THE ROLE OF THE INSULIN-LIKE GROWTH FACTOR BINDING PROTEINS AND THE IGFBP PROTEASES IN MODULATING IGF ACTION

New Perspectives in Cell Adhesion: RGD and Integrins

1987 • 4,835 citations

Insulin-Like Growth Factors and Their Binding Proteins: Biological Actions*

1995 • 4,419 citations

Insulin-like growth factors and their binding proteins: biological actions

1995 • 1,976 citations

An insulin-like growth factor (IGF) binding protein enhances the biologic response to IGF-I.

1987 • 682 citations

Identification and molecular characterization of insulin-like growth factor binding proteins (IGFBP-1, -2, -3, -4, -5 and -6)

1991 • 680 citations

Extracellular matrix contains insulin-like growth factor binding protein-5: potentiation of the effects of IGF-I.

1993 • 543 citations

Insulin-like growth factor binding protein 1 stimulates cell migration and binds to the alpha 5 beta 1 integrin by means of its Arg-Gly-Asp sequence.

1993 • 515 citations

Growth hormone-dependent insulin-like growth factor (IGF) binding protein both inhibits and potentiates IGF-I-stimulated DNA synthesis in human skin fibroblasts

1988 • 488 citations

Insulin-like growth factor-binding proteins (IGFBPs) and their regulatory dynamics

1996 • 483 citations

Insulin-like growth factor (IGF)-independent action of IGF-binding protein-3 in Hs578T human breast cancer cells. Cell surface binding and growth inhibition

1993 • 481 citations

Prostate-specific antigen (PSA) is an insulin-like growth factor binding protein-3 protease found in seminal plasma.

1992 • 478 citations

Regulation and Function of Insulin-Like Growth Factor-Binding Protein-1

1993 • 387 citations

Insulin-Like Growth Factor Binding Proteins in Maternal Serum Throughout Gestation and in the Puerperium: Effects of a Pregnancy-Associated Serum Protease Activity*

1990 • 368 citations

Human osteoblast-derived insulin-like growth factor (IGF) binding protein-5 stimulates osteoblast mitogenesis and potentiates IGF action.

1992 • 351 citations

Insulin-Like Growth Factor Binding Proteins in the Human Circulation: A Review

1994 • 346 citations

Matrix metalloproteinases degrade insulin-like growth factor-binding protein-3 in dermal fibroblast cultures.

1994 • 345 citations

The effect of anorexia nervosa and refeeding on growth hormone-binding protein, the insulin-like growth factors (IGFs), and the IGF-binding proteins.

1992 • 329 citations

Effects of caloric or protein restriction on insulin-like growth factor-I (IGF-I) and IGF-binding proteins in children and adults.

1995 • 325 citations

The human insulin-like growth factor (IGF) binding protein-3 inhibits the growth of fibroblasts with a targeted disruption of the IGF-I receptor gene.

1995 • 318 citations

Demonstration of receptors for insulin-like growth factor binding protein-3 on Hs578T human breast cancer cells.

1993 • 317 citations

Studies on the Mechanisms by Which Insulin-like Growth Factor (IGF) Binding Protein-4 (IGFBP-4) and IGFBP-5 Modulate IGF Actions in Bone Cells

1995 • 309 citations

Biological effects of prostate specific antigen as an insulin-like growth factor binding protein-3 protease

1994 • 273 citations

INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN-1 MODULATES BLOOD GLUCOSE LEVELS

1991 • 262 citations

Transforming Growth Factor- β-induced Cell Growth Inhibition in Human Breast Cancer Cells Is Mediated through Insulin-like Growth Factor-binding Protein-3 Action

1995 • 241 citations

Hormonal and Nutritional Regulation of IGF-I and Its Binding Proteins

1994 • 227 citations

Recombinant human insulin-like growth factor I induces its own specific carrier protein in hypophysectomized and diabetic rats.

1989 • 221 citations

Enhanced expression of an insulin growth factor-like binding protein (mac25) in senescent human mammary epithelial cells and induced expression with retinoic acid.

1995 • 202 citations

Elevated levels of insulin-like growth factor-binding protein-2 in the serum of prostate cancer patients.

1993 • 201 citations

Molecular Forms of Serum Insulin-Like Growth Factor (IGF)-Binding Proteins in Man: Relationships with Growth Hormone and IGFs and Physiological Significance*

1989 • 190 citations

In vivo proteolysis of serum insulin-like growth factor (IGF) binding protein-3 results in increased availability of IGF to target cells.

