Rho GTPases and their effector proteins

Rho GTPases and the Actin Cytoskeleton

1998 • 6,129 citations

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension

1997 • 2,847 citations

Regulation of Myosin Phosphatase by Rho and Rho-Associated Kinase (Rho-Kinase)

1996 • 2,843 citations

Rho GTPases and signaling networks

1997 • 2,380 citations

Phosphorylation and Activation of Myosin by Rho-associated Kinase (Rho-kinase)

1996 • 1,964 citations

Proteins regulating Ras and its relatives

1993 • 1,930 citations

The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway

1995 • 1,653 citations

Signaling from Rho to the Actin Cytoskeleton Through Protein Kinases ROCK and LIM-kinase

1999 • 1,581 citations

A brain serine/threonine protein kinase activated by Cdc42 and Rac1

1994 • 1,520 citations

Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

1995 • 1,499 citations

Rho GTPases Control Polarity, Protrusion, and Adhesion during Cell Movement

1999 • 1,452 citations

Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase

1998 • 1,384 citations

The Interaction between N-WASP and the Arp2/3 Complex Links Cdc42-Dependent Signals to Actin Assembly

1999 • 1,332 citations

The Rho family GTPases RhoA, Racl , and CDC42Hsregulate transcriptional activation by SRF

1995 • 1,280 citations

Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization

1998 • 1,263 citations

Coiled coils: new structures and new functions

1996 • 1,196 citations

The DNA sequence of human chromosome 22

1999 • 1,167 citations

An Essential Role for Rho, Rac, and Cdc42 GTPases in Cell Cycle Progression Through G ₁

1995 • 1,142 citations

Isolation of a novel gene mutated in Wiskott-Aldrich syndrome

1994 • 1,053 citations

Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics

1999 • 1,048 citations

Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho.

1996 • 1,045 citations

The Ras-Related Protein Cdc42Hs and Bradykinin Promote Formation of Peripheral Actin Microspikes and Filopodia in Swiss 3T3 Fibroblasts

1995 • 1,033 citations

Identification of Two Distinct Mechanisms of Phagocytosis Controlled by Different Rho GTPases

1998 • 993 citations

Activation of the NADPH oxidase involves the small GTP-binding protein p21rac1

1991 • 961 citations

Scar1 and the related Wiskott–Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex

1998 • 933 citations

Cooperation between mDia1 and ROCK in Rho-induced actin reorganization

1999 • 884 citations

Wiskott–Aldrich Syndrome Protein, a Novel Effector for the GTPase CDC42Hs, Is Implicated in Actin Polymerization

1996 • 873 citations

The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase.

1996 • 872 citations

The p160 RhoA-Binding Kinase ROKα Is a Member of a Kinase Family and Is Involved in the Reorganization of the Cytoskeleton

1996 • 866 citations

Rho-Kinase Phosphorylates COOH-terminal Threonines of Ezrin/Radixin/Moesin (ERM) Proteins and Regulates Their Head-to-Tail Association

1998 • 849 citations

p140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilin

1997 • 819 citations

Coiled coils: new structures and new functions

1996 • 812 citations

Role of Substrates and Products of PI 3-kinase in Regulating Activation of Rac-Related Guanosine Triphosphatases by Vav

1998 • 798 citations

Scar, a WASp-related protein, activates nucleation of actin filaments by the Arp2/3 complex

1999 • 771 citations

PAK Kinases Are Directly Coupled to the PIX Family of Nucleotide Exchange Factors

1998 • 745 citations

Autoinhibition and activation mechanisms of the Wiskott–Aldrich syndrome protein

2000 • 739 citations

Rho Family GTPases Regulate p38 Mitogen-activated Protein Kinase through the Downstream Mediator Pak1

1995 • 733 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 725 citations

WAVE, a novel WASP-family protein involved in actin reorganization induced by Rac

1998 • 696 citations

Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells

1997 • 687 citations

Regulation of Phagocyte Oxygen Radical Production by the GTP-Binding Protein Rac 2

1991 • 669 citations

N-WASP, a novel actin-depolymerizing protein, regulates the cortical cytoskeletal rearrangement in a PIP2-dependent manner downstream of tyrosine kinases.

