Small GTPases and regulation of cadherin dependent cell-cell adhesion

Calcium's Role in Mechanotransduction during Muscle Development

2014 • 14,293 citations

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

Cell Adhesion: The Molecular Basis of Tissue Architecture and Morphogenesis

1996 • 3,454 citations

Rho GTPases and signaling networks

1997 • 2,380 citations

Reversion of the Malignant Phenotype of Human Breast Cells in Three-Dimensional Culture and In Vivo by Integrin Blocking Antibodies

1997 • 1,444 citations

A causal role for E-cadherin in the transition from adenoma to carcinoma

1998 • 1,415 citations

The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species.

1989 • 1,393 citations

Regulation of Cell Motility by Mitogen-activated Protein Kinase

1997 • 1,238 citations

Structural basis of cell-cell adhesion by cadherins

1995 • 1,173 citations

Role of Phosphoinositide 3-OH Kinase in Cell Transformation and Control of the Actin Cytoskeleton by Ras

1997 • 1,064 citations

From cadherins to catenins: cytoplasmic protein interactions and regulation of cell adhesion

1993 • 997 citations

An essential role for Rac in Ras transformation

1995 • 895 citations

Cell binding function of E-cadherin is regulated by the cytoplasmic domain.

1988 • 811 citations

MOLECULAR AND FUNCTIONAL ANALYSIS OF CADHERIN-BASED ADHERENS JUNCTIONS

1997 • 800 citations

The Small GTPases Rho and Rac Are Required for the Establishment of Cadherin-dependent Cell–Cell Contacts

1997 • 772 citations

Uvomorulin-catenin complex formation is regulated by a specific domain in the cytoplasmic region of the cell adhesion molecule.

1990 • 753 citations

Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K

1997 • 746 citations

Alpha 1(E)-catenin is an actin-binding and -bundling protein mediating the attachment of F-actin to the membrane adhesion complex.

1995 • 739 citations

The role of the cell-adhesion molecule E-cadherin as a tumour-suppressor gene

1999 • 738 citations

Beta-catenin mediates the interaction of the cadherin-catenin complex with epidermal growth factor receptor.

1994 • 712 citations

Activation of Rac1, RhoA, and Mitogen-Activated Protein Kinases Is Required for Ras Transformation

1995 • 683 citations

Matrix-dependent Tiam1/Rac Signaling in Epithelial Cells Promotes Either Cell–Cell Adhesion or Cell Migration and Is Regulated by Phosphatidylinositol 3-Kinase

1998 • 667 citations

Thrombin receptor ligation and activated rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets

1995 • 665 citations

Multiple ras functions can contribute to mammalian cell transformation

1995 • 658 citations

E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton.

1994 • 647 citations

Activation of Rac and Cdc42 by Integrins Mediates Cell Spreading

1998 • 638 citations

Molecular interactions in cell adhesion complexes

1997 • 583 citations

The Juxtamembrane Region of the Cadherin Cytoplasmic Tail Supports Lateral Clustering, Adhesive Strengthening, and Interaction with p120ctn

1998 • 566 citations

Identification of a neural α-catenin as a key regulator of cadherin function and multicellular organization

1992 • 562 citations

Assembly of the cadherin-catenin complex in vitro with recombinant proteins

1994 • 557 citations

Regulation of Cell–Cell Adhesion by Rac and Rho Small G Proteins in MDCK Cells

1997 • 555 citations

Embryonic axis induction by the armadillo repeat domain of beta-catenin: evidence for intracellular signaling.

1995 • 545 citations

A role for Rho in Ras transformation.

1995 • 538 citations

Rho GTPases

1998 • 534 citations

Identification of an invasion-inducing gene, Tiam-1, that encodes a protein with homology to GDP-GTP exchangers for Rho-like proteins

1994 • 518 citations

Role of IQGAP1, a Target of the Small GTPases Cdc42 and Rac1, in Regulation of E-Cadherin- Mediated Cell-Cell Adhesion

1998 • 505 citations

The Dbl family of oncogenes

1996 • 497 citations

Identification of a new catenin: the tyrosine kinase substrate p120cas associates with E-cadherin complexes.

1994 • 490 citations

E-Cadherin–dependent Growth Suppression is Mediated by the Cyclin-dependent Kinase Inhibitor p27KIP1

1998 • 451 citations

Inhibition of Invasion of Epithelial Cells by Tiam1-Rac Signaling

1997 • 448 citations

Ras effectors

1996 • 445 citations

Calcium-dependent cell-cell adhesion molecules (cadherins): subclass specificities and possible involvement of actin bundles.

1987 • 432 citations

Rho protein regulates tight junctions and perijunctional actin organization in polarized epithelia.

1995 • 418 citations

IQGAP1, a calmodulin-binding protein with a rasGAP-related domain, is a potential effector for cdc42Hs.

1996 • 387 citations

Assembly of the tight junction: the role of diacylglycerol.

1993 • 381 citations

Role of Actin Polymerization and Adhesion to Extracellular Matrix in Rac- and Rho-induced Cytoskeletal Reorganization

1997 • 378 citations

Lateral clustering of the adhesive ectodomain: a fundamental determinant of cadherin function

1997 • 357 citations

A role for cadherins in tissue formation

1996 • 355 citations

Oncogenic Ras Activation of Raf/Mitogen-Activated Protein Kinase-Independent Pathways Is Sufficient To Cause Tumorigenic Transformation

1996 • 350 citations

Structural and Functional Regulation of Tight Junctions by RhoA and Rac1 Small GTPases

1998 • 349 citations

Genetic and biochemical dissection of protein linkages in the cadherin-catenin complex.

1995 • 341 citations

Ral-GTPases mediate a distinct downstream signaling pathway from Ras that facilitates cellular transformation.

