Two cis-DNA elements involved in myeloid-cell-specific expression and gamma interferon (IFN-gamma) activation of the human high-affinity Fc gamma receptor gene: a novel IFN regulatory mechanism.

Experiments in molecular genetics

1972 • 28,260 citations

High-efficiency transformation of mammalian cells by plasmid DNA.

1987 • 5,377 citations

Expression of a single transfected cDNA converts fibroblasts to myoblasts

1987 • 3,373 citations

INTERFERONS AND THEIR ACTIONS

1987 • 1,838 citations

Myogenin, a factor regulating myogenesis, has a domain homologous to MyoD

1989 • 1,286 citations

The macrophage and B cell-specific transcription factor PU.1 is related to the ets oncogene

1990 • 993 citations

Cloning of cDNA for the major DNA-binding protein of the erythroid lineage through expression in mammalian cells

1989 • 931 citations

Interferon-Dependent Tyrosine Phosphorylation of a Latent Cytoplasmic Transcription Factor

1992 • 906 citations

Homeo Boxes in the Study of Development

1987 • 905 citations

A protein tyrosine kinase in the interferon αβ signaling pathway

1992 • 876 citations

MyoD1: A Nuclear Phosphoprotein Requiring a Myc Homology Region to Convert Fibroblasts to Myoblasts

1988 • 839 citations

High-Efficiency Transformation of Mammalian Cells by Plasmid DNA

1987 • 729 citations

Interferon-induced nuclear factors that bind a shared promoter element correlate with positive and negative transcriptional control.

1988 • 583 citations

Gamma interferon enhances macrophage transcription of the tumor necrosis factor/cachectin, interleukin 1, and urokinase genes, which are controlled by short-lived repressors.

1986 • 532 citations

A cloned octamer transcription factor stimulates transcription from lymphoid–specific promoters in non–B cells

1988 • 494 citations

Cytoplasmic activation of ISGF3, the positive regulator of interferon-alpha-stimulated transcription, reconstituted in vitro.

1989 • 484 citations

ISGF3, the transcriptional activator induced by interferon alpha, consists of multiple interacting polypeptide chains.

1990 • 475 citations

Induction of a novel epidermal growth factor-secreting cell lineage by mucosal ulceration in human gastrointestinal stem cells

1990 • 465 citations

An octamer oligonucleotide upstream of a TATA motif is sufficient for lymphoid-specific promoter activity

1987 • 398 citations

Induction of sequence-specific binding of Drosophila heat shock activator protein without protein synthesis

1987 • 382 citations

Cytoplasmic activation of GAF, an IFN-gamma-regulated DNA-binding factor.

1991 • 378 citations

Use of a selectable marker regulated by alpha interferon to obtain mutations in the signaling pathway.

1989 • 373 citations

An interferon gamma-regulated protein that binds the interferon-inducible enhancer element of major histocompatibility complex class I genes.

1990 • 368 citations

Interferon-alpha regulates nuclear translocation and DNA-binding affinity of ISGF3, a multimeric transcriptional activator.

1990 • 321 citations

Interferon-activated genes

1986 • 301 citations

Interferon response element of the human gene 6-16.

1988 • 292 citations

Regulation of human interleukin-2 gene: Functional DNA sequences in the 5′ flanking region for the gene expression in activated T lymphocytes

1986 • 288 citations

Overlapping elements in the guanylate-binding protein gene promoter mediate transcriptional induction by alpha and gamma interferons.

1991 • 278 citations

CCAAT displacement protein as a repressor of the myelomonocytic-specific gp91-phox gene promoter.

1991 • 274 citations

High-frequency mutagenesis of human cells and characterization of a mutant unresponsive to both alpha and gamma interferons.

1991 • 269 citations

A single DNA response element can confer inducibility by both alpha- and gamma-interferons.

1989 • 262 citations

Isolation and Expression of Functional High-Affinity Fc Receptor Complementary DNAs

1989 • 257 citations

Myogenic lineage determination and differentiation: Evidence for a regulatory gene pathway

1988 • 253 citations

Interferon response sequence potentiates activity of an enhancer in the promoter region of a mouse H–2 gene

1986 • 252 citations

A unique set of polypeptides is induced by γ interferon in addition to those induced in common with α and β interferons

1983 • 234 citations

Synergistic interaction between interferon-alpha and interferon-gamma through induced synthesis of one subunit of the transcription factor ISGF3.

1990 • 220 citations

Rapid activation by interferon alpha of a latent DNA-binding protein present in the cytoplasm of untreated cells.

1989 • 218 citations

Conserved major histocompatibility complex class II boxes--X and Y--are transcriptional control elements and specifically bind nuclear proteins.

1987 • 212 citations

Structure of two forms of the interferon-induced (2′-5′) oligo A synthetase of human cells based on cDNAs and gene sequences.

1985 • 201 citations

Enhancer-like interferon responsive sequences of the human and murine (2′-5′) oligoadenylate synthetase gene promoters.

1988 • 188 citations

Interferon-stimulated transcription: isolation of an inducible gene and identification of its regulatory region.

1986 • 185 citations

Characterization of the promoter of the human gene encoding the high-affinity IgG receptor: transcriptional induction by gamma-interferon is mediated through common DNA response elements.

1991 • 178 citations

Structure and evolution of a human erythroid transcription factor

1990 • 160 citations

Regulation of a transfected human class II major histocompatibility complex gene in human fibroblasts.

