Insulin and insulin-like growth factor-I (IGF-I) receptor overexpression in breast cancers leads to insulin/IGF-I hybrid receptor overexpression: evidence for a second mechanism of IGF-I signaling.

Isolation and Characterization of a Spontaneously Immortalized Human Breast Epithelial Cell Line, MCF-10

1990 • 1,495 citations

Insulin-like growth factors and cancer

1992 • 622 citations

The insulin-like growth factor I receptor: a key to tumor growth?

1995 • 549 citations

Monoclonal antibodies to receptors for insulin and somatomedin-C.

1983 • 423 citations

Induction of transformation and continuous cell lines from normal human mammary epithelial cells after exposure to benzo[a]pyrene.

1985 • 416 citations

Overexpression of the human insulinlike growth factor I receptor promotes ligand-dependent neoplastic transformation.

1990 • 404 citations

Growth Factors in Breast Cancer

1995 • 378 citations

Blockade of the type I somatomedin receptor inhibits growth of human breast cancer cells in athymic mice.

1989 • 334 citations

Elevated insulin receptor content in human breast cancer.

1990 • 332 citations

Insulin-like growth factor receptor expression and function in human breast cancer.

1990 • 321 citations

Rat glioblastoma cells expressing an antisense RNA to the insulin-like growth factor-1 (IGF-1) receptor are nontumorigenic and induce regression of wild-type tumors.

1994 • 310 citations

Insulin receptor/IGF-I receptor hybrids are widely distributed in mammalian tissues: quantification of individual receptor species by selective immunoprecipitation and immunoblotting

1997 • 280 citations

Purified hybrid insulin/insulin-like growth factor-I receptors bind insulin-like growth factor-I, but not insulin, with high affinity

1993 • 271 citations

Insulin-like Growth Factor I Receptor β-Subunit Heterogeneity

1989 • 259 citations

Insulin-like growth factor-I receptors are overexpressed and predict a low risk in human breast cancer.

1993 • 248 citations

Monoclonal antibodies reacting with multiple epitopes on the human insulin receptor

1986 • 203 citations

Insulin receptor expression and function in human breast cancer cell lines.

1992 • 202 citations

Receptors for insulin and insulin-like growth factor-I can form hybrid dimers. Characterisation of hybrid receptors in transfected cells

1990 • 199 citations

Tissue Culture Methods

1980 • 195 citations

Isolation and growth of human mammary epithelial cells

1985 • 185 citations

Growth inhibition of MCF-7 breast cancer cells by stable expression of an insulin-like growth factor I receptor antisense ribonucleic acid.

1995 • 126 citations

Monoclonal antibodies to the human insulin receptor block insulin binding and inhibit insulin action.

1982 • 122 citations

A panel of monoclonal antibodies for the type I insulin-like growth factor receptor. Epitope mapping, effects on ligand binding, and biological activity.

1992 • 118 citations

Effect of monoclonal antibodies on human insulin receptor autophosphorylation, negative cooperativity, and down-regulation.

1987 • 110 citations

Relationship between alpha subunit ligand occupancy and beta subunit autophosphorylation in insulin/insulin-like growth factor-1 hybrid receptors.

1993 • 105 citations

Insulin-like growth factor expression in breast cancer epithelium and stroma

1992 • 105 citations

The cysteine-rich domains of the insulin and insulin-like growth factor I receptors are primary determinants of hormone binding specificity. Evidence from receptor chimeras.

1990 • 104 citations

Insulin receptor expression and clinical outcome in node-negative breast cancer.

1997 • 94 citations

Overexpression of Insulin Receptors in Fibroblast and Ovary Cells Induces a Ligand-Mediated Transformed Phenotype

1991 • 92 citations

Characterization of human placental insulin-like growth factor-I/insulin hybrid receptors by protein microsequencing and purification

1993 • 78 citations

A functional assessment of insulin/insulin-like growth factor-I hybrid receptors.

1995 • 78 citations

Purification of insulin-like growth factor I receptor from human placental membranes.

1986 • 51 citations

Insulin Receptor

1997 • 33 citations

Deletion of residues 485-599 from the human insulin receptor abolishes antireceptor antibody binding and influences tyrosine kinase activation.

1994 • 11 citations