Insulin Receptor Knockout Mice

Cell Signaling by Receptor Tyrosine Kinases

2010 • 7,477 citations

Insulin signalling and the regulation of glucose and lipid metabolism

2001 • 4,995 citations

Cell Signaling by Receptor Tyrosine Kinases

2000 • 3,570 citations

Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)

1993 • 2,880 citations

IRS-1-Mediated Inhibition of Insulin Receptor Tyrosine Kinase Activity in TNF-α- and Obesity-Induced Insulin Resistance

1996 • 2,561 citations

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

1985 • 2,257 citations

Role of Brain Insulin Receptor in Control of Body Weight and Reproduction

2000 • 2,178 citations

daf-2 , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegans

1997 • 2,174 citations

The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans

1997 • 1,905 citations

Transcriptional regulation of adipogenesis

2000 • 1,875 citations

Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity.

1986 • 1,866 citations

Disruption of IRS-2 causes type 2 diabetes in mice

1998 • 1,766 citations

A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting

1990 • 1,650 citations

The human insulin receptor cDNA: The structural basis for hormone-activated transmembrane signalling

1985 • 1,485 citations

daf-16 : An HNF-3/forkhead Family Member That Can Function to Double the Life-Span of Caenorhabditis elegans

1997 • 1,468 citations

Dual Roles for Glucokinase in Glucose Homeostasis as Determined by Liver and Pancreatic β Cell-specific Gene Knock-outs Using Cre Recombinase

1999 • 1,284 citations

Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene

1994 • 1,240 citations

Increased Energy Expenditure, Decreased Adiposity, and Tissue-Specific Insulin Sensitivity in Protein-Tyrosine Phosphatase 1B-Deficient Mice

2000 • 1,218 citations

Loss of Insulin Signaling in Hepatocytes Leads to Severe Insulin Resistance and Progressive Hepatic Dysfunction

2000 • 1,213 citations

Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver

2001 • 1,202 citations

A Muscle-Specific Insulin Receptor Knockout Exhibits Features of the Metabolic Syndrome of NIDDM without Altering Glucose Tolerance

1998 • 1,173 citations

Tissue-Specific Knockout of the Insulin Receptor in Pancreatic β Cells Creates an Insulin Secretory Defect Similar to that in Type 2 Diabetes

1999 • 1,151 citations

Unified nomenclature for the winged helix/forkhead transcription factors

2000 • 1,136 citations

Insulin receptors are widely distributed in the central nervous system of the rat

1978 • 1,092 citations

Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1

1994 • 1,076 citations

Development of obesity in transgenic mice after genetic ablation of brown adipose tissue

1993 • 1,057 citations

Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling

2001 • 1,013 citations

A Role for AMP-Activated Protein Kinase in Contraction- and Hypoxia-Regulated Glucose Transport in Skeletal Muscle

2001 • 935 citations

Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog

1997 • 929 citations

A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans

1996 • 870 citations

Insulin Receptor Isoform A, a Newly Recognized, High-Affinity Insulin-Like Growth Factor II Receptor in Fetal and Cancer Cells

1999 • 865 citations

Insulin-like growth factor II receptor as a multifunctional binding protein

1987 • 858 citations

Adipose Tissue Selective Insulin Receptor Knockout Protects against Obesity and Obesity-Related Glucose Intolerance

2002 • 806 citations

Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance

2000 • 733 citations

A Lesson in Metabolic Regulation Inspired by the Glucokinase Glucose Sensor Paradigm

1996 • 728 citations

Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor

1998 • 680 citations

Impaired Glucose Transport as a Cause of Decreased Insulin-Stimulated Muscle Glycogen Synthesis in Type 2 Diabetes

1999 • 666 citations

Cellular Localization of Somatomedin (Insulin-Like Growth Factor) Messenger RNA in the Human Fetus

1987 • 663 citations

Regulation of insulin action and pancreatic β-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1

2002 • 616 citations

Dynamics of β-cell Mass in the Growing Rat Pancreas: Estimation With a Simple Mathematical Model

1995 • 607 citations

Non-Insulin-Dependent Diabetes Mellitus — A Genetically Programmed Failure of the Beta Cell to Compensate for Insulin Resistance

1996 • 607 citations

Early neonatal death in mice homozygous for a null allele of the insulin receptor gene

1996 • 596 citations

Development of a Novel Polygenic Model of NIDDM in Mice Heterozygous for IR and IRS-1 Null Alleles

1997 • 549 citations

Somatomedin-C/insulin-like growth factor-I and insulin-like growth factor-II mRNAs in rat fetal and adult tissues.

