Identification of a Novel Human Rho Protein with Unusual Properties: GTPase Deficiency and In Vivo Farnesylation

ras oncogenes in human cancer: a review.

1989 • 5,116 citations

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

The GTPase superfamily: conserved structure and molecular mechanism

1991 • 3,365 citations

The GTPase superfamily: a conserved switch for diverse cell functions

1990 • 2,330 citations

Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2

1993 • 1,531 citations

GTPase inhibiting mutations activate the α chain of Gs and stimulate adenylyl cyclase in human pituitary tumours

1989 • 1,405 citations

A Cytoplasmic Protein Stimulates Normal N- ras p21 GTPase, But Does Not Affect Oncogenic Mutants

1987 • 1,197 citations

Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis.

1990 • 1,077 citations

A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane

1990 • 1,049 citations

Two G Protein Oncogenes in Human Endocrine Tumors

1990 • 1,038 citations

Small GTP-Binding Proteins and the Regulation of the Actin Cytoskeleton

1994 • 822 citations

Comparative biochemical properties of normal and activated human ras p21 protein

1984 • 713 citations

STRUCTURE AND FUNCTION OF SIGNAL-TRANSDUCING GTP-BINDING PROTEINS

1991 • 630 citations

Structure of the GDP Domain of EF-Tu and Location of the Amino Acids Homologous to ras Oncogene Proteins

1985 • 626 citations

Sequence dependence of protein isoprenylation

1991 • 580 citations

The product of ras is a GTPase and the T24 oncogenic mutant is deficient in this activity

1984 • 539 citations

Biological and biochemical properties of human rasH genes mutated at codon 61

1986 • 538 citations

Molecular Cloning of Two Types of GAP Complementary DNA from Human Placenta

1988 • 492 citations

Function of Ras as a molecular switch in signal transduction.

1992 • 425 citations

Post-translational modifications of p21rho proteins.

1992 • 422 citations

Activation of phosphoinositide 3-kinase activity by Cdc42Hs binding to p85.

1994 • 392 citations

Protein farnesyltransferase and geranylgeranyltransferase share a common α subunit

1991 • 371 citations

Molecular cloning of cDNAs encoding the GAP-associated protein p190: Implications for a signaling pathway from ras to the nucleus

1992 • 343 citations

Association between GTPase activators for Rho and Ras families

1992 • 322 citations

Sequence requirement for peptide recognition by rat brain p21ras protein farnesyltransferase.

1991 • 312 citations

Rad: a Member of the Ras Family Overexpressed in Muscle of Type II Diabetic Humans

1993 • 301 citations

Role of Protein Modification Reactions in Programming Interactions Between Ras-Related GTPases and Cell Membranes

1994 • 279 citations

Nucleotide Sequence of the p21 Transforming Protein of Harvey Murine Sarcoma Virus

1982 • 272 citations

Identification of distinct cytoplasmic targets for ras/R-ras and rho regulatory proteins

1989 • 258 citations

Subcellular localization of Cdc42p, a Saccharomyces cerevisiae GTP-binding protein involved in the control of cell polarity.

1993 • 256 citations

Nucleotide Sequence of the Oncogene Encoding the p21 Transforming Protein of Kirsten Murine Sarcoma Virus

1982 • 256 citations

GAPs for rho-related GTPases

1994 • 248 citations

Regulation and function of the Rho subfamily of small GTPases

1994 • 233 citations

The N-terminal region of GAP regulates cytoskeletal structure and cell adhesion.

1993 • 205 citations

The effect of Mg2+ on the guanine nucleotide exchange rate of p21N-ras.

1986 • 203 citations

Biochemical properties of Ha-ras encoded p21 mutants and mechanism of the autophosphorylation reaction.

1988 • 196 citations

Relationship Among Guanine Nucleotide Exchange, GTP Hydrolysis, and Transforming Potential of Mutated ras Proteins

1988 • 196 citations

Translocation of activated Rho from the cytoplasm to membrane ruffling area, cell-cell adhesion sites and cleavage furrows.

1995 • 192 citations

GTP hydrolysis by ADP-ribosylation factor is dependent on both an ADP-ribosylation factor GTPase-activating protein and acid phospholipids.

1994 • 192 citations

Gem: an Induced, Immediate Early Protein Belonging to the Ras Family

1994 • 172 citations

CAAX Geranylgeranyl Transferase Transfers Farnesyl as Efficiently as Geranylgeranyl to RhoB

1995 • 163 citations

Characterization of rhoGAP. A GTPase-activating protein for rho-related small GTPases.

1994 • 159 citations

Carboxyl-terminal isoprenylation of ras-related GTP-binding proteins encoded by rac1, rac2, and ralA

1991 • 157 citations

Cloning and expression of a human CDC42 GTPase-activating protein reveals a functional SH3-binding domain.

1993 • 123 citations

The COOH-terminal domain of the Rap1A (Krev-1) protein is isoprenylated and supports transformation by an H-Ras:Rap1A chimeric protein.

1991 • 109 citations

rasH mutants deficient in GTP binding.

1986 • 107 citations

Differing structural requirements for GTPase-activating protein responsiveness and NADPH oxidase activation by Rac.

1994 • 93 citations

Biochemical comparisons of the Saccharomyces cerevisiae Bem2 and Bem3 proteins. Delineation of a limit Cdc42 GTPase-activating protein domain.

1993 • 81 citations

Characterization of Rad, a New Member of Ras/GTPase Superfamily, and Its Regulation by a Unique GTPase-activating protein (GAP)-like Activity

1995 • 57 citations

p190 RhoGAP, the major RasGAP-associated protein, binds GTP directly.

1994 • 54 citations

Biochemical characterization of polypeptides encoded by mutated human Ha-ras1 genes.

1986 • 42 citations

ADP‐ribosylation of Rho enhances adhesion of U937 cells to fibronectin via the α5β1 integrin receptor

1995 • 33 citations

Amino acid 61 is a determinant of sensitivity of rap proteins to the ras GTPase activating protein.

1990 • 22 citations

An altered DNA sequence encompassing therasgene of Harvey marine sarcoma virus

1984 • 16 citations

Biochemical Characterization of Polypeptides Encoded by Mutated Human Ha-ras1 Genes

1986 • 10 citations