1994 • 184 citations

INSULIN DIFFERENTIALLY ALTERS TRANSCAPILLARY MOVEMENT OF INTRAVASCULAR IGFBP-1, IGFBP-2 AND ENDOTHELIAL CELL IGF-BINDING PROTEINS IN THE RAT HEART

1990 • 175 citations

Posttranslational regulation of insulin-like growth factor binding protein-4 in normal and transformed human fibroblasts. Insulin-like growth factor dependence and biological studies.

1993 • 167 citations

Cellular localization and regulation of gene expression for components of the insulin-like growth factor ternary binding protein complex.

1994 • 166 citations

Autocrine regulation of cell proliferation by the insulin-like growth factor (IGF) and IGF binding protein-3 protease system in a human prostate carcinoma cell line (PC-3).

1995 • 164 citations

Transfection of the human insulin-like growth factor binding protein-3 gene into Balb/c fibroblasts inhibits cellular growth.

1993 • 160 citations

Characterization of insulin-like growth factor-binding protein 5-degrading proteases produced throughout murine osteoblast differentiation.

1995 • 158 citations

Insulin-Like Growth Factor-Binding Protein (IGF-BP) Inhibition of Granulosa Cell Function: Effect on Cyclic Adenosine 3’5’-Monophosphate, Deoxyribonucleic Acid Synthesis, and Comparison with the Effect of an IGF-I Antibody*

1990 • 158 citations

Glucocorticoid regulation of insulin-like growth factor-binding protein expression in normal human osteoblast-like cells.

1994 • 141 citations

Gene expression of insulin-like growth factors (IGFs), the type 1 IGF receptor, and IGF-binding proteins in dexamethasone-induced fetal growth retardation.

1992 • 133 citations

1,25-Dihydroxyvitamin D3 Differentially Regulates the Production of Insulin-Like Growth Factor I (IGF-I) and IGF-Binding Protein-4 in Mouse Osteoblasts*

1991 • 132 citations

Insulin-Like Growth Factor (IGF)-Binding Protein-3 Blocks IGF-I-Induced Receptor Down-Regulation and Cell Desensitization in Cultured Bovine Fibroblasts*

1991 • 130 citations

IGFBP-3 and IGFBP-5 association with endothelial cells: role of C-terminal heparin binding domain.

1995 • 129 citations

Multihormonal Regulation of Insulin-Like Growth Factor-Binding Protein-1 in Rat H4IIE Hepatoma Cells: The Dominant Role of Insulin*

1991 • 127 citations

Insulin-like growth factor binding protein-3 is functionally altered in pregnancy plasma.

1994 • 126 citations

Hormonal and metabolic effects and pharmacokinetics of recombinant insulin-like growth factor-I in growth hormone receptor deficiency/Laron syndrome.

1993 • 126 citations

Acid-activated insulin-like growth factor-binding protein-3 proteolysis in normal and transformed cells. Role of cathepsin D.

1994 • 121 citations

Insulin-Like Growth Factor Binding Proteins: Structural and Molecular Relationships

1991 • 120 citations

Insulin-like growth factor binding protein (IGFBP) proteases: Functional regulators of cell growth

1995 • 117 citations

Discrete alterations of the insulin-like growth factor I molecule which alter its affinity for insulin-like growth factor-binding proteins result in changes in bioactivity.

1990 • 114 citations

Abnormal Regulation of Insulin-Like Growth Factor Binding Proteins in Adolescents with Insulin-Dependent Diabetes*

1991 • 112 citations

Leukotriene D4 facilitates airway smooth muscle cell proliferation via modulation of the IGF axis

1995 • 109 citations

Proteolysis of insulin-like growth factor binding protein-3 during rat pregnancy: a role for matrix metalloproteinases.

1994 • 106 citations

Leukotriene D4 induces MMP-1, which functions as an IGFBP protease in human airway smooth muscle cells

1996 • 106 citations

Insulin-like growth factor axis abnormalities in prostatic stromal cells from patients with benign prostatic hyperplasia.

1994 • 103 citations

Clinical aspects of insulin-like growth factor binding proteins.

1991 • 101 citations

Endogenous cathepsin D-mediated hydrolysis of insulin-like growth factor-binding proteins in cultured human prostatic carcinoma cells.

