CYTOPLASMIC ATP-DEPENDENT REGULATION OF ION TRANSPORTERS AND CHANNELS: Mechanisms and Messengers

Phosphorylation-Dephosphorylation of Enzymes

1979 • 2,205 citations

Cloning of the β Cell High-Affinity Sulfonylurea Receptor: a Regulator of Insulin Secretion

1995 • 1,310 citations

Origins of Cell Polarity

1996 • 1,024 citations

Phosphoinositides as Regulators in Membrane Traffic

1996 • 717 citations

Properties and functions of ATP-sensitive K-channels

1990 • 690 citations

Regulation of Cardiac Na ⁺ ,Ca ²⁺ Exchange and K _ATP Potassium Channels by PIP ₂

1996 • 655 citations

Mammalian AMP-activated Protein Kinase Subfamily

1996 • 631 citations

Adenosine Diphosphate as an Intracellular Regulator of Insulin Secretion

1996 • 532 citations

Modulation of ION Channels by Protein Phosphorylation and Dephosphorylation

1994 • 530 citations

Phosphoinositides and Calcium as Regulators of Cellular Actin Assembly and Disassembly

1994 • 524 citations

Membrane Mechanisms and Intracellular Signalling in Cell Volume Regulation

1995 • 469 citations

Role of the AMP-activated protein kinase in the cellular stress response

1994 • 430 citations

Single channel measurements of the calcium release channel from skeletal muscle sarcoplasmic reticulum. Activation by Ca2+ and ATP and modulation by Mg2+.

1986 • 403 citations

Hormonal regulation, pharmacology, and membrane sorting of vertebrate Na+/H+ exchanger isoforms

1995 • 394 citations

Functional Coupling Between Glycolysis and Sarcoplasmic Reticulum Ca ²⁺ Transport

1995 • 311 citations

Translocation of the glucose transporter (GLUT4) to the cell surface in permeabilized 3T3-L1 adipocytes: effects of ATP insulin, and GTP gamma S and localization of GLUT4 to clathrin lattices

1992 • 307 citations

The Na+/H+ exchanger isoform 1 (NHE1) is a novel member of the calmodulin-binding proteins. Identification and characterization of calmodulin-binding sites.

1994 • 305 citations

The Na-K-Cl cotransporters

1994 • 304 citations

Stimulation of glucose transport in skeletal muscle by hypoxia

1991 • 299 citations

Significance of PIP2 hydrolysis and regulation of phospholipase C isozymes

1995 • 293 citations

ATP-DEPENDENT TRANSPORT SYSTEMS IN BACTERIA AND HUMANS: Relevance to Cystic Fibrosis and Multidrug Resistance

1993 • 290 citations

Actin filaments regulate epithelial Na+ channel activity

1991 • 283 citations

The stress-activated protein kinases are major c-Jun amino-terminal kinases activated by ischemia and reperfusion

1994 • 266 citations

The Na-K-Cl cotransport protein of shark rectal gland. II. Regulation by direct phosphorylation.

1992 • 256 citations

[Na] and [K] dependence of the Na/K pump current-voltage relationship in guinea pig ventricular myocytes.

1989 • 254 citations

Ischemia induces translocation of the insulin-responsive glucose transporter GLUT4 to the plasma membrane of cardiac myocytes.

1994 • 246 citations

Review Lecture: Protein phosphorylation and hormone action

1988 • 237 citations

Receptors for adenine nucleotides and nucleosides: subclassification, distribution, and molecular characterization.

1994 • 235 citations

Cardiac ATP-sensitive K+ channels. Evidence for preferential regulation by glycolysis.

1989 • 230 citations

A Cytoskeletal Mechanism for Ca2+ Channel Metabolic Dependence and Inactivation by Intracellular Ca2+

1993 • 215 citations

Cellular Stresses Differentially Activate c-Jun N-terminal Protein Kinases and Extracellular Signal-regulated Protein Kinases in Cultured Ventricular Myocytes

1995 • 212 citations

Membrane-bound ATP fuels the Na/K pump. Studies on membrane-bound glycolytic enzymes on inside-out vesicles from human red cell membranes.

