The Structural Basis of Rho Effector Recognition Revealed by the Crystal Structure of Human RhoA Complexed with the Effector Domain of PKN/PRK1

[20] Processing of X-ray diffraction data collected in oscillation mode

1997 • 33,348 citations

PROCHECK: a program to check the stereochemical quality of protein structures

1993 • 23,689 citations

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

1998 • 15,791 citations

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1991 • 14,222 citations

Improved methods for building protein models in electron density maps and the location of errors in these models

1991 • 12,831 citations

SCOP: A structural classification of proteins database for the investigation of sequences and structures

1995 • 6,372 citations

Rho GTPases and the Actin Cytoskeleton

1998 • 6,129 citations

Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons

1991 • 5,267 citations

AMoRe: an automated package for molecular replacement

1994 • 4,990 citations

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

Protein Structure Comparison by Alignment of Distance Matrices

1993 • 3,989 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

Protein kinase C and lipid signaling for sustained cellular responses

1995 • 2,527 citations

Rho GTPases and signaling networks

1997 • 2,380 citations

Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho.

1996 • 1,045 citations

Molecular Switch for Signal Transduction: Structural Differences Between Active and Inactive Forms of Protooncogenic ras Proteins

1990 • 1,037 citations

The Ras-Related Protein Cdc42Hs and Bradykinin Promote Formation of Peripheral Actin Microspikes and Filopodia in Swiss 3T3 Fibroblasts

1995 • 1,033 citations

Regulation of the Cytoskeleton and Cell Adhesion by the Rho Family GTPases in Mammalian Cells

1999 • 1,015 citations

The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase.

1996 • 872 citations

The p160 RhoA-Binding Kinase ROKα Is a Member of a Kinase Family and Is Involved in the Reorganization of the Cytoskeleton

1996 • 866 citations

p140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilin

1997 • 819 citations

Crystal Structure of the Catalytic Domains of Adenylyl Cyclase in a Complex with G _sα ·GTPγS

1997 • 780 citations

ROCK‐I and ROCK‐II, two isoforms of Rho‐associated coiled‐coil forming protein serine/threonine kinase in mice

1996 • 757 citations

A Novel Serine/Threonine Kinase Binding the Ras-related RhoA GTPase Which Translocates the Kinase to Peripheral Membranes

1995 • 711 citations

The 2.2 Å crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with RaplA and a GTP analogue

1995 • 627 citations

A Conserved Binding Motif Defines Numerous Candidate Target Proteins for Both Cdc42 and Rac GTPases

1995 • 625 citations

A second class of synthetase structure revealed by X-ray analysis of Escherichia coli seryl-tRNA synthetase at 2.5 Å

1990 • 620 citations

Rac and Cdc42 Induce Actin Polymerization and G1 Cell Cycle Progression Independently of p65PAK and the JNK/SAPK MAP Kinase Cascade

1996 • 571 citations

Asparagine residue in the rho Gene Product Is the Modification Site for Botulinum ADP-ribosyltransferase

1989 • 550 citations

The 2.9 Å Crystal Structure of T. thermophilus Seryl-tRNA Synthetase Complexed with tRNA ^Ser

1994 • 452 citations

Identification of a Putative Target for Rho as the Serine-Threonine Kinase Protein Kinase N

1996 • 417 citations

Role of citron kinase as a target of the small GTPase Rho in cytokinesis

1998 • 385 citations

Protein Kinase N (PKN) and PKN-Related Protein Rhophilin as Targets of Small GTPase Rho

1996 • 384 citations

Rhotekin, a New Putative Target for Rho Bearing Homology to a Serine/Threonine Kinase, PKN, and Rhophilin in the Rho-binding Domain

1996 • 378 citations

Structural Basis of Rab Effector Specificity

1999 • 347 citations

Structural View of the Ran–Importin β Interaction at 2.3 Å Resolution

1999 • 344 citations

Structure of the nuclear transport complex karyopherin-β2–Ran˙GppNHp

1999 • 340 citations

Structure of Cdc42 in complex with the GTPase-binding domain of the ‘Wiskott–Aldrich syndrome’ protein

1999 • 319 citations

Bni1p implicated in cytoskeletal control is a putative target of Rho1p small GTP binding protein in Saccharomyces cerevisiae.

1996 • 284 citations

RAC Regulation of Actin Polymerization and Proliferation by a Pathway Distinct from Jun Kinase

1996 • 264 citations

Crystal structure of a small G protein in complex with the GTPase-activating protein rhoGAP

1997 • 252 citations

Structural basis for the interaction of Ras with RaIGDS

1998 • 251 citations

RhoA effector mutants reveal distinct effector pathways for cytoskeletal reorganization, SRF activation and transformation

1998 • 243 citations

Solvent-induced distortions and the curvature of α-helices

1983 • 223 citations

Crystal Structure of Human RhoA in a Dominantly Active Form Complexed with a GTP Analogue

1998 • 214 citations

Analysis of RhoA-binding Proteins Reveals an Interaction Domain Conserved in Heterotrimeric G Protein β Subunits and the Yeast Response Regulator Protein Skn7

1998 • 208 citations

Structure of the small G protein Cdc42 bound to the GTPase-binding domain of ACK

1999 • 162 citations

Cloning and Expression Patterns of two Members of A Novel Protein‐kinase‐C‐related Kinase Family

1995 • 146 citations

Ras Interaction with Two Distinct Binding Domains in Raf-1 5 Be Required for Ras Transformation

1996 • 140 citations

Identification of the Rho-binding Domain of p160 , a Rho-associated Coiled-coil Containing Protein Kinase

1996 • 137 citations

Crystal structure of the GreA transcript cleavage factor from Escherichia coli

1995 • 133 citations

The Drosophila Pkn protein kinase is a Rho/Rac effector target required for dorsal closure during embryogenesis

1999 • 129 citations

Interaction of PKN with α-Actinin

1997 • 117 citations

Solution Structure of the Ras-Binding Domain of c-Raf-1 and Identification of Its Ras Interaction Surface

1995 • 109 citations

Multiple Interactions of PRK1 with RhoA

1998 • 103 citations

Interaction of the Rho Family Small G Proteins with Kinectin, an Anchoring Protein of Kinesin Motor

1996 • 76 citations

A Protein Kinase, PKN, Accumulates in Alzheimer Neurofibrillary Tangles and Associated Endoplasmic Reticulum-Derived Vesicles and Phosphorylates Tau Protein

1998 • 66 citations

Characterization of the interaction between RhoA and the amino‐terminal region of PKN

1996 • 60 citations

The Role of the Unique Motifs in the Amino-Terminal Region of PKN on Its Enzymatic Activity

1996 • 46 citations

Loop 6 of RhoA Confers Specificity for Effector Binding, Stress Fiber Formation, and Cellular Transformation

1999 • 42 citations

Biochemical and Crystallographic Characterization of a Rho Effector Domain of the Protein Serine/Threonine Kinase N in a Complex with RhoA

1999 • 11 citations