The Acid-Labile Subunit of Human Ternary Insulin-Like Growth Factor Binding Protein Complex in Serum: Hepatosplanchnic Release, Diurnal Variation, Circulating Concentrations in Healthy Subjects, and Diagnostic Use in Patients with Growth Hormone Deficiency

Serum insulin-like growth factor-I in 1030 healthy children, adolescents, and adults: relation to age, sex, stage of puberty, testicular size, and body mass index

1994 • 696 citations

Insulin-like growth factors I and II in healthy man.

1989 • 513 citations

A Specific Radioimmunoassay for the Growth Hormone (GH)-Dependent Somatomedin-Binding Protein: Its Use for Diagnosis of GH Deficiency

1990 • 460 citations

Serum levels of insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) in healthy infants, children, and adolescents: the relation to IGF-I, IGF-II, IGFBP-1, IGFBP-2, age, sex, body mass index, and pubertal maturation.

1995 • 439 citations

The Diagnosis of Growth Hormone Deficiency in Adults

1997 • 427 citations

Enhancement of the anabolic effects of growth hormone and insulin-like growth factor I by use of both agents simultaneously.

1993 • 336 citations

Effect of insulin on the hepatic production of insulin-like growth factor-binding protein-1 (IGFBP-1), IGFBP-3, and IGF-I in insulin-dependent diabetes.

1994 • 328 citations

High molecular weight insulin-like growth factor binding protein complex

1989 • 315 citations

Spontaneous Growth Hormone Secretion Increases during Puberty in Normal Girls and Boys*

1991 • 286 citations

Circulating Levels and Molecular Distribution of the Acid-Labile (α) Subunit of the High Molecular Weight Insulin-Like Growth Factor-Binding Protein Complex*

1990 • 259 citations

Characterization of the Acid-Labile Subunit of the Growth Hormone-Dependent Insulin-Like Growth Factor Binding Protein Complex*

1988 • 239 citations

Diurnal Rhythm of Growth Hormone-Independent Binding Protein for Insulin-like Growth Factors in Human Plasma*

1987 • 227 citations

Insulinlike Growth Factor 1 Production Is Inhibited in Human Sepsis

1988 • 198 citations

The Somatomedin C Binding Protein: Evidence for a Heterologous Subunit Structure*

1980 • 193 citations

Analysis of 24-hour growth hormone profiles in healthy boys and girls of normal stature: relation to puberty.

1994 • 185 citations

Splanchnic and renal elimination and release of catecholamines in cirrhosis. Evidence of enhanced sympathetic nervous activity in patients with decompensated cirrhosis.

1984 • 183 citations

Cellular localization and regulation of gene expression for components of the insulin-like growth factor ternary binding protein complex.

1994 • 166 citations

Free Insulin-Like Growth Factor I Serum Levels in 1430 Healthy Children and Adults, and Its Diagnostic Value in Patients Suspected of Growth Hormone Deficiency1

1997 • 164 citations

Monitoring of growth hormone replacement therapy in adults, based on measurement of serum markers.

1996 • 157 citations

Abdominal adiposity and physical fitness are major determinants of the age associated decline in stimulated GH secretion in healthy adults.

1996 • 137 citations

Growth Hormone (GH) Provocative Retesting of 108 Young Adults with Childhood-Onset GH Deficiency and the Diagnostic Value of Insulin-Like Growth Factor I (IGF-I) and IGF-Binding Protein-3¹

1997 • 137 citations

Test of growth hormone secretion in adults: poor reproducibility of the insulin tolerance test

1995 • 125 citations

Differential cellular synthesis of insulin-like growth factor binding protein-1 (IGFBP-1) and IGFBP-3 within human liver.

1994 • 98 citations

Growth Hormone Stimulates Transcription of the Gene Encoding the Acid-Labile Subunit (ALS) of the Circulating Insulin-Like Growth Factor-Binding Protein Complex and ALS Promoter Activity in Rat Liver

1997 • 98 citations

Synthesis of insulinlike growth factor binding proteins and of the acid-labile subunit in primary cultures of rat hepatocytes, of Kupffer cells, and in cocultures: Regulation by insulin, insulinlike growth factor, and growth hormone

1996 • 95 citations

Hepatic blood flow determination

1987 • 90 citations

Acid-Labile Subunit of Human Insulin-Like Growth Factor-Binding Protein Complex: Measurement, Molecular, and Clinical Evaluation

1997 • 83 citations

Insulin-like growth factor binding protein-3: factors affecting binary and ternary complex formation.

1996 • 70 citations

Insulin‐Like Growth Factors (IGFs) and IGF Binding Proteins in Chronic Renal Failure: Evidence for Reduced Secretion of IGFs

1991 • 66 citations

Effects of Growth Hormone Replacement Therapy on IGF-Related Parameters and on the Pituitary-Gonadal Axis in GH-Deficient Males

1998 • 58 citations

Glycosaminoglycans inhibit formation of the 140 kDa insulin-like growth factor-binding protein complex

1990 • 58 citations

Serum Insulin-Like Growth Factor I (IGF-I), IGF-Binding Protein-1 and -3, and the Acid-Labile Subunit as Serum Markers of Body Composition during Growth Hormone (GH) Therapy in Adults with GH Deficiency¹

1997 • 54 citations

Circadian patterns of serum insulin-like growth factor (IGF) II and IGF binding protein 3 in growth hormone-deficient patients and age- and sex-matched normal subjects

1990 • 49 citations

Pharmacokinetics of insulin-like growth factor-1 in advanced chronic renal failure

1996 • 48 citations

Decreased Serum Somatomedin C Concentrations during Sleep: Temporal Relationship to the Nocturnal Surges of Growth Hormone and Prolactin*

1981 • 48 citations

Pharmacokinetics of recombinant human insulin-like growth factor-1 in dialysis patients

1995 • 44 citations

Immunoblot studies of the acid‐labile subunit (ALS) in biological fluids, normal human serum and in children with GH deficiency and GH receptor deficiency before and after long‐term therapy with GH or IGF‐I respectively

1997 • 37 citations

Regulation of the acid‐labile subunit of the insulin‐like growth factor ternary complex in patients with insulin‐dependent diabetes mellitus and severe burns

1996 • 30 citations

Pharmacokinetic Profile of Recombinant Human Insulin‐Like Growth Factor I Given Subcutaneously in Normal Subjects

1991 • 29 citations

Immunoblot studies of the IGF-related acid-labile subunit.

1994 • 23 citations

24-hour secretion of growth hormone (GH), insulin-like growth factors-I and -II (IGF-I, -II), prolactin (PRL) and thyrotropin (TSH) in young adults of normal and tall stature.

1996 • 17 citations

A Compartmental Model for Simulation of IGF-I Kinetics and Metabolism

1994 • 13 citations

Effect of the somatostatin analog, octreotide, and of other hormones on the release of the acid-labile subunit of the 150 kDa complex by rat hepatocyte in primary culture

1997 • 10 citations

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