1996 • 667 citations

Thrombin receptor ligation and activated rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets

1995 • 665 citations

Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP

1998 • 656 citations

Cdc42 and PAK-mediated Signaling Leads to Jun Kinase and p38 Mitogen-activated Protein Kinase Activation

1995 • 639 citations

A Conserved Binding Motif Defines Numerous Candidate Target Proteins for Both Cdc42 and Rac GTPases

1995 • 625 citations

Modulation of gelsolin function by phosphatidylinositol 4,5-bisphosphate

1987 • 624 citations

The respiratory burst oxidase.

1994 • 608 citations

Activation of the nuclear factor-kappaB by Rho, CDC42, and Rac-1 proteins.

1997 • 605 citations

Inhibition of Myosin Light Chain Kinase by p21-Activated Kinase

1999 • 592 citations

Rac and Cdc42 Induce Actin Polymerization and G1 Cell Cycle Progression Independently of p65PAK and the JNK/SAPK MAP Kinase Cascade

1996 • 571 citations

Phosphorylation of Myosin-Binding Subunit (Mbs) of Myosin Phosphatase by Rho-Kinase in Vivo

1999 • 559 citations

Cdc42: An Essential Rho-Type GTPase Controlling Eukaryotic Cell Polarity

1999 • 546 citations

A Role for Cdc42 in Macrophage Chemotaxis

1998 • 537 citations

Regulation of vinculin binding to talin and actin by phosphatidyl-inositol-4-5-bisphosphate

1996 • 522 citations

p160^ROCK, a Rho‐associated coiled‐coil forming protein kinase, works downstream of Rho and induces focal adhesions

1997 • 510 citations

The Dbl family of oncogenes

1996 • 497 citations

Structure of the Rho Family GTP-Binding Protein Cdc42 in Complex with the Multifunctional Regulator RhoGDI

2000 • 494 citations

Structure at 1.65 Å of RhoA and its GTPase-activating protein in complex with a transition-state analogue

1997 • 487 citations

Rho Guanine Dissociation Inhibitors

1999 • 487 citations

Rho Family GTPases Bind to Phosphoinositide Kinases

1995 • 469 citations

Paxillin LD4 Motif Binds PAK and PIX through a Novel 95-kD Ankyrin Repeat, ARF–GAP Protein: A Role in Cytoskeletal Remodeling

1999 • 466 citations

A Comparative Analysis of the Phosphoinositide Binding Specificity of Pleckstrin Homology Domains

1997 • 458 citations

The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has separate rac-specific and rho-specific guanine nucleotide exchange factor domains.

1996 • 452 citations

Requirements for Both Rac1 and Cdc42 in Membrane Ruffling and Phagocytosis in Leukocytes

1997 • 445 citations

Rac Regulation of Transformation, Gene Expression, and Actin Organization by Multiple, PAK-Independent Pathways

1997 • 433 citations

The protein kinase homologue Ste20p is required to link the yeast pheromone response G-protein beta gamma subunits to downstream signalling components.

1992 • 427 citations

Post-translational modifications of p21rho proteins.

1992 • 422 citations

Identification of a Putative Target for Rho as the Serine-Threonine Kinase Protein Kinase N

1996 • 417 citations

Signaling to Rho GTPases

1999 • 411 citations

Nonsyndromic Deafness DFNA1 Associated with Mutation of a Human Homolog of the Drosophila Gene diaphanous

1997 • 409 citations

diaphanous is required for cytokinesis in Drosophila and shares domains of similarity with the products of the limb deformity gene

1994 • 408 citations

Two GTPases, Cdc42 and Rac, bind directly to a protein implicated in the immunodeficiency disorder Wiskott–Aldrich syndrome

1996 • 397 citations

Tools of the trade: use of dominant-inhibitory mutants of Ras-family GTPases

1999 • 397 citations

Identification of a Mouse p21Cdc42/Rac Activated Kinase

1995 • 395 citations

Activation of phosphoinositide 3-kinase activity by Cdc42Hs binding to p85.

