Role of the Insulin-Like Growth Factor Family in Cancer Development and Progression

Insulin-Like Growth Factors and Their Binding Proteins: Biological Actions*

1995 • 4,419 citations

Plasma Insulin-Like Growth Factor-I and Prostate Cancer Risk: A Prospective Study

1998 • 2,010 citations

Circulating concentrations of insulin-like growth factor I and risk of breast cancer

1998 • 1,850 citations

Insulin-Like Growth Factors I and II. Peptide, Messenger Ribonucleic Acid and Gene Structures, Serum, and Tissue Concentrations*

1989 • 1,796 citations

Nutritional Regulation of the Insulin-Like Growth Factors*

1994 • 1,537 citations

Normal growth and development in the absence of hepatic insulin-like growth factor I

1999 • 1,430 citations

Molecular and Cellular Aspects of the Insulin-Like Growth Factor I Receptor

1995 • 1,361 citations

Prospective Study of Colorectal Cancer Risk in Men and Plasma Levels of Insulin-Like Growth Factor (IGF)-I and IGF-Binding Protein-3

1999 • 1,128 citations

Insulin-Like Growth Factor-Binding Proteins in Serum and Other Biological Fluids: Regulation and Functions*

1997 • 1,056 citations

Insulin‐like growth factors I and II

1990 • 1,006 citations

Liver-derived insulin-like growth factor I (IGF-I) is the principal source of IGF-I in blood but is not required for postnatal body growth in mice

1999 • 938 citations

Insulin-like growth factors and their binding proteins

1990 • 929 citations

Increased cell division as a cause of human cancer.

1990 • 894 citations

Induction of the growth inhibitor IGF-binding protein 3 by p53

1995 • 884 citations

Insulin-like growth factor II receptor as a multifunctional binding protein

1987 • 858 citations

Growth, differentiation, and survival: multiple physiological functions for insulin-like growth factors

1996 • 783 citations

Insulin-like Growth Factor (IGF)-binding Protein-3 Induces Apoptosis and Mediates the Effects of Transforming Growth Factor-β1 on Programmed Cell Death through a p53- and IGF-independent Mechanism

1997 • 725 citations

The insulin-like growth factor (IGF)-dependent IGF binding protein-4 protease secreted by human fibroblasts is pregnancy-associated plasma protein-A

1999 • 699 citations

Serum insulin-like growth factor-I in 1030 healthy children, adolescents, and adults: relation to age, sex, stage of puberty, testicular size, and body mass index

1994 • 696 citations

Insulin-like growth factors and cancer

1992 • 622 citations

Insulin-Like Growth Factor 1 and Prostate Cancer Risk: A Population-Based, Case-Control Study

1998 • 592 citations

Plasma Levels of Insulin-Like Growth Factor-I and Lung Cancer Risk: a Case-Control Analysis

1999 • 558 citations

The insulin-like growth factor I receptor: a key to tumor growth?

1995 • 549 citations

Insulin-like Growth Factor Binding Protein-1: Recent Findings and New Directions

1997 • 532 citations

Insulin-like growth factor binding proteins and their role in controlling IGF actions

1997 • 510 citations

Insulin-like growth factor-binding proteins (IGFBPs) and their regulatory dynamics

1996 • 483 citations

Insulin-like growth factor (IGF)-independent action of IGF-binding protein-3 in Hs578T human breast cancer cells. Cell surface binding and growth inhibition

1993 • 481 citations

Prostate-specific antigen (PSA) is an insulin-like growth factor binding protein-3 protease found in seminal plasma.

1992 • 478 citations

Serum levels of insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) in healthy infants, children, and adolescents: the relation to IGF-I, IGF-II, IGFBP-1, IGFBP-2, age, sex, body mass index, and pubertal maturation.

1995 • 439 citations

Dietary restriction reduces insulin-like growth factor I levels, which modulates apoptosis, cell proliferation, and tumor progression in p53-deficient mice.

1997 • 432 citations

Parental genomic imprinting of the human IGF2 gene

1993 • 422 citations

Sequence of cDNA encoding human insulin-like growth factor I precursor

1983 • 401 citations

Role of insulin-like growth factors and the type I insulin-like growth factor receptor in the estrogen-stimulated proliferation of human breast cancer cells.

1990 • 385 citations

Insulin-like growth factor 1 in relation to prostate cancer and benign prostatic hyperplasia

1997 • 376 citations

Differential impact of age, sex steroid hormones, and obesity on basal versus pulsatile growth hormone secretion in men as assessed in an ultrasensitive chemiluminescence assay.

1995 • 371 citations

Reduction of Plasma Immunoreactive Somatomedin C during Fasting in Humans*

1981 • 369 citations

Wild-type and mutant p53 differentially regulate transcription of the insulin-like growth factor I receptor gene.

1996 • 365 citations

Estrogen Induces Insulin—Like Growth Factor—I Expression in the Rat Uterus

1987 • 353 citations

Expression of insulin-like growth factor-II transcripts in Wilms' tumour

1985 • 352 citations

Matrix metalloproteinases degrade insulin-like growth factor-binding protein-3 in dermal fibroblast cultures.

1994 • 345 citations

Insulin-like growth factor-I receptor overexpression mediates cellular radioresistance and local breast cancer recurrence after lumpectomy and radiation.

1997 • 343 citations

Serum insulin‐like growth factor I in a random population sample of men and women: relation to age, sex, smoking habits, coffee consumption and physical activity, blood pressure and concentrations of plasma lipids, fibrinogen, parathyroid hormone and osteocalcin

1994 • 343 citations

Effects of caloric or protein restriction on insulin-like growth factor-I (IGF-I) and IGF-binding proteins in children and adults.

