p140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilin

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Basic local alignment search tool

1990 • 87,358 citations

Molecular cloning: A laboratory manual

1990 • 85,659 citations

Calcium's Role in Mechanotransduction during Muscle Development

2014 • 14,293 citations

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

Regulation of Myosin Phosphatase by Rho and Rho-Associated Kinase (Rho-Kinase)

1996 • 2,843 citations

Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product.

1985 • 2,456 citations

Mammalian Ras interacts directly with the serine/threonine kinase raf

1993 • 1,983 citations

Integrin function: molecular hierarchies of cytoskeletal and signaling molecules.

1995 • 1,202 citations

Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho.

1996 • 1,045 citations

Wiskott–Aldrich Syndrome Protein, a Novel Effector for the GTPase CDC42Hs, Is Implicated in Actin Polymerization

1996 • 873 citations

The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase.

1996 • 872 citations

A novel macromolecular structure is a target of the promyelocyte-retinoic acid receptor oncoprotein

1994 • 798 citations

Isolation of Monoclonal Antibodies Specific for Human c-myc Proto-Oncogene Product

1985 • 788 citations

ROCK‐I and ROCK‐II, two isoforms of Rho‐associated coiled‐coil forming protein serine/threonine kinase in mice

1996 • 757 citations

A Novel Serine/Threonine Kinase Binding the Ras-related RhoA GTPase Which Translocates the Kinase to Peripheral Membranes

1995 • 711 citations

Thrombin receptor ligation and activated rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets

1995 • 665 citations

The structure of crystalline profilin–β-actin

1993 • 662 citations

The small GTP-binding protein Rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cells

1994 • 647 citations

A Conserved Binding Motif Defines Numerous Candidate Target Proteins for Both Cdc42 and Rac GTPases

1995 • 625 citations

How profilin promotes actin filament assembly in the presence of thymosin β4

1993 • 532 citations

Phosphoinositides and Calcium as Regulators of Cellular Actin Assembly and Disassembly

1994 • 524 citations

p160^ROCK, a Rho‐associated coiled‐coil forming protein kinase, works downstream of Rho and induces focal adhesions

1997 • 510 citations

The proline-rich focal adhesion and microfilament protein VASP is a ligand for profilins.

1995 • 479 citations

The Molecular Architecture of Focal Adhesions

1995 • 479 citations

diaphanous is required for cytokinesis in Drosophila and shares domains of similarity with the products of the limb deformity gene

1994 • 408 citations

Protein Kinase N (PKN) and PKN-Related Protein Rhophilin as Targets of Small GTPase Rho

1996 • 384 citations

Intracellular localization of the P21rho proteins.

1992 • 382 citations

Rhotekin, a New Putative Target for Rho Bearing Homology to a Serine/Threonine Kinase, PKN, and Rhophilin in the Rho-binding Domain

1996 • 378 citations

Regulation of cytoplasmic division of Xenopus embryo by rho p21 and its inhibitory GDP/GTP exchange protein (rho GDI).

1993 • 363 citations

Cellular transformation and guanine nucleotide exchange activity are catalyzed by a common domain on the dbl oncogene product.

1994 • 314 citations

Bni1p implicated in cytoskeletal control is a putative target of Rho1p small GTP binding protein in Saccharomyces cerevisiae.

1996 • 284 citations

Involvement of profilin in the actin-based motility of L. monocytogenes in cells and in cell-free extracts

1994 • 282 citations

Acanthamoeba profilin interacts with G-actin to increase the rate of exchange of actin-bound adenosine 5'-triphosphate

1980 • 275 citations

Profilin mutations disrupt multiple actin-dependent processes during Drosophila development

1994 • 265 citations

Mechanism of the interaction of human platelet profilin with actin.

1991 • 235 citations

Dictyostelium amoebae that lack G-actin-sequestering profilins show defects in F-actin content, cytokinesis, and development

1994 • 233 citations

A rho-like protein is involved in the organisation of the contractile ring in dividing sand dollar eggs

1993 • 230 citations

The Schizosaccharomyces pombe cdc3+ gene encodes a profilin essential for cytokinesis.

1994 • 228 citations

Inhibition of PMA-induced, LFA-1-dependent lymphocyte aggregation by ADP ribosylation of the small molecular weight GTP binding protein, rho.