1994 • 392 citations

PAK to the future

1999 • 391 citations

IQGAP1, a calmodulin-binding protein with a rasGAP-related domain, is a potential effector for cdc42Hs.

1996 • 387 citations

Role of citron kinase as a target of the small GTPase Rho in cytokinesis

1998 • 385 citations

Interaction of Rac with p67 ^phox and Regulation pf Phagocytic NADPH Oxidase Activity

1994 • 384 citations

Protein Kinase N (PKN) and PKN-Related Protein Rhophilin as Targets of Small GTPase Rho

1996 • 384 citations

Rhotekin, a New Putative Target for Rho Bearing Homology to a Serine/Threonine Kinase, PKN, and Rhophilin in the Rho-binding Domain

1996 • 378 citations

Molecular mechanisms of nonmuscle myosin-II regulation

1999 • 376 citations

WIP, a protein associated with Wiskott–Aldrich syndrome protein, induces actin polymerization and redistribution in lymphoid cells

1997 • 376 citations

Putting a new twist on actin: ADF/cofilins modulate actin dynamics

1999 • 371 citations

Regulation of cortical structure by the ezrin-radixin-moesin protein family

1999 • 365 citations

PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia

1998 • 356 citations

A New Member of the Rho Family, Rnd1, Promotes Disassembly of Actin Filament Structures and Loss of Cell Adhesion

1998 • 349 citations

Signaling from the Small GTP-binding Proteins Rac1 and Cdc42 to the c-Jun N-terminal Kinase/Stress-activated Protein Kinase Pathway

1996 • 340 citations

GEFs: structural basis for their activation of small GTP-binding proteins

1999 • 334 citations

A Conserved Negative Regulatory Region in αPAK: Inhibition of PAK Kinases Reveals Their Morphological Roles Downstream of Cdc42 and Rac1

1998 • 325 citations

A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42

1993 • 319 citations

Structure of Cdc42 in complex with the GTPase-binding domain of the ‘Wiskott–Aldrich syndrome’ protein

1999 • 319 citations

Identification of IQGAP as a Putative Target for the Small GTPases, Cdc42 and Rac1

1996 • 315 citations

Wiskott-Aldrich Syndrome Protein Physically Associates with Nck through Src Homology 3 Domains

1995 • 315 citations

The Arp2/3 complex: a multifunctional actin organizer

1999 • 314 citations

Cellular transformation and guanine nucleotide exchange activity are catalyzed by a common domain on the dbl oncogene product.

1994 • 314 citations

A Novel Regulator of p21-activated Kinases

1998 • 313 citations

Interaction of the Nck Adapter Protein with p21-activated Kinase (PAK1)

1996 • 309 citations

Bni1p and Bnr1p: downstream targets of the Rho family small G-proteins which interact with profilin and regulate actin cytoskeleton in Saccharomyces cerevisiae

1997 • 309 citations

Evidence for a Role of Rho-like GTPases and Stress-activated Protein Kinase/c-Jun N-terminal Kinase (SAPK/JNK) in Transforming Growth Factor β-mediated Signaling

1997 • 301 citations

MEK kinases are regulated by EGF and selectively interact with Rac/Cdc42

1997 • 300 citations

Phosphorylation of Adducin by Rho-Kinase Plays a Crucial Role in Cell Motility

1999 • 300 citations

Membrane targeting of p21-activated kinase 1(PAK1) induces neurite outgrowth from PC12 cells