1995 • 325 citations

Insulin-like Growth Factors and Cancer

1995 • 321 citations

High molecular weight insulin-like growth factor binding protein complex

1989 • 315 citations

Expression and characterization of a functional human insulin-like growth factor I receptor.

1988 • 313 citations

Insulin and related factors in premenopausal breast cancer risk

1998 • 309 citations

Phosphorylation of insulin-like growth factor (IGF)-binding protein 1 in cell culture and in vivo: effects on affinity for IGF-I.

1991 • 294 citations

Enhanced levels of insulin-like growth factor messenger RNA in human colon carcinomas and liposarcomas.

1986 • 293 citations

Insulinlike Growth Factor-Binding Proteins

1990 • 291 citations

Loss of imprinting in normal tissue of colorectal cancer patients with microsatellite instability

1998 • 290 citations

Insulin receptor activation by IGF-II in breast cancers: evidence for a new autocrine/paracrine mechanism

1999 • 280 citations

Plasma insulin-like growth factor-1 (IGF-1) concentrations in human breast cancer

1993 • 276 citations

Altered body composition and increased frequency of diverse malignancies in insulin-like growth factor-II transgenic mice.

1994 • 274 citations

Biological effects of prostate specific antigen as an insulin-like growth factor binding protein-3 protease

1994 • 273 citations

Increased expression of the insulin-like growth factor I receptor gene, IGF1R, in Wilms tumor is correlated with modulation of IGF1R promoter activity by the WT1 Wilms tumor gene product.

1993 • 268 citations

Human chromosomal mapping of genes for insulin-like growth factors I and II and epidermal growth factor

1984 • 267 citations

Mitogenic Signaling of Insulin-like Growth Factor I in MCF-7 Human Breast Cancer Cells Requires Phosphatidylinositol 3-Kinase and Is Independent of Mitogen-activated Protein Kinase

1997 • 262 citations

Insulin-like growth factor binding protein 3 mediates retinoic acid- and transforming growth factor beta2-induced growth inhibition in human breast cancer cells.

1996 • 257 citations

Insulin and insulin-like growth factor-I (IGF-I) receptor overexpression in breast cancers leads to insulin/IGF-I hybrid receptor overexpression: evidence for a second mechanism of IGF-I signaling.

1999 • 254 citations

Insulin-like growth factor-I receptors are overexpressed and predict a low risk in human breast cancer.

1993 • 248 citations

The human cation-independent mannose 6-phosphate receptor. Cloning and sequence of the full-length cDNA and expression of functional receptor in COS cells.

1988 • 244 citations

Influence of Physical Activity on Insulin-Like Growth Factor-I in Healthy Younger and Older Men*

1990 • 242 citations

Transforming Growth Factor- β-induced Cell Growth Inhibition in Human Breast Cancer Cells Is Mediated through Insulin-like Growth Factor-binding Protein-3 Action

1995 • 241 citations

Epidemiology of Insulin-like Growth Factor-I in Elderly Men and Women: The Rancho Bernardo Study

1997 • 241 citations

Inhibition of growth of prostatic cancer cell lines by peptide analogues of insulin-like growth factor 1.

1993 • 240 citations

Energy Intake and Prostate Tumor Growth, Angiogenesis, and Vascular Endothelial Growth Factor Expression

1999 • 240 citations

Expression of insulin-like growth factor-1 receptor in human colorectal cancer

1999 • 238 citations

Serum Insulin-Like Growth Factors I and II Concentrations and Growth Hormone and Insulin Responses to Arginine Infusion in Children with Protein-Energy Malnutrition before and after Nutritional Rehabilitation

1986 • 229 citations

THE ROLE OF THE INSULIN-LIKE GROWTH FACTOR BINDING PROTEINS AND THE IGFBP PROTEASES IN MODULATING IGF ACTION

1996 • 227 citations

Serum insulin-like growth factor-binding protein-2 (IGFBP-2) is increased and IGFBP-3 is decreased in patients with prostate cancer: correlation with serum prostate-specific antigen.

1993 • 227 citations

Estradiol and Antiestrogens Regulate a Growth Inhibitory Insulin-like Growth Factor Binding Protein 3 Autocrine Loop in Human Breast Cancer Cells

1996 • 225 citations

Peptide growth factor cross-talk with the estrogen receptor requires the A/B domain and occurs independently of protein kinase C or estradiol.

1996 • 225 citations

Promoter-specific imprinting of the human insulin-like growth factor-II gene

1994 • 222 citations

Insulin-like growth factors I and II in evaluation of growth retardation

1986 • 220 citations

Insulin‐like growth‐factor‐binding protein 3 is decreased in early‐stage operable pre‐menopausal breast cancer

1995 • 219 citations

Insulin-like Growth Factor-binding Protein (IGFBP-3) Predisposes Breast Cancer Cells to Programmed Cell Death in a Non-IGF-dependent Manner

1997 • 219 citations

Prognostic value of receptors for insulin-like growth factor 1, somatostatin, and epidermal growth factor in human breast cancer.

1989 • 217 citations

Insulin-like growth factor-I in relation to premenopausal ductal carcinoma in situ of the breast.

1998 • 209 citations

Regulation by fasting of rat insulin-like growth factor I and its receptor. Effects on gene expression and binding.

1989 • 208 citations

Receptors for epidermal growth factor and insulin-like growth factor I and their relation to steroid receptors in human breast cancer.

1988 • 208 citations

Insulin-Like Growth Factor-1 Inhibition of Apoptosis Is Associated with Increased Expression of the bcl-xL Gene Product

1997 • 208 citations

Elevated levels of insulin-like growth factor-binding protein-2 in the serum of prostate cancer patients.

