adult rat ventricular myocytes by polyunsaturated fatty acids

1998 • 61 citations

Arrhythmogenic Action of Thrombin During Myocardial Reperfusion via Release of Inositol 1,4,5-Triphosphate

1996 • 61 citations

Early changes in extracellular potassium in ischemic rabbit myocardium. The role of extracellular carbon dioxide accumulation and diffusion.

1992 • 61 citations

Characterization of the acetylcholine‐induced potassium current in rabbit cardiac Purkinje fibres.

1986 • 61 citations

Antiarrhythmic effects of cariporide, a novel Na+–H+ exchange inhibitor, on reperfusion ventricular arrhythmias in rat hearts

1997 • 60 citations

Nucleotide regulation of ATP sensitive potassium channels

1994 • 60 citations

Large-conductance chloride channels of new-born rat cardiac myocytes are activated by hypotonic media

1992 • 60 citations

Dual activation of the cardiac Ca2+ channel alpha 1C-subunit and its modulation by the beta-subunit

1995 • 60 citations

Influence of long-chain acylcarnitines on voltage-dependent calcium current in adult ventricular myocytes

1992 • 60 citations

Epinephrine and the pacemaking mechanisms at plateau potentials in sheep cardiac Purkinje fibers

1979 • 60 citations

Ventricular fibrillation

1985 • 60 citations

CFTR chloride channels in human and simian heart

1996 • 60 citations

Acidosis-induced abnormal repolarization and repetitive activity in isolated dog Purkinje fibers.

1980 • 59 citations

Autonomic response to coronary occlusion in animals susceptible to ventricular fibrillation

1989 • 59 citations

Outward currents underlying repolarization in human atrial myocytes

1995 • 59 citations

The T-type Ca channel in guinea-pig ventricular myocytes is insensitive to isoproterenol

1988 • 59 citations

Activation of cardiac vagal receptors during myocardial ischemia

1971 • 59 citations

Enhanced inositol trisphosphate response to alpha 1-adrenergic stimulation in cardiac myocytes exposed to hypoxia.

1989 • 59 citations

Pyruvate augments calcium transients and cell shortening in rat ventricular myocytes

1998 • 59 citations

Ca(2+)-dependent inactivation of cardiac L-type Ca2+ channels does not affect their voltage sensor.

1993 • 58 citations

Voltage-dependent block by tetrodotoxin of the sodium channel in rabbit cardiac Purkinje fibers

1987 • 58 citations

Properties of the low threshold Ca current in single frog atrial cardiomyocytes. A comparison with the high threshold Ca current.

1992 • 58 citations

A disrupter of actin microfilaments impairs sulfonylurea-inhibitory gating of cardiac KATP channels

1996 • 58 citations

Arrhythmic activity in reoxygenated guinea pig papillary muscles and ventricular cells.

1987 • 58 citations

Permeation through the calcium release channel of cardiac muscle

1997 • 58 citations

A Gs protein couples P2-purinergic stimulation to cardiac Ca channels without cyclic AMP production.

1992 • 58 citations

Inositol trisphosphate enhances Ca2+ oscillations but not Ca2+-induced Ca2+ release from cardiac sarcoplasmic reticulum

1991 • 58 citations

The role of calcium in ischemic myocardial injury.

1987 • 58 citations

Open sodium channel properties of single canine cardiac Purkinje cells

1987 • 57 citations

Intercellular Ca²⁺ waves in rat heart muscle

1998 • 57 citations

Gating of mammalian cardiac gap junction channels by transjunctional voltage

1992 • 57 citations

Intracellular calcium does not directly modulate cardiac pacemaker (if) channels

1991 • 57 citations

Induction and removal of inward‐going rectification in sheep cardiac Purkinje fibres

1982 • 57 citations

Comparative mechanisms of 4-aminopyridine-resistant Ito in human and rabbit atrial myocytes

1995 • 57 citations

Persistent Activation of a Swelling-Activated Cation Current in Ventricular Myocytes From Dogs With Tachycardia-Induced Congestive Heart Failure

1998 • 57 citations

Nitric Oxide Signaling Mediates Stimulation of L-Type Ca2+ Current Elicited by Withdrawal of Acetylcholine in Cat Atrial Myocytes

1998 • 56 citations

Properties of L-type calcium channel gating current in isolated guinea pig ventricular myocytes.

1991 • 56 citations

Control of Maximum Sarcoplasmic Reticulum Ca Load in Intact Ferret Ventricular Myocytes

1998 • 56 citations

Structural requirements for charged lipid molecules to directly increase or suppress K+ channel activity in smooth muscle cells. Effects of fatty acids, lysophosphatidate, acyl coenzyme A and sphingosine.