1993 • 223 citations

ADP-ribosylation of rho p21 inhibits lysophosphatidic acid-induced protein tyrosine phosphorylation and phosphatidylinositol 3-kinase activation in cultured Swiss 3T3 cells.

1993 • 212 citations

'Formins': proteins deduced from the alternative transcripts of the limb deformity gene

1990 • 201 citations

Involvement of rho p21 and its inhibitory GDP/GTP exchange protein (rho GDI) in cell motility.

1993 • 200 citations

Translocation of activated Rho from the cytoplasm to membrane ruffling area, cell-cell adhesion sites and cleavage furrows.

1995 • 192 citations

Poly(<scp>l</scp>‐proline)‐binding proteins from chick embryos are a profilin and a profilactin

1985 • 176 citations

rac p21 is involved in insulin-induced membrane ruffling and rho p21 is involved in hepatocyte growth factor- and 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced membrane ruffling in KB cells.

1994 • 171 citations

Opposite effects of cofilin and profilin from porcine brain on rate of exchange of actin-bound adenosine 5'-triphosphate

1985 • 171 citations

A novel partner for the GTP‐bound forms of rho and rac

1995 • 166 citations

Cappuccino, a Drosophila maternal effect gene required for polarity of the egg and embryo, is related to the vertebrate limb deformity locus.

1995 • 159 citations

Profilin as a potential mediator of membrane-cytoskeleton communication

1993 • 159 citations

Distribution of profilin in fibroblasts correlates with the presence of highly dynamic actin filaments

1992 • 146 citations

A rho gene product in human blood platelets. II. Effects of the ADP-ribosylation by botulinum C3 ADP-ribosyltransferase on platelet aggregation.

1992 • 144 citations

Rho-dependent membrane folding causes Shigella entry into epithelial cells.

1996 • 141 citations

Botulinum C3 exoenzyme blocks the tyrosine phosphorylation of p125^FAK and paxillin induced by bombesin and endothelin

1994 • 138 citations

Effects of profilin and profilactin on actin structure and function in living cells

1992 • 124 citations

p190-B, a New Member of the Rho GAP Family, and Rho Are Induced to Cluster after Integrin Cross-linking

1995 • 118 citations

Characterization offus1ofSchizosaccharomyces pombe: a Developmentally Controlled Function Needed for Conjugation

1995 • 114 citations

A chimeric toxin to study the role of the 21 kDa GTP binding protein rho in the control of actin microfilament assembly.

1993 • 96 citations

Association of profilin with filament-free regions of human leukocyte and platelet membranes and reversible membrane binding during platelet activation.

1989 • 94 citations

Plant and animal profilins are functionally equivalent and stabilize microfilaments in living animal cells

1996 • 82 citations

Guanosine 5′-3-O-(Thio)triphosphate Stimulates Tyrosine Phosphorylation of p125FAK and Paxillin in Permeabilized Swiss 3T3 Cells

1995 • 72 citations

Interaction of fibronectin-coated beads with attached and spread fibroblasts

1986 • 63 citations

Differential colocalization of profilin with microfilaments in PtK2 cells

1997 • 61 citations

[22] Preparation of native and recombinant Clostridium botulinum C3 ADP-ribosyltransferase and identification of Rho proteins by ADP-ribosylation

1995 • 57 citations

A variant limb deformity transcript expressed in the embryonic mouse limb defines a novel formin.

1992 • 47 citations

Involvement of rho p21 and Its Inhibitory GDP/GTP Exchange Protein (rho GDI) in Cell Motility

1993 • 46 citations

Identification of developmental regulatory genes in Aspergillus nidulans by overexpression.

1995 • 44 citations

[9] Polyproline affinity method for purification of platelet profilin and modification with pyrene-maleimide

1991 • 39 citations

rac p21 Is Involved in Insulin-Induced Membrane Ruffling and rho p21 Is Involved in Hepatocyte Growth Factor- and 12-O-Tetradecanoylphorbol-13-Acetate (TPA)-Induced Membrane Ruffling in KB Cells

1994 • 39 citations

Characterization of a Monoclonal Antibody Specific for the Ras-Related GTP-Binding Protein Rho A

1993 • 35 citations