1986 • 531 citations

Distinct and Overlapping Functions of Insulin and IGF-I Receptors

2001 • 515 citations

Banting Lecture 1997. Control of glucose uptake and release by the liver in vivo.

1999 • 499 citations

Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2

2000 • 499 citations

Adaptations of glucose and fatty acid metabolism during perinatal period and suckling-weaning transition

1992 • 481 citations

Early diabetes and abnormal postnatal pancreatic islet development in mice lacking Glut-2

1997 • 419 citations

Increased insulin sensitivity and hypoglycaemia in mice lacking the p85α subunit of phosphoinositide 3–kinase

1999 • 396 citations

Growth-Promoting Interaction of IGF-II with the Insulin Receptor during Mouse Embryonic Development

1997 • 391 citations

Loci on chromosomes 2 (NIDDM1) and 15 interact to increase susceptibility to diabetes in Mexican Americans

1999 • 386 citations

daf-2, daf-16 and daf-23: genetically interacting genes controlling Dauer formation in Caenorhabditis elegans.

1994 • 375 citations

Functional inactivation of the IGF-I and insulin receptors in skeletal muscle causes type 2 diabetes

2001 • 367 citations

Genetics of mouse growth.

1998 • 342 citations

Redistribution of substrates to adipose tissue promotes obesity in mice with selective insulin resistance in muscle

2000 • 340 citations

Central melanocortin receptors regulate insulin action

2001 • 335 citations

Lilly Lecture: Molecular Mechanisms of Insulin Resistance: Lessons From Patients With Mutations in the Insulin-Receptor Gene

1992 • 319 citations

Central melanocortin receptors regulate insulin action

2001 • 317 citations

Two Mutant Alleles of the Insulin Receptor Gene in a Patient with Extreme Insulin Resistance

1988 • 308 citations

Chemical Composition of Newly Born Mammals

1950 • 306 citations

Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85α

2000 • 291 citations

Contrasting Effects of IRS-1 Versus IRS-2 Gene Disruption on Carbohydrate and Lipid Metabolism in Vivo

2000 • 291 citations

Targeted disruption of the insulin receptor gene in the mouse results in neonatal lethality.

1996 • 287 citations

Transgenic knockouts reveal a critical requirement for pancreatic β cell glucokinase in maintaining glucose homeostasis

1995 • 277 citations

Altered function of insulin receptor substrate-1–deficient mouse islets and cultured β-cell lines

1999 • 276 citations

Insulin action and resistance in obesity and noninsulin-dependent type II diabetes mellitus

1982 • 276 citations

Phenotypic alterations in insulin-deficient mutant mice

1997 • 272 citations

Selective Insulin Signaling through A and B Insulin Receptors Regulates Transcription of Insulin and Glucokinase Genes in Pancreatic β Cells

2001 • 268 citations

CEACAM1 regulates insulin clearance in liver

2002 • 263 citations

Embryogenesis of the murine endocrine pancreas; early expression of pancreatic polypeptide gene

1991 • 262 citations

Reduced expression of the murine p85α subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes

2002 • 245 citations

Exercise modulates postreceptor insulin signaling and glucose transport in muscle-specific insulin receptor knockout mice

1999 • 239 citations

Pancreatic β-Cell-specific Targeted Disruption of Glucokinase Gene

1995 • 235 citations

Phosphoenolpyruvate Carboxykinase Is Necessary for the Integration of Hepatic Energy Metabolism

2000 • 232 citations

Primary Structure of a Putative Receptor for a Ligand of the Insulin Family

1989 • 224 citations

Brown adipose tissue–specific insulin receptor knockout shows diabetic phenotype without insulin resistance

2001 • 216 citations

Embryogenesis of the Human Pancreatic Islets: A Light and Electron Microscopic Study

1972 • 214 citations

Effects of Acute and Chronic Administration of the Melanocortin Agonist MTII in Mice With Diet-Induced Obesity

2002 • 210 citations

Reversibility of defective adipocyte insulin receptor kinase activity in non-insulin-dependent diabetes mellitus. Effect of weight loss.

