Insulin-Like Growth Factor-Binding Protein-5 Is Cleaved by Physiological Concentrations of Thrombin*

Insulin-Like Growth Factors and Their Binding Proteins: Biological Actions*

1995 • 4,419 citations

Extracellular matrix contains insulin-like growth factor binding protein-5: potentiation of the effects of IGF-I.

1993 • 543 citations

Thrombin stimulates proliferation of cultured rat aortic smooth muscle cells by a proteolytically activated receptor.

1993 • 506 citations

Human osteoblast-derived insulin-like growth factor (IGF) binding protein-5 stimulates osteoblast mitogenesis and potentiates IGF action.

1992 • 351 citations

Identification of the forms of insulin-like growth factor-binding proteins produced by human fibroblasts and the mechanisms that regulate their secretion.

1992 • 295 citations

Purification of a 31,000-dalton insulin-like growth factor binding protein from human amniotic fluid. Isolation of two forms with different biologic actions.

1988 • 233 citations

Thrombin active site regions required for fibroblast receptor binding and initiation of cell division.

1980 • 186 citations

Alpha-thrombin induces release of platelet-derived growth factor-like molecule(s) by cultured human endothelial cells.

1986 • 173 citations

Characterization of insulin-like growth factor-binding protein 5-degrading proteases produced throughout murine osteoblast differentiation.

1995 • 158 citations

Plasminogen activator inhibitor is associated with the extracellular matrix of cultured bovine smooth muscle cells.

1987 • 158 citations

Evidence that human bone cells in culture produce insulin-like growth factor-binding protein-4 and -5 proteases.

1994 • 132 citations

Carboxy-Truncated Insulin-like Growth Factor-Binding Protein-5 Stimulates Mitogenesis in Osteoblast-like Cells

1993 • 129 citations

The mitogenic effect of thrombin in vascular smooth muscle cells is largely due to basic fibroblast growth factor.

1993 • 111 citations

Human neutrophil elastase modulates platelet function by limited proteolysis of membrane glycoproteins.

1985 • 111 citations

Cloning and sequence determination of bovine insulin‐like growth factor binding protein‐2 (IGFBP‐2): Comparison of its structral and functional properties with IGFBP‐1

1992 • 110 citations

Insulin-like Growth Factor-I (IGF-I) Regulates IGF-binding Protein-5 Synthesis through Transcriptional Activation of the Gene in Aortic Smooth Muscle Cells

1996 • 97 citations

Properties of an insulin-like growth factor-binding protein-4 protease that is secreted by smooth muscle cells.

1995 • 91 citations

Protease-resistant form of insulin-like growth factor-binding protein 5 is an inhibitor of insulin-like growth factor-I actions on porcine smooth muscle cells in culture.

1997 • 90 citations

Thrombin receptor activation elicits rapid protein tyrosine phosphorylation and stimulation of the raf-1/MAP kinase pathway preceding delayed mitogenesis in cultured rat aortic smooth muscle cells: evidence for an obligate autocrine mechanism promoting cell proliferation induced by G-protein-coupled receptor agonist.

1996 • 87 citations

Serum-derived vitronectin influences the pericellular distribution of type 1 plasminogen activator inhibitor.

1990 • 86 citations

Human fibroblasts secrete a serine protease that cleaves insulin-like growth factor-binding protein-5.

1994 • 82 citations

Proteolysis of IGFBP-3 may be a common regulatory mechanism of IGF action in vivo.

1993 • 81 citations

Cellular Localization of Enzymatically Active Thrombin in Intact Human Tissues by Hirudin Binding

1995 • 81 citations

Insulin-Like Growth Factor Binding Protein-5 Binds to Plasminogen Activator Inhibitor-I*

1997 • 78 citations

Thrombin neutralizes plasminogen activator inhibitor 1 (PAI-1) that is complexed with vitronectin in the endothelial cell matrix.

1991 • 76 citations

G-protein coupled and tyrosine kinase receptors: evidence that activation of the insulin-like growth factor I receptor is required for thrombin-induced mitogenesis of rat aortic smooth muscle cells.

1996 • 74 citations

Rapid sulfopropyl-disk chromatographic purification of bovine and human thrombin

1986 • 73 citations

The role of thrombin's Tyr-Pro-Pro-Trp motif in the interaction with fibrinogen, thrombomodulin, protein C, antithrombin III, and the Kunitz inhibitors.

1993 • 67 citations

Porcine Aortic Smooth Muscle Cells Secrete a Serine Protease for Insulin-like Growth Factor Binding Protein-2

1995 • 67 citations

IGFBP-3 proteolysis by plasmin, thrombin, serum: heparin binding, IGF binding, and structure of fragments

1996 • 66 citations

Insulin-like growth factors (IGFs) block FSH-induced proteolysis of IGF-binding protein-5 (BP-5) in cultured rat granulosa cells.

1993 • 62 citations

The Effect of Thrombin Inhibitors on Tissue Plasminogen Activator Induced Thrombolysis in a Rat Model

1992 • 60 citations

Antithrombotic therapy for deep arterial injury by angioplasty. Efficacy of common platelet inhibition compared with thrombin inhibition in pigs.

1991 • 58 citations

7S nerve growth factor is an insulin-like growth factor-binding protein protease.

1996 • 56 citations

Characterization and determination of the relative abundance of two types of insulin-like growth factor binding protein-5 proteases that are secreted by human fibroblasts.

1996 • 38 citations

Proteolysis of insulin-like growth factor binding protein-5 by pregnancy serum and amniotic fluid.

1994 • 34 citations

Internalization of Vitronectin-Thrombin-Antithrombin Complex by Endothelial Cells Leads to Deposition of the Complex into the Subendothelial Matrix

1995 • 27 citations

Effect of thrombin on release of plasminogen activator inhibitor-1 from cultured primate arterial smooth muscle cells

1995 • 26 citations

Thrombin Activity Appearing on the Vessel Wall After Trauma

1985 • 17 citations

Transcriptional Regulation of Tissue- and Urokinase-type Plasminogen Activator Genes by Thrombin in Human Fetal Lung Fibroblasts

1995 • 13 citations

Comparison of the Effects of Heparin and Hirudin on Thrombin Binding to the Normal and the De-Endothelialized Rabbit Aorta In Vitro

1991 • 10 citations