1994 • 56 citations

Sympatho-adrenergic activation of the ischemic myocardium and its arrhythmogenic impact

1994 • 56 citations

Cytoskeleton modulates coupling between availability and activation of cardiac sodium channel

1997 • 55 citations

Intramitochondrial free calcium in cardiac myocytes in relation to dehydrogenase activation

1993 • 55 citations

Two types of delayed rectifying K+ channels in atrial cells of guinea pig heart.

1990 • 55 citations

Effects of phorbol ester on gap junctions of neonatal rat heart cells

1993 • 55 citations

Mechanism of extracellular ATP-induced depolarization in rat isolated ventricular cardiomyocytes

1990 • 55 citations

Cell swelling has differential effects on the rapid and slow components of delayed rectifier potassium current in guinea pig cardiac myocytes.

1995 • 55 citations

Conductance properties of the Na(+)‐activated K+ channel in guinea‐pig ventricular cells.

1991 • 55 citations

Probing the structure of the conduction pathway of the sheep cardiac sarcoplasmic reticulum calcium-release channel with permeant and impermeant organic cations.

1993 • 55 citations

Beta‐adrenergic and cholinergic modulation of inward rectifier K+ channel function and phosphorylation in guinea‐pig ventricle.

1995 • 54 citations

The effect of lipid intermediates on Ca2+ and Na+ permeability and (Na+ + K+)-ATPase of cardiac sarcolemma. A possible role in myocardial ischemia

1984 • 54 citations

Effect of metabolic inhibitors and second messengers upon Na(+)‐H+ exchange in the sheep cardiac Purkinje fibre.

1994 • 54 citations

Effect of arachidonic acid on the L‐type calcium current in frog cardiac myocytes.

1996 • 54 citations

Role of Calcium Loading in Early Afterdepolarizations Generated by Cs⁺ in Canine and Guinea Pig Purkinje Fibers

1995 • 54 citations

Identification of a specific radioligand for the cardiac rapidly activating delayed rectifier K+ channel.

1993 • 54 citations

A rapidly activating delayed rectifier K+ channel in rabbit sinoatrial node cells

1995 • 54 citations

ATP‐sensitive K+ channel modification by metabolic inhibition in isolated guinea‐pig ventricular myocytes.

1993 • 54 citations

Cyclic AMP prevents activation of a swelling‐induced chloride‐sensitive conductance in chick heart cells.

1995 • 54 citations

Barium- and calcium-permeable channels open at negative membrane potentials in rat ventricular myocytes

1989 • 54 citations

Arachidonic acid metabolites alter G protein-mediated signal transduction in heart. Effects on muscarinic K+ channels.

1990 • 54 citations

Arrhythmogenic and electrophysiological effects of alpha adrenoceptor stimulation during myocardial ischaemia and reperfusion

1987 • 53 citations

Cytosolic and mitochondrial [Ca2+] in whole hearts using indo-1 acetoxymethyl ester: effects of high extracellular Ca2+

1996 • 53 citations

On the role of G protein activation and phosphorylation in desensitization to acetylcholine in guinea‐pig atrial cells.

1993 • 53 citations

Calcium and sodium control in hypoxic-reoxygenated cardiomyocytes

1993 • 53 citations

Identification and properties of an ATP‐sensitive K+ current in rabbit sino‐atrial node pacemaker cells.

1996 • 53 citations

Changes of the subsarcolemmal Na+ concentration in internally perfused cardiac cells

1991 • 53 citations

Electrophysiological properties and responses to simulated ischemia in cat ventricular myocytes of endocardial and epicardial origin.

1990 • 53 citations

Heterogeneities in [K ⁺ ] _o and TQ Potential and the Inducibility of Ventricular Fibrillation During Acute Regional Ischemia in the Isolated Perfused Porcine Heart

1995 • 53 citations

Beta‐adrenergic and muscarinic regulation of the chloride current in guinea‐pig ventricular cells.

1991 • 53 citations

Rectification of whole cell cystic fibrosis transmembrane conductance regulator chloride current

1995 • 53 citations

Mode of regulation by G protein of the ATP‐sensitive K+ channel in guinea‐pig ventricular cell membrane.

1994 • 53 citations

Properties of normal and non-inactivating single cardiac Na ⁺ channels

1987 • 52 citations

Contribution of shrinkage of extracellular space to extracellular K+ accumulation in myocardial ischaemia of the rabbit.

