Hormones in male sexual development

Male development of chromosomally female mice transgenic for Sry

1991 • 2,157 citations

WT-1 is required for early kidney development

1993 • 1,976 citations

Estrogen Receptor Null Mice: What Have We Learned and Where Will They Lead Us?

1999 • 1,965 citations

Female development in mammals is regulated by Wnt-4 signalling

1999 • 1,219 citations

Primordial germ cells in the mouse embryo during gastrulation

1990 • 995 citations

An unusual member of the nuclear hormone receptor superfamily responsible for X-linked adrenal hypoplasia congenita

1994 • 857 citations

Targeted disruption of the estrogen receptor gene in male mice causes alteration of spermatogenesis and infertility.

1996 • 827 citations

HMG domain proteins: architectural elements in the assembly of nucleoprotein structures

1994 • 813 citations

Requirement for LIml in head-organizer function

1995 • 801 citations

Evidence for evolutionary conservation of sex-determining genes

1998 • 769 citations

Mutations in the DAX-1 gene give rise to both X-linked adrenal hypoplasia congenita and hypogonadotropic hypogonadism

1994 • 764 citations

Cryptorchidism in mice mutant for Insl3

1999 • 719 citations

Tissue distribution and ontogeny of steroid 5 alpha-reductase isozyme expression.

1993 • 714 citations

Sertoli cell signaling by Desert hedgehog regulates the male germline

1996 • 664 citations

Müllerian-inhibiting substance function during mammalian sexual development

1994 • 661 citations

Targeted Disruption of the Insl3 Gene Causes Bilateral Cryptorchidism

1999 • 658 citations

Dmrt1, a gene related to worm and fly sexual regulators, is required for mammalian testis differentiation

2000 • 655 citations

Impairment of spermatogenesis in mice lacking a functional aromatase (cyp 19) gene

1999 • 595 citations

Wilms' Tumor 1 and Dax-1 Modulate the Orphan Nuclear Receptor SF-1 in Sex-Specific Gene Expression

1998 • 593 citations

Developmental expression of mouse steroidogenic factor-1, an essential regulator of the steroid hydroxylases.

1994 • 589 citations

Postnatal Sex Reversal of the Ovaries in Mice Lacking Estrogen Receptors α and β

1999 • 583 citations

Direct Interaction of SRY-Related Protein SOX9 and Steroidogenic Factor 1 Regulates Transcription of the Human Anti-Müllerian Hormone Gene

1998 • 578 citations

Nuclear receptor steroidogenic factor 1 regulates the müllerian inhibiting substance gene: A link to the sex determination cascade

1994 • 562 citations

Dax1 antagonizes Sry action in mammalian sex determination

1998 • 556 citations

X-linked Gene for Testicular Feminization in the Mouse

1970 • 551 citations

A Dosage Sensitive Locus at Chromosome Xp21 Is Involved in Male to Female Sex Reversal

1995 • 541 citations

Estrogen Receptor Null Mice: What Have We Learned and Where Will They Lead Us?

1999 • 526 citations

Sexually dimorphic sterility phenotypes in HoxalO-deficient mice

1995 • 516 citations

Behavioral effects of estrogen receptor gene disruption in male mice

1997 • 502 citations

Expression of Dmrt1 in the Genital Ridge of Mouse and Chicken Embryos Suggests a Role in Vertebrate Sexual Development

1999 • 481 citations

Expression of the mouse anti-Müllerian hormone gene suggests a role in both male and female sexual differentiation

1991 • 458 citations

Role of Ahch in gonadal development and gametogenesis

1998 • 451 citations

Targeted Mutagenesis of the Endogenous Mouse Mis Gene Promoter

1999 • 431 citations

The LIM homeobox gene Lhx9 is essential for mouse gonad formation

2000 • 403 citations

Hoxa 11 structure, extensive antisense transcription, and function in male and female fertility

1995 • 390 citations

Mammalian sex determination: a molecular drama

1999 • 368 citations

Association of Diethylstilbestrol Exposure in Utero With Cryptorchidism, Testicular Hypoplasia and Semen Abnormalities

1979 • 356 citations

Transcription factor GATA-4 is expressed in a sexually dimorphic pattern during mouse gonadal development and is a potent activator of the Müllerian inhibiting substance promoter

1998 • 355 citations

Genetic analysis of the Müllerian-inhibiting substance signal transduction pathway in mammalian sexual differentiation.

1996 • 354 citations

The Syndromes of Androgen Resistance

1980 • 314 citations

Developmental expression of mouse steroidogenic factor-1, an essential regulator of the steroid hydroxylases

1994 • 301 citations

In situ analysis of fetal, prepuberal and adult XX ↔ XY chimaeric mouse testes: Sertoli cells are predominantly, but not exclusively, XY

1991 • 293 citations

A novel member of the transmembrane serine/threonine kinase receptor family is specifically expressed in the gonads and in mesenchymal cells adjacent to the müllerian duct

1994 • 290 citations

Cloning of a cDNA for a novel insulin-like peptide of the testicular Leydig cells.