1993 • 201 citations

IGF-I and IGF-II in relation to colorectal cancer

1999 • 190 citations

Mammary cancer in transgenic mice expressing insulin-like growth factor II (IGF-II)

1995 • 190 citations

Insulin-like growth factors (IGF-I, free IGF-I, and IGF-II) and insulin-like growth factor binding proteins (IGFBP-2, IGFBP-3, IGFBP-6, and ALS) in blood circulation

1999 • 187 citations

The Matrix Metalloproteinase-9 Regulates the Insulin-like Growth Factor-triggered Autocrine Response in DU-145 Carcinoma Cells

1999 • 186 citations

Treatment of Obese, Diet-Restricted Subjects with Growth Hormone for 11 Weeks: Effects on Anabolism, Lipolysis, and Body Composition*

1988 • 185 citations

Activation of estrogen receptor-mediated gene transcription by IGF-I in human breast cancer cells

1997 • 183 citations

Effect of Fasting on Insulin-Like Growth Factor-I (IGF-I) and Growth Hormone Receptor mRNA Levels and IGF-I Gene Transcription in Rat Liver

1990 • 182 citations

Insulin-like growth factor binding protein-3 and insulin receptor substrate-1 in breast cancer: correlation with clinical parameters and disease-free survival.

1997 • 181 citations

Insulin-like growth factor 1 receptors in human breast cancer and their relation to estradiol and progesterone receptors.

1988 • 173 citations

Imprinting of a genomic domain of 11p15 and loss of imprinting in cancer: an introduction.

1999 • 172 citations

Physical fitness, endurance training, and the growth hormone-insulin-like growth factor I system in adolescent females.

1996 • 170 citations

Elevated insulin-like growth factor I receptor autophosphorylation and kinase activity in human breast cancer.

1998 • 169 citations

Free Insulin-Like Growth Factor I Serum Levels in 1430 Healthy Children and Adults, and Its Diagnostic Value in Patients Suspected of Growth Hormone Deficiency1

1997 • 164 citations

Autocrine regulation of cell proliferation by the insulin-like growth factor (IGF) and IGF binding protein-3 protease system in a human prostate carcinoma cell line (PC-3).

1995 • 164 citations

Type-2 IGF Receptor: A Multi-Ligand Binding Protein

1999 • 163 citations

Protein and messenger ribonucleic acid (mRNA) for the type 1 insulin-like growth factor (IGF) receptor is decreased and IGF-II mRNA is increased in human prostate carcinoma compared to benign prostate epithelium.

1996 • 162 citations

Nutritional regulation of hormones and growth factors that control mammalian growth

1994 • 159 citations

Epidermal growth factor (EGF) receptor blockade inhibits the action of EGF, insulin-like growth factor I, and a protein kinase A activator on the mitogen-activated protein kinase pathway in prostate cancer cell lines.

1999 • 159 citations

Increased physical activity and the growth hormone-IGF-I axis in adolescent males

1998 • 157 citations

Insulin‐like growth factor‐binding protein enhancement of insulin‐like growth factor‐i (IGF‐I)–mediated DNA synthesis and IGF‐I binding in a human breast carcinoma cell line

1994 • 154 citations

Transcriptional repression of the insulin-like growth factor I receptor (IGF-I-R) gene by the tumor suppressor WT1 involves binding to sequences both upstream and downstream of the IGF-I-R gene transcription start site.

1994 • 154 citations

Insights from Bcl-2 and Myc: malignancy involves abrogation of apoptosis as well as sustained proliferation.

1999 • 153 citations

Estradiol enhances the stimulatory effect of insulin-like growth factor-I (IGF-I) on mammary development and growth hormone-induced IGF-I messenger ribonucleic acid.

1995 • 152 citations

Insulin-like Growth Factor Binding Protein-3 Induces Apoptosis in MCF7 Breast Cancer Cells

1997 • 152 citations

p53 Regulates Insulin-Like Growth Factor-I (IGF-I) Receptor Expression and IGF-I-Induced Tyrosine Phosphorylation in an Osteosarcoma Cell Line: Interaction between p53 and Sp1

1998 • 151 citations

Effect of Dietary Protein Deprivation on Insulin-Like Growth Factor (IGF)-I and -II, IGF Binding Protein-2, and Serum Albumin Gene Expression in Rat*

1990 • 148 citations

Involvement of IGF-II in human cancer

1996 • 148 citations

Expression of mRNA for the insulin-like growth factors and their receptors in human preimplantation embryos

1997 • 148 citations

Differential expression of the human insulin-like growth factor II gene Characterization of the IGF-II mRNAs and an mRNA encoding a putative IGF-II-associated protein

1988 • 146 citations

Inhibition of basal and mitogen-stimulated pancreatic cancer cell growth by cyclin D1 antisense is associated with loss of tumorigenicity and potentiation of cytotoxicity to cisplatinum.

1998 • 145 citations

Growth inhibition of both MCF-7 and Hs578T human breast cancer cell lines by vitamin D analogues is associated with increased expression of insulin-like growth factor binding protein-3

1998 • 144 citations

Repression of the insulin receptor promoter by the tumor suppressor gene product p53: a possible mechanism for receptor overexpression in breast cancer.

1996 • 144 citations

Somatomedin-C, Physical Fitness, and Bone Density*

1990 • 143 citations

Blockade of the insulin‐like growth‐factor‐I receptor inhibits growth of human colorectal cancer cells: Evidence of a functional IGF‐II‐mediated autocrine loop

1994 • 143 citations

The Insulin-Like Growth Factor I Receptor as a Physiologically Relevant Target of p53 in Apoptosis Caused by Interleukin-3 Withdrawal

1997 • 141 citations

Relations of endogenous anabolic hormones and physical activity to bone mineral density and lean body mass in elderly men

1994 • 140 citations

Tamoxifen interferes with the insulin-like growth factor I receptor (IGF-IR) signaling pathway in breast cancer cells.

