The human insulin receptor cDNA: The structural basis for hormone-activated transmembrane signalling

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.

1980 • 8,711 citations

A new method for sequencing DNA.

1977 • 7,941 citations

Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs

1984 • 3,334 citations

3′ Non-coding region sequences in eukaryotic messenger RNA

1976 • 3,001 citations

Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells

1984 • 2,762 citations

Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences

1984 • 2,564 citations

The isolation of structural genes from libraries of eucaryotic DNA

1978 • 1,877 citations

CELLULAR ONCOGENES AND RETROVIRUSES

1983 • 1,671 citations

Simian Sarcoma Virus onc Gene, v- sis , Is Derived from the Gene (or Genes) Encoding a Platelet-Derived Growth Factor

1983 • 1,550 citations

Synthesis and Processing of Asparagine-Linked Oligosaccharides

1981 • 1,403 citations

The human LDL receptor: A cysteine-rich protein with multiple Alu sequences in its mRNA

1984 • 1,386 citations

Rat Insulin Genes: Construction of Plasmids Containing the Coding Sequences

1977 • 1,252 citations

[17] Isolation of microgram quantities of proteins from polyacrylamide gels for amino acid sequence analysis

1983 • 1,115 citations

The Syndromes of Insulin Resistance and Acanthosis Nigricans

1976 • 1,086 citations

Yeast RNA Polymerase II Genes: Isolation with Antibody Probes

1983 • 1,084 citations

Codon catalog usage is a genome strategy modulated for gene expressivity

1981 • 951 citations

Structure of human factor VIII

1984 • 898 citations

Mechanisms for the incorporation of proteins in membranes and organelles.

1982 • 875 citations

Autophosphorylation sites on the epidermal growth factor receptor

1984 • 730 citations

The subunit structures of two distinct receptors for insulin-like growth factors I and II and their relationship to the insulin receptor.

1982 • 709 citations

[36] High-sensitivity sequencing with a gas-phase sequenator

1983 • 670 citations

Form and Function of Retroviral Proviruses

1982 • 627 citations

Sequence of the human insulin gene

1980 • 553 citations

Primary structures of β- and δ-subunit precursors of Torpedo californica acetylcholine receptor deduced from cDNA sequences

1983 • 527 citations

The highly polymorphic region near the human insulin gene is composed of simple tandemly repeating sequences

1982 • 524 citations

Interaction of cross-linking agents with the insulin effector system of isolated fat cells. Covalent linkage of 125I-insulin to a plasma membrane receptor protein of 140,000 daltons.

1979 • 422 citations

Insulin Receptor: Evidence That It Is a Protein Kinase

1983 • 413 citations

Somatomedin-C stimulates the phosphorylation of the beta-subunit of its own receptor.

1983 • 395 citations

Generation by Insulin of a Chemical Mediator That Controls Protein Phosphorylation and Dephosphorylation

1979 • 373 citations

Establishment of a continuously growing cell line from primary carcinoma of the liver.

1976 • 335 citations

Characteristics of the Human Lymphocyte Insulin Receptor

1973 • 320 citations

Properties of the Insulin Receptor Isolated from Liver and Fat Cell Membranes

1972 • 299 citations

Size heterogeneity in the 3′ end of dihydrofolate reductase messenger RNAs in mouse cells

1980 • 288 citations

Nucleotide sequence and evolution of a mammalian α-Tubulin messenger RNA

1981 • 275 citations

Purification of insulin receptor with full binding activity.

1983 • 273 citations

Growth and maturation factors

1983 • 269 citations

High-Resolution Chromosome Sorting and DNA Spot-Blot Analysis Assign McArdle's Syndrome to Chromosome 11

1984 • 240 citations

Pyruvate Dehydrogenase Activation in Adipocyte Mitochondria by an Insulin-Generated Mediator from Muscle

1979 • 222 citations

Automatic monitoring of primary amines in preparative column effluents with fluorescamine

1975 • 217 citations

Kinetic properties and sites of autophosphorylation of the partially purified insulin receptor from hepatoma cells.

1984 • 208 citations

Role of glycosylation in the processing of newly translated insulin proreceptor in 3T3-L1 adipocytes.

1984 • 207 citations

Oligonucleotide directed mutagenesis of the human β-globin gene: a general method for producing specific point mutations in cloned DNA

1981 • 207 citations

Insulin Receptor: Structure and Function

1981 • 187 citations

Multiple polyadenylation sites in a mouse α-amylase gene

1981 • 184 citations

Microsequence analysis of peptides and proteins

1982 • 183 citations

Epidermal growth factor-receptor-protein kinase interactions.

1981 • 171 citations

Insulin Receptors, Receptor Antibodies, and the Mechanism of Insulin Action

1981 • 170 citations

A unique proteolytic cleavage site on the beta subunit of the insulin receptor.

1981 • 167 citations

Nucleotide sequence of avian sarcoma virus UR2 and comparison of its transforming gene with other members of the tyrosine protein kinase oncogene family

1985 • 167 citations

The Proteins of Oncogenes

1984 • 163 citations

[20] Removal of sodium dodecyl sulfate from proteins by ion-pair extraction

1983 • 144 citations

Characterization of the receptor for platelet-derived growth factor on human fibroblasts. Demonstration of an intimate relationship with a 185,000-Dalton substrate for the platelet-derived growth factor-stimulated kinase.

1983 • 144 citations

Nucleotide sequence of a cDNA clone encoding human preproinsulin

1979 • 141 citations

Assignment of the human gene for the low density lipoprotein receptor to chromosome 19: synteny of a receptor, a ligand, and a genetic disease.

1984 • 138 citations

Monoclonal antibodies to the human insulin receptor block insulin binding and inhibit insulin action.

1982 • 122 citations

Synthesis of oligonucleotides on cellulose by a phosphotriester method

1980 • 113 citations

The insulin gene is located on chromosome 11 in humans

1980 • 109 citations

Genetics of cell surface receptors for bioactive polypeptides: Binding of epidermal growth factor is associated with the presence of human chromosome 7 in human-mouse cell hybrids

1980 • 92 citations

Surface redistribution of 125I-insulin in cultured human lymphocytes.

1981 • 79 citations

Expression of the human insulin gene and cDNA in a heterologous mammalian system.

1983 • 77 citations

Microsequence analysis of peptides and proteins

1982 • 51 citations

Insulin-stimulated phosphorylation of the insulin receptor precursor

1983 • 28 citations

Insulin Receptors, Receptor Antibodies and the Mechanism of Insulin Action

1980 • 24 citations

Insulin binds to and promotes the phosphorylation of a M_r 210 000 component of its receptor in detergent extracts of rat liver microsomes

1983 • 18 citations

The Growth Promoting Effects of Insulin.

1997 • 7 citations

Deleted Work

1955 • 0 citations