1981 • 210 citations

Kinetics of activation and inactivation of swelling-stimulated K+/Cl- transport. The volume-sensitive parameter is the rate constant for inactivation.

1990 • 200 citations

Phosphorylation-dependent Regulation of Cardiac Na+/Ca2+ Exchanger via Protein Kinase C

1996 • 190 citations

Role of band 3 tyrosine phosphorylation in the regulation of erythrocyte glycolysis

1991 • 186 citations

Voltage-dependent potentiation of L-type Ca2+ channels in skeletal muscle cells requires anchored cAMP-dependent protein kinase.

1994 • 185 citations

Regulation of Ion Channels by ABC Transporters That Secrete ATP

1995 • 174 citations

ATP modulates the function of inositol 1,4,5-trisphosphate-gated channels at two sites

1993 • 167 citations

Growth factor activation and “H(+)-sensing” of the Na+/H+ exchanger isoform 1 (NHE1). Evidence for an additional mechanism not requiring direct phosphorylation.

1994 • 166 citations

Activation of epithelial Na+ channels by protein kinase A requires actin filaments

1993 • 163 citations

The giant cardiac membrane patch method: stimulation of outward Na(+)‐Ca2+ exchange current by MgATP.

1992 • 162 citations

ATP-dependent Regulation of Sodium-Calcium Exchange in Chinese Hamster Ovary Cells Transfected with the Bovine Cardiac Sodium-Calcium Exchanger

1995 • 160 citations

The volume-sensitive organic osmolyte-anion channel VSOAC is regulated by nonhydrolytic ATP binding

1994 • 156 citations

Regulation of Epithelial Sodium Channels by Short Actin Filaments

1996 • 153 citations

Actin

1990 • 142 citations

The CFTR Chloride Channel of Mammalian Heart

1995 • 140 citations

Functional linkage of the cardiac ATP-sensitive K+ channel to the actin cytoskeleton

1996 • 138 citations

Cytoskeleton disruption and apical redistribution of proximal tubule Na(+)-K(+)-ATPase during ischemia

1992 • 132 citations

The inositol 1,4,5-trisphosphate (InsP3) receptor

1995 • 132 citations

Kinase and phosphatase activities intimately associated with a reconstituted calcium-dependent potassium channel

1995 • 131 citations

Isoform-specific Purification and Substrate Specificity of the 5′-AMP-activated Protein Kinase

1996 • 131 citations

Phosphorylation-Independent Modulation of L-Type Calcium Channels by Magnesium-Nucleotide Complexes

1992 • 125 citations

Compartmentalized ATP synthesis in skeletal muscle triads

1992 • 121 citations

Activation of protein kinase C by phorbol ester induces downregulation of the Na+/K+-ATPase in oocytes ofXenopus laevis

1990 • 120 citations

Current-voltage analysis of apical sodium transport in toad urinary bladder: Effects of inhibitors of transport and metabolism

1980 • 117 citations

Role of the actin cytoskeleton on epithelial Na+ channel regulation

1995 • 114 citations

Phosphorylation affects voltage gating of the delayed rectifier K+ channel by electrostatic interactions

1990 • 112 citations

Cloned Ca2+-dependent K+ channel modulated by a functionally associated protein kinase

1994 • 103 citations

Phospholipid composition modulates the Na+−Ca2+ exchange activity of cardiac sarcolemma in reconstituted vesicles

1988 • 103 citations

Mechanism of cardiac Na(+)‐Ca2+ exchange current stimulation by MgATP: possible involvement of aminophospholipid translocase.