1995 • 99 citations

Development, validation, and application of a radioimmunoassay for insulin-like growth factor binding protein-5 in human serum and other biological fluids.

1995 • 98 citations

Differential cellular synthesis of insulin-like growth factor binding protein-1 (IGFBP-1) and IGFBP-3 within human liver.

1994 • 98 citations

Insulin-like Growth Factor-I (IGF-I) Regulates IGF-binding Protein-5 Synthesis through Transcriptional Activation of the Gene in Aortic Smooth Muscle Cells

1996 • 97 citations

Age-related changes in IGFBP-4 and IGFBP-5 levels in human serum and bone: Implications for bone loss with aging

1995 • 93 citations

Insulin-like growth factor-binding protein-2 concentrations in cerebrospinal fluid and serum of children with malignant solid tumors or acute leukemia.

1994 • 85 citations

Human insulin-like growth factor binding protein-6 is O-glycosylated

1992 • 84 citations

Cortisol increases plasma insulin-like growth factor binding protein-1 in humans

1993 • 82 citations

Increased wound-breaking strength induced by insulin-like growth factor I in combination with insulin-like growth factor binding protein-1.

1994 • 82 citations

Coculture of primary rat hepatocytes and nonparenchymal cells permits expression of insulin-like growth factor binding protein-3 in vitro.

1994 • 80 citations

Regulation of insulin-like growth factor binding protein-5 messenger ribonucleic acid expression and protein availability in rat osteoblast-like cells.

1993 • 79 citations

Insulin-like growth factor (IGF) I and retinoic acid induce the synthesis of IGF-binding protein 5 in rat osteoblastic cells.

1995 • 76 citations

Insulin-like growth factor (IGF)-I and -II and IGF-binding proteins-1, -2, and -3 in children and adolescents with diabetes mellitus: correlation with metabolic control and height attainment.

1995 • 74 citations

Recombinant human insulin-like growth factor (IGF)-binding protein-6 inhibits IGF-II-induced differentiation of L6A1 myoblasts.

1994 • 72 citations

Radioimmunoassay of insulin-like growth factor-binding protein-6 in human serum and other body fluids

1992 • 70 citations

Report On The Nomenclature Of The IGF Binding Proteins

1990 • 70 citations

Regulation of insulin‐like growth factor‐binding‐protein‐1, 2, 3, 4, 5, and 6: Synthesis, secretion, and gene expression in estrogen receptor‐negative human breast carcinoma cells

1993 • 67 citations

Episomal expression of sense and antisense insulin-like growth factor (IGF)-binding protein-4 complementary DNA alters the mitogenic response of a human colon cancer cell line (HT-29) by mechanisms that are independent of and dependent upon IGF-I.

1994 • 67 citations

Insulin-like growth factor system gene expression in the human kidney.

1992 • 63 citations

A factor contained in plasma is required for IGF binding protein‐1 to potentiate the effect of IGF‐I on smooth muscle cell DNA synthesis

1990 • 63 citations

Roles of insulin-like growth factor (IGF) receptors and IGF-binding proteins in IGF-II-induced proliferation and differentiation of L6A1 rat myoblasts.

1995 • 62 citations

Retinoic acid regulates insulin-like growth factor-binding protein expression in human osteoblast cells.

1996 • 60 citations

Long-term treatment of Laron type dwarfs with insulin-like growth factor-1 increases serum insulin-like growth factor-binding protein-3 in the absence of growth hormone activity

1993 • 59 citations

Effect of glucocorticoid on insulin-like growth factor (IGF) regulation of IGF-binding protein expression in fibroblasts.

1995 • 58 citations

Insulin‐like growth factor binding proteins and their regulation

1994 • 57 citations

7S nerve growth factor is an insulin-like growth factor-binding protein protease.

1996 • 56 citations

Skeletal Growth Factors Regulate the Synthesis of Insulin-like Growth Factor Binding Protein-5 in Bone Cell Cultures

1995 • 56 citations

In vivo effects of systemic insulin-like growth factor-I alone and complexed with insulin-like growth factor binding protein-3 on corticosteroid suppressed wounds.

