Proteolysis of Insulin-Like Growth Factor Binding Proteins by a Novel 50-Kilodalton Metalloproteinase in Human Pregnancy Serum¹

Insulin-Like Growth Factors and Their Binding Proteins: Biological Actions*

1995 • 4,419 citations

A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells

1997 • 3,094 citations

Electrophoretic analysis of plasminogen activators in polyacrylamide gels containing sodium dodecyl sulfate and copolymerized substrates

1980 • 1,991 citations

Insulin-like growth factors and their binding proteins: biological actions

1995 • 1,976 citations

Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-α

1997 • 1,608 citations

Processing of tumour necrosis factor-α precursor by metalloproteinases

1994 • 1,200 citations

Cellular Mechanisms for Human Procollagenase-3 (MMP-13) Activation

1996 • 741 citations

Protection against a lethal dose of endotoxin by an inhibitor of tumour necrosis factor processing

1994 • 607 citations

Prostate-specific antigen (PSA) is an insulin-like growth factor binding protein-3 protease found in seminal plasma.

1992 • 478 citations

Insulin-Like Growth Factor Binding Proteins in Maternal Serum Throughout Gestation and in the Puerperium: Effects of a Pregnancy-Associated Serum Protease Activity*

1990 • 368 citations

Evidence of Enzymatic Degradation of Insulin-Like Growth Factor-Binding Proteins in the 150K Complex during Pregnancy*

1990 • 349 citations

Matrix metalloproteinases degrade insulin-like growth factor-binding protein-3 in dermal fibroblast cultures.

1994 • 345 citations

ADAMs in Fertilization and Development

1996 • 259 citations

The activity of the tissue inhibitors of metalloproteinases is regulated by C-terminal domain interactions: A kinetic analysis of the inhibition of gelatinase A

1993 • 237 citations

Characterization of gelatinase from pig polymorphonuclear leucocytes. A metalloproteinase resembling tumour type IV collagenase

1989 • 233 citations

Physiological role of the insulin-like growth factor binding proteins

1995 • 197 citations

Prostate-specific antigen (PSA) is an insulin-like growth factor binding protein-3 protease found in seminal plasma

1992 • 189 citations

In vivo proteolysis of serum insulin-like growth factor (IGF) binding protein-3 results in increased availability of IGF to target cells.

1994 • 184 citations

Characterization of recombinant human insulin-like growth factor binding proteins 4, 5, and 6 produced in yeast.

1992 • 183 citations

[28] Gelatinases A and B

1995 • 182 citations

Immunolocalisation studies on six matrix metalloproteinases and their inhibitors, TIMP-1 and TIMP-2, in synovia from patients with osteo- and rheumatoid arthritis.

1995 • 173 citations

Insulin-like growth factor-binding protein-3 proteolysis is induced after elective surgery.

1992 • 172 citations

Circulating binding proteins for the insulinlike growth factors

1993 • 162 citations

Characterization of insulin-like growth factor-binding protein 5-degrading proteases produced throughout murine osteoblast differentiation.

1995 • 158 citations

Regulation of Serum Insulin-Like Growth Factor-I (IGF I) and IGF Binding Proteins during Rat Pregnancy*

1990 • 156 citations

Amino acid sequence of a Crotalus atrox venom metalloproteinase which cleaves type IV collagen and gelatin

1989 • 152 citations

Involvement of the plasmin system in dissociation of the insulin-like growth factor-binding protein complex.

1992 • 141 citations

Insulin-like growth factor binding protein-3 is functionally altered in pregnancy plasma.

1994 • 126 citations

Molecular cloning of MADM: a catalytically active mammalian disintegrin-metalloprotease expressed in various cell types

1996 • 121 citations

Increased proteolysis of insulin-like growth factor-binding protein-3 (IGFBP-3) in noninsulin-dependent diabetes mellitus serum, with elevation of a 29-kilodalton (kDa) glycosylated IGFBP-3 fragment contained in the approximately 130- to 150-kDa ternary complex.

1994 • 116 citations

Proteolysis of insulin-like growth factor binding protein-3 during rat pregnancy: a role for matrix metalloproteinases.