1992 • 101 citations

Extracorporeal shock waves stimulate frog sciatic nerves indirectly via a cavitation-mediated mechanism

1994 • 99 citations

Role of protein kinases in regulating sheep erythrocyte K-Cl cotransport

1996 • 94 citations

Activation of cardiac ATP-sensitive K+ current during hypoxia: correlation with tissue ATP levels

1991 • 94 citations

Comparison of endogenous and exogenous sources of ATP in fueling Ca2+ uptake in smooth muscle plasma membrane vesicles.

1992 • 92 citations

Activation and conductance properties of ryanodine-sensitive calcium channels from brain microsomal membranes incorporated into planar lipid bilayers

1989 • 92 citations

cAMP-independent regulation of CFTR by the actin cytoskeleton

1995 • 91 citations

Cytoskeletal regulation of membrane transport events ¹

1994 • 90 citations

Myocardial stretch stimulates phosphatidylinositol turnover.

1989 • 88 citations

Cell swelling activates ATP-dependent voltage-gated chloride channels in M-1 mouse cortical collecting duct cells.

1996 • 88 citations

Vanadate and fluoride effects on Na+-K+-Cl- cotransport in squid giant axon

1988 • 85 citations

Neurohumoral and Metabolic Effects of Short-Term Dietary NaCl Restriction in Men Relationship to Salt-Sensitivity Status

1991 • 82 citations

The Croonian Lecture, 1988 - Inositol lipids and calcium signalling

1988 • 81 citations

The MARCKS family of protein kinase-C substrates

1995 • 80 citations

Enhancement of glucose transport in response to inhibition of oxidative metabolism: pre- and posttranslational mechanisms

1992 • 79 citations

Insulin increases the Na(+)-K(+)-ATPase alpha 2-subunit in the surface of rat skeletal muscle: morphological evidence

1993 • 77 citations

Regulatory interaction between calmodulin and ATP on the red cell Ca2+ pump

1980 • 77 citations

Regulation of Na ‐ Ca Exchange

1991 • 76 citations

Downregulation of surface sodium pumps by endocytosis during meiotic maturation of Xenopus laevis oocytes

1990 • 72 citations

Historical perspectives on protein phosphorylation and a classification system for protein kinases

1983 • 72 citations

The human erythrocyte sugar transporter is also a nucleotide binding protein

1989 • 71 citations

The Giant Membrane Patch

1995 • 68 citations

Na-K-2Cl cotransport in intestinal epithelial cells. Influence of chloride efflux and F-actin on regulation of cotransporter activity and bumetanide binding.

1994 • 65 citations

Characterization of an ATP-stimulatable calcium2+ independent phospholipase A2 from clonal insulin-secreting HIT cells and rat pancreatic islets: a possible molecular component of the .beta.-cell fuel sensor

1994 • 65 citations

Phosphorylation sites in human erythrocyte band 3 protein

1991 • 62 citations

Relationship of the regulatory nucleotide site to the catalytic site of the sarcoplasmic reticulum Ca2+-ATPase.

1987 • 61 citations

ATP depletion induces an increase in the assembly of a labile pool of polymerized actin in endothelial cells

1993 • 61 citations

Nucleotide regulation of ATP sensitive potassium channels

1994 • 60 citations

The cytoskeleton and membrane transport

1994 • 60 citations

Cytoskeletal disruption in A6 kidney cells: Impact on endo/exocytosis and NaCl transport regulation by antidiuretic hormone

1995 • 59 citations

ATP Dependence of Na+/H+ Exchange

1997 • 59 citations

Characterization of an ATP‐modulated large conductance Ca(2+)‐activated K+ channel present in rat cortical neurones.

1995 • 57 citations

The role of ATP in swelling-stimulated K-Cl cotransport in human red cell ghosts. Phosphorylation-dephosphorylation events are not in the signal transduction pathway.

1993 • 54 citations

Na(+)-K(+)-ATPase that redistributes to apical membrane during ATP depletion remains functional

1993 • 54 citations

ATP depletion and inactivation of an ATP-sensitive taurine channel by classic ion channel blockers.

