Sodium Current-Induced Release of Calcium from Cardiac Sarcoplasmic Reticulum

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1981 • 18,584 citations

Calcium-induced release of calcium from the cardiac sarcoplasmic reticulum

1983 • 1,884 citations

The dependence of calcium efflux from cardiac muscle on temperature and external ion composition

1968 • 1,024 citations

Voltage Dependent Charge Movement in Skeletal Muscle: a Possible Step in Excitation–Contraction Coupling

1973 • 978 citations

Time and calcium dependence of activation and inactivation of calcium-induced release of calcium from the sarcoplasmic reticulum of a skinned canine cardiac Purkinje cell.

1985 • 904 citations

Mechanism of calcium channel blockade by verapamil, D600, diltiazem and nitrendipine in single dialysed heart cells

1983 • 869 citations

Two kinds of calcium channels in canine atrial cells. Differences in kinetics, selectivity, and pharmacology.

1985 • 715 citations

Calcium gradients in single smooth muscle cells revealed by the digital imaging microscope using Fura-2

1985 • 660 citations

The antagonism between Ca and Na ions on the frog's heart

1958 • 497 citations

Regulation of Calcium Release Is Gated by Calcium Current, Not Gating Charge, in Cardiac Myocytes

1989 • 451 citations

Simulated calcium current can both cause calcium loading in and trigger calcium release from the sarcoplasmic reticulum of a skinned canine cardiac Purkinje cell.

1985 • 445 citations

Mechanism of release of calcium from sarcoplasmic reticulum of guinea‐pig cardiac cells.

1988 • 418 citations

Na-Ca exchange current in mammalian heart cells

1986 • 370 citations

Effect of Membrane Potential Changes on the Calcium Transient in Single Rat Cardiac Muscle Cells

1987 • 353 citations

Ion fluxes in cardiac excitation and contraction and their relation to myocardial contractility.

1968 • 314 citations

Excitation-contraction coupling in heart muscle: Membrane control of development of tension

1973 • 304 citations

Increase in intracellular sodium ion activity during stimulation in mammalian cardiac muscle.

1982 • 258 citations

Na-Ca exchange: stoichiometry and electrogenicity

1985 • 256 citations

Does the organic calcium channel blocker D600 act from inside or outside on the cardiac cell membrane?

1982 • 254 citations

Two types of calcium channels in guinea pig ventricular myocytes.

1986 • 230 citations

Ionic basis of the different action potential configurations of single guinea‐pig atrial and ventricular myocytes.

1985 • 223 citations

Identification of Na-Ca exchange current in single cardiac myocytes

1986 • 220 citations

Mechanism of action of therapeutic levels of cardiac glycosides

1980 • 184 citations

Sodium-Calcium Exchange in Heart: Membrane Currents and Changes in [Ca ²⁺ ] _i

1987 • 175 citations

Sodium‐calcium exchange during the action potential in guinea‐pig ventricular cells.

1989 • 163 citations

Calcium transients and intramembrane charge movement in skeletal muscle fibres

1979 • 152 citations

Membrane Adenosinetriphosphatase: A Digitalis Receptor?

1977 • 143 citations

Intramembrane charge movement and calcium release in frog skeletal muscle.

1986 • 137 citations

Effects of some inhibitors of ionic permeabilities on ventricular action potential and contraction of rat and guinea-pig hearts

1968 • 128 citations

The quantitative relationship between twitch tension and intracellular sodium activity in sheep cardiac Purkinje fibres.

1984 • 125 citations

200 years of digitalis: the emerging central role of the sodium ion in the control of cardiac force

1985 • 122 citations

The role of calcium in the control of myocardial contractility: An update

1980 • 121 citations

On the mechanism underlying the action of D-600 on slow inward current and tension in mammalian myocardium.

1977 • 116 citations

Voltage clamp and internal perfusion of single rat heart muscle cells.

1981 • 113 citations

Relaxation of Isolated Ventricular Cardiomyocytes by a Voltage-Dependent Process

1988 • 108 citations

Excitation-contraction coupling in skeletal muscle

1985 • 101 citations

Can Ca entry via Na-Ca exchange directly activate cardiac muscle contraction?

1988 • 100 citations

Role of Ca2+ channel in development of tension in heart muscle

1987 • 97 citations

"Creep currents" in single frog atrial cells may be generated by electrogenic Na/Ca exchange.

1986 • 86 citations

Lidocaine's negative inotropic and antiarrhythmic actions. Dependence on shortening of action potential duration and reduction of intracellular sodium activity.

1985 • 81 citations

ACTION POTENTIAL, MEMBRANE CURRENTS AND FORCE OF CONTRACTION IN MAMMALIAN HEART MUSCLE FIBRES TREATED WITH QUINIDINE

1978 • 77 citations

New studies of the excitatory sodium currents in heart muscle.

1985 • 68 citations

A study of the contractures induced in frog atrial trabeculae by a reduction of the bathing sodium concentration

1974 • 63 citations

Negative inotropic effects of tetrodotoxin and seven class 1 antiarrhythmic drugs in relation to sodium channel blockade

1986 • 54 citations

The cellular basis of cardiotonic steroid action

1985 • 40 citations

Local anesthetics and the role of sodium in the force development by canine ventricular muscle and purkinje fibers.

1980 • 27 citations

Effects of tetrodotoxin on electrical and mechanical activity of cardiac Purkinje fibers

1982 • 27 citations

Block of sodium currents by the calcium antagonist D600 in human heart cell segments

1985 • 26 citations

Calcium channel antagonist properties of Bay K 8644 in single guinea pig ventricular cells.

1988 • 22 citations

Sodium ion and the cardiac actions of digitalis

1985 • 10 citations

Cardiotonic agents and the sodium transient

1981 • 3 citations

Response : Does Voltage Affect Excitation-Contraction Coupling in the Heart?

1989 • 2 citations