1998 • 296 citations

The 70 kDa S6 Kinase Complexes with and Is Activated by the Rho Family G Proteins Cdc42 and Rac1

1996 • 293 citations

The COOH Terminus of Rho-kinase Negatively Regulates Rho-kinase Activity

1999 • 271 citations

Myotonic Dystrophy Kinase-Related Cdc42-Binding Kinase Acts as a Cdc42 Effector in Promoting Cytoskeletal Reorganization

1998 • 269 citations

The adaptor protein Nck links receptor tyrosine kinases with the serine-threonine kinase Pak1

1996 • 268 citations

The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3

1998 • 266 citations

Identification of a Novel Human Rho Protein with Unusual Properties: GTPase Deficiency and In Vivo Farnesylation

1996 • 265 citations

RAC Regulation of Actin Polymerization and Proliferation by a Pathway Distinct from Jun Kinase

1996 • 264 citations

A requirement for Rho and Cdc42 during cytokinesis in Xenopus embryos

1997 • 259 citations

Activation of Pak by membrane localization mediated by an SH3 domain from the adaptor protein Nck

1997 • 259 citations

The Ras GTPase-Activating-Protein-Related Human Protein IQGAP2 Harbors a Potential Actin Binding Domain and Interacts with Calmodulin and Rho Family GTPases

1996 • 256 citations

Activation of ERM proteins in vivo by Rho involves phosphatidyl-inositol 4-phosphate 5-kinase and not ROCK kinases

1999 • 255 citations

Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway

1996 • 253 citations

Crystal structure of a small G protein in complex with the GTPase-activating protein rhoGAP

1997 • 252 citations

Functional analysis of the interaction between the small GTP binding protein Cdc42 and the Ste20 protein kinase in yeast.

1996 • 248 citations

GAPs for rho-related GTPases

1994 • 248 citations

RhoA effector mutants reveal distinct effector pathways for cytoskeletal reorganization, SRF activation and transformation

1998 • 243 citations

Molecular Cloning of a New Member of the p21-Cdc42/Rac-activated Kinase (PAK) Family

1995 • 240 citations

The essential role of profilin in the assembly of actin for microspike formation

1998 • 237 citations

p140Sra-1 (Specifically Rac1-associated Protein) Is a Novel Specific Target for Rac1 Small GTPase

1998 • 237 citations

A role for POR1, a Rac1-interacting protein, in ARF6-mediated cytoskeletal rearrangements

1997 • 234 citations

Activation of the yeast Arp2/3 complex by Bee1p, a WASP-family protein

1999 • 231 citations

Type Iα phosphatidylinositol-4-phosphate 5-kinase mediates Rac-dependent actin assembly

2000 • 230 citations

A rho-like protein is involved in the organisation of the contractile ring in dividing sand dollar eggs

1993 • 230 citations

Localization of p21-Activated Kinase 1 (PAK1) to Pinocytic Vesicles and Cortical Actin Structures in Stimulated Cells

1997 • 230 citations

Direct interaction of the Wiskott-Aldrich syndrome protein with the GTPase Cdc42.

1996 • 229 citations

A Tyrosine-phosphorylated Protein That Binds to an Important Regulatory Region on the Cool Family of p21-activated Kinase-binding Proteins

1999 • 221 citations

Crystal Structure of the Dbl and Pleckstrin Homology Domains from the Human Son of Sevenless Protein

1998 • 220 citations

Corequirement of Specific Phosphoinositides and Small GTP-binding Protein Cdc42 in Inducing Actin Assembly in Xenopus Egg Extracts

1998 • 219 citations

Physical association of the small GTPase Rho with a 68-kDa phosphatidylinositol 4-phosphate 5-kinase in Swiss 3T3 cells.

