Insulin-like Growth Factors and Cancer

Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)

1993 • 2,880 citations

Role of insulin-like growth factors in embryonic and postnatal growth

1993 • 2,349 citations

WT-1 is required for early kidney development

1993 • 1,976 citations

Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locus

1990 • 1,882 citations

Insulin-Like Growth Factors I and II. Peptide, Messenger Ribonucleic Acid and Gene Structures, Serum, and Tissue Concentrations*

1989 • 1,796 citations

The insulin signaling system.

1994 • 1,733 citations

A hormonally controlled serum factor which stimulates sulfate incorporation by cartilage in vitro. 1956.

1990 • 1,075 citations

Relaxation of imprinted genes in human cancer

1993 • 792 citations

Insulin-like Growth Factor Binding Proteins

1993 • 754 citations

Relaxation of insulin-like growth factor II gene imprinting implicated in Wilms' tumour

1993 • 710 citations

Insulin-like growth factors and cancer

1992 • 622 citations

Simian virus 40 large tumor antigen is unable to transform mouse embryonic fibroblasts lacking type 1 insulin-like growth factor receptor.

1993 • 554 citations

Repression of the Insulin-Like Growth Factor II Gene by the Wilms Tumor Suppressor WT1

1992 • 535 citations

Effect of a null mutation of the insulin-like growth factor I receptor gene on growth and transformation of mouse embryo fibroblasts.

1994 • 527 citations

Development of antiestrogens and their use in breast cancer: eighth Cain memorial award lecture.

1990 • 419 citations

Overexpression of the human insulinlike growth factor I receptor promotes ligand-dependent neoplastic transformation.

1990 • 404 citations

Analysis of Insulin-Like Growth Factor I Gene Expression in Malignancy: Evidence for a Paracrine Role in Human Breast Cancer

1989 • 403 citations

Nuclear localization of the protein encoded by the Wilms’ tumor gene WT1 in embryonic and adult tissues

1993 • 319 citations

Rat glioblastoma cells expressing an antisense RNA to the insulin-like growth factor-1 (IGF-1) receptor are nontumorigenic and induce regression of wild-type tumors.

1994 • 310 citations

Increased expression of the insulin-like growth factor I receptor gene, IGF1R, in Wilms tumor is correlated with modulation of IGF1R promoter activity by the WT1 Wilms tumor gene product.

1993 • 268 citations

A model for embryonal rhabdomyosarcoma tumorigenesis that involves genome imprinting.

1989 • 260 citations

The WT1 Wilms tumor gene product: a developmentally regulated transcription factor in the kidney that functions as a tumor suppressor

1993 • 254 citations

Insulin-like growth factor II mRNA expression in human breast cancer.

1988 • 245 citations

Insulin-like growth factor II acts as an autocrine growth and motility factor in human rhabdomyosarcoma tumors.

1990 • 242 citations

Activation of an imprinted allele of the insulin-like growth factor II gene implicated in rhabdomyosarcoma.

1994 • 218 citations

In vivo treatment with antibody against IGF-1 receptor suppresses growth of human rhabdomyosarcoma and down-regulates p34cdc2.

1994 • 186 citations

Insulin-like Growth Factors in Health and Disease

1992 • 164 citations

HYPOGLYCEMIA IN ASSOCIATION WITH EXTRAPANCREATIC TUMORS: DEMONSTRATION OF ELEVATED PLASMA NSILA–s BY A NEW RADIORECEPTOR ASSAY

1974 • 152 citations

Insulin-Like Growth Factor Binding Protein Secretion by Breast Carcinoma Cell Lines: Correlation with Estrogen Receptor Status*

1990 • 135 citations

Human osteosarcoma cell lines are dependent on insulin-like growth factor I for in vitro growth.

1994 • 125 citations

Effect of tamoxifen on plasma insulin-like growth factor I in patients with breast cancer.

1989 • 118 citations

Tamoxifen reduces serum insulin-like growth factor I (IGF-I)

1992 • 115 citations

Cell cycle and growth control.

1993 • 110 citations

Impaired Formation of the Ternary Insulin-Like Growth Factor-Binding Protein Complex in Patients with Hypoglycemia due to Nonislet Cell Tumors*

1991 • 105 citations

The growth-stimulatory effect of simian virus 40 T antigen requires the interaction of insulinlike growth factor 1 with its receptor.

1992 • 99 citations

Insulin-like growth factor-I (IGF-I) and retinoic acid modulation of IGF-binding proteins (IGFBPs): IGFBP-2, -3, and -4 gene expression and protein secretion in a breast cancer cell line.

1992 • 96 citations

Insulinlike Growth Factor I: A Potent Mitogen for Human Osteogenic Sarcoma

1990 • 90 citations

Antibody to type I insulinlike growth factor receptor inhibits growth of Wilms' tumor in culture and in athymic mice.

1989 • 88 citations

Inhibition of Metastatic Behavior of Murine Osteosarcoma by Hypophysectomy

1992 • 83 citations

The synthetic retinoid fenretinide lowers plasma insulin-like growth factor I levels in breast cancer patients.

1993 • 79 citations

Insulin-like growth factor system gene expression in the human kidney.

1992 • 63 citations

Insulin-Like Growth Factor-II in Nonislet Cell Tumors Associated with Hypoglycemia: Increased Levels of Messenger Ribonucleic Acid*

1989 • 55 citations

Insulin-like growth factor (IGF)-I, -II and IGF binding protein-2 (IGFBP-2) in the plasma of children with Wilms' tumour

1993 • 54 citations

Growth factors in breast cancer: Mitogenesis to transformation

1992 • 52 citations

Insulin-like growth factor 1 receptors (IGF1-R) and IGF1 in human breast tumors

1990 • 48 citations

IGFBP-3 gene expression and estrogen receptor status in human breast carcinoma.

1992 • 40 citations

Partition of insulin-like growth factor (IGF)-binding sites between the IGF-I and IGF-II receptors and IGF-binding proteins in the human kidney.

1994 • 35 citations

Hormone Responsiveness of a Transplantable Rat Chondrosarcoma. II. Evidence forin VivoHormone Dependence*

1980 • 32 citations

Insulin-like growth factor II and WT1 transcript localization in human fetal kidney and Wilms' tumor.

1993 • 25 citations