Rac regulates phosphorylation of the myosin-II heavy chain, actinomyosin disassembly and cell spreading

TGF-β SIGNAL TRANSDUCTION

1998 • 7,582 citations

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

Regulation of Myosin Phosphatase by Rho and Rho-Associated Kinase (Rho-Kinase)

1996 • 2,843 citations

Phosphorylation and Activation of Myosin by Rho-associated Kinase (Rho-kinase)

1996 • 1,964 citations

FOCAL ADHESIONS, CONTRACTILITY, AND SIGNALING

1996 • 1,900 citations

Rho-stimulated contractility drives the formation of stress fibers and focal adhesions.

1996 • 1,614 citations

Actin-Based Cell Motility and Cell Locomotion

1996 • 1,536 citations

A brain serine/threonine protein kinase activated by Cdc42 and Rac1

1994 • 1,520 citations

The Ras-Related Protein Cdc42Hs and Bradykinin Promote Formation of Peripheral Actin Microspikes and Filopodia in Swiss 3T3 Fibroblasts

1995 • 1,033 citations

Episomal Vectors Rapidly and Stably Produce High-Titer Recombinant Retrovirus

1996 • 768 citations

Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells

1997 • 687 citations

Matrix-dependent Tiam1/Rac Signaling in Epithelial Cells Promotes Either Cell–Cell Adhesion or Cell Migration and Is Regulated by Phosphatidylinositol 3-Kinase

1998 • 667 citations

Inhibition of lysophosphatidate- and thrombin-induced neurite retraction and neuronal cell rounding by ADP ribosylation of the small GTP-binding protein Rho.

1994 • 617 citations

Rho Family GTPases and Neuronal Growth Cone Remodelling: Relationship between Increased Complexity Induced by Cdc42Hs, Rac1, and Acetylcholine and Collapse Induced by RhoA and Lysophosphatidic Acid

1997 • 601 citations

Inhibition of Myosin Light Chain Kinase by p21-Activated Kinase

1999 • 592 citations

Turning of nerve growth cones induced by neurotransmitters

1994 • 583 citations

A role for Rac in Tiaml-induced membrane ruffling and invasion

1995 • 562 citations

Expression of Constitutively Active α-PAK Reveals Effects of the Kinase on Actin and Focal Complexes

1997 • 560 citations

Molecular Dissection of the Rho-associated Protein Kinase (p160ROCK)-regulated Neurite Remodeling in Neuroblastoma N1E-115 Cells

1998 • 465 citations

The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338

1998 • 435 citations

p21-Activated Kinase 1 (Pak1) Regulates Cell Motility in Mammalian Fibroblasts

1999 • 380 citations

The Guanine Nucleotide Exchange Factor Tiam1 Affects Neuronal Morphology; Opposing Roles for the Small GTPases Rac and Rho

1997 • 360 citations

CONTROL OF NONMUSCLE MYOSINS BY PHOSPHORYLATION

1992 • 338 citations

Regulation of Phosphorylation Pathways by p21 GTPases

1996 • 300 citations

Membrane targeting of p21-activated kinase 1(PAK1) induces neurite outgrowth from PC12 cells

1998 • 296 citations

Dictyostelium myosin heavy chain phosphorylation sites regulate myosin filament assembly and localization in vivo

1993 • 279 citations

Kinase-Deficient Pak1 Mutants Inhibit Ras Transformation of Rat-1 Fibroblasts

1997 • 199 citations

Xenopus nonmuscle myosin heavy chain isoforms have different subcellular localizations and enzymatic activities.

1996 • 167 citations

Antigen-induced Secretion of Histamine and the Phosphorylation of Myosin by Protein Kinase C in Rat Basophilic Leukemia Cells

1989 • 161 citations

Generation of inositol phosphates, cytosolic Ca2+, and ionic fluxes in PC12 cells treated with bradykinin.

1988 • 146 citations

Different Molecular Mechanisms for Rho Family GTPase-dependent, Ca2+-independent Contraction of Smooth Muscle

1998 • 143 citations

A Nck-Pak1 signaling module is required for T-cell receptor-mediated activation of NFAT, but not of JNK

1998 • 124 citations

Two Nonmuscle Myosin II Heavy Chain Isoforms Expressed in Rabbit Brains: Filament Forming Properties, the Effects of Phosphorylation by Protein Kinase C and Casein Kinase II, and Location of the Phosphorylation Sites

1998 • 102 citations

Activation of Myosin-I by Members of the Ste20p Protein Kinase Family

1996 • 100 citations

Regulation of Class I and Class II Myosins by Heavy Chain Phosphorylation

1996 • 95 citations

Cloning and Characterization of a Dictyostelium Myosin I Heavy Chain Kinase Activated by Cdc42 and Rac

1996 • 88 citations

The Catalytic Domain of Acanthamoeba Myosin I Heavy Chain Kinase

1996 • 56 citations

Rac-dependent and -independent Pathways Mediate Growth Factor-induced Ca2+ Influx

1996 • 45 citations

Myosin phosphorylation by human cdc42-dependent S6/H4 kinase/gammaPAK from placenta and lymphoid cells.

1997 • 42 citations

The Catalytic Domain of Acanthamoeba Myosin I Heavy Chain Kinase

1996 • 24 citations

Nutrient Stimulation Results in a Rapid Ca2+-dependent Threonine Phosphorylation of Myosin Heavy Chain in Rat Pancreatic Islets and RINm5F Cells

1998 • 20 citations

Myosin reorganization in activated RBL cells correlates temporally with stimulated secretion

1994 • 20 citations