HaCaT human keratinocytes express IGF-II, IGFBP-6, and an acid-activated protease with activity against IGFBP-6

Insulin-Like Growth Factors and Their Binding Proteins: Biological Actions*

1995 • 4,419 citations

Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line.

1988 • 4,008 citations

Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)

1993 • 2,880 citations

Insulin-like Growth Factor Binding Proteins

1993 • 754 citations

Insulin-like growth factor-binding protein from human plasma. Purification and characterization.

1986 • 343 citations

Altered body composition and increased frequency of diverse malignancies in insulin-like growth factor-II transgenic mice.

1994 • 274 citations

Isolation and Molecular Cloning of Insulin-Like Growth Factor-Binding Protein-6

1991 • 233 citations

Potentiation of insulin-like growth factor (IGF) action by IGF-binding protein-3: studies of underlying mechanism.

1992 • 228 citations

Expression of Growth Hormone Receptor, Insulin-Like Growth Factor 1 (IGF-1) and IGF-1 Receptor mRNA and Proteins in Human Skin

1992 • 205 citations

Characterization of recombinant human insulin-like growth factor binding proteins 4, 5, and 6 produced in yeast.

1992 • 183 citations

Nucleotide sequences of cDNAs encoding precursors of human insulin‐like growth factor II (IGF‐II) and an IGF‐II variant

1985 • 164 citations

Involvement of IGF-II in human cancer

1996 • 148 citations

Cathepsin D: A protease involved in breast cancer metastasis

1990 • 140 citations

Binding of mutants of human insulin-like growth factor II to insulin-like growth factor binding proteins 1-6

1993 • 136 citations

Acid-activated insulin-like growth factor-binding protein-3 proteolysis in normal and transformed cells. Role of cathepsin D.

1994 • 121 citations

Purification and properties of a novel insulin-like growth factor-II binding protein from transformed human fibroblasts.

1990 • 103 citations

Disproportionate growth in mice with Igf-2 transgenes.

1994 • 102 citations

Proteolysis of Insulin-Like Growth Factors (IGF) and IGF Binding Proteins by Cathepsin D¹

1997 • 98 citations

Structural requirements of procathepsin D activation and maturation.

1994 • 95 citations

Human insulin-like growth factor binding protein-6 is O-glycosylated

1992 • 84 citations

Human fibroblasts secrete a serine protease that cleaves insulin-like growth factor-binding protein-5.

1994 • 82 citations

A Human Keratinocyte Cell Line Produces Two Autocrine Growth Inhibitors, Transforming Growth Factor-β and Insulin-like Growth Factor Binding Protein-6, in a Calcium- and Cell Density-dependent Manner

1995 • 74 citations

Recombinant human insulin-like growth factor (IGF)-binding protein-6 inhibits IGF-II-induced differentiation of L6A1 myoblasts.

1994 • 72 citations

Identification of O-Glycosylation Sites and Partial Characterization of Carbohydrate Structure and Disulfide Linkages of Human Insulin-like Growth Factor Binding Protein 6

1998 • 70 citations

Specific Mannose-6-Phosphate Receptor-Independent Sorting of Pro-Cathepsin D in Breast Cancer Cells

1994 • 64 citations

Complete nucleotide sequence of the high molecular weight human IGF-I mRNA

1991 • 63 citations

7S nerve growth factor is an insulin-like growth factor-binding protein protease.

1996 • 56 citations

INSULIN-LIKE GROWTH FACTOR (IGF) BINDING PROTEIN-3 IN PREGNANCY SERUM BINDS NATIVE IGF-I BUT NOT IODO-IGF-L

1991 • 50 citations

Proteolytic Activation of Human Procathepsin D

1991 • 45 citations

A Keratinocyte Cell Line Synthesizes a Predominant Insulin-Like Growth Factor-Binding Protein (IGFBP-3) that Modulates Insulin-Like Growth Factor-I Action

1994 • 44 citations

Regulation of insulin-like growth factor (IGF)-binding protein-6 and mannose 6-phosphate/IGF-II receptor expression in IGF-IL-overexpressing NIH 3T3 cells.

1995 • 37 citations

Biochemical and immunological studies of lysosomal and related proteinases in health and disease

1981 • 37 citations

Localization of messenger ribonucleic acid for insulin-like growth factor-binding proteins in human skin by in situ hybridization.

1994 • 37 citations

Insulin-like growth factor binding protein-4, -5 and -6 mRNAs in the human fetus: localization to sites of growth and differentiation?

1993 • 36 citations

Cathepsin B and D expression in squamous cell carcinoma

1996 • 35 citations

Effects of Insulin-like Growth Factor (IGF) Binding Proteins (BPs)-3 and -6 on DNA Synthesis of Rat Osteoblasts: Further Evidence for a Role of Auto-/Paracrine IGF I but Not IGF II in Stimulating Osteoblast Growth

1995 • 34 citations

Expression of cathepsin D and B in invasion and metastasis of squamous cell carcinoma

1997 • 22 citations

Proteolysis of Insulin-Like Growth Factor-Binding Protein-3 by Human Skin Keratinocytes in Culture in Comparison to that in Skin Interstitial Fluid: The Role and Regulation of Components of the Plasmin System1

1997 • 17 citations

Expression of cathepsin D and B in invasion and metastasis of squamous cell carcinoma

1997 • 14 citations

Identification of insulin‐like growth factor binding proteins from cultured human epidermal keratinocytes

1995 • 14 citations

Evaluation of Cathepsin D as Prognostic Predictor in Breast Cancer

1994 • 12 citations

Direct detection of insulin-like growth factor II (IGF-II) by chemiluminescence without interference by IGF binding proteins.

1994 • 11 citations

Comparison of the carbohydrate moieties of recombinant soluble Fc? receptor (sFc? RII/sCD23) expressed inSaccharomyces cerevisiae and Chinese hamster ovary cells. Different O-glycosylation sites are used by yeast and mammalian cells

1992 • 8 citations