1996 • 52 citations

Effects of extracellular Mg2+ on T- and L-type Ca2+ currents in single atrial myocytes

1990 • 52 citations

Time course of postnatal changes in rat heart action potential and in transient outward current is different

1994 • 52 citations

Regulation of adenosine triphosphate-sensitive potassium channels from rabbit ventricular myocytes by protein kinase C and type 2A protein phosphatase

1995 • 52 citations

Effects of external protons on single cardiac sodium channels from guinea pig ventricular myocytes.

1991 • 52 citations

Sodium channel inactivation from resting states in guinea‐pig ventricular myocytes.

1991 • 51 citations

Inositol trisphosphate promotes Na-Ca exchange current by releasing calcium from sarcoplasmic reticulum in cardiac myocytes.

1991 • 51 citations

Transmural pH gradient in canine myocardial ischemia

1984 • 51 citations

Effects of anoxia on K and Ca currents in isolated guinea pig cardiocytes

1990 • 51 citations

Dependence of Na+ pump current on external monovalent cations and membrane potential in rabbit cardiac Purkinje cells.

1991 • 51 citations

Effects of phenylephrine on calcium current and contractility of feline ventricular myocytes

1988 • 51 citations

Modulation of the Hyperpolarization-Activated Current (I _f ) by Adenosine in Rabbit Sinoatrial Myocytes

1996 • 51 citations

Ionic Mechanisms of the Cardiac Pacemaker Potential.

1996 • 51 citations

Action potentials, ionic currents and cell water in guinea pig ventricular preparations exposed to dimethyl sulfoxide.

1995 • 51 citations

Endothelin activation of an inwardly rectifying K+ current in atrial cells.

1991 • 51 citations

Fuzzy space and control of Na⁺, K⁺‐pump rate in heart and skeletal muscle

1996 • 51 citations

Continuous determination of extracellular space and changes of K+, Na+, Ca2+, and H+ during global ischaemia in isolated rat hearts

1990 • 50 citations

Effect of H+ on ATP-regulated K+ channels in feline ventricular myocytes

1991 • 50 citations

Permeability of canine cardiac sarcoplasmic reticulum vesicles to K+, Na+, H+, and Cl-.

1982 • 50 citations

Comparison of Ito in young and adult human atrial myocytes: evidence for developmental changes

1995 • 50 citations

Functional interaction between K(ATP) channels and the Na(+)‐K(+) pump in metabolically inhibited heart cells of the guinea‐pig.

1996 • 50 citations

Modulation of the T-type cardiac Ca channel by changes in proton concentration.

1990 • 50 citations

Autonomic regulation of delayed rectifier K+ current in mammalian heart involves G proteins

1989 • 50 citations

Effect of changes in load on monophasic action potential and segment length of pig heart in situ

1989 • 49 citations

Ca2+ and Mg-ATP activated potassium channels from rat pulmonary artery

1992 • 49 citations

Unitary Chloride Channels Activated by Protein Kinase C in Guinea Pig Ventricular Myocytes

1995 • 49 citations

A direct negative inotropic effect of acetylcholine on rat ventricular myocytes

1993 • 49 citations

Reperfusion-induced arrhythmias. A role for washout of extracellular protons?

1992 • 49 citations

Kinetics of ATP-sensitive K+ channel revealed with oil-gate concentration jump method

1989 • 49 citations

Modulation of cardiac sodium channel gating by lysophosphatidylcholine

1991 • 49 citations

Modulation of L-type Ca2+ current by fast and slow Ca2+ buffering in guinea pig ventricular cardiomyocytes

1997 • 49 citations

Effects of acetylcholine on electrophysiological properties of rabbit cardiac Purkinje fibers.

1983 • 49 citations

Intracellular H+ and Ca2+ modulation of trypsin-modified ATP-sensitive K+ channels in rabbit ventricular myocytes.

1993 • 49 citations

Intracellular Ca modulates K-inward rectification in cardiac myocytes

1989 • 49 citations

Ionic mechanisms of transient inward current in the absence of Na(+)‐Ca2+ exchange in rabbit cardiac Purkinje fibres.

1992 • 48 citations

Stretch-activated channel blockers modulate cell volume in cardiac ventricular myocytes

1995 • 48 citations

ATP-dependent activation of atrial muscarinic K+ channels in the absence of agonist and G-nucleotides

1990 • 48 citations

Ischemic poison lysophosphatidylcholine modifies heart sodium channels gating inducing long-lasting bursts of openings

1989 • 48 citations

Intracellular protons inhibit inward rectifier K+ channel of guinea-pig ventricular cell membrane

1992 • 48 citations

Enhancement of ATP‐sensitive potassium current in cat ventricular myocytes by beta‐adrenoreceptor stimulation.