1986 • 159 citations

Interactions of alpha- and gamma-interferon in the transcriptional regulation of the gene encoding a guanylate-binding protein.

1989 • 159 citations

Comparative effects of various classes of mouse interferons on macrophage activation for tumor cell killing.

1985 • 151 citations

Isolation and characterization of a new mutant human cell line unresponsive to alpha and beta interferons.

1991 • 147 citations

Structure of the human neutrophil elastase gene.

1988 • 142 citations

Function and regulation of a murine macrophage-specific IgG Fc receptor, Fc gamma R-alpha.

1988 • 138 citations

Interferon-responsive regulatory elements in the promoter of the human 2',5'-oligo(A) synthetase gene.

1987 • 137 citations

Genomic characterization of a gamma-interferon-inducible gene (IP-10) and identification of an interferon-inducible hypersensitive site.

1987 • 137 citations

Gene induction by interferons and double-stranded RNA: selective inhibition by 2-aminopurine.

1988 • 126 citations

Genomic Organization and Chromosomal Localization of the Human Cathepsin G Gene

1989 • 126 citations

Purification of Growth Hormone-Specific Transcription Factor GHF-1 Containing Homeobox

1989 • 121 citations

B-cell-specific and interferon-gamma-inducible regulation of the HLA-DR alpha gene.

1988 • 118 citations

A gamma-interferon-induced factor that binds the interferon response sequence of the MHC class I gene, H-2Kb.

1989 • 113 citations

A purine-rich DNA sequence motif present in SV40 and lymphotropic papovavirus binds a lymphoid-specific factor and contributes to enhancer activity in lymphoid cells.

1987 • 110 citations

Use of a Selectable Marker Regulated by Alpha Interferon To Obtain Mutations in the Signaling Pathway

1989 • 106 citations

Transcriptional activation of HLA-DR alpha by interferon gamma requires a trans-acting protein.

1988 • 105 citations

Interferons increase transcription of a major histocompatibility class I gene via a 5' interferon consensus sequence.

1987 • 105 citations

Detailed delineation of an interferon-gamma-responsive element important in human HLA-DRA gene expression in a glioblastoma multiform line.

1988 • 101 citations

Interferons And Their Actions

1987 • 91 citations

Interferon gamma response region in the promoter of the human DPA gene.

1990 • 86 citations

5' regulatory region of a novel cytokine gene mediates selective activation by interferon gamma.

1991 • 85 citations

A Collection of mRNA Species That Are Inducible in the RAW 264.7 Mouse Macrophage Cell Line by Gamma Interferon and Other Agents

1992 • 82 citations

Characterization of the myeloid-specific CD11b promoter

1992 • 81 citations

Characterization of the myeloid-specific CD11b promoter

1992 • 78 citations

Coordinate induction of Ia alpha, beta, and Ii mRNA in a macrophage cell line.

1985 • 69 citations

Gene organization of the human high affinity receptor for IgG, Fc gamma RI (CD64). Characterization and evidence for a second gene

1991 • 61 citations

Multiple regulatory regions on the 5' side of the mouse E alpha gene.

1988 • 55 citations

A collection of mRNA species that are inducible in the RAW 264.7 mouse macrophage cell line by gamma interferon and other agents.

1992 • 48 citations

NF-X, a transcription factor implicated in MHC class II gene regulation.

1991 • 45 citations

Gene Induction by Interferons and Double-Stranded RNA: Selective Inhibition by 2-Aminopurine

1988 • 41 citations

Regulation of HLA class II molecule expressions by IFN-gamma. The signal transduction mechanism in glioblastoma cell lines.

1990 • 35 citations

Characterization of human and mouse c-fes cDNA clones and identification of the 5' end of the gene.

1990 • 34 citations

Overlapping Elements in the Guanylate-Binding Protein Gene Promoter Mediate Transcriptional Induction by Alpha and Gamma Interferons

1991 • 33 citations

Interferon-gamma-inducible regulation of the human invariant chain gene

1991 • 32 citations

Definition of interferon gamma-response elements in a novel human Fc gamma receptor gene (Fc gamma RIb) and characterization of the gene structure.

1992 • 32 citations

Cycloheximide, an inhibitor of protein synthesis, prevents ?-interferon-induced expression of class II mRNA in a macrophage cell line

1988 • 26 citations

Isolation and Characterization of a New Mutant Human Cell Line Unresponsive to Alpha and Beta Interferons

1991 • 22 citations

Synergistic Effect of Interferon-γ and Tumor Necrosis Factor-α on Antiviral Activity and (2′–5′) Oligo (A) Synthetase Induction in a Myelomonocytic Cell Line

1990 • 19 citations

Interferon-Responsive Regulatory Elements in the Promoter of the Human 2′,5′-Oligo(A) Synthetase Gene

1987 • 19 citations

Synergism of type I and type II Interferons in stimulating the activity of the same DNA enhancer

1990 • 15 citations

A matched set of cat vectors for rapid mutational analysis of eukaryotic promoters and enhancers

1991 • 15 citations

Interferons Increase Transcription of a Major Histocompatibility Class I Gene Via a 5′ Interferon Consensus Sequence

1987 • 15 citations

REGULATION OF HLA CLASS II MOLECULE EXPRESSION BY INTERFERON-γ: THE SIGNAL TRANSDUCTION MECHANISM IN GLIOBLASTOMA CELL LINES.

1990 • 1 citations