Involvement of Wiskott-Aldrich Syndrome Protein in B-Cell Cytoplasmic Tyrosine Kinase Pathway

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1995 • 2,534 citations

Production of high-titer helper-free retroviruses by transient transfection.

1993 • 2,280 citations

The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification ¹

1995 • 2,199 citations

pEF-BOS, a powerful mammalian expression vector

1990 • 1,641 citations

The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases

1993 • 1,438 citations

Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia

1993 • 1,338 citations

Isolation of a novel gene mutated in Wiskott-Aldrich syndrome

1994 • 1,053 citations

Structural basis for the binding of proline-rich peptides to SH3 domains

1994 • 1,016 citations

Catalytic specificity of protein-tyrosine kinases is critical for selective signalling

1995 • 929 citations

Wiskott–Aldrich Syndrome Protein, a Novel Effector for the GTPase CDC42Hs, Is Implicated in Actin Polymerization

1996 • 873 citations

Mutation of Unique Region of Bruton's Tyrosine Kinase in Immunodeficient XID Mice

1993 • 868 citations

Mechanism of Inhibition of Protein-tyrosine Phosphatases by Vanadate and Pervanadate

1997 • 811 citations

Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP

1998 • 656 citations

Colocalization of X-Linked Agammaglobulinemia and X-Linked Immunodeficiency Genes

1993 • 631 citations

Rac and Cdc42 Induce Actin Polymerization and G1 Cell Cycle Progression Independently of p65PAK and the JNK/SAPK MAP Kinase Cascade

1996 • 571 citations

PEDIGREE DEMONSTRATING A SEX-LINKED RECESSIVE CONDITION CHARACTERIZED BY DRAINING EARS, ECZEMATOID DERMATITIS AND BLOODY DIARRHEA

1954 • 512 citations

A role for Bruton's tyrosine kinase in B cell antigen receptor-mediated activation of phospholipase C-gamma 2.

1996 • 494 citations

Activation of BTK by a Phosphorylation Mechanism Initiated by SRC Family Kinases

1996 • 445 citations

An EBV-Genome-Negative Cell Line Established from an American Burkitt Lymphoma; Receptor Characteristics. EBV Infectibility and Permanent Conversion into EBV-Positive Sublines by <i>in vitro</i> Infection

1975 • 434 citations

Crystal Structure of the Conserved Core of HIV-1 Nef Complexed with a Src Family SH3 Domain

1996 • 433 citations

Btk/Tec kinases regulate sustained increases in intracellular Ca2+ following B-cell receptor activation

1998 • 410 citations

Solution Structure of the SH3 Domain of Src and Identification of Its Ligand-Binding Site

1992 • 334 citations

The Wiskott-Aldrich syndrome: studies of lymphocytes, granulocytes, and platelets

1980 • 327 citations

The pleckstrin homology domain of Bruton tyrosine kinase interacts with protein kinase C.

1994 • 322 citations

Regulation of Btk Function by a Major Autophosphorylation Site Within the SH3 Domain

1996 • 321 citations

Pervanadate [peroxide(s) of vanadate] mimics insulin action in rat adipocytes via activation of the insulin receptor tyrosine kinase

1989 • 317 citations

Wiskott-Aldrich Syndrome Protein Physically Associates with Nck through Src Homology 3 Domains

1995 • 315 citations

Stimulatory effects of the protein tyrosine phosphatase inhibitor, pervanadate, on T-cell activation events.

1993 • 312 citations

Characterization of a leukemic cell line of the pre‐B phenotype

1979 • 257 citations

Wiskott-Aldrich Syndrome/X-Linked Thrombocytopenia: WASP Gene Mutations, Protein Expression, and Phenotype

1997 • 252 citations

Temporal differences in the activation of three classes of non-transmembrane protein tyrosine kinases following B-cell antigen receptor surface engagement.

1994 • 250 citations

Binding of beta gamma subunits of heterotrimeric G proteins to the PH domain of Bruton tyrosine kinase.

1994 • 240 citations

Direct interaction of the Wiskott-Aldrich syndrome protein with the GTPase Cdc42.

1996 • 229 citations

Tyrosine phosphorylation and activation of Bruton tyrosine kinase upon Fc epsilon RI cross-linking.

1994 • 221 citations

The Wiskott-Aldrich syndrome and X-linked congenital thrombocytopenia are caused by mutations of the same gene

1995 • 211 citations

THE WISKOTT-ALDRICH SYNDROME A DISORDER WITH A POSSIBLE DEFECT IN ANTIGEN PROCESSING OR RECOGNITION

1968 • 197 citations

Bruton tyrosine kinase is tyrosine phosphorylated and activated in pre-B lymphocytes and receptor-ligated B cells.