1997 • 139 citations

Expression of insulin-like growth factor-1 receptor in synovial sarcoma: association with an aggressive phenotype.

1999 • 139 citations

Prognostic significance of insulin-like growth factor 1 receptors in human breast cancer.

1990 • 136 citations

Insulin-Like Growth Factor Binding Protein Secretion by Breast Carcinoma Cell Lines: Correlation with Estrogen Receptor Status*

1990 • 135 citations

Insulin-like growth factor-binding protein-2 in patients with prostate carcinoma and benign prostatic hyperplasia.

1997 • 135 citations

Testosterone, Growth Hormone and IGF-I Responses to Acute and Chronic Resistive Exercise in Men Aged 55-70 Years

1995 • 130 citations

Increased expression of the insulin-like growth factor I (IGF-I) receptor gene in hepatocellular carcinoma cell lines: implications of IGF-I receptor gene activation by hepatitis B virus X gene product.

1996 • 127 citations

Growth inhibition of MCF-7 breast cancer cells by stable expression of an insulin-like growth factor I receptor antisense ribonucleic acid.

1995 • 126 citations

Phosphorylation of insulin-like growth factor binding proteins

1997 • 125 citations

The mannose 6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R), a putative breast tumor suppressor gene

1998 • 125 citations

Influence of dietary fat, caloric restriction, and voluntary exercise on N-nitrosomethylurea-induced mammary tumorigenesis in rats.

1988 • 124 citations

Characterization of Insulin-Like Growth Factor Binding Protein-3 (IGFBP-3) Binding to Human Breast Cancer Cells: Kinetics of IGFBP-3 Binding and Identification of Receptor Binding Domain on the IGFBP-3 Molecule*

1999 • 123 citations

In vivo inhibition of insulin-like growth factor I gene expression by tamoxifen.

1993 • 123 citations

Insulin-like growth factor binding protein-3 proteolysis in children with insulin-dependent diabetes mellitus: a possible role for insulin in the regulation of IGFBP-3 protease activity.

1995 • 123 citations

Intact but not truncated insulin-like growth factor binding protein-3 (IGFBP-3) blocks IGF I-induced stimulation of osteoblasts: Control of IGF signalling to bone cells by IGFBP-3-specific proteolysis?

1991 • 123 citations

Structure and function of the insulin-like growth factor I receptor

1998 • 122 citations

Differential regulation of transcription initiation from insulin-like growth factor-I (IGF-I) leader exons and of tissue IGF-I expression in response to changed growth hormone and nutritional status in sheep.

1993 • 121 citations

Insulin‐Like Growth Factor (IGF) System Components in Human Prostatic Cancer Cell‐Lines: LNCaP, DU145, and PC‐3 Cells

1996 • 121 citations

Estrogen and antiestrogen modulation of MCF7 human breast cancer cell proliferation is associated with specific alterations in accumulation of insulin-like growth factor-binding proteins in conditioned media.

1993 • 120 citations

Insulin-like growth factor-1 receptors and insulin-like growth factor-1-like activity in human primary breast cancer

1989 • 119 citations

Insulin-like growth factor-binding protein-2 and -3 expression in benign human prostate epithelium, prostate intraepithelial neoplasia, and adenocarcinoma of the prostate.

1996 • 115 citations

Serum Form of the Rat Insulin-like Growth Factor II/Mannose 6-Phosphate Receptor Is Truncated in the Carboxyl-terminal Domain

1989 • 114 citations

Insulin-Like Growth Factor I Modulates Induction of Apoptotic Signaling in H9C2 Cardiac Muscle Cells¹

1998 • 113 citations

Elevated Serum Insulin-Like Growth Factor-Binding Protein 2 (IGFBP-2) and Decreased IGFBP-3 in Epithelial Ovarian Cancer: Correlation with Cancer Antigen 125 and Tumor-Associated Trypsin Inhibitor1

1997 • 113 citations

Plasma Insulin-Like Growth Factor-I and Serum IGF-Binding Protein 3 Can Be Associated with the Progression of Breast Cancer, and Predict the Risk of Recurrence and the Probability of Survival in African-American and Hispanic Women

1999 • 112 citations

PTEN gene transfer in human malignant glioma: sensitization to irradiation and CD95L-induced apoptosis

1999 • 112 citations

Differential IGF-independent effects of insulin-like growth factor binding proteins (1-6) on apoptosis of breast epithelial cells

1999 • 109 citations

Low concentrations of insulin-like growth factor-I in abdominal obesity.

1993 • 109 citations

Alterations in serum levels of insulin‐like growth factors and insulin‐like growth‐factor‐binding proteins in patients with colorectal cancer

1994 • 108 citations

Effects of aging and sex on plasma insulin-like growth factor I (IGF-I) levels in normal adults

1991 • 107 citations

Age, Sex, and Smoking Are Predictors of Circulating Insulin-Like Growth Factor 1 and Insulin-Like Growth Factor–Binding Protein 3

1999 • 107 citations

IL-4 and insulin-like growth factor-I inhibit the decline in Bcl-2 and promote the survival of IL-3-deprived myeloid progenitors.

1997 • 106 citations

Igf-independent regulation of breast cancer growth by IGF binding proteins

1998 • 105 citations

Relationship between alpha subunit ligand occupancy and beta subunit autophosphorylation in insulin/insulin-like growth factor-1 hybrid receptors.

1993 • 105 citations

Type II insulin-like growth factor receptor is present in rat serum.