1994 • 48 citations

Characteristics of the time-dependent slow inward current in adult human atrial single myocytes

1986 • 48 citations

ATP-sensitive potassium channels are modulated by intracellular lactate in rabbit ventricular myocytes

1993 • 48 citations

Oxygen-Derived Free Radical Stress Activates Nonselective Cation Current in Guinea Pig Ventricular Myocytes

1995 • 48 citations

Modulation of L‐type Ca2+ current by extracellular ATP in ferret isolated right ventricular myocytes.

1993 • 48 citations

Effects of thiol-modifying agents on KATP channels in guinea pig ventricular cells

1995 • 48 citations

Ultra-slow voltage-dependent inactivation of the calcium current in guinea-pig and ferret ventricular myocytes

1994 • 47 citations

The effect of internal sodium and caesium on phasic contraction of patch‐clamped rabbit ventricular myocytes.

1996 • 47 citations

Sarcolemmal Na+-Ca2+ exchange activity in hearts subjected to hypoxia reoxygenation

1987 • 47 citations

Intramembrane charge movement in guinea‐pig and rat ventricular myocytes.

1989 • 47 citations

The mechanism of rectification of iK1 in canine Purkinje myocytes.

1990 • 47 citations

Factors affecting the propagation of locally activated systolic Ca transients in rat ventricular myocytes

1993 • 47 citations

Reperfusion damage: free radicals mediate delayed membrane changes rather than early ventricular arrhythmias

1990 • 47 citations

Effects of lysophosphatidylcholine on electrophysiological properties and excitation-contraction coupling in isolated guinea pig ventricular myocytes.

1991 • 47 citations

Singlet oxygen interaction with Ca(2+)-ATPase of cardiac sarcoplasmic reticulum.

1991 • 47 citations

Oxidant stress inhibits Na-Ca-exchange current in cardiac myocytes: mediation by sulfhydryl groups?

1994 • 47 citations

Regulation of the mitochondrial outer membrane channel, VDAC

1987 • 47 citations

Properties of a protein kinase C-activated chloride current in guinea pig ventricular myocytes.

1994 • 46 citations

Activation of KATP Channels by Na/K pump in Isolated Cardiac Myocytes and Giant Membrane Patches

1998 • 46 citations

Interdependence of intracellular taurine and sodium in guinea pig heart

1992 • 46 citations

New Insights Into the Gating Mechanisms of Cardiac Ryanodine Receptors Revealed by Rapid Changes in Ligand Concentration

1995 • 46 citations

Development of inwardly rectifying K+ channel family in rat ventricular myocytes

1997 • 46 citations

Ca2+-calmodulin Mediated Modulation of the Electrical Coupling of Ventricular Myocytes Isolated from Guinea Pig Heart

1994 • 46 citations

Properties of single outwardly rectifying Cl- channels in heart.

1994 • 46 citations

Inhibitory effects of palmitoylcarnitine and lysophosphatidylcholine on the sodium current of cardiac ventricular cells

1992 • 46 citations

Inward rectification of the IRK1 channel expressed in Xenopus oocytes: effects of intracellular pH reveal an intrinsic gating mechanism.

1996 • 45 citations

Early Afterdepolarization Formation in Cardiac Myocyte:.

1994 • 45 citations

Regional differences in the negative inotropic effect of acetylcholine within the canine ventricle.

1996 • 45 citations

Stretch activation of a toad smooth muscle K+ channel may be mediated by fatty acids.

1995 • 45 citations

Voltage‐dependent blockade of HERG channels expressed in Xenopus oocytes by external Ca²⁺ and Mg²⁺

1998 • 45 citations

Mechanism of chloride-dependent release of Ca2+ in the sarcoplasmic reticulum of rabbit skeletal muscle

1994 • 45 citations

Late Na channels in cardiac cells: the physiological role of background Na channels

1994 • 45 citations

Molecular Regulation of the Na⁺‐Ca²⁺ Exchanger

1996 • 45 citations

Comparison of effects of acetylcholine on calcium and potassium currents in frog atrium and ventricle.

1987 • 45 citations

L- and T-type Ca2+ channels in canine cardiac Purkinje cells. Single-channel demonstration of L-type Ca2+ window current.