1993 • 55 citations

Current Directions in Insulin-Like Growth Factor Research

1993 • 53 citations

Insulin-like growth factor-binding protein-1 inhibits binding of IGF-I on fetal skin fibroblasts but stimulates their DNA synthesis

1990 • 52 citations

Physiologic and clinical relevance of the insulin-like growth factor binding proteins

1994 • 51 citations

An IGF binding protein is an inhibitor of fgf stimulation

1991 • 47 citations

Effect of human insulin-like growth factor-binding protein-1 on the half-life and action of administered insulin-like growth factor-I in rats

1993 • 44 citations

Clinical Significance of Insulin-Like Growth Factor Binding Proteins (IGFBPs)

1995 • 44 citations

Insulin-like growth factor (IGF)-I and -II and IGF-binding proteins-1, - 2, and -3 in children and adolescents with diabetes mellitus: correlation with metabolic control and height attainment

1995 • 44 citations

Growth hormone and parathyroid hormone stimulate IGFBP-3 in rat osteoblasts

1994 • 42 citations

Recombinant human insulin-like growth factor binding protein-3 (rhIGFBP-3): effects on the glycemic and growth promoting activities of rhIGF-1 in the rat.

1993 • 41 citations

Evidence that human bone cells in culture secrete insulin-like growth factor (IGF)-II and IGF binding protein-3 but not acid-labile subunit both under basal and regulated conditions

1995 • 38 citations

The HOX complex neighbored by the EVX gene, as well as two other homeobox‐containing genes, the GBX‐class and the EN‐class, are located on the same chromosomes 2 and 7 in humans

1993 • 38 citations

The RIA for IGFBP-2 in man--a meagre catch?

1993 • 38 citations

Regulation of insulin-like growth factor (IGF)-binding protein-6 and mannose 6-phosphate/IGF-II receptor expression in IGF-IL-overexpressing NIH 3T3 cells.

1995 • 37 citations

Properties of glycosylated and non-glycosylated human recombinant IGF binding protein-3 (IGFBP-3).

1993 • 37 citations

Growth Stimulation by Transfection of Intestinal Epithelial Cells with an Antisense Insulin-like Growth Factor-Binding Protein-2 Construct

1995 • 36 citations

Regulation of insulin-like growth factor-binding protein-4 in human endometrial stromal cell cultures: evidence for ligand-induced proteolysis.

1995 • 36 citations

Proteolysis of insulin-like growth factor binding protein-5 by pregnancy serum and amniotic fluid.

1994 • 34 citations

Structure and function of the HOX A1 human homeobox gene cDNA

1995 • 30 citations

Acid-activated insulin-like growth factor binding protein protease activity of Cathepsin D in normal and malignant prostatic epithelial cells and seminal plasma

1997 • 29 citations

Expression and Down‐Regulation by Retinoic Acid of IGF Binding Protein‐2 and ‐4 in Medium from Human Neuroblastoma Cells

1994 • 28 citations

Limited Proteolysis of Insulin-Like Growth Factor Binding Protein-3 (IGFBP-3) : A Physiological Mechanism in the Regulation of IGF Bioavailability

1994 • 28 citations

Organization, Expression, and Chromosomal Location of the Mouse Insulin-like Growth Factor Binding Protein 5 Gene

1994 • 27 citations

Recombinant human insulin-like growth factor binding proteins 4, 5, and 6: biological and physiochemical characterization.

1993 • 23 citations

Structural and Functional Studies of Insulin-Like Growth Factor Binding Proteins in the Ovary

1993 • 23 citations

Structure and chromosomal localization of human insulin-like growth factor-binding protein genes.

1993 • 22 citations

Production of Insulin-like Growth Factors and Their Binding Proteins in Primary Cultures of Rat Liver Parenchymal and Nonparenchymal Cells

1995 • 22 citations

Report on the nomenclature of the IGF binding proteins

1992 • 20 citations

Characterization of the insulin-like growth factors (IGF) axis in a cultured mouse Leydig cell line (TM-3).

1995 • 19 citations

Human insulin-like growth factor binding protein-6 is O-glycosylated.

1993 • 19 citations

Current directions in insulin-like growth factor research

1995 • 19 citations

Differential regulation by TGF-beta 1 and insulin of insulin-like growth factor binding protein-2 in IEC-6 cells

1995 • 18 citations

Involvement of G proteins in the effect of insulin-like growth factor I on gonadotropin-induced rat granulosa cell differentiation.

1994 • 17 citations

Cellular Actions of Insulin-Like Growth Factor Binding Protein-3

1994 • 15 citations

Role of Post Translational Modifications in Modifying the Biologic Activity of Insulin Like Growth Factor Binding Proteins

1994 • 14 citations