1987 • 104 citations

Platelet-Derived Growth Factor Increases the Activity of the Promoter of the Insulin-like Growth Factor-1 (IGF-1) Receptor Gene

1994 • 103 citations

Insulin/IGF-I hybrid receptors play a major role in IGF-I signaling in thyroid cancer

1999 • 102 citations

Effect of caloric restriction on age-associated cancers

1992 • 101 citations

Insulin-like growth factor-binding protein-3 production by MCF-7 breast cancer cells: stimulation by retinoic acid and cyclic adenosine monophosphate and differential effects of estradiol.

1995 • 101 citations

Differential Regulation of Insulin-like Growth Factor-I (IGF-I) Receptor Gene Expression by IGF-I and Basic Fibroblastic Growth Factor

1997 • 100 citations

Regulation of insulin-like growth factor II P3 promotor by p53: a potential mechanism for tumorigenesis.

1996 • 99 citations

Effects of zinc and other nutritional factors on insulin-like growth factor I and insulin-like growth factor binding proteins in postmenopausal women

1998 • 99 citations

Regulation of insulin-like growth factor (IGF) II and IGF binding protein 3 autocrine loop in human PC-3 prostate cancer cells by vitamin D metabolite 1,25(OH)2D3 and its analog EB1089.

1998 • 98 citations

Serum free IGF‐I, total IGF‐I, IGFBP‐1 and IGFBP‐3 levels in an elderly population: relation to age and sex steroid levels

1998 • 98 citations

Proteolysis of Insulin-Like Growth Factors (IGF) and IGF Binding Proteins by Cathepsin D¹

1997 • 98 citations

Insulin-like growth factor-I (IGF-I) and IGF-binding protein-2 are increased in cyst fluids of epithelial ovarian cancer.

1994 • 97 citations

Correlation of Insulin-Like Growth Factor-Binding Protein-3 Messenger RNA With Protein Expression in Primary Breast Cancer Tissues: Detection of Higher Levels in Tumors With Poor Prognostic Features

1996 • 96 citations

Insulin-like growth factor gene expression in human smooth muscle tumors.

1990 • 96 citations

Reduced serum concentrations of insulin-like growth factor-I (IGF-I) in protein-restricted growing rats are accompanied by reduced IGF-I mRNA levels in liver and skeletal muscle

1991 • 95 citations

Age-Related Changes in Serum Insulin-Like Growth Factor-Binding Proteins in Women*

1990 • 95 citations

Regional loss of imprinting of the insulin-like growth factor II gene occurs in human prostate tissues.

1995 • 94 citations

Type I insulin-like growth factor receptor gene expression in normal human breast tissue treated with oestrogen and progesterone

1997 • 94 citations

Age-related changes in IGFBP-4 and IGFBP-5 levels in human serum and bone: Implications for bone loss with aging

1995 • 93 citations

Insulin-like growth factor binding proteins in human breast cancer tissue.

1992 • 92 citations

Responses of total and free insulin‐like growth factor‐I and insulin‐like growth factor binding protein‐3 after resistance exercise and training in elderly subjects

1999 • 92 citations

Insulin-like growth factor I gene expression in the uterus is stimulated by tamoxifen and inhibited by the pure antiestrogen ICI 182780.

1993 • 92 citations

Estradiol Down-Regulates the Mannose-6-Phosphate/Insulin-Like Growth Factor-II Receptor Gene and Induces Cathepsin-D in Breast Cancer Cells: A Receptor Saturation Mechanism to Increase the Secretion of Lysosomal Proenzymes

1991 • 90 citations

Expression of insulin‐like growth factor binding proteins in human breast cancer correlates with estrogen receptor status

1993 • 90 citations

Effect of Exercise on Cytokines and Growth Mediators in Prepubertal Children

1999 • 90 citations

Effect of dietary proteins on insulin-like growth factor-1 (IGF-1) messenger ribonucleic acid content in rat liver

1992 • 90 citations

Role for membrane and secreted insulin-like growth factor-binding protein-2 in the regulation of insulin-like growth factor action in lung tumors

1994 • 88 citations

Antiproliferative Action of Vitamin D-Related Compounds and Insulin-Like Growth Factor-Binding Protein 5 Accumulation

1997 • 87 citations

Hormonal response to overfeeding

1989 • 86 citations

Proliferation and differentiation of a human colon cancer cell line (CaCo2) is associated with significant changes in the expression and secretion of insulin-like growth factor (IGF) IGF-II and IGF binding protein-4: role of IGF-II.

1996 • 85 citations

The Acid-Labile Subunit of Human Ternary Insulin-Like Growth Factor Binding Protein Complex in Serum: Hepatosplanchnic Release, Diurnal Variation, Circulating Concentrations in Healthy Subjects, and Diagnostic Use in Patients with Growth Hormone Deficiency

1998 • 84 citations

Associations between insulin-like growth factors and their binding proteins and other prognostic indicators in breast cancer

1996 • 84 citations

Frequent loss of imprinting of the H19 and IGF-II genes in ovarian tumors

1998 • 84 citations

Sporadic amplification of the insulin-like growth factor 1 receptor gene in human breast tumors.

1992 • 84 citations

Interactions between insulin-like growth factor-I (IGF-I) and the system of plasminogen activators and their inhibitors in the control of IGF-binding protein-3 production and proteolysis in human osteosarcoma cells.

1994 • 84 citations

Acid-Labile Subunit of Human Insulin-Like Growth Factor-Binding Protein Complex: Measurement, Molecular, and Clinical Evaluation

1997 • 83 citations

Identification of multiple transcription start sites in the human insulin-like growth factor-I gene

1991 • 82 citations

Interleukin-1 and tumor necrosis factor-α increase insulin-like growth factor-binding protein-3 (IGFBP-3) production and IGFBP-3 protease activity in human articular chondrocytes

1995 • 82 citations

Increased Circulating Levels of Insulin-Like Growth Factor-I and Decreased Circulating Levels of Insulin-Like Growth Factor Binding Protein-1 in Postmenopausal Women with Endometrial Cancer.

