PTEN gene transfer in human malignant glioma: sensitization to irradiation and CD95L-induced apoptosis

PTEN , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer

1997 • 4,753 citations

The Tumor Suppressor, PTEN/MMAC1, Dephosphorylates the Lipid Second Messenger, Phosphatidylinositol 3,4,5-Trisphosphate

1998 • 3,053 citations

Regulation of Neuronal Survival by the Serine-Threonine Protein Kinase Akt

1997 • 2,442 citations

Mechanisms and consequences of activation of protein kinase B/Akt

1998 • 1,305 citations

Inhibition of Cell Migration, Spreading, and Focal Adhesions by Tumor Suppressor PTEN

1998 • 1,215 citations

P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase

1997 • 778 citations

PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond

1997 • 699 citations

Phosphatidylinositol 3-Kinase and Akt Protein Kinase Are Necessary and Sufficient for the Survival of Nerve Growth Factor-Dependent Sympathetic Neurons

1998 • 577 citations

Somatic mutations of PTEN in glioblastoma multiforme.

1997 • 526 citations

Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain

1997 • 437 citations

Anti-Fas/APO-1 antibody-mediated apoptosis of cultured human glioma cells. Induction and modulation of sensitivity by cytokines.

1994 • 361 citations

PTEN mutations in gliomas and glioneuronal tumors

1998 • 348 citations

Mutation analysis of the putative tumor suppressor gene PTEN/MMAC1 in primary breast carcinomas.

1997 • 259 citations

PTEN/MMAC1 mutations and EGFR amplification in glioblastomas.

1997 • 199 citations

APO2 ligand: a novel lethal weapon against malignant glioma?

1998 • 193 citations

Predicting chemoresistance in human malignant glioma cells: The role of molecular genetic analyses

1998 • 171 citations

Protection of CD95-mediated apoptosis by activation of phosphatidylinositide 3-kinase and protein kinase B

1998 • 111 citations

Cooperative Interception of Neuronal Apoptosis by BCL‐2 and BAG‐1 Expression: Prevention of Caspase Activation and Reduced Production of Reactive Oxygen Species

1997 • 108 citations

Immunochemotherapy of malignant glioma: synergistic activity of CD95 ligand and chemotherapeutics

1997 • 96 citations

Hypericin-induced apoptosis of human malignant glioma cells is light-dependent, independent of bcl-2 expression, and does not require wild-type p53

1997 • 68 citations

Cahier de graphiques

1995 • 7 citations