Interferons and interleukin-6 suppress the DNA-binding activity of E2F in growth-sensitive hematopoietic cells.

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product.

1985 • 2,456 citations

E2F: a Link Between the Rb Tumor Suppressor Protein and Viral Oncoproteins

1992 • 1,552 citations

The E2F transcription factor is a cellular target for the RB protein

1991 • 1,461 citations

Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product

1988 • 1,440 citations

Cyclin A is required at two points in the human cell cycle.

1992 • 1,380 citations

Monoclonal antibodies specific for simian virus 40 tumor antigens

1981 • 1,110 citations

Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties

1992 • 846 citations

The human c-myc oncogene: Structural consequences of translocation into the igh locus in Burkitt lymphoma

1983 • 732 citations

Retinoblastoma protein switches the E2F site from positive to negative element

1992 • 663 citations

A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F

1992 • 652 citations

The transcription factor E2F interacts with the retinoblastoma product and a p107-cyclin A complex in a cell cycle-regulated manner

1992 • 588 citations

The interaction of RB with E2F coincides with an inhibition of the transcriptional activity of E2F.

1992 • 587 citations

Identification of a cellular transcription factor involved in E1A trans-activation

1986 • 551 citations

Identification of cellular proteins that can interact specifically with the T/ElA-binding region of the retinoblastoma gene product

1991 • 541 citations

Differentiation of a cell line of myeloid leukemia

1969 • 520 citations

Cyclin E/cdk2 and cyclin A/cdk2 kinases associate with p107 and E2F in a temporally distinct manner.

1992 • 449 citations

The retinoblastoma protein copurifies with E2F-I, an E1A-regulated inhibitor of the transcription factor E2F

1991 • 446 citations

Adenovirus E1a prevents the retinoblastoma gene product from complexing with a cellular transcription factor

1991 • 435 citations

The T/E1A-binding domain of the retinoblastoma product can interact selectively with a sequence-specific DNA-binding protein

1991 • 420 citations

Transforming growth factor beta 1 suppression of c-myc gene transcription: role in inhibition of keratinocyte proliferation.

1990 • 397 citations

Independent binding of the retinoblastoma protein and p107 to the transcription factor E2F

1992 • 381 citations

Cell cycle regulation of the E2F transcription factor involves an interaction with cyclin A

1991 • 374 citations

A cyclin A-protein kinase complex possesses sequence-specific DNA binding activity: p33cdk2 is a component of the E2F-cyclin A complex

1992 • 361 citations

Close link between reduction of c-myc expression by interferon and G0/G1 arrest

1985 • 358 citations

Adenovirus E1A proteins can dissociate heteromeric complexes involving the E2F transcription factor: A novel mechanism for E1A trans-activation

1990 • 358 citations

Molecular cloning of cellular genes encoding retinoblastoma-associated proteins: identification of a gene with properties of the transcription factor E2F.

1992 • 331 citations

Amino-terminal domains of c-myc and N-myc proteins mediate binding to the retinoblastoma gene product

1991 • 326 citations

Cyclin A and the retinoblastoma gene product complex with a common transcription factor

1991 • 296 citations

A new component of the transcription factor DRTF1/E2F

1993 • 293 citations

Transcription Factor E2F Is Required for Efficient Expression of the Hamster Dihydrofolate Reductase Gene In Vitro and In Vivo

1989 • 292 citations

E1A-dependent trans-activation of the human MYC promoter is mediated by the E2F factor.

1989 • 283 citations

Nuclear factor E2F mediates basic transcription and trans-activation by E1a of the human MYC promoter.

1989 • 262 citations

A role for the adenovirus inducible E2F transcription factor in a proliferation dependent signal transduction pathway.

1990 • 253 citations

Transcriptional repression of the E2-containing promoters EIIaE, c-myc, and RB1 by the product of the RB1 gene.

1992 • 250 citations

Association of cdk2 Kinase with the Transcription Factor E2F During S Phase

1992 • 239 citations

Human DNA polymerase alpha gene: sequences controlling expression in cycling and serum-stimulated cells.

1991 • 231 citations

The retinoblastoma protein as a transcriptional repressor

1993 • 176 citations

Role of E2F transcription factor in E1A-mediated trans activation of cellular genes

1991 • 142 citations

Antibodies specific for the human retinoblastoma protein identify a family of related polypeptides.

1991 • 131 citations

Interferons and interleukin 6 suppress phosphorylation of the retinoblastoma protein in growth-sensitive hematopoietic cells.

1992 • 120 citations

Cellular factors that interact with the hepatitis B virus enhancer.

1989 • 108 citations

Phosphorylation-dependent activation of the adenovirus-inducible E2F transcription factor in a cell-free system.

1989 • 107 citations

The Adenovirus EIIA Enhancer

1989 • 100 citations

A closer look at E2F

1992 • 95 citations

Activation of the E2F transcription factor in adenovirus-infected cells involves E1A-dependent stimulation of DNA-binding activity and induction of cooperative binding mediated by an E4 gene product

1990 • 90 citations

Cytokine triggered molecular pathways that control cell cycle arrest

1992 • 89 citations

Multiple protein - DNA interactions in the TATAA-less mouse thymidylate synthase promoter

1991 • 77 citations

A transcriptional tryst

1991 • 69 citations

Retinoblastoma-repression of E2F-dependent transcription depends on the ability of the retinoblastoma protein to interact with E2F and is abrogated by the adenovirus E1A oncoprotein

1992 • 56 citations

Deregulated c-myc expression abrogates the interferon- and interleukin 6-mediated G0/G1 cell cycle arrest but not other inhibitory responses in M1 myeloblastic cells.

1991 • 38 citations

Identification of a 60-Kilodalton Rb-Binding Protein, RBP60, That Allows the Rb-E2F Complex To Bind DNA

1992 • 27 citations

The involvement of protein kinase C in mediating growth suppressive signals of interferons in hematopoietic cells.

1991 • 23 citations

Recessive Genetic Deregulation Abrogates c-myc Suppression by Interferon and Is Implicated in Oncogenesis

1988 • 21 citations

Trans-activation of human MYC: the second promoter is target for the stimulation by adenovirus E1a proteins.

1989 • 20 citations

Two different protein-protein interactions in oligomeric complexes of SV40 large T antigen with the cellular oncoprotein p53.

1989 • 10 citations

Interleukin 6 induces DNA binding activity of AP1 in M1 myeloblastic cells but not in a growth resistant cell derivative.

1993 • 6 citations