Regulation of Insulin-Like Growth Factor I Receptor Promoter Activity by Wild-Type and Mutant Versions of the WT1 Tumor Suppressor¹

Molecular and Cellular Aspects of the Insulin-Like Growth Factor I Receptor

1995 • 1,361 citations

Germline mutations in the Wilms' tumor suppressor gene are associated with abnormal urogenital development in Denys-Drash syndrome

1991 • 944 citations

Identification of a New Family of Tissue-Specific Basic Helix-Loop-Helix Proteins with a Two-Hybrid System

1995 • 655 citations

Repression of the Insulin-Like Growth Factor II Gene by the Wilms Tumor Suppressor WT1

1992 • 535 citations

Transcriptional Repression Mediated by the WT1 Wilms Tumor Gene Product

1991 • 492 citations

Zinc fingers are sticking together

1998 • 464 citations

Overexpression of the human insulinlike growth factor I receptor promotes ligand-dependent neoplastic transformation.

1990 • 404 citations

Rat glioblastoma cells expressing an antisense RNA to the insulin-like growth factor-1 (IGF-1) receptor are nontumorigenic and induce regression of wild-type tumors.

1994 • 310 citations

The Role of the Insulin-like Growth Factor System in Human Cancer

1996 • 295 citations

Increased expression of the insulin-like growth factor I receptor gene, IGF1R, in Wilms tumor is correlated with modulation of IGF1R promoter activity by the WT1 Wilms tumor gene product.

1993 • 268 citations

Repression of Pax-2 by WT1 during normal kidney development

1995 • 265 citations

Growth inhibition of human melanoma cells in nude mice by antisense strategies to the type 1 insulin-like growth factor receptor.

1994 • 234 citations

The Wilms' tumor gene product, WT1, represses transcription of the platelet-derived growth factor A-chain gene.

1992 • 225 citations

Modulation of DNA Binding Specificity by Alternative Splicing of the Wilms Tumor wt1 Gene Transcript

1992 • 221 citations

RNA binding by the Wilms tumor suppressor zinc finger proteins.

1996 • 218 citations

Repression of the transforming growth factor-beta 1 gene by the Wilms' tumor suppressor WT1 gene product.

1994 • 193 citations

Altered expression of the WT1 Wilms tumor suppressor gene in human breast cancer

1997 • 193 citations

RNA editing in the Wilms' tumor susceptibility gene, WT1.

1994 • 186 citations

WT1-mediated Transcriptional Activation Is Inhibited by Dominant Negative Mutant Proteins

1995 • 172 citations

Truncated WT1 mutants alter the subnuclear localization of the wild-type protein.

1995 • 158 citations

The role of WT1 in Wilms tumorigenesis

1993 • 156 citations

Transcriptional repression of the insulin-like growth factor I receptor (IGF-I-R) gene by the tumor suppressor WT1 involves binding to sequences both upstream and downstream of the IGF-I-R gene transcription start site.

1994 • 154 citations

Essential role of tyrosine residues 1131, 1135, and 1136 of the insulin-like growth factor-I (IGF-I) receptor in IGF-I action.

1994 • 145 citations

Blockade of the insulin‐like growth‐factor‐I receptor inhibits growth of human colorectal cancer cells: Evidence of a functional IGF‐II‐mediated autocrine loop

1994 • 143 citations

A second transcriptionally active DNA-binding site for the Wilms tumor gene product, WT1.

1993 • 139 citations

The Wilms' tumor suppressor gene WT1 is negatively autoregulated.

1994 • 133 citations

Growth inhibition of MCF-7 breast cancer cells by stable expression of an insulin-like growth factor I receptor antisense ribonucleic acid.

1995 • 126 citations

The Wilms' Tumor 1 Gene: Oncogene or Tumor Suppressor Gene?

1998 • 121 citations

Type 1 IGF receptor in human breast diseases

1992 • 120 citations

Inhibition of Cellular Proliferation by the Wilms’ Tumor Suppressor WT1 Is Associated with Suppression of Insulin-Like Growth Factor I Receptor Gene Expression

1995 • 110 citations

Antagonism of WT1 activity by protein self-association.

1995 • 108 citations

A structure-function analysis of transcriptional repression mediated by the WT1, Wilms' tumor suppressor protein.

1993 • 107 citations

DNA binding capacity of the WT1 protein is abolished by Denys—Drash syndrome WT1 point mutations

1995 • 106 citations

The Role of the Tyrosine Kinase Domain of the Insulin-like Growth Factor-I Receptor in Intracellular Signaling, Cellular Proliferation, and Tumorigenesis

1995 • 106 citations

Structural and functional analysis of the insulin-like growth factor I receptor gene promoter.

1992 • 98 citations

Repression of the retinoic acid receptor-alpha gene by the Wilms' tumor suppressor gene product, wt1.

1995 • 90 citations

Products of alternatively spliced transcripts of the Wilms' tumor suppressor gene, wt1, have altered DNA binding specificity and regulate transcription in different ways.

1995 • 88 citations

An In Vitro Assay of β-Galactosidase from Yeast

1996 • 81 citations

Regulation of insulin-like growth factor I receptor gene expression by Sp1: physical and functional interactions of Sp1 at GC boxes and at a CT element.

1995 • 80 citations

Human osteosarcoma (U‐2 OS) cells express both insulin‐like growth factor‐I (IGF‐I) receptors and insulin‐like growth factor‐II/mannose‐6‐phosphate (IGF‐II/M6P) receptors and synthesize IGF‐II: Autocrine growth stimulation by IGF‐II via the IGF‐I receptor

1994 • 70 citations

Tumorigenic and mitogenic capacities are reduced in transfected fibroblasts expressing mutant insulin-like growth factor (IGF)-I receptors. The role of tyrosine residues 1250, 1251, and 1316 in the carboxy-terminus of the IGF-I receptor.

1996 • 62 citations

Regulation of nov by WT1: a potential role for nov in nephrogenesis.

1996 • 60 citations

Identification of nuclear localization signals within the zinc fingers of the WT1 tumor suppressor gene product

1996 • 57 citations

Growth regulation of human glioblastoma t98g cells by insulin‐like growth factor‐1 and its receptor

1994 • 53 citations

Two N-Terminal Self-Association Domains Are Required for the Dominant Negative Transcriptional Activity of WT1 Denys-Drash Mutant Proteins

1997 • 40 citations

Altered trans-activational properties of a mutated WT1 gene product in a WAGR-associated Wilms' tumor.

1993 • 36 citations

Regulation of renal EGF receptor expression is normal in Denys-Drash syndrome

1997 • 8 citations