Activation of Pak by membrane localization mediated by an SH3 domain from the adaptor protein Nck

Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase

1988 • 6,107 citations

SH2 domains recognize specific phosphopeptide sequences

1993 • 2,685 citations

Protein modules and signalling networks

1995 • 2,447 citations

The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway

1995 • 1,653 citations

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

1992 • 1,636 citations

Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase

1994 • 1,590 citations

A brain serine/threonine protein kinase activated by Cdc42 and Rac1

1994 • 1,520 citations

Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

1995 • 1,499 citations

Identification of a Ten-Amino Acid Proline-Rich SH3 Binding Site

1993 • 1,205 citations

Structural basis for the binding of proline-rich peptides to SH3 domains

1994 • 1,016 citations

Purification of a RAS-responsive adenylyl cyclase complex from Saccharomyces cerevisiae by use of an epitope addition method.

1988 • 983 citations

Modular binding domains in signal transduction proteins

1995 • 962 citations

Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav.

1994 • 886 citations

Small GTP-Binding Proteins and the Regulation of the Actin Cytoskeleton

1994 • 822 citations

Rho Family GTPases Regulate p38 Mitogen-activated Protein Kinase through the Downstream Mediator Pak1

1995 • 733 citations

Cdc42 and PAK-mediated Signaling Leads to Jun Kinase and p38 Mitogen-activated Protein Kinase Activation

1995 • 639 citations

Binding of SH2 Domains of Phospholipase Cγ1, GAP, and Src to Activated Growth Factor Receptors

1990 • 608 citations

C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains

1992 • 603 citations

Rac and Cdc42 Induce Actin Polymerization and G1 Cell Cycle Progression Independently of p65PAK and the JNK/SAPK MAP Kinase Cascade

1996 • 571 citations

The pathway to signal achievement

1993 • 563 citations

A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos

1993 • 555 citations

An SH3-SH2-SH3 protein is required for p21Ras1 activation and binds to sevenless and Sos proteins in vitro

1993 • 451 citations

Regulation of Human Leukocyte p21-Activated Kinases Through G Protein—Coupled Receptors

1995 • 415 citations

Identification of sequences required for the efficient localization of the focal adhesion kinase, pp125FAK, to cellular focal adhesions.

1993 • 408 citations

Identification of a Mouse p21Cdc42/Rac Activated Kinase

1995 • 395 citations

A novel serine kinase activated by rac1/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20.

1995 • 365 citations

Signaling from the Small GTP-binding Proteins Rac1 and Cdc42 to the c-Jun N-terminal Kinase/Stress-activated Protein Kinase Pathway

1996 • 340 citations

Wiskott-Aldrich Syndrome Protein Physically Associates with Nck through Src Homology 3 Domains

1995 • 315 citations

Interaction of the Nck Adapter Protein with p21-activated Kinase (PAK1)

1996 • 309 citations

Actions of Rho Family Small G Proteins and p21-Activated Protein Kinases on Mitogen-Activated Protein Kinase Family Members

1996 • 275 citations

The adaptor protein Nck links receptor tyrosine kinases with the serine-threonine kinase Pak1

1996 • 268 citations

Direct association of pp125FAK with paxillin, the focal adhesion-targeting mechanism of pp125FAK.

1995 • 261 citations

Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway

1996 • 253 citations

Rho family members: Activators of MAP kinase cascades

1995 • 253 citations

Drosophila Photoreceptor Axon Guidance and Targeting Requires the Dreadlocks SH2/SH3 Adapter Protein

1996 • 248 citations

Molecular Cloning of a New Member of the p21-Cdc42/Rac-activated Kinase (PAK) Family

1995 • 240 citations

Differential Inhibition of Signaling Pathways by Dominant-Negative SH2/SH3 Adapter Proteins

1995 • 233 citations

The noncatalytic src homology region 2 segment of abl tyrosine kinase binds to tyrosine-phosphorylated cellular proteins with high affinity.

1991 • 224 citations

Nck, a melanoma cDNA encoding a cytoplasmic protein consisting of the src homology units SH2 and SH3

1990 • 209 citations

Nck associates with the SH2 domain-docking protein IRS-1 in insulin-stimulated cells.

1993 • 207 citations

An N-terminal peptide from p60src can direct myristylation and plasma membrane localization when fused to heterologous proteins

1985 • 201 citations

Two signaling molecules share a phosphotyrosine-containing binding site in the platelet-derived growth factor receptor.

1993 • 189 citations

Mutagenic analysis of the roles of SH2 and SH3 domains in regulation of the Abl tyrosine kinase.

1994 • 175 citations

The SH2 and SH3 domain-containing Nck protein is oncogenic and a common target for phosphorylation by different surface receptors.

1992 • 174 citations

The Small GTP-binding Protein Rho Activates c-Jun N-terminal Kinases/Stress-activated Protein Kinases in Human Kidney 293T Cells

1996 • 171 citations

Physical association between Src homology 3 elements and the protein product of the c-cbl proto-oncogene

1994 • 148 citations

Isolation of a NCK-associated Kinase, PRK2, an SH3-binding Protein and Potential Effector of Rho Protein Signaling

1996 • 141 citations

Activation of Mitogen-activated Protein Kinase Cascades by p21-activated Protein Kinases in Cell-free Extracts of Xenopus Oocytes

1995 • 98 citations

Binding of NCK to SOS and Activation of ras-Dependent Gene Expression

1995 • 94 citations

Phosphorylation of Nek in Response to a Variety of Receptors, Phorbol Myristate Acetate, and Cyclic AMP

1992 • 94 citations

The SH2/SH3 domain-containing protein Nck is recognized by certain anti-phospholipase C-gamma 1 monoclonal antibodies, and its phosphorylation on tyrosine is stimulated by platelet-derived growth factor and epidermal growth factor treatment.

1992 • 88 citations

The SH2- and SH3-containing Nck protein transforms mammalian fibroblasts in the absence of elevated phosphotyrosine levels.

1992 • 85 citations

A general strategy for producing conditional alleles of Src-like tyrosine kinases.

1995 • 77 citations

Rac is required for v-Abl tyrosine kinase to activate mitogenesis

1996 • 74 citations

Phosphorylation of Nck in response to a variety of receptors, phorbol myristate acetate, and cyclic AMP.

1992 • 55 citations

A Novel Ligand for SH3 Domains

1995 • 43 citations

Nck inhibits NGF and basic FGF induced PC12 cell differentiation via mitogen-activated protein kinase-independent pathway.

1996 • 29 citations