The essential role of profilin in the assembly of actin for microspike formation

Calcium's Role in Mechanotransduction during Muscle Development

2014 • 14,293 citations

Rho GTPases and the Actin Cytoskeleton

1998 • 6,129 citations

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

Cell Migration: A Physically Integrated Molecular Process

1996 • 3,909 citations

Regulation of Myosin Phosphatase by Rho and Rho-Associated Kinase (Rho-Kinase)

1996 • 2,843 citations

Phosphorylation and Activation of Myosin by Rho-associated Kinase (Rho-kinase)

1996 • 1,964 citations

Actin-Based Cell Motility and Cell Locomotion

1996 • 1,536 citations

A brain serine/threonine protein kinase activated by Cdc42 and Rac1

1994 • 1,520 citations

Formation of Actin Stress Fibers and Focal Adhesions Enhanced by Rho-Kinase

1997 • 1,085 citations

Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho.

1996 • 1,045 citations

The Ras-Related Protein Cdc42Hs and Bradykinin Promote Formation of Peripheral Actin Microspikes and Filopodia in Swiss 3T3 Fibroblasts

1995 • 1,033 citations

Structural basis for the binding of proline-rich peptides to SH3 domains

1994 • 1,016 citations

The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase.

1996 • 872 citations

The p160 RhoA-Binding Kinase ROKα Is a Member of a Kinase Family and Is Involved in the Reorganization of the Cytoskeleton

1996 • 866 citations

Specific interaction between phosphatidylinositol 4,5-bisphosphate and profilactin

1985 • 824 citations

p140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilin

1997 • 819 citations

Actin polymerizability is influenced by profilin, a low molecular weight protein in non-muscle cells

1977 • 673 citations

Mena, a Relative of VASP and Drosophila Enabled, Is Implicated in the Control of Microfilament Dynamics

1996 • 667 citations

N-WASP, a novel actin-depolymerizing protein, regulates the cortical cytoskeletal rearrangement in a PIP2-dependent manner downstream of tyrosine kinases.

1996 • 667 citations

Thrombin receptor ligation and activated rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets

1995 • 665 citations

The structure of crystalline profilin–β-actin

1993 • 662 citations

Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP

1998 • 656 citations

A Conserved Binding Motif Defines Numerous Candidate Target Proteins for Both Cdc42 and Rac GTPases

1995 • 625 citations

Rho Family GTPases and Neuronal Growth Cone Remodelling: Relationship between Increased Complexity Induced by Cdc42Hs, Rac1, and Acetylcholine and Collapse Induced by RhoA and Lysophosphatidic Acid

1997 • 601 citations

Actin polymerization is induced by Arp 2/3 protein complex at the surface of Listeria monocytogenes

1997 • 598 citations

How profilin promotes actin filament assembly in the presence of thymosin β4

1993 • 532 citations

Purification of a cortical complex containing two unconventional actins from Acanthamoeba by affinity chromatography on profilin-agarose.

1994 • 484 citations

The proline-rich focal adhesion and microfilament protein VASP is a ligand for profilins.

1995 • 479 citations

Identification of a Putative Target for Rho as the Serine-Threonine Kinase Protein Kinase N

1996 • 417 citations

Protein Kinase N (PKN) and PKN-Related Protein Rhophilin as Targets of Small GTPase Rho

1996 • 384 citations

Role of Actin Polymerization and Adhesion to Extracellular Matrix in Rac- and Rho-induced Cytoskeletal Reorganization

1997 • 378 citations

In mouse brain profilin I and profilin II associate with regulators of the endocytic pathway and actin assembly

1998 • 353 citations

Control of cAMP-regulated enhancers by the viral transactivator Tax through CREB and the co-activator CBP

1996 • 344 citations

A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42

1993 • 319 citations

Signal transduction and actin filament organization

1996 • 309 citations

Rho- and Rac-dependent Assembly of Focal Adhesion Complexes and Actin Filaments in Permeabilized Fibroblasts: An Essential Role for Ezrin/Radixin/Moesin Proteins

1997 • 303 citations

Involvement of profilin in the actin-based motility of L. monocytogenes in cells and in cell-free extracts

1994 • 282 citations

Myotonic Dystrophy Kinase-Related Cdc42-Binding Kinase Acts as a Cdc42 Effector in Promoting Cytoskeletal Reorganization

1998 • 269 citations

Gelsolin is a downstream effector of rac for fibroblast motility

1998 • 267 citations

The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3

1998 • 266 citations

Calcineurin functions in Ca(2+)-activated cell death in mammalian cells.

1995 • 260 citations

Components of a stat recognition code: Evidence for two layers of molecular selectivity

1995 • 254 citations

Specific interactions outside the proline-rich core of two classes of Src homology 3 ligands.

1995 • 240 citations

Mechanism of the interaction of human platelet profilin with actin.

1991 • 235 citations

[1] Purification of recombinant Rho/Rac/G25K from Escherichia coli

1995 • 190 citations

Phage display selection of ligand residues important for Src homology 3 domain binding specificity.

1995 • 187 citations

The three faces of profilin

1993 • 179 citations

Poly(<scp>l</scp>‐proline)‐binding proteins from chick embryos are a profilin and a profilactin

1985 • 176 citations

Interactions of Drebrin and Gephyrin with Profilin

1998 • 145 citations

The mammalian profilin isoforms display complementary affinities for PIP2 and proline-rich sequences

1997 • 142 citations

Direct Binding of the Verprolin-Homology Domain in N-WASP to Actin Is Essential for Cytoskeletal Reorganization

1998 • 141 citations

Association of Ash/Grb-2 with dynamin through the Src homology 3 domain.

1994 • 125 citations

Dynamic actin structures stabilized byprofilin.

1994 • 122 citations

[1] Equilibrium and kinetic inhibition assays based upon fluorescence polarization

1981 • 87 citations

Cloning and expression of a novel human profilin variant, profilin II

1993 • 80 citations

ABM-1 and ABM-2 Homology Sequences: Consensus Docking Sites for Actin-Based Motility Defined by Oligoproline Regions in Listeria ActA Surface Protein and Human VASP

1997 • 57 citations

Identification of N-WASP homologs in human and rat brain

1997 • 53 citations

[9] Polyproline affinity method for purification of platelet profilin and modification with pyrene-maleimide

1991 • 39 citations

Interaction of Ash/Grb-2 via its SH3 domains with neuron-specific p150 and p65

1996 • 18 citations