1993 • 282 citations

Cloning, expression, and alternative splicing of the receptor for anti-Müllerian hormone.

1994 • 279 citations

Targeted disruption of the estrogen receptor gene in male mice causes alteration of spermatogenesis and infertility

1996 • 275 citations

Receptors for anti-Müllerian hormone on Leydig cells are responsible for its effects on steroidogenesis and cell differentiation

1998 • 248 citations

Primary Structure of a Putative Receptor for a Ligand of the Insulin Family

1989 • 224 citations

Migratory arrest of gonadotropin-releasing hormone neurons in transgenic mice.

1991 • 214 citations

A BIPHASIC MODEL FOR THE HORMONAL CONTROL OF TESTICULAR DESCENT

1985 • 213 citations

Sry and Sox9: mammalian testis-determining genes

1999 • 212 citations

The nuclear receptor SF-1 mediates sexually dimorphic expression of Müllerian Inhibiting Substance, in vivo

1997 • 196 citations

Cell-autonomous action of the testis-determining gene: Sertoli cells are exclusively XY in XX ↔XY chimaeric mouse testes

1988 • 193 citations

A Molecular Basis for Estrogen-Induced Cryptorchidism

2000 • 187 citations

Targeted Disruption of the Insl3 Gene Causes Bilateral Cryptorchidism

1999 • 185 citations

Testicular feminization: A model for testicular descent in mice and men

1986 • 182 citations

Deletion 9p and sex reversal.

1993 • 169 citations

Relaxin-Like Factor Expression as a Marker of Differentiation in the Mouse Testis and Ovary¹

1998 • 167 citations

Cryptorchidism and homeotic transformations of spinal nerves and vertebrae in Hoxa-10 mutant mice.

1995 • 166 citations

Engagement of Bone Morphogenetic Protein Type IB Receptor and Smad1 Signaling by Anti-Müllerian Hormone and Its Type II Receptor

2000 • 166 citations

A 27 base-pair deletion of the anti-mullerian type II receptor gene is the most common cause of the persistent mullerian duct syndrome

1996 • 153 citations

Endogenous expression of Müllerian inhibiting substance in early postnatal rat Sertoli cells requires multiple steroidogenic factor-1 and GATA-4-binding sites

2000 • 153 citations

Mouse Leydig insulin-like (Ley I-L) gene: Structure and expression during testis and ovary development

1997 • 151 citations

Involvement of Insulin-Like Factor 3 (Insl3) in Diethylstilbestrol-Induced Cryptorchidism

2000 • 149 citations

Effect of Anti-Mullerian Hormone on Sertoli and Leydig Cell Functions in Fetal and Immature Rats¹

1998 • 147 citations

Fetal Death in Mice Lacking 5α-Reductase Type 1 Caused by Estrogen Excess

1997 • 147 citations

Identification of INSL5, a New Member of the Insulin Superfamily

1999 • 143 citations

Experimental intersexuality. The effects of estrogens on the antenatal sexual development of the rat

1940 • 134 citations

Molecular mechanisms of hormone-mediated Müllerian duct regression: involvement of β-catenin

2000 • 132 citations

Current concepts in the pathophysiology of testicular undescent

1995 • 123 citations

Time-Specific Androgen Blockade with Flutamide Inhibits Testicular Descent in the Rat^*

1991 • 119 citations

Identification of INSL6, a New Member of the Insulin Family That Is Expressed in the Testis of the Human and Rat1

2000 • 117 citations

Embryology and endocrinology of genital development

1998 • 105 citations

Cloning, expression, and alternative splicing of the receptor for anti- Mullerian hormone

1994 • 103 citations

Ontogeny of Reproductive Abnormalities Induced by Deregulation of Anti-Müllerian Hormone Expression in Transgenic Mice

1995 • 103 citations

Müllerian-Inhibiting Substance Regulates Androgen Synthesis at the Transcriptional Level1

1999 • 103 citations

Molecular cloning and expression of the relaxin-like factor from the mouse testis.

