Na–H Exchange Acts Downstream of RhoA to Regulate Integrin-induced Cell Adhesion and Spreading

Calcium's Role in Mechanotransduction during Muscle Development

2014 • 14,293 citations

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

Cell Adhesion: The Molecular Basis of Tissue Architecture and Morphogenesis

1996 • 3,454 citations

Integrins and Signal Transduction Pathways: the Road Taken

1995 • 3,002 citations

Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension

1997 • 2,847 citations

Regulation of Myosin Phosphatase by Rho and Rho-Associated Kinase (Rho-Kinase)

1996 • 2,843 citations

Intracellular pH measurements in Ehrlich ascites tumor cells utilizing spectroscopic probes generated in situ

1979 • 2,166 citations

FOCAL ADHESIONS, CONTRACTILITY, AND SIGNALING

1996 • 1,900 citations

Rho-stimulated contractility drives the formation of stress fibers and focal adhesions.

1996 • 1,614 citations

Tyrosine phosphorylation of paxillin and pp125FAK accompanies cell adhesion to extracellular matrix: a role in cytoskeletal assembly.

1992 • 1,330 citations

Integrin function: molecular hierarchies of cytoskeletal and signaling molecules.

1995 • 1,202 citations

Signal transduction through the fibronectin receptor induces collagenase and stromelysin gene expression.

1989 • 1,073 citations

Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho.

1996 • 1,045 citations

Regulation of focal adhesion-associated protein tyrosine kinase by both cellular adhesion and oncogenic transformation

1992 • 831 citations

Molecular cloning, primary structure, and expression of the human growth factor-activatable antiporter

1989 • 774 citations

Cell adhesion or integrin clustering increases phosphorylation of a focal adhesion-associated tyrosine kinase.

1992 • 743 citations

A Novel Serine/Threonine Kinase Binding the Ras-related RhoA GTPase Which Translocates the Kinase to Peripheral Membranes

1995 • 711 citations

Integrin-mediated cell adhesion activates mitogen-activated protein kinases.

1994 • 660 citations

The small GTP-binding protein Rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cells

1994 • 647 citations

A specific mutation abolishing Na+/H+ antiport activity in hamster fibroblasts precludes growth at neutral and acidic pH.

1984 • 544 citations

p160^ROCK, a Rho‐associated coiled‐coil forming protein kinase, works downstream of Rho and induces focal adhesions

1997 • 510 citations

Convergence of integrin and growth factor receptor signaling pathways within the focal adhesion complex.

1995 • 503 citations

Role of Rho in Chemoattractant-Activated Leukocyte Adhesion Through Integrins

1996 • 494 citations

Integrin Activation by R-ras

1996 • 414 citations

The assembly of integrin adhesion complexes requires both extracellular matrix and intracellular rho/rac GTPases.

1995 • 410 citations

Insoluble fibronectin activates the Na/H antiporter by clustering and immobilizing integrin alpha 5 beta 1, independent of cell shape.

1991 • 368 citations

Activation of protein kinase C precedes alpha 5 beta 1 integrin-mediated cell spreading on fibronectin.

1993 • 358 citations

Integrin-mediated signalling: regulation by protein tyrosine kinases and small GTP-binding proteins

1996 • 305 citations

The Na+/H+ antiporter cytoplasmic domain mediates growth factor signals and controls "H(+)-sensing".

1992 • 291 citations

Matrix/Integrin Interaction Activates the Mitogen-activated Protein Kinase, p44erk-1 and p42erk-2

1995 • 274 citations

Assembly of focal adhesions: progress, paradigms, and portents

1996 • 265 citations

Functional characterization of three isoforms of the Na+/H+ exchanger stably expressed in Chinese hamster ovary cells. ATP dependence, osmotic sensitivity, and role in cell proliferation.

1994 • 257 citations

Control of intracellular pH and growth by fibronectin in capillary endothelial cells.

1990 • 241 citations

Distinct functions of integrin alpha and beta subunit cytoplasmic domains in cell spreading and formation of focal adhesions

1993 • 223 citations

Inhibition of PMA-induced, LFA-1-dependent lymphocyte aggregation by ADP ribosylation of the small molecular weight GTP binding protein, rho.