1994 • 196 citations

Identification of Itk/Tsk Src Homology 3 Domain Ligands

1996 • 193 citations

B-cell antigen receptor stimulation activates the human Bruton's tyrosine kinase, which is deficient in X-linked agammaglobulinemia.

1994 • 187 citations

Evidence for a preformed transducer complex organized by the B cell antigen receptor.

1996 • 186 citations

BAP-135, a target for Bruton’s tyrosine kinase in response to B cell receptor engagement

1997 • 182 citations

IL-5 receptor-mediated tyrosine phosphorylation of SH2/SH3-containing proteins and activation of Bruton's tyrosine and Janus 2 kinases.

1994 • 178 citations

Deficient Expression of Bruton's Tyrosine Kinase in Monocytes From X-Linked Agammaglobulinemia as Evaluated by a Flow Cytometric Analysis and Its Clinical Application to Carrier Detection

1998 • 172 citations

Binding of Bruton's tyrosine kinase to Fyn, Lyn, or Hck through a Src homology 3 domain-mediated interaction.

1994 • 172 citations

Wiskott–Aldrich syndrome protein (WASp) is a binding partner for c-Src family protein-tyrosine kinases

1996 • 154 citations

Src Family Protein Tyrosine Kinases Induce Autoactivation of Bruton's Tyrosine Kinase

1995 • 151 citations

Catalytic Specificity of Phosphotyrosine Kinases Blk, Lyn, c-Src and Syk as Assessed by Phage Display

1996 • 139 citations

Tyrosine Phosphorylation Regulates the SH3-mediated Binding of the Wiskott-Aldrich Syndrome Protein to PSTPIP, a Cytoskeletal-associated Protein

1998 • 137 citations

Nonrandom inactivation of the X chromosome in early lineage hematopoietic cells in carriers of Wiskott-Aldrich syndrome

1995 • 137 citations

The protein product of the c-cbl protooncogene is phosphorylated after B cell receptor stimulation and binds the SH3 domain of Bruton's tyrosine kinase.

1995 • 131 citations

Identification of Bruton's tyrosine kinase (Btk) gene mutations and characterization of the derived proteins in 35 X-linked agammaglobulinemia families: a nationwide study of Btk deficiency in Japan

1996 • 130 citations

Only site-directed antibodies reactive with the highly conserved src-homologous region of the v-abl protein neutralize kinase activity

1984 • 119 citations

GENETIC STUDIES BY RECORD LINKAGE

1965 • 114 citations

Role of Bruton's tyrosine kinase in immunodeficiency

1994 • 112 citations

Evidence that the Wiskott-Aldrich syndrome protein may be involved in lymphoid cell signaling pathways.

1996 • 109 citations

Evidence for defective transmembrane signaling in B cells from patients with Wiskott-Aldrich syndrome.

1992 • 91 citations

CD38 ligation induces tyrosine phosphorylation of Bruton tyrosine kinase and enhanced expression of interleukin 5-receptor alpha chain: synergistic effects with interleukin 5.

1995 • 86 citations

Wiskott-Aldrich syndrome: Clinical, immunologic, and pathologic observations

1967 • 76 citations

The SH3 Domain of Bruton's Tyrosine Kinase Interacts with Vav, Sam68 and EWS

1997 • 76 citations

Identification and Characterization of a Novel SH3-Domain Binding Protein, Sab, Which Preferentially Associates with Bruton's Tyrosine Kinase (Btk)

1998 • 64 citations

An SH3-binding Site Conserved in Bruton's Tyrosine Kinase and Related Tyrosine Kinases Mediates Specific Protein Interactions in Vitro and in Vivo

1995 • 55 citations

Tyrosine kinase signaling regulates Wiskott-Aldrich syndrome protein function, which is essential for megakaryocyte differentiation.

1997 • 51 citations

Chromosome Evolution of Near-Haploid Clones in an Established Human Acute Lymphoblastic Leukemia Cell Line (NALM-16)<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref><xref ref-type="fn" rid="FN4">4</xref>

1980 • 43 citations

Cross-linking of B cell antigen receptor-related structure of pre-B cell lines induces tyrosine phosphorylation of p85 and p110 subunits and activation of phosphatidylinositol 3-kinase

1996 • 30 citations

Expression Plasmid Vectors with Convenient Subcloning Sites in λgtll That Efficiently Produce Detectable Tagged Proteins

1997 • 8 citations