1996 • 102 citations

Cloning of a New Member of the Insulin Gene Superfamily (INSL4) Expressed in Human Placenta

1995 • 101 citations

Hormonal control of testicular descent and the cause of cryptorchidism

1994 • 98 citations

Testicular descent in the rat and a comparison of this process in the rat with that in the pig

1986 • 95 citations

Cloning of Two Novel Mammalian Paralogs of Relaxin/Insulin Family Proteins and Their Expression in Testis and Kidney

1999 • 86 citations

The Embryology of Testicular Descent

1988 • 84 citations

Maternal hormone levels in early gestation of cryptorchid males: a case-control study

1988 • 80 citations

Characterization of Hoxa-10/Hoxa-11 Transheterozygotes Reveals Functional Redundancy and Regulatory Interactions

2000 • 80 citations

The roles of steroidogenic factor 1 in endocrine development and function

1998 • 80 citations

The Role of Gonadal Steroids in Sexual Differentiation

1981 • 74 citations

Synergy of Abdominal Pressure and Androgens in Testicular Descent

1983 • 72 citations

The Identification of 5α-Reductase-2 and 17β-Hydroxysteroid Dehydrogenase-3 Gene Defects in Male Pseudohermaphrodites from a Turkish Kindred1

1998 • 71 citations

Fetal Death in Mice Lacking 5 -Reductase Type 1 Caused by Estrogen Excess

1997 • 68 citations

Relaxin-Like Factor Expression as a Marker of Differentiation in the Mouse Testis and Ovary

1998 • 65 citations

Relaxin-like factor (RLF): a new specific marker for Leydig cells in the ovary.

1999 • 64 citations

Role of the fetal pituitary in cryptorchidism induced by exogenous maternal oestrogen during pregnancy in mice

1988 • 64 citations

New insights into mullerian inhibiting substance and its mechanism of action

1998 • 63 citations

Paracrine-Mediated Apoptosis in Reproductive Tract Development

1999 • 62 citations

Relaxin-Like Factor (RLF)

1999 • 61 citations

High Specificity of Müllerian-Inhibiting Substance Signaling in Vivo*

1999 • 57 citations

Effect of human recombinant mullerian inhibiting substance on isolated epithelial and mesenchymal cells during mullerian duct regression in the rat.

1992 • 55 citations

Specific, High Affinity Relaxin-like Factor Receptors

1999 • 50 citations

Molecular cloning and expression of the relaxin-like factor from the mouse testis

1996 • 47 citations

Serine/threonine kinase receptors and ligands

1997 • 47 citations

An unbalanced autosomal translocation (7;9) associated with feminization

1988 • 46 citations

Involvement of Insulin-Like Factor 3 (Insl3) in Diethylstilbestrol-Induced Cryptorchidism

2000 • 42 citations

Proliferation of Gubernaculum Cells Induced by a Substance of Low Molecular Mass Obtained From Fetal Pig Testes

1995 • 37 citations

New Solutions to an Ancient Riddle: Defining the Differences between Adam and Eve

1999 • 35 citations

Effect of Anti-Mullerian Hormone on Sertoli and Leydig Cell Functions in Fetal and Immature Rats

1998 • 34 citations

Identification, Chromosomal Mapping, and Partial Characterization of MouseIns16:A New Member of the Insulin Family

2000 • 33 citations

The roles of steroidogenic factor 1 in endocrine development and function

1998 • 33 citations

The Gubernaculum during Testicular Descent in the Pig Fetus

1985 • 30 citations

Immunopurified Anti-Müllerian Hormone does not Inhibit Spontaneous Resumption of Meiosis in Vitro of Rat Oocytes1

1988 • 28 citations

The Identification of 5 -Reductase-2 and 17 -Hydroxysteroid Dehydrogenase-3 Gene Defects in Male Pseudohermaphrodites from a Turkish Kindred

1998 • 26 citations

The Fetal Rat Gubernaculum Contains Higher Levels of Androgen Receptor than Does the Postnatal Gubernaculum

1993 • 22 citations

Mullerian-Inhibiting Substance Regulates Androgen Synthesis at the Transcriptional Level

1999 • 22 citations

Cloning of Two Novel Mammalian Paralogs of Relaxin/Insulin Family Proteins and Their Expression in Testis and Kidney

1999 • 21 citations

A TrkB/insulin receptor-related receptor chimeric receptor induces PC12 cell differentiation and exhibits prolonged activation of mitogen-activated protein kinase.

1999 • 21 citations

Effect of human recombinant mullerian inhibiting substance on isolated epithelial and mesenchymal cells during mullerian duct regression in the rat

1992 • 20 citations

High Specificity of Mullerian-Inhibiting Substance Signaling in Vivo

1999 • 14 citations

Epidemiology of HIV, HBV and HCV and the Safety of Blood Products. Concerning Stark K, et al: Infections with HIV, HBV and HCV among blood donors in Germany 1998 and 1999. Infus Ther Transfus Med 2002;29:305–307 / Authors' Reply

2003 • 12 citations

Identification, Chromosomal Mapping, and Partial Characterization of Mouse Ins16: A New Member of the Insulin Family

2000 • 10 citations