1988 • 195 citations

Hormones in male sexual development

2000 • 185 citations

Early pattern of differentiation in the human pancreas.

2000 • 176 citations

Evidence That IRS-2 Phosphorylation Is Required for Insulin Action in Hepatocytes

1998 • 169 citations

Dynamics of beta-cell mass in the growing rat pancreas. Estimation with a simple mathematical model

1995 • 162 citations

Hypoglycemic effect of insulin-like growth factor-1 in mice lacking insulin receptors.

1997 • 156 citations

Banting Lecture 1995. A lesson in metabolic regulation inspired by the glucokinase glucose sensor paradigm

1996 • 155 citations

Impaired glucose tolerance in mice with a targeted impairment of insulin action in muscle and adipose tissue

1998 • 143 citations

Identification of INSL5, a New Member of the Insulin Superfamily

1999 • 143 citations

Insulin: new roles for an ancient hormone

1999 • 133 citations

Metabolic and endocrine findings in appropriate and small for gestational age fetuses

1991 • 133 citations

Homozygous deletion of the human insulin receptor gene results in leprechaunism

1993 • 127 citations

Expression, Characterization, and Crystallization of the Catalytic Core of the Human Insulin Receptor Protein-tyrosine Kinase Domain

1995 • 126 citations

Factors Affecting the Secretion of Insulin and Glucagon by the Rat Fetus

1974 • 126 citations

Identification of INSL6, a New Member of the Insulin Family That Is Expressed in the Testis of the Human and Rat1

2000 • 117 citations

Distinct and Overlapping Functions of Insulin and IGF-I Receptors

2001 • 114 citations

Preserved Pancreatic β-Cell Development and Function in Mice Lacking the Insulin Receptor-Related Receptor

2001 • 108 citations

Lilly Lecture: molecular mechanisms of insulin resistance. Lessons from patients with mutations in the insulin-receptor gene

1992 • 107 citations

Cloning of a New Member of the Insulin Gene Superfamily (INSL4) Expressed in Human Placenta

1995 • 101 citations

Homozygous nonsense mutation in the insulin receptor gene in infant with leprechaunism

1993 • 100 citations

Hypoglycemia in Beckwith-Wiedemann syndrome

2000 • 92 citations

Oxidative and non-oxidative glucose metabolism in non-obese Type 2 (non-insulin-dependent) diabetic patients

1988 • 91 citations

THE INFANT OF THE DIABETIC MOTHER

1996 • 86 citations

Cloning of Two Novel Mammalian Paralogs of Relaxin/Insulin Family Proteins and Their Expression in Testis and Kidney

1999 • 86 citations

Phosphatidylinositol 3-Kinase Suppresses Glucose-Stimulated Insulin Secretion by Affecting Post-Cytosolic [Ca2+] Elevation Signals

2002 • 77 citations

Pancreatic Insulin-, Glucagon-, and Somatostatin-Positive Islet Cell Populations during the Perinatal Development of the Rat

1980 • 76 citations

A Link between Insulin Resistance and Hyperinsulinemia: Inhibitors of Phosphatidylinositol 3-Kinase Augment Glucose-Induced Insulin Secretion from Islets of Lean, But Not Obese, Rats¹

2000 • 69 citations

A homozygous kinase-defective mutation in the insulin receptor gene in a patient with leprechaunism

1997 • 68 citations

THE GENETICIST'S APPROACH TO COMPLEX DISEASE

1996 • 63 citations

Ontogenetic appearance of immunoreactive endocrine cells in rat pancreatic islets

1982 • 62 citations

Polyhormonal aspect of the endocrine cells of the human fetal pancreas

1999 • 61 citations

Hypoglycemia and Hyperinsulinism in Infants with Erythroblastosis Fetalis

1968 • 60 citations

Progressive Decline in Insulin Levels in Rabson-Mendenhall Syndrome¹

1999 • 57 citations

Insulin receptor-related receptor is expressed in pancreatic beta-cells and stimulates tyrosine phosphorylation of insulin receptor substrate-1 and -2.