1997 • 82 citations

The human hepatitis B virus transactivator X gene product regulates Sp1 mediated transcription of an insulin-like growth factor II promoter 4

1998 • 81 citations

Disruption of Ligand Binding to the Insulin-like Growth Factor II/Mannose 6-Phosphate Receptor by Cancer-associated Missense Mutations

1999 • 81 citations

Disrupted IGF2 promoter control by silencing of promoter P1 in human hepatocellular carcinoma.

1997 • 80 citations

Insulin-like growth factor-I induces cyclin-D1 expression in MG63 human osteosarcoma cells in vitro.

1994 • 79 citations

Effect of regular physical training on age‐associated alteration of body composition in men

1996 • 78 citations

Insulin-Like Growth Factors I and II Are Autocrine Factors in Stimulating Proteoglycan Synthesis, a Marker of Differentiated Chondrocytes, Acting through Their Respective Receptors on a Clonal Human Chondrosarcoma-Derived Chondrocyte Cell Line, HCS-2/8¹

1997 • 77 citations

Vitamin D derivatives inhibit the mitogenic effects of IGF-I on MCF-7 human breast cancer cells

1997 • 77 citations

Overexpression of the insulin-like growth factor-1 receptor and autocrine stimulation in human cervical cancer cells.

1996 • 76 citations

Expression of the wild-type insulin-like growth factor II receptor gene suppresses growth and causes death in colorectal carcinoma cells

1999 • 75 citations

Identification of insulin-like growth factor binding proteins in breast cancer cells

1991 • 75 citations

Plasma Insulin-Like Growth Factor-I and High Affinity Growth Hormone-Binding Protein Levels Increase After Two Weeks of Strenuous Physical Training

1997 • 74 citations

Insulin‐like growth factor binding proteins: a proposed superfamily

1999 • 72 citations

Fibroblast Growth Factor Inhibits Insulin-Like Growth Factor-II (IGF-II) Gene Expression and Increases IGF-I Receptor Abundance in BC3H-1 Muscle Cells

1991 • 71 citations

Insulin-like growth factor 1 (IGF-1), IGF-1 density, and IGF-1/PSA ratio for prostate cancer detection

1999 • 68 citations

A role for insulin-like growth factor binding protein 5 in the antiproliferative action of the antiestrogen ICI 182780.

1996 • 66 citations

Loss of imprinting of IGF2 and not H19 in breast cancer, adjacent normal tissue and derived fibroblast cultures

1998 • 65 citations

Tissue-specific transcription start site usage in the leader exons of the rat insulin-like growth factor-I gene: evidence for differential regulation in the developing kidney.

1992 • 65 citations

Characterization of the chromosomal gene and promoter for human insulin-like growth factor binding protein-5.

1994 • 64 citations

Specific Expression of Insulin-like Growth Factor-II in Rhabdomyosarcoma Tumor Cells

1994 • 64 citations

Decreased insulin-like growth factor-II/mannose 6-phosphate receptor expression enhances tumorigenicity in JEG-3 cells.

1999 • 62 citations

Insulin-like growth factor-I and binding protein-3 in relation to childhood leukaemia

1999 • 62 citations

Insulin-like growth factor-binding proteins (IGFBP)-4, -5, and -6 in the benign and malignant human prostate: IGFBP-5 messenger ribonucleic acid localization differs from IGFBP-5 protein localization.

1996 • 62 citations

Association of insulin‐like growth‐factor‐I‐induced DNA synthesis with phosphorylation and nuclear exclusion of p53 in human breast cancer MCF‐7 cells

1993 • 62 citations

Regulation by Fasting of Rat Insulin-like Growth Factor I and Its Receptor

1989 • 62 citations

Insulin-like growth factor–binding protein-3 and breast cancer survival

1998 • 61 citations

The Soluble Type 2 Insulin-like Growth Factor (IGF-II) Receptor Reduces Organ Size by IGF-II-mediated and IGF-II-independent Mechanisms

1998 • 60 citations

Identification of the insulin-like growth factor binding proteins 5 and 6 (IGFBP-5 and 6) in human breast cancer cells

1992 • 60 citations

Retinoic acid regulates insulin-like growth factor-binding protein expression in human osteoblast cells.

1996 • 60 citations

Impaired estrogen action in the uterus of insulin-like growth factor binding protein-1 transgenic mice.

1996 • 59 citations

Oestradiol treatment increases the sensitivity of MCF-7 cells for the growth stimulatory effect of IGF-I

1992 • 59 citations

Insulin-like growth factor binding protein 1 expression inhibits insulin-like growth factor I action in MCF-7 breast cancer cells.

1994 • 59 citations

Secretion and biological actions of insulin‐like growth factor binding proteins in two human tumor‐derived cell lines in vitro

1991 • 59 citations

A Novel Human Insulin-Like Growth Factor I Messenger RNA is Expressed in Normal and Tumor Cells

1990 • 59 citations

Insulin-Like Growth Factor-Binding Protein-5 Is Cleaved by Physiological Concentrations of Thrombin*

1998 • 59 citations

Activation of fetal promoters of insulinlike growth factors II gene in hepatitis C virus-related chronic hepatitis, cirrhosis, and hepatocellular carcinoma

1996 • 58 citations

Expression levels of the insulin-like growth factor-II gene (IGF2) in the human liver: developmental relationships of the four promoters

1996 • 57 citations

The Role of Histone Acetylation in the Allelic Expression of the Imprinted Human Insulin-like Growth Factor II Gene

1998 • 57 citations

7S nerve growth factor is an insulin-like growth factor-binding protein protease.