1996 • 215 citations

Rac regulates phosphorylation of the myosin-II heavy chain, actinomyosin disassembly and cell spreading

1999 • 214 citations

A Cdc42 target protein with homology to the non-kinase domain of FER has a potential role in regulating the actin cytoskeleton

1997 • 214 citations

Crystal Structure of Human RhoA in a Dominantly Active Form Complexed with a GTP Analogue

1998 • 214 citations

PAK promotes morphological changes by acting upstream of Rac

1998 • 211 citations

Regulation of the Association of Adducin with Actin Filaments by Rho-associated Kinase (Rho-kinase) and Myosin Phosphatase

1998 • 209 citations

A new Rac target POSH is an SH3-containing scaffold protein involved in the JNK and NF-kappa B signalling pathways

1998 • 208 citations

Protein prenylation: more than just glue?

1992 • 208 citations

p160ROCK mediates RhoA activation of Na-H exchange

1998 • 204 citations

MSS4, a Phosphatidylinositol-4-phosphate 5-Kinase Required for Organization of the Actin Cytoskeleton in Saccharomyces cerevisiae

1998 • 204 citations

Regulation of cadherin-mediated cell–cell adhesion by the Rho family GTPases

1999 • 204 citations

Regulation of Cross-linking of Actin Filament by IQGAP1, a Target for Cdc42

1997 • 202 citations

Identification of Kinase-Phosphatase Signaling Modules Composed of p70 S6 Kinase-Protein Phosphatase 2A (PP2A) and p21-activated Kinase-PP2A

1999 • 201 citations

Differential Effects of PAK1-activating Mutations Reveal Activity-dependent and -independent Effects on Cytoskeletal Regulation

1998 • 201 citations

Coupling of Jun amino-terminal kinase and Decapentaplegic signaling pathways in Drosophila morphogenesis.

1997 • 200 citations

Na–H Exchange Acts Downstream of RhoA to Regulate Integrin-induced Cell Adhesion and Spreading

1998 • 199 citations

Structures of Cdc42 bound to the active and catalytically compromised forms of Cdc42GAP

1998 • 198 citations

FH proteins as cytoskeletal organizers

1998 • 195 citations

The PRK2 Kinase Is a Potential Effector Target of both Rho and Rac GTPases and Regulates Actin Cytoskeletal Organization

1997 • 195 citations

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 193 citations

Translocation of activated Rho from the cytoplasm to membrane ruffling area, cell-cell adhesion sites and cleavage furrows.

1995 • 192 citations

Rho family small GTP-binding proteins in growth cone signalling

1997 • 190 citations

Rac GTPase interacts specifically with phosphatidylinositol 3-kinase

1996 • 186 citations

Massive Actin Polymerization Induced by Phosphatidylinositol-4-phosphate 5-Kinase in Vivo

1997 • 174 citations

Gα13 Stimulates Na+-H+ Exchange through Distinct Cdc42-dependent and RhoA-dependent Pathways

1996 • 171 citations

Identification of a novel Rac1-interacting protein involved in membrane ruffling.

1996 • 171 citations

NMR Structure and Mutagenesis of the N-Terminal Dbl Homology Domain of the Nucleotide Exchange Factor Trio

1998 • 171 citations

C-terminal binding domain of Rho GDP-dissociation inhibitor directs N-terminal inhibitory peptide to GTPases

1997 • 169 citations

A novel partner for the GTP‐bound forms of rho and rac

1995 • 166 citations

The world according to Arp: regulation of actin nucleation by the Arp2/3 complex

1999 • 166 citations

Distinct Actions and Cooperative Roles of ROCK and mDia in Rho Small G Protein-induced Reorganization of the Actin Cytoskeleton in Madin–Darby Canine Kidney Cells

1999 • 165 citations

Roles of Rho-associated Kinase in Cytokinesis; Mutations in Rho-associated Kinase Phosphorylation Sites Impair Cytokinetic Segregation of Glial Filaments