1999 • 56 citations

Extreme Insulin Resistance in Association with Abnormally High Binding Affinity of Insulin Receptors from a Patient with Leprechaunism: Evidence for a Defect Intrinsic to the Receptor

1982 • 56 citations

Uptake of glucose carbon in muscle glycogen and adipose tissue triglycerides in vivo in humans

1992 • 55 citations

Non-insulin-dependent diabetes mellitus and gestational diabetes mellitus: Same disease, another name?

1995 • 54 citations

The molecular basis of persistent hyperinsulinemic hypoglycemia of infancy and its pathologic substrates

2000 • 51 citations

Pancreatic Insulin-, Glucagon-, and Somatostatin-Positive Isle Cell Populations during the Perinatal Development of the Rat

1980 • 50 citations

Progressive Decline in Insulin Levels in Rabson-Mendenhall Syndrome

1999 • 49 citations

A Novel Human Insulin Receptor Gene Mutation Uniquely Inhibits Insulin Binding Without Impairing Posttranslational Processing

1994 • 48 citations

Differential Signaling of Insulin and IGF-1 Receptors to Glycogen Synthesis in Murine Hepatocytes

1999 • 46 citations

Effect of Intravenous Insulin-like Growth Factor I in Two Patients with Leprechaunism

1994 • 43 citations

GLUCOSE-INDUCED INCREASE OF PLASMA INSULIN IN THE RAT FOETUS IN UTERO

1974 • 42 citations

Genetics of Type 2 Diabetes Insight from Targeted Mouse Mutants

2001 • 40 citations

Homozygosity for a null allele of the insulin receptor gene in a patient with leprechaunism

1995 • 40 citations

Glucose Kinetics in Leprechaunism: Accelerated Fasting due to Insulin Resistance*

1980 • 38 citations

Increased IGFR activity and glucose transport in cultured skeletal muscle from insulin receptor null mice

2001 • 34 citations

Identification, Chromosomal Mapping, and Partial Characterization of MouseIns16:A New Member of the Insulin Family

2000 • 33 citations

Homozygous nonsense mutation in the insulin receptor gene of a patient with severe congenital insulin resistance: leprechaunism and the role of the insulin‐like growth factor receptor

1996 • 30 citations

Synthesis and Accumulation of Proinsulin and Insulin during Development of the Embryonic Rat Pancreas*

1979 • 28 citations

Primitive Islets Contain Two Populations of Cells with Differing Glucagon Immunoreactivity

1981 • 23 citations

Brown adipose tissue–specific insulin receptor knockout shows diabetic phenotype without insulin resistance

2001 • 23 citations

HYPOGLYCEMIA AND RH ERYTHROBLASTOSIS FETALIS

1967 • 22 citations

Major Circadian Variations of Glucose Homeostasis in a Patient with Rabson-Mendenhall Syndrome and Primary Insulin Resistance Due to a Mutation(Cys284 → Tyr) in the Insulin Receptor α-Subunit

1997 • 21 citations

Cloning of Two Novel Mammalian Paralogs of Relaxin/Insulin Family Proteins and Their Expression in Testis and Kidney

1999 • 21 citations

A Link between Insulin Resistance and Hyperinsulinemia: Inhibitors of Phosphatidylinositol 3-Kinase Augment Glucose-Induced Insulin Secretion from Islets of Lean, But Not Obese, Rats

2000 • 20 citations

Mitogenic and Metabolic Effects of Type I IGF Receptor Overexpression in Insulin Receptor-Deficient Hepatocytes

2001 • 17 citations

Reduced expression of the murine p85α subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes

2002 • 15 citations

A novel human insulin receptor gene mutation uniquely inhibits insulin binding without impairing posttranslational processing

1994 • 14 citations

Primitive islets contain two populations of cells with differing glucagon immunoreactivity

1981 • 11 citations

Identification, Chromosomal Mapping, and Partial Characterization of Mouse Ins16: A New Member of the Insulin Family

2000 • 10 citations

Mitogenic and Metabolic Effects of Type I IGF Receptor Overexpression in Insulin Receptor-Deficient Hepatocytes

2001 • 5 citations

[Physiopathological approach and antenatal diagnosis of diabetes mellitus insulin resistant: apropos of a case with leprechaunism].

1994 • 4 citations

No evidence for an indirect effect of insulin to suppress glucose production in liver-specific insulin receptor knockout mice

2001 • 2 citations