Mammary cancer in transgenic mice expressing insulin-like growth factor II (IGF-II)

Efficientin vitrosynthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter

1984 • 6,459 citations

PLAQUE FORMATION AND ISOLATION OF PURE LINES WITH POLIOMYELITIS VIRUSES

1954 • 3,832 citations

Linkage of Early-Onset Familial Breast Cancer to Chromosome 17q21

1990 • 2,505 citations

Role of insulin-like growth factors in embryonic and postnatal growth

1993 • 2,349 citations

A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting

1990 • 1,650 citations

Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice

1994 • 982 citations

c-Myc-induced apoptosis in fibroblasts is inhibited by specific cytokines.

1994 • 747 citations

A second signal supplied by insulin-like growth factor II in oncogene-induced tumorigenesis

1994 • 391 citations

Mesenchyme-Dependent Morphogenesis and Epithelium-Specific Cytodifferentiation in Mouse Mammary Gland

1976 • 348 citations

Altered body composition and increased frequency of diverse malignancies in insulin-like growth factor-II transgenic mice.

1994 • 274 citations

Insulin receptor expression and function in human breast cancer cell lines.

1992 • 202 citations

Insulin-like growth factor II in human adrenal pheochromocytomas and Wilms tumors: expression at the mRNA and protein level.

1987 • 191 citations

Insulin-like growth factors 1 and 2 in bovine colostrum. Sequences and biological activities compared with those of a potent truncated form

1988 • 190 citations

Posttranslational regulation of insulin-like growth factor binding protein-4 in normal and transformed human fibroblasts. Insulin-like growth factor dependence and biological studies.

1993 • 167 citations

Evolution of Insulin-Like Growth Factor II: Characterization of the Mouse IGF-II Gene and Identification of Two Pseudo-Exons

1990 • 131 citations

Developmentally programmed induction of differentiation inhibiting activity and the control of stem cell populations.

1990 • 126 citations

Position-independent expression of the ovine β-lactoglobulin gene in transgenic mice

1992 • 120 citations

Type 1 IGF receptor in human breast diseases

1992 • 120 citations

Characterization of the gene encoding ovine beta-lactoglobulin

1988 • 116 citations

Disproportionate growth in mice with Igf-2 transgenes.

1994 • 102 citations

The molecular and cellular biology of insulin-like growth factor II

1992 • 100 citations

Sporadic amplification of the insulin-like growth factor 1 receptor gene in human breast tumors.

1992 • 84 citations

Induction of gene expression during involution of the lactating mammary gland of the rat

1994 • 80 citations

Prenatal determination of obesity, tumor susceptibility, and coat color pattern in viable yellow (Avy/a) mice

1986 • 79 citations

Insulin-like growth factors and their binding proteins in plasma and milk after growth hormone-stimulated galactopoiesis in normally lactating women

1993 • 69 citations

Insulin-Like Growth Factors I and II and Their Binding Proteins in Rat Milk

1991 • 68 citations

Relative abundance and molecular size of immunoreactive insulin-like growth factors I and II in human fetal tissues

1990 • 61 citations

Molecular dissection of multi-stage tumorigenesis in transgenic mice.

1994 • 55 citations

Complete nucleotide sequence of the genomic ovine β-lactoglobulin gene

1988 • 52 citations

Insulin-Like Growth Factors I and II and Their Binding Proteins in Human Milk

1991 • 51 citations

Insulin-like growth factors and the multiplication of Tera-2, A human teratoma-derived cell line

1988 • 46 citations

High plasma insulin-like growth factor-II and low lipid content in transgenic mice: measurements of lipid metabolism

1994 • 45 citations

Mammary tumorigenesis and metastasis in transgenic mice.

1994 • 43 citations

Body weight and cancer

1987 • 40 citations

Parental imprinting of an IGF‐2 transgene

1993 • 34 citations

Alteration of morphogenesis by the v-myc oncogene in transplants of mammary gland.

1988 • 34 citations

IGF-I and IGF-II expression in human breast cancer xenografts: Relationship to hormone independence

1992 • 29 citations

Insulin-like growth factor-II enhancement of human fibroblast growth via a nonreceptor-mediated mechanism.

1994 • 24 citations

Discriminating translation of insulin‐like growth factor‐II (IGF‐II) during mouse embryogenesis

1994 • 23 citations

Oncogenes, tumour suppressor genes and growth factors in breast cancer: novel targets for diagnosis, prognosis and therapy.

1993 • 12 citations

Analysis of the IGF-II receptor gene copy number in breast carcinoma

1994 • 9 citations