1994 • 106 citations

A novel metalloprotease/disintegrin–like gene at 17q21.3 is somatically rearranged in two primary breast cancers

1993 • 97 citations

Binding of latent and high M r active forms of stromelysin to collagen is mediated by the C-terminal domain

1991 • 95 citations

Properties of an insulin-like growth factor-binding protein-4 protease that is secreted by smooth muscle cells.

1995 • 91 citations

Collagenase-I, stromelysin-I, and matrilysin are expressed within theplacenta during multiple stages of human pregnancy

1996 • 86 citations

Interactions between insulin-like growth factor-I (IGF-I) and the system of plasminogen activators and their inhibitors in the control of IGF-binding protein-3 production and proteolysis in human osteosarcoma cells.

1994 • 84 citations

Purification and Characterisation of Human 72-kDa Gelatinase (Type IV Collagenase). Use of Immunolocalisation to Demonstrate the Non-coordinate Regulation of the 72-kDa and 95-kDa Gelatinases by Human Fibroblasts

1991 • 80 citations

Insulin-like growth factor-binding protein-3 proteolysis is induced after elective surgery

1992 • 78 citations

Ontogeny of Insulin-Like Growth Factor-Binding Protein-1, −2, and −3: Quantitative Measurements by Radioimmunoassay in Human Fetal Serum

1994 • 73 citations

Insulin-like growth factor-binding protein-3 is functionally normal in pregnancy serum.

1992 • 73 citations

Relaxed Specificity of Matrix Metalloproteinases (MMPS) and TIMP Insensitivity of Tumor Necrosis Factor-α (TNF-α) Production Suggest the Major TNF-α Converting Enzyme Is Not an MMP

1996 • 69 citations

Involvement of the plasmin system in dissociation of the insulin-like growth factor-binding protein complex

1992 • 64 citations

Increased proteolysis of insulin-like growth factor-binding protein-3 (IGFBP-3) in noninsulin-dependent diabetes mellitus serum, with elevation of a 29-kilodalton (kDa) glycosylated IGFBP-3 fragment contained in the approximately 130- to 150-kDa ternary complex

1994 • 59 citations

Insulin-like growth factor binding protein-3 is functionally altered in pregnancy plasma

1994 • 53 citations

Insulin-like growth factor-binding protein-3 is functionally normal in pregnancy serum

1992 • 45 citations

Human Pregnancy Serum Contains at Least Two Distinct Proteolytic Activities with the Ability To Degrade Insulin-Like Growth Factor Binding Protein-3¹

1997 • 41 citations

Characterization and determination of the relative abundance of two types of insulin-like growth factor binding protein-5 proteases that are secreted by human fibroblasts.

1996 • 38 citations

Characterization of insulin-like growth factor-binding protein 5- degrading proteases produced throughout murine osteoblast differentiation

1995 • 37 citations

Proteolysis of insulin-like growth factor binding protein-3 during rat pregnancy: a role for matrix metalloproteinases

1994 • 36 citations

Localization of the sites of iodination of human .beta.2-microglobulin; quaternary structure implications for histocompatibility antigens

1983 • 35 citations

Expression of serum insulin-like growth factors, insulin-like growth factor-binding proteins, and the growth hormone-binding protein in heterozygote relatives of Ecuadorian growth hormone receptor deficient patients

1992 • 35 citations

Proteolysis of insulin-like growth factor binding protein-5 by pregnancy serum and amniotic fluid.

1994 • 34 citations

Most of the circulating insulin-like growth factors-I and -II are present in the 150 kDa complex during human pregnancy

1991 • 34 citations

Interactions between insulin-like growth factor-I (IGF-I) and the system of plasminogen activators and their inhibitors in the control of IGF-binding protein-3 production and proteolysis in human osteosarcoma cells

1994 • 33 citations

Properties of an insulin-like growth factor-binding protein-4 protease that is secreted by smooth muscle cells

1995 • 32 citations

Proteolysis of insulin-like growth factor binding protein-5 by pregnancy serum and amniotic fluid

1994 • 17 citations

Characterization and determination of the relative abundance of two types of insulin-like growth factor binding protein-5 proteases that are secreted by human fibroblasts

1996 • 11 citations

Human Pregnancy Serum Contains at Least Two Distinct Proteolytic Activities with the Ability To Degrade Insulin-Like Growth Factor Binding Protein-3

1997 • 11 citations