1995 • 53 citations

Actin and villin compartmentation during ATP depletion and recovery in renal cultured cells

1995 • 52 citations

Effects of anoxia on K and Ca currents in isolated guinea pig cardiocytes

1990 • 51 citations

The Na-K-Cl cotransporter of avian salt gland. Phosphorylation in response to cAMP-dependent and calcium-dependent secretogogues.

1992 • 50 citations

ATP depletion inhibits capacitative Ca2+ entry in rat thymic lymphocytes

1995 • 50 citations

Metabolic regulation of apical sodium permeability in toad urinary bladder in the presence and absence of aldosterone

1983 • 49 citations

Role of F-actin in the activation of Na+-K+-Cl? cotransport by forskolin and vasopressin in mouse kidney cultured thick ascending limb cells

1994 • 47 citations

Phosphorylation modulates potassium conductance and gating current of perfused giant axons of squid.

1990 • 47 citations

Modulation of single slow (L-type) calcium channels by intracellular ATP in vascular smooth muscle cells

1989 • 46 citations

Catalytic and regulatory ATP-binding sites of the red cell Ca2+ pump studied by irreversible modification with fluorescein isothiocyanate.

1983 • 46 citations

Regulation of ATP-sensitive K+ channel by membrane-bound protein phosphatases in rat principal tubule cell

1995 • 45 citations

Surface charge and properties of cardiac ATP-sensitive K+ channels.

1994 • 43 citations

Thiol-dependent passive K+-Cl- transport in sheep red blood cells. V. Dependence on metabolism

1983 • 43 citations

The ATP and Mg2+ dependence of Na+-K+-2Cl? cotransport reflects a requirement for protein phosphorylation: studies using calyculin A

1993 • 43 citations

Does the binding of clusters of basic residues to acidic lipids induce domain formation in membranes?

1995 • 42 citations

Osmotic Swelling Activates Intermediate-Conductance Cl- Channels in Human Intestinal Epithelial Cells.

1994 • 42 citations

Effects of vanadate on MgATP stimulation of Na-Ca exchange support kinase-phosphatase modulation in squid axons

1994 • 41 citations

ATP-sensitive potassium channels in physiology, pathophysiology, and pharmacology

1992 • 40 citations

An ATP-modulated specific association of glyceraldehyde-3-phosphate dehydrogenase with human erythrocyte glucose transporter.

1990 • 40 citations

Physarum actin is phosphorylated as the actin-fragmin complex at residues Thr203 and Thr202 by a specific 80 kDa kinase.

1992 • 40 citations

G Proteins

1992 • 40 citations

Mechanism for reactivation of the ATP‐sensitive K+ channel by MgATP complexes in guinea‐pig ventricular myocytes.

1994 • 39 citations

Batch-To-Batch Variation of Chelex-100 Confounds Metal-Catalysed Oxidation. Leaching of Inhibitory Compounds from A Batch of Chelex-100 and Their Removal by a Pre-Washing Procedure

1995 • 35 citations

Single channel studies of the phosphorylation of K+ channels in the squid giant axon. II. Nonstationary conditions.

1991 • 34 citations

Modulation of K channels in dialyzed squid axons. ATP-mediated phosphorylation.

1989 • 33 citations

Effects of okadaic acid and intracellular Cl- on Na(+)-K(+)-Cl- cotransport

1995 • 33 citations

Potassium conductance of the squid giant axon is modulated by ATP.

1986 • 33 citations

ATP-sensitive Binding of a 70-kDa Cytosolic Protein to the Glucose Transporter in Rat Adipocytes

1995 • 31 citations

ATP receptors

1994 • 28 citations

Effects of some metal‐ATP complexes on Na(+)‐Ca2+ exchange in internally dialysed squid axons.

1993 • 28 citations

Receptor-mediated signalling pathways acting through hydrolysis of membrane phospholipids in cardiomyocytes.