1993 • 223 citations

Selective Inhibition of Fibronectin-Mediated Cell Adhesion by Monoclonal Antibodies to a Cell-Surface Glycoprotein

1985 • 217 citations

ADP-ribosylation of rho p21 inhibits lysophosphatidic acid-induced protein tyrosine phosphorylation and phosphatidylinositol 3-kinase activation in cultured Swiss 3T3 cells.

1993 • 212 citations

p160ROCK mediates RhoA activation of Na-H exchange

1998 • 204 citations

Targeted disruption of vinculin genes in F9 and embryonic stem cells changes cell morphology, adhesion, and locomotion.

1995 • 203 citations

Focal localization of the NHE-1 isoform of the Na+/H+ antiport: assessment of effects on intracellular pH.

1993 • 189 citations

Cytoskeletal Rearrangements and Transcriptional Activation of c-fos Serum Response Element by Rho-kinase

1997 • 176 citations

G alpha 13 stimulates Na-H exchange.

1994 • 175 citations

Gα13 Stimulates Na+-H+ Exchange through Distinct Cdc42-dependent and RhoA-dependent Pathways

1996 • 171 citations

Modulation of cell adhesion by changes in alpha L beta 2 (LFA-1, CD11a/CD18) cytoplasmic domain/cytoskeleton interaction.

1995 • 167 citations

Growth factor activation and “H(+)-sensing” of the Na+/H+ exchanger isoform 1 (NHE1). Evidence for an additional mechanism not requiring direct phosphorylation.

1994 • 166 citations

Induction of Tyrosine Phosphorylation and Na+/H+Exchanger Activation during Shrinkage of Human Neutrophils

1997 • 154 citations

A calcineurin homologous protein inhibits GTPase-stimulated Na-H exchange.

1996 • 151 citations

A rho gene product in human blood platelets. II. Effects of the ADP-ribosylation by botulinum C3 ADP-ribosyltransferase on platelet aggregation.

1992 • 144 citations

Integrins and inside-out signal transduction: converging signals from PKC and PIP3

1997 • 139 citations

Histamine as a growth factor and chemoattractant for human carcinoma and melanoma cells: action through Ca2(+)-mobilizing H1 receptors.

1990 • 139 citations

Botulinum C3 exoenzyme blocks the tyrosine phosphorylation of p125^FAK and paxillin induced by bombesin and endothelin

1994 • 138 citations

Effect of cell spreading on cytoplasmic pH in normal and transformed fibroblasts.

1989 • 131 citations

Intracellular pH regulation during spreading of human neutrophils.

1996 • 128 citations

Requirement for Rho in Integrin Signalling

1997 • 127 citations

Tumorigenic 3T3 cells maintain an alkaline intracellular pH under physiological conditions.

1990 • 119 citations

Modulation of Band 3-Ankyrin Interaction by Protein 4.1

1996 • 84 citations

Shrinkage-induced activation of Na+/H+ exchange in primary rat astrocytes: role of myosin light-chain kinase

1995 • 82 citations

Gα12 Differentially Regulates Na+-H+ Exchanger Isoforms

1996 • 81 citations

Transformation by Rho exchange factor oncogenes is mediated by activation of an integrin-dependent pathway.

1996 • 79 citations

Activation of Na+-H+ Exchange Is Necessary for RhoA-induced Stress Fiber Formation

1996 • 68 citations

[22] Preparation of native and recombinant Clostridium botulinum C3 ADP-ribosyltransferase and identification of Rho proteins by ADP-ribosylation

1995 • 57 citations

Monoclonal antibodies to distinctive epitopes on the α and β subunits of the fibronectin receptor

1988 • 54 citations

Na⁺/H⁺ antiporter gene expression increases during retinoic acid‐induced granulocytic differentiation of HL60 cells

1992 • 52 citations

Serum regulates Na+/H+ exchange in Caco-2 cells by a mechanism which is dependent on F-actin.

1992 • 48 citations

Contact-dependent regulation of vinculin expression in cultured fibroblasts: a study with vinculin-specific cDNA probes.

1987 • 46 citations

Mapping of Ankyrin Binding Determinants on the Erythroid Anion Exchanger, AE1

1996 • 33 citations

Mechanism of Control of Erythrocyte Shape: A Possible Relationship to Band 3

1994 • 23 citations

Differences in Turnover Rates of Vinculin and Talin Caused by Viral Transformation and Cell Density

1996 • 8 citations

Modulation of Band 3-Ankyrin interaction by protein 4.1 : functional implications in regulation of erythrocyte membrane mechanical properties

1997 • 8 citations