1998 • 164 citations

Structure of the small G protein Cdc42 bound to the GTPase-binding domain of ACK

1999 • 162 citations

Regulation of Actin Polymerization in Cell-free Systems by GTPγS and Cdc42

1997 • 160 citations

Evidence for Rho-mediated Agonist Stimulation of Phospholipase D in Rat1 Fibroblasts

1996 • 149 citations

The Structural Basis of Rho Effector Recognition Revealed by the Crystal Structure of Human RhoA Complexed with the Effector Domain of PKN/PRK1

1999 • 149 citations

Characterization of a Rac1- and RhoGDI-Associated Lipid Kinase Signaling Complex

1998 • 147 citations

Activation of the small GTPase Cdc42 by the inflammatory cytokines TNFα and IL-1, and by the Epstein-Barr virus transforming protein LMP1

1999 • 146 citations

The Borgs, a New Family of Cdc42 and TC10 GTPase-Interacting Proteins

1999 • 145 citations

The Cdc42/Rac Interactive Binding Region Motif of the Wiskott Aldrich Syndrome Protein (WASP) Is Necessary but Not Sufficient for Tight Binding to Cdc42 and Structure Formation

1998 • 143 citations

The Drosophila Ste20-related kinase misshapen is required for embryonic dorsal closure and acts through a JNK MAPK module on an evolutionarily conserved signaling pathway

1998 • 142 citations

Direct Binding of the Verprolin-Homology Domain in N-WASP to Actin Is Essential for Cytoskeletal Reorganization

1998 • 141 citations

Identification of an Actin Cytoskeletal Complex That Includes IQGAP and the Cdc42 GTPase

1997 • 141 citations

Isolation of a NCK-associated Kinase, PRK2, an SH3-binding Protein and Potential Effector of Rho Protein Signaling

1996 • 141 citations

Identification of a Putative Effector for Cdc42Hs with High Sequence Similarity to the RasGAP-related Protein IQGAP1 and a Cdc42Hs Binding Partner with Similarity to IQGAP2

1996 • 139 citations

Calmodulin Modulates the Interaction between IQGAP1 and Cdc42

1997 • 137 citations

TTF, a gene encoding a novel small G protein, fuses to the lymphoma-associated LAZ3 gene by t(3;4) chromosomal translocation.

1995 • 137 citations

The Pleckstrin Homology Domain Mediates Transformation by Oncogenic Dbl through Specific Intracellular Targeting

1996 • 136 citations

Rac Binding to p67

1997 • 135 citations

Phosphorylation of Glial Fibrillary Acidic Protein at the Same Sites by Cleavage Furrow Kinase and Rho-associated Kinase

1997 • 131 citations

The small GTP-binding proteins, Rac and Rho, regulate cytoskeletal organization and exocytosis in mast cells by parallel pathways.

1996 • 130 citations

Proteolytic activation of PKN by caspase-3 or related protease during apoptosis

1998 • 129 citations

Activation of PRK1 by Phosphatidylinositol 4,5-Bisphosphate and Phosphatidylinositol 3,4,5-Trisphosphate

1995 • 127 citations

Rac GTPase interacts with GAPs and target proteins through multiple effector sites.

1995 • 126 citations

αPix Stimulates p21-activated Kinase Activity through Exchange Factor-dependent and -independent Mechanisms

1999 • 122 citations

A modulator of rho family G proteins, rhoGDI, binds these G proteins via an immunoglobulin-like domain and a flexible N-terminal arm

1997 • 118 citations

Stimulation of phospholipase C-β₂by the Rho GTPases Cdc42Hs and Rac1

1998 • 117 citations

Tyrosine phosphorylation of the Wiskott‐Aldrich Syndrome protein by Lyn and Btk is regulated by CDC42

1998 • 111 citations

Involvement of Wiskott-Aldrich Syndrome Protein in B-Cell Cytoplasmic Tyrosine Kinase Pathway

1999 • 108 citations

Cloning and Characterization of a Novel Cdc42-associated Tyrosine Kinase, ACK-2, from Bovine Brain