1993 • 27 citations

Solution Structure of a Band 3 Peptide Inhibitor Bound to Aldolase: A Proposed Mechanism for Regulating Binding by Tyrosine Phosphorylation

1995 • 26 citations

Modulation of K-Cl cotransport in volume-clamped low-K sheep erythrocytes by pH, magnesium, and ATP

1996 • 26 citations

ATP‐sensitive K⁺ channels in heart muscle cells first open and subsequently close at maintained anoxia

1994 • 25 citations

ATP dependence of calcium uptake by the Na-Ca exchanger of adult heart cells.

1992 • 25 citations

The GLUT4 glucose transporter and the α₂ subunit of the Na⁺,K⁺‐ATPase do not localize to the same intracellular vesicles in rat skeletal muscle

1995 • 24 citations

Inositol lipids and calcium signalling

1990 • 24 citations

Effects of ATP and cyclic AMP on the (Na+ + K+ + 2Cl−)-cotransport system in turkey erythrocytes

1985 • 23 citations

Activation of furosemide-sensitive K+ fluxes in myocytes by ouabain and recovery from metabolic inhibition

1990 • 23 citations

Band 3 modulation and hypotonic-stimulated taurine efflux in skate erythrocytes

1994 • 22 citations

The effects of metabolism on Na(+)‐K(+)‐Cl‐ co‐transport in ferret red cells.

1991 • 20 citations

Volume-sensitive K-Cl cotransport in inside-out vesicles made from erythrocyte membranes from sheep of low-K phenotype.

1990 • 20 citations

Ion channels as sensors of cellular energy

1993 • 20 citations

Dynamic actin

1993 • 20 citations

Kinetic mechanism of ATP action in Na(+)-K(+)-Cl- cotransport of HeLa cells determined by Rb+ influx studies

1990 • 19 citations

Intracellular calcium release channels.

1994 • 18 citations

Intracellular ATP and GTP are both required to preserve modulation of N-type calcium channel current by norepinephrine

1993 • 17 citations

Properties of volume-sensitive Cl- channels in a human epithelial cell line.

1994 • 16 citations

Creatine kinase is required for swelling-activated K-Cl cotransport in dog red blood cells

1995 • 14 citations

Alterations of ionic currents after reoxygenation in isolated cardiocytes of guinea-pigs

1991 • 14 citations

Inotropic effects of activation and pharmacological mechanisms in cardiac muscle

1981 • 13 citations

Protein methylation inhibits Na+-Ca2+ exchange activity in cardiac sarcolemmal vesicles

1988 • 13 citations

Flash Photolysis of Magnesium-DM-Nitrophen in Heart Cells

1991 • 12 citations

ATP does not regulate the reconstituted glucose transporter

1989 • 11 citations

Modulation of Na+,Ca2+ exchange current by EGTA calcium buffering in giant cardiac membrane patches

1995 • 9 citations

ATP-regulated chloride conductance in endoplasmic reticulum (ER)-enriched pig pancreas microsomes

1993 • 9 citations

Reconstitution of glucose transport activity from erythrocyte membranes without detergent and its use in studying effects of ATP depletion

1986 • 9 citations

Cellular water content and volume regulation in animal cells

1995 • 8 citations

Accelerating effect of ATP on calcium binding to sarcoplasmic reticulum ATPase

1988 • 8 citations

Functional linkage of the cardiac ATP-sensitive K + channel to the actin cytoskeleton

1996 • 7 citations

ATP Stimulation of a Na⁺Gradient‐Dependent Ca²⁺Uptake in Cardiac Sarcolemmal Vesicles

1996 • 6 citations

ATP dependence of K-Cl cotransport in dog red blood cells

1993 • 6 citations

Modulation of Ca²⁺‐dependent currents in metabolically stressed cultured sensory neurones by intracellular photorelease of ATP

1995 • 6 citations

Effects of ATP depletion on the mechanism of hexose transport in intact human erythrocytes

1988 • 4 citations

Nucleotides and Ion Channel Regulation

1992 • 3 citations