p53 Regulates Human Insulin-Like Growth Factor II Gene Expression through Active P4 Promoter in Rhabdomyosarcoma Cells

High-efficiency transformation of mammalian cells by plasmid DNA.

1987 • 5,377 citations

Suppression of Human Colorectal Carcinoma Cell Growth by Wild-Type p53

1990 • 1,796 citations

Oncogenic forms of p53 inhibit p53-regulated gene expression

1992 • 933 citations

Insulin-like growth factor-II gene expression in Wilms' tumour and embryonic tissues

1985 • 413 citations

A second signal supplied by insulin-like growth factor II in oncogene-induced tumorigenesis

1994 • 391 citations

The insulin-like growth factor I receptor protects tumor cells from apoptosis in vivo.

1995 • 385 citations

Wild-type and mutant p53 differentially regulate transcription of the insulin-like growth factor I receptor gene.

1996 • 365 citations

A specific chromosomal abnormality in rhabdomyosarcoma

1987 • 326 citations

Altered body composition and increased frequency of diverse malignancies in insulin-like growth factor-II transgenic mice.

1994 • 274 citations

Growth inhibition of human melanoma cells in nude mice by antisense strategies to the type 1 insulin-like growth factor receptor.

1994 • 234 citations

In vivo treatment with antibody against IGF-1 receptor suppresses growth of human rhabdomyosarcoma and down-regulates p34cdc2.

1994 • 186 citations

Antisense-mediated reduction in insulin-like growth factor-I receptor expression suppresses the malignant phenotype of a human alveolar rhabdomyosarcoma.

1994 • 170 citations

Differential expression of the human insulin-like growth factor II gene Characterization of the IGF-II mRNAs and an mRNA encoding a putative IGF-II-associated protein

1988 • 146 citations

The gene structure of the insulin-like growth factor family

1989 • 143 citations

Initial characterization of the four promoters of the human insulin-like growth factor II gene

1991 • 140 citations

Regulation of insulin-like growth factor II P3 promotor by p53: a potential mechanism for tumorigenesis.

1996 • 99 citations

Identification and initial characterization of a fourth leader exon and promoter of the human IGF-II gene

1990 • 91 citations