Interferon augments PML and PML/RAR alpha expression in normal myeloid and acute promyelocytic cells and cooperates with all-trans retinoic acid to induce maturation of a retinoid-resistant promyelocytic cell line

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

Proposals for the Classification of the Acute Leukaemias F<scp>rench</scp>‐A<scp>merican</scp>‐B<scp>ritish</scp> (FAB) C<scp>o‐operative</scp> G<scp>roup</scp>

1976 • 5,620 citations

Rapid colorimetric assay for cell growth and survival

1986 • 4,672 citations

Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia

1988 • 2,380 citations

Number and evolutionary conservation of α- and β-tubulin and cytoplasmic β- and γ-actin genes using specific cloned cDNA probes

1980 • 1,884 citations

Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RARα with a novel putative transcription factor, PML

1991 • 1,463 citations

The PML-RARα fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR

1991 • 1,371 citations

The t(15;17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor α gene to a novel transcribed locus

1990 • 1,349 citations

Differentiation Therapy of Acute Promyelocytic Leukemia with Tretinoin (All-trans-Retinoic Acid)

1991 • 1,298 citations

All-trans retinoic acid as a differentiation therapy for acute promyelocytic leukemia. I. Clinical results [see comments]

1990 • 1,224 citations

NB4, a maturation inducible cell line with t(15;17) marker isolated from a human acute promyelocytic leukemia (M3)

1991 • 884 citations

Molecular Analysis of Acute Promyelocytic Leukemia Breakpoint Cluster Region on Chromosome 17

1990 • 650 citations

The acute promyelocytic leukemia-specific PML-RARα fusion protein inhibits differentiation and promotes survival of myeloid precursor cells

1993 • 602 citations

Acute promyelocytic leukemia: from genetics to treatment

1994 • 474 citations

All-trans retinoic acid in acute promyelocytic leukemias. II. In vitro studies: structure-function relationship

1990 • 390 citations

HSV-1 IE protein Vmw110 causes redistribution of PML.

1994 • 354 citations

Clinical and molecular characterization of a rare syndrome of acute promyelocytic leukemia associated with translocation (11;17)

1995 • 352 citations

The solution structure of the RING finger domain from the acute promyelocytic leukaemia proto-oncoprotein PML.

1995 • 324 citations

PMLRAR homodimers: distinct DNA binding properties and heteromeric interactions with RXR.

1993 • 307 citations

PML, a growth suppressor disrupted in acute promyelocytic leukemia.

1994 • 296 citations

Structure and origin of the acute promyelocytic leukemia myl/RAR alpha cDNA and characterization of its retinoid-binding and transactivation properties.

1991 • 291 citations

The nuclear location of PML, a cellular member of the C3HC4 zinc-binding domain protein family, is rearranged during herpes simplex virus infection by the C3HC4 viral protein ICP0

1994 • 281 citations

Genomic variability and alternative splicing generate multiple PML/RAR alpha transcripts that encode aberrant PML proteins and PML/RAR alpha isoforms in acute promyelocytic leukaemia.

1992 • 277 citations

Transcriptional induction of the PML growth suppressor gene by interferons is mediated through an ISRE and a GAS element.

1995 • 268 citations

Translocation breakpoint of acute promyelocytic leukemia lies within the retinoic acid receptor alpha locus.

1991 • 253 citations

The PML growth-suppressor has an altered expression in human oncogenesis.

1995 • 241 citations

All-transretinoic acid followed by intensive chemotherapy gives a high complete remission rate and may prolong remissions in newly diagnosed acute promyelocytic leukemia: a pilot study on 26 cases

1992 • 240 citations

PML protein expression in hematopoietic and acute promyelocytic leukemia cells

1993 • 237 citations

The acute promyelocytic leukaemia-associated PML gene is induced by interferon.

1995 • 228 citations

Induction of the PML protein by interferons in normal and APL cells.

1995 • 216 citations

Rearrangements and aberrant expression of the retinoic acid receptor alpha gene in acute promyelocytic leukemias.

1990 • 212 citations

Alternative splicing of PML transcripts predicts coexpression of several carboxy-terminally different protein isoforms.

1992 • 162 citations

Expression pattern of the RAR alpha-PML fusion gene in acute promyelocytic leukemia.

1992 • 149 citations

The PML gene encodes a phosphoprotein associated with the nuclear matrix

1995 • 136 citations

Occurrence of resistance to retinoic acid in the acute promyelocytic leukemia cell line NB4 is associated with altered expression of the pml/RAR alpha protein

1993 • 111 citations

Interferon-gamma activates human neutrophil oxygen metabolism and exocytosis.

1988 • 106 citations

Characterization of a new monoclonal antibody (PG-M3) directed against the aminoterminal portion of the PML gene product: immunocytochemical evidence for high expression of PML proteins on activated macrophages, endothelial cells, and epithelia

1995 • 106 citations

Combinations of recombinant human interferons and retinoic acid synergistically induce differentiation of the human promyelocytic leukemia cell line HL-60

1987 • 100 citations

PML suppresses oncogenic transformation of NIH/3T3 cells by activated neu.

1995 • 97 citations

The Family of Retinoic Acid Nuclear Receptors

2015 • 85 citations

Acute promyelocytic leukemia

1979 • 75 citations

Activation by gamma interferon of human macrophage capability to produce toxic oxygen molecules is accompanied by decreased km of the superoxide-generating NADPH oxidase

1985 • 68 citations

Retinoic acid cooperates with tumor necrosis factor and immune interferon in inducing differentiation and growth inhibition of the human promyelocytic leukemic cell line HL-60

1987 • 51 citations

TRANSLOCATION OF THE RARα LOCUS TO THE PML OR PLZF GENE IN ACUTE PROMYELOCYTIC LEUKAEMIA

1994 • