Estradiol and Antiestrogens Regulate a Growth Inhibitory Insulin-like Growth Factor Binding Protein 3 Autocrine Loop in Human Breast Cancer Cells

Insulin-Like Growth Factors and Their Binding Proteins: Biological Actions*

1995 • 4,419 citations

A potent specific pure antiestrogen with clinical potential.

1991 • 1,111 citations

An insulin-like growth factor (IGF) binding protein enhances the biologic response to IGF-I.

1987 • 682 citations

Identification and molecular characterization of insulin-like growth factor binding proteins (IGFBP-1, -2, -3, -4, -5 and -6)

1991 • 680 citations

The insulin-like growth factor I receptor: a key to tumor growth?

1995 • 549 citations

Insulin-like growth factor (IGF)-independent action of IGF-binding protein-3 in Hs578T human breast cancer cells. Cell surface binding and growth inhibition

1993 • 481 citations

Development of antiestrogens and their use in breast cancer: eighth Cain memorial award lecture.

1990 • 419 citations

Endocrine Pharmacology of Antiestrogens as Antitumor Agents*

1990 • 403 citations

The insulin-like growth factor I receptor protects tumor cells from apoptosis in vivo.

1995 • 385 citations

Comparison of the Effects of a Pure Steroidal antiestrogen With Those of Tamoxifen in a Model of Human Breast Cancer

1995 • 363 citations

Response to a specific antioestrogen (ICI 182780) in tamoxifen-resistant breast cancer

1995 • 351 citations

Induction of transforming growth factor beta 1 in human breast cancer in vivo following tamoxifen treatment.

1992 • 344 citations

The human insulin-like growth factor (IGF) binding protein-3 inhibits the growth of fibroblasts with a targeted disruption of the IGF-I receptor gene.

1995 • 318 citations

Demonstration of receptors for insulin-like growth factor binding protein-3 on Hs578T human breast cancer cells.

1993 • 317 citations

Effect of Tamoxifen on Serum Insulinlike Growth Factor I Levels in Stage I Breast Cancer Patients

1990 • 264 citations

Transforming Growth Factor- β-induced Cell Growth Inhibition in Human Breast Cancer Cells Is Mediated through Insulin-like Growth Factor-binding Protein-3 Action

1995 • 241 citations

Inhibition of biological activity of multiplication-stimulating activity by binding to its carrier protein.

1980 • 212 citations

Transfection of the human insulin-like growth factor binding protein-3 gene into Balb/c fibroblasts inhibits cellular growth.

1993 • 160 citations

Insulin-like growth factor binding protein-3. Organization of the human chromosomal gene and demonstration of promoter activity.

1990 • 131 citations

In vivo inhibition of insulin-like growth factor I gene expression by tamoxifen.

1993 • 123 citations

Insulin-like growth factor-I (IGF-I) and transforming growth factor-beta 1 release IGF-binding protein-3 from human fibroblasts by different mechanisms.

1992 • 123 citations

Acid-activated insulin-like growth factor-binding protein-3 proteolysis in normal and transformed cells. Role of cathepsin D.

1994 • 121 citations

Retinoid Modulation of Insulin-Like Growth Factor-Binding Proteins and Inhibition of Breast Carcinoma Proliferation*

1991 • 110 citations

Regulation of Insulin-Like Growth Factor-Binding Protein (IGFBP) Expression by Breast Cancer Cells: Use of IGFBP-1 as as Inhibitor of Insulin-like Growth Factor Action

1992 • 107 citations

Insulin-like growth factor binding protein 3 accumulates to high levels in culture medium of senescent and quiescent human fibroblasts.

1991 • 101 citations

Insulin-like growth factor I gene expression in the uterus is stimulated by tamoxifen and inhibited by the pure antiestrogen ICI 182780.

1993 • 92 citations

Transforming Growth Factor-β Stimulates Production of Insulin-Like Growth Factor-Binding Protein-3 by Human Skin Fibroblasts*

1991 • 77 citations

Insulin-like Growth Factor Binding Protein 3 (IGF-BP3) Inhibits Estrogen-Stimulated Breast Cancer Cell Proliferation

1994 • 71 citations

Adjuvant therapy of cancer VII

1994 • 63 citations

Insulin-like growth factor binding protein (IGFBP-3), an inhibitor of serum growth factors other than IGF-I and -II

1992 • 50 citations

Uterotrophic actions of estradiol and tamoxifen are associated with inhibition of uterine insulin-like growth factor binding protein 3 gene expression.

1994 • 46 citations

Epidermal growth factor suppresses insulin-like growth factor binding protein 3 levels in human papillomavirus type 16-immortalized cervical epithelial cells and thereby potentiates the effects of insulin-like growth factor 1.

1994 • 42 citations

Cloning and Expression of Human Insulin-Like Growth Factor Binding Protein 3

1990 • 28 citations

Purification and characterization of human recombinant insulin-like growth factor binding protein 3 expressed in chinese hamster ovary cells

1991 • 25 citations