1992 • 45 citations

Interaction of sympathetic and parasympathetic nervous system on ventricular refractoriness assessed by local fibrillation intervals in the canine heart

1993 • 45 citations

Inactivation properties of T-type calcium current in canine cardiac Purkinje cells

1989 • 44 citations

α ₁ -Adrenergic Activation Inhibits β-Adrenergic–Stimulated Unitary Ca ²⁺ Currents in Cardiac Ventricular Myocytes

1996 • 44 citations

ATPo but not cAMPi activates a chloride conductance in mouse ventricular myocytes

1995 • 44 citations

Intracellular magnesium blocks sodium outward currents in a voltage- and dose-dependent manner

1989 • 44 citations

Activation of a nonselective cation channel by swelling in atrial cells

1993 • 44 citations

Ischemia Potentiates the Mechanosensitive Modulation of Atrial ATP‐Sensitive Potassium Channels a

1994 • 44 citations

Properties of an early outward current in single cells of the mouse ventricle.

1988 • 44 citations

Biphasic Response of Action Potential Duration to Metabolic Inhibition in Rabbit and Human Ventricular Myocytes: Role of Transient Outward Current and ATP-regulated Potassium Current

1996 • 44 citations

Arrhythmia and Delayed Recovery of Cardiac Action Potential During Reperfusion After Ischemia

1995 • 44 citations

Single chloride-selective channel from cardiac sarcoplasmic reticulum studied in planar lipid bilayers

1989 • 44 citations

Exogenous lysophosphatidylcholine increases non-selective cation current in guinea-pig ventricular myocytes

1996 • 44 citations

Small Changes of Cytosolic Sodium in Rat Ventricular Myocytes Measured with SBFI in Emission Ratio Mode

1997 • 43 citations

Surface charge and properties of cardiac ATP-sensitive K+ channels.

1994 • 43 citations

The role of cAMP and Ca on the modulation of junctional conductance: An integrated hypothesis

1983 • 43 citations

Two mechanisms for inward rectification of current flow through the purinoceptor P2X₂ class of ATP‐gated channels

1998 • 43 citations

Mitochondrial free Ca2+ concentration in living cells

1994 • 43 citations

Slow recovery of the maximal rate of rise ( $$\dot V_{max} $$ ) of the action potential in sheep cardiac Purkinje fibers

1982 • 43 citations

Catecholamine release and potassium accumulation in the isolated globally ischemic rabbit heart

1988 • 43 citations

Ca-activated chloride current and Na-Ca exchange have different timecourses during sarcoplasmic reticulum Ca release in ferret ventricular myocytes

1998 • 43 citations

Thrombin activates a membrane-associated calcium-independent PLA₂ in ventricular myocytes

1998 • 43 citations

Gating currents associated with Na channels in canine cardiac Purkinje cells.

1990 • 43 citations

Diastolic SR Ca efflux in atrial pacemaker cells and Ca-overloaded myocytes

1997 • 42 citations

Hydroxyl radical production during myocardial ischemia and reperfusion in cats

1996 • 42 citations

Effects of1-adrenergic Stimulation on L-type Ca2+Current in Rat Ventricular Myocytes

1998 • 42 citations

Nitric oxide mediates the anti-adrenergic effect of adenosine on calcium current in isolated rabbit atrioventricular nodal cells

1996 • 42 citations

Surface charge potentiates conduction through the cardiac ryanodine receptor channel.

1994 • 42 citations

Kinetic evidence distinguishing volume‐sensitive chloride current from other types in guinea‐pig ventricular myocytes.

1996 • 42 citations

Phenylephrine-induced stimulation of Na+/Ca2+ exchange in rat ventricular myocytes

1998 • 42 citations

Recent Insights Pertaining to Sarcolemmal Phospholipid Alterations Underlying Arrhythmogenesis in the Ischemic Heart

1993 • 41 citations

Inositol 1,4,5-trisphosphate releases intracellular Ca2+ in permeabilized chick atria

1990 • 41 citations

An Electrophysiological Study of Yeast Mitochondria

1995 • 41 citations

Role of cAMP‐dependent protein kinase A in activation of a voltage‐sensitive release mechanism for cardiac contraction in guinea‐pig myocytes

1998 • 41 citations

High permeation of L-type Ca2+ channels at physiological [Ca2+]: homogeneity and dependence on the alpha 1-subunit

1996 • 41 citations

Role of L‐Type Calcium Channel Window Current in Generating Current‐Induced Early Afterdepolarizations

1994 • 41 citations

Distribution of extracellular potassium and electrophysiologic changes during two-stage coronary ligation in the isolated, perfused canine heart.

1989 • 41 citations

Cation‐dependent gating of the hyperpolarization‐activated cation current in the rabbit sino‐atrial node cells.