1996 • 335 citations

Activation of Both MAP Kinase and Phosphatidylinositide 3-Kinase by Ras Is Required for Hepatocyte Growth Factor/Scatter Factor–induced Adherens Junction Disassembly

1998 • 330 citations

Quantitative analysis of cadherin-catenin-actin reorganization during development of cell-cell adhesion.

1996 • 316 citations

Identification of IQGAP as a Putative Target for the Small GTPases, Cdc42 and Rac1

1996 • 315 citations

Receptor protein tyrosine phosphatase PTPmu associates with cadherins and catenins in vivo.

1995 • 313 citations

Cdc42 Regulates Anchorage-Independent Growth and Is Necessary for Ras Transformation

1997 • 312 citations

Lateral dimerization is required for the homophilic binding activity of C-cadherin.

1996 • 307 citations

Tyrosine phosphorylation regulates the adhesions of ras-transformed breast epithelia.

1995 • 304 citations

Effects of Regulated Expression of Mutant RhoA and Rac1 Small GTPases on the Development of Epithelial (MDCK) Cell Polarity

1998 • 297 citations

Association of p120, a tyrosine kinase substrate, with E-cadherin/catenin complexes.

1995 • 290 citations

A truncated beta-catenin disrupts the interaction between E-cadherin and alpha-catenin: a cause of loss of intercellular adhesiveness in human cancer cell lines.

1994 • 284 citations

Purified N-cadherin is a potent substrate for the rapid induction of neurite outgrowth.

1990 • 273 citations

Regulation of Cadherin Function by Rho and Rac: Modulation by Junction Maturation and Cellular Context

1999 • 257 citations

Tyrosine Phosphorylation and Src Family Kinases Control Keratinocyte Cell–Cell Adhesion

1998 • 254 citations

Association between a transmembrane protein tyrosine phosphatase and the cadherin-catenin complex.

1996 • 251 citations

IQGAP1, a Rac- and Cdc42-binding Protein, Directly Binds and Cross-links Microfilaments

1997 • 248 citations

Soluble 80‐kd fragment of cell‐CAM 120/80 disrupts cell‐cell adhesion

1987 • 239 citations

Cadherin-11 is expressed in invasive breast cancer cell lines.

1999 • 235 citations

N-Cadherin Promotes Adhesion Between Invasive Breast Cancer Cells and the Stroma

1997 • 229 citations

Evidence that cadherins play a role in the downregulation of integrin expression that occurs during keratinocyte terminal differentiation

1994 • 223 citations

Regulated binding of PTP1B-like phosphatase to N-cadherin: control of cadherin-mediated adhesion by dephosphorylation of beta-catenin.

1996 • 221 citations

V-src kinase shifts the cadherin-based cell adhesion from the strong to the weak state and beta catenin is not required for the shift.

1995 • 216 citations

Mechanism for transition from initial to stable cell-cell adhesion: kinetic analysis of E-cadherin-mediated adhesion using a quantitative adhesion assay.

1996 • 200 citations

Integrin and Cadherin Synergy Regulates Contact Inhibition of Migration and Motile Activity

1998 • 192 citations

CDC42 and Rac1 control different actin-dependent processes in the Drosophila wing disc epithelium.

1995 • 190 citations

A dominant inhibitory version of the small GTP-binding protein Rac disrupts cytoskeletal structures and inhibits developmental cell shape changes in Drosophila

1995 • 169 citations

p27 is involved in N-cadherin-mediated contact inhibition of cell growth and S-phase entry

1999 • 165 citations

Rho-stimulated Contractility Contributes to the Fibroblastic Phenotype of Ras-transformed Epithelial Cells

1997 • 161 citations

p120, a p120-related protein (p100), and the cadherin/catenin complex.

1995 • 156 citations

The malignant capacity of skin tumours induced by expression of a mutant H-ras transgene depends on the cell type targeted

1998 • 154 citations

Adhesive But Not Lateral E-cadherin Complexes Require Calcium and Catenins for Their Formation

1998 • 154 citations

Identification of a Putative Effector for Cdc42Hs with High Sequence Similarity to the RasGAP-related Protein IQGAP1 and a Cdc42Hs Binding Partner with Similarity to IQGAP2

1996 • 139 citations

Plasticity in epithelial cell phenotype: modulation by expression of different cadherin cell adhesion molecules.

1995 • 135 citations

Identification of a New Catenin: the Tyrosine Kinase Substrate p120^cas Associates with E-Cadherin Complexes

1994 • 102 citations

Activation of the 41/43 kDa mitogen-activated protein kinase signaling pathway is required for hepatocyte growth factor-induced cell scattering

1998 • 95 citations

Cadherin-mediated cell interactions are necessary for the activation of MyoD in Xenopus mesoderm.

1994 • 81 citations

Control of N-cadherin-mediated intercellular adhesion in migrating neural crest cells in vitro

1995 • 73 citations

Basal Extracellular Signal-Regulated Kinase Activity Modulates Cell-Cell and Cell-Matrix Interactions

1998 • 60 citations

Modulation of hepatocyte growth factor-induced scattering of HT29 colon carcinoma cells: Involvement of the MAPK pathway

1998 • 53 citations

E-Cadherin Engagement Stimulates Tyrosine Phosphorylation

1997 • 47 citations

Modulation of scatter factor/hepatocyte growth factor activity by cell-substratum adhesion

1994 • 37 citations

Regulation of cadherin-mediated adhesion by the small GTP-binding protein Rho in small cell lung carcinoma cells.

1997 • 35 citations

Calcium-Induced Intercellular Adhesion of Keratinocytes Does not Involve Accumulation of β₁Integrins at Cell-Cell Contacts and Does not Involve Changes in the Levels or Phosphorylation of Catenins

1998 • 17 citations