1997 • 104 citations

Multiple Interactions of PRK1 with RhoA

1998 • 103 citations

Genetic Evidence for Pak1 Autoinhibition and Its Release by Cdc42

1999 • 98 citations

Iqg1p, a Yeast Homologue of the Mammalian IQGAPs, Mediates Cdc42p Effects on the Actin Cytoskeleton

1998 • 96 citations

Diacylglycerol Kinase θ Binds to and Is Negatively Regulated by Active RhoA

1999 • 89 citations

Role of Rho Family Proteins in Phospholipase D Activation by Growth Factors

1997 • 83 citations

α-Helical coiled-coil oligomerization domains in extracellular proteins

1997 • 79 citations

Determination of Interaction Sites on the Small G Protein RhoA for Phospholipase D

1998 • 77 citations

How RhoGDI binds Rho

1999 • 76 citations

Interaction of the Rho Family Small G Proteins with Kinectin, an Anchoring Protein of Kinesin Motor

1996 • 76 citations

DGAP1, a homologue of rasGTPase activating proteins that controls growth, cytokinesis, and development in Dictyostelium discoideum

1996 • 76 citations

Genghis Khan (Gek) as a putative effector forDrosophilaCdc42 and regulator of actin polymerization

1997 • 71 citations

Untying the Gordian Knot of Cytokinesis

2000 • 69 citations

Activation of Na+-H+ Exchange Is Necessary for RhoA-induced Stress Fiber Formation

1996 • 68 citations

Cdc42, Rac1, and Their Effector IQGAP1 as Molecular Switches for Cadherin-Mediated Cell–Cell Adhesion

1999 • 67 citations

Interaction of Rac1 with GTPase-activating Proteins and Putative Effectors

1998 • 65 citations

Kinetics of Cdc42 Membrane Extraction by Rho-GDI Monitored by Real-Time Fluorescence Resonance Energy Transfer

1999 • 63 citations

Mutational Analysis of the Regulatory Mechanism of PKN: The Regulatory Region of PKN Contains an Arachidonic Acid-Sensitive Autoinhibitory Domain

1999 • 59 citations

Disease mechanism: Unravelling Wiskott–Aldrich syndrome

1996 • 59 citations

Localization of the PAK1-, WASP-, and IQGAP1-specifying Regions of Cdc42

1999 • 58 citations

Rho GTPases in Development

1999 • 56 citations

Cytokinesis: IQGAPs find a function

1998 • 54 citations

The Role of the Unique Motifs in the Amino-Terminal Region of PKN on Its Enzymatic Activity

1996 • 46 citations

Proteolytic cleavage and activation of PAK2 during UV irradiation-induced apoptosis in A431 cells

1998 • 45 citations

Small GTPases and regulation of cadherin dependent cell-cell adhesion

1999 • 43 citations

MSE55, a Cdc42 effector protein, induces long cellular extensions in fibroblasts

1999 • 42 citations

Loop 6 of RhoA Confers Specificity for Effector Binding, Stress Fiber Formation, and Cellular Transformation

1999 • 42 citations

Use of a Fluorescence Spectroscopic Readout To Characterize the Interactions of Cdc42Hs with Its Target/Effector, mPAK-3

1997 • 34 citations

Rac regulation of transformation, gene expression, and actin organization by multiple, PAK-independent pathways.

1997 • 27 citations

ISOLATION OF A NOVEL GENE MUTATED IN WISKOTT-ALDRICH SYNDROME

1995 • 17 citations

The potential role for Cdc42 protein from rat brain cytosol in phospholipase D activation

1998 • 11 citations

Proteolytic cleavage and activation of PAK2 during UV irradiation‐induced apoptosis in A431 cells

1998 • 3 citations

Activation of Na+-H+ exchange is necessary for RhoA-induced stress fiber formation.

1996 • 3 citations

GTPases targetted by bacterial toxins

2000 • 2 citations