1996 • 56 citations

Contiguous localization of the genes encoding human insulin-like growth factor binding proteins 1(IGBP1) and 3(IGBP3) on chromosome 7

1992 • 56 citations

Essential promoter elements are located within the 5′ untranslated region of human insulin-like growth factor-I exon I

1997 • 56 citations

The insulin-like growth factor family of ligands, receptors, and binding proteins

1992 • 55 citations

Stimulation of endometrial cancer cell growth by tamoxifen is associated with increased insulin-like growth factor (IGF)-I induced tyrosine phosphorylation and reduction in IGF binding proteins.

1996 • 55 citations

Soluble Insulin-like Growth Factor II/Mannose 6-Phosphate Receptor Carries Multiple High Molecular Weight Forms of Insulin-like Growth Factor II in Fetal Bovine Serum

1995 • 54 citations

Increased insulin-like growth factor binding protein-2 (IGFBP-2) gene expression and protein production lead to high IGFBP-2 content in malignant ovarian cyst fluid

1996 • 54 citations

Nutritional regulation of IGF-I and IGFBPs.

1996 • 54 citations

IGFBP-2 expression in a human cell line is associated with increased IGFBP-3 proteolysis, decreased IGFBP-1 expression and increased tumorigenicity

1998 • 53 citations

Regulation of Soluble Insulin-Like Growth Factor II/Mannose 6-Phosphate Receptor in Human Serum: Measurement by Enzyme-Linked Immunosorbent Assay1

1999 • 53 citations

Population-based reference values for IGF-I and IGF-binding protein-1: relations with metabolic and anthropometric variables

1997 • 53 citations

Postoperative Induction of Insulin-Like Growth Factor Binding Protein-3 Proteolytic Activity: Relation to Insulin and Insulin Sensitivity¹

1998 • 53 citations

Expression of IGF ligand and receptor genes during preimplantation mammalian development

1993 • 53 citations

Induction of tumor suppression and glandular differentiation of A549 lung carcinoma cells by dominant-negative IGF-I receptor

1999 • 52 citations

Serum Insulin‐Like Growth Factor I in Healthy Older Men in Relation to Physical Activity

1994 • 52 citations

Relationship between carbohydrate metabolism and serum insulin-like growth factor system in postmenopausal women: comparison of endometrial cancer patients with healthy controls.

1993 • 52 citations

Physiologic and clinical relevance of the insulin-like growth factor binding proteins

1994 • 51 citations

Hormonal regulation of insulin-like growth factor II and insulin-like growth factor binding protein expression by breast cancer cells in vivo: evidence for stromal epithelial interactions.

1994 • 51 citations

EFFECTS OF ALCOHOL AND LIVER CIRRHOSIS ON THE GH-IGF-I AXIS

1995 • 49 citations

Cortisol enhances the transcription of insulin-like growth factor-binding protein-6 in cultured osteoblasts.

1996 • 49 citations

Varying patterns of expression of insulin-like growth factors I and II and their receptors in murine mammary adenocarcinomas of different metastasizing ability

1996 • 49 citations

Proteolysis of Insulin-Like Growth Factor Binding Proteins by a Novel 50-Kilodalton Metalloproteinase in Human Pregnancy Serum¹

1998 • 47 citations

Increased expression of insulin-like growth factor 2 in hepatocellular carcinoma is primarily regulated at the transcriptional level.

1996 • 46 citations

Transcriptional and Post-Transcriptional Regulation of the Human IGF-II Gene Expression

1994 • 45 citations

p53 Regulates Human Insulin-Like Growth Factor II Gene Expression through Active P4 Promoter in Rhabdomyosarcoma Cells

1998 • 45 citations

Imprinting of the mouse Igf2r gene depends on an intronic CpG island

1998 • 44 citations

Thyroid hormone and retinoic acid induce the synthesis of insulin-like growth factor-binding protein-4 in mouse osteoblastic cells.

1996 • 43 citations

Prognostic Significance of Insulin-like Growth Factor-Binding Protein Expression in Axillary Lymph Node-Negative Breast Cancer

1994 • 43 citations

Epidermal growth factor suppresses insulin-like growth factor binding protein 3 levels in human papillomavirus type 16-immortalized cervical epithelial cells and thereby potentiates the effects of insulin-like growth factor 1.

1994 • 42 citations

Evidence for Insulin-Like Growth Factor (IGF)-Independent Transcriptional Regulation of IGF Binding Protein-3 by Growth Hormone in SKHEP-1 Human Hepatocarcinoma Cells*

1997 • 42 citations

Effect of Fasting on Insulin-Like Growth Factor (IGF)-IA and IGF-IB Messenger Ribonucleic Acids and Prehormones in Rat Liver*

1997 • 41 citations

Human Pregnancy Serum Contains at Least Two Distinct Proteolytic Activities with the Ability To Degrade Insulin-Like Growth Factor Binding Protein-3¹

1997 • 41 citations

Insulin-like growth factor II mediates epidermal growth factor-induced mitogenesis in cervical cancer cells.

1995 • 41 citations

Detection of insulin-like growth factor binding proteins (IGFBPs) by ligand blotting in breast cancer tissues

1994 • 40 citations

IGFBP-3 gene expression and estrogen receptor status in human breast carcinoma.

1992 • 40 citations

Insulin-Like Growth Factor-Binding Protein-1 and Prostate Cancer

1999 • 38 citations

Retinoic acid stimulates IGF binding protein (IGFBP)-6 and depresses IGFBP-2 and IGFBP-4 in SK-N-SH human neuroblastoma cells

1998 • 37 citations

Differential regulation of signaling pathways for insulin and insulin-like growth factor I.

1999 • 36 citations

THE ROLE OF IGFBP-3 IN THE REGULATION OF IGFBP-4 PROTEOLYSIS

1996 • 36 citations

Insulin-like growth factors (IGF)-I and -II and IGF binding protein-1, -2, and -3 in patients with acromegaly before and after adenomectomy

1994 • 34 citations

Developmental Regulation of the Soluble Form of Insulin-Like Growth Factor-II/Mannose 6-Phosphate Receptor in Human Serum and Amniotic Fluid¹

1998 • 34 citations

Insulin-Like Growth Factor-I and II Receptor Expression in Rat Colon Mucosa Are Affected by Dietary Lipid Intake

1998 • 34 citations

Regulation of Insulin-Like Growth Factor I Receptor Promoter Activity by Wild-Type and Mutant Versions of the WT1 Tumor Suppressor¹

1999 • 33 citations

Serum IGF-binding protein-6 and prostate specific antigen in breast cancer

1999 • 33 citations

Estrogen and Progesterone Regulate Secretion of Insulin-like Growth Factor Binding Proteins by Human Breast Cancer Cells

1993 • 32 citations

Growth factor regulation of insulin-like growth factor binding protein-6 expression in osteoblasts

1997 • 32 citations

HaCaT human keratinocytes express IGF-II, IGFBP-6, and an acid-activated protease with activity against IGFBP-6

1999 • 32 citations

Serum Levels of Insulin-Like Growth Factor-I in Operable Breast Cancer in Relation to the Main Prognostic Variables and their Perioperative Changes in Relation to those of Prolactin

1994 • 30 citations

Expression of insulin-like growth factor II in female breast cancer as related to established prognostic factors and long-term prognosis.

1995 • 29 citations

Insulin-like growth factor-I (IGF-I) and IGF-binding proteins blood serum levels in women with early- and late-stage breast cancer: mutual relationship and possible correlations with patients' hormonal status

1995 • 28 citations

Caloric Restriction and Experimental Carcinogenesis

1992 • 28 citations

Dysregulation of the Type 1 IGF receptor as a paradigm in tumor progression

1998 • 26 citations

Different In Situ Expression of Insulin-Like Growth Factor Type II in Hepatocellular Carcinoma

1994 • 26 citations

Tumor markers in patients with advanced breast cancer as prognosticators: A preliminary study

1994 • 26 citations

Proteolysis of IGFBPs by cathepsin D in vitro and in cathepsin D-deficient mice

1995 • 25 citations

No Effect of Growth Hormone on Serum Insulin-Like Growth Factor Binding Protein-3 Proteolysis¹

1998 • 25 citations

Ethanol Enhances the Stimulatory Effects of Insulin and Insulin-like Growth Factor-I on DNA Synthesis in NIH 3T3 Fibroblasts

1995 • 24 citations

Insulin-like growth factor-I expression in normal and diseased endometrium

1999 • 24 citations

Effect of obesity on plasma insulin-like growth factor-I in cancer patients.

1991 • 23 citations

In vitro effects of insulin‐like growth factor‐1 (IGF‐1) on proliferation and constitutive cytokine secretion by acute myelogenous leukemia blasts

1999 • 22 citations

Expression of insulin-like growth factor I (IGF-I) mRNA variants in rat bone

1996 • 22 citations

Regulation of insulin-like growth factor-binding protein-4 protease activity by estrogen and parathyroid hormone in SaOS-2 cells: implications for the pathogenesis of postmenopausal osteoporosis

1996 • 22 citations

Promoter-specific insulin-like growth factor 2 gene imprinting in human fetal liver and hepatoblastoma

1998 • 21 citations

Relaxation of Insulin-Like Growth Factor-ll Gene Imprinting in Human Gynecologic Tumors

1997 • 20 citations

Coordinate expression of insulin-like growth factor II (IGF-II) and IGF-II/mannose-6-phosphate receptor mRNA and stable expression of IGF-I receptor mRNA during differentiation of human colon carcinoma cells (Caco-2)

1996 • 18 citations

Circulating epidermal growth factor (EGF) and insulin-like growth factor-I (IGF-I) in patients with epithelial ovarian carcinoma.

1994 • 17 citations

Effects of Ethanol on the Intraovarian Insulin‐Like Growth Factor‐1 System in the Prepubertal Rat

1999 • 17 citations

Effects of various growth factors on growth of a cloned human esophageal squamous cancer cell line in a protein-free medium.

1991 • 17 citations

Insulin-like growth factor binding protein production in human follicular thyroid carcinoma cells.

1995 • 17 citations

Endometrial transcripts of human insulin-like growth factors arise by differential promoter usage

1997 • 16 citations

The Human Insulin-like Growth Factor-Binding Protein 4 Gene Maps to Chromosome Region 17q12-q21.1 and Is Close to the Gene for Hereditary Breast-Ovarian Cancer

1993 • 16 citations

Serum Concentrations of Insulin-Like Growth Factor 1 in Colonic Neoplasia

1994 • 15 citations

Opposite regulation of IGF-I and IGF-I receptor mRNA and concomitant changes of GH receptor and IGF-II/M6P receptor mRNA in human IM-9 lymphoblasts

1996 • 15 citations

Characterization and chromosomal localization of the human insulin-like growth factor-binding protein 6 gene

1999 • 14 citations

Aging, physical activity, insulin-like growth factor I, and body composition in Guatemalan women

1997 • 14 citations

Tissue-specific effects of chronic dietary protein restriction and gastrostomy on the insulin-like growth factor-I pathway in the liver and colon of adult rats

1997 • 9 citations

Loss of Imprinting of the IGF2 Gene in a Wilms' Tumor in an Adult

1997 • 8 citations

Effects of insulin-like growth factors I and II on oestrone sulphatase activity in human breast cancer cell lines.

1999 • 6 citations

Suppression of mammary-derived growth inhibitor gene expression by growth hormone and insulin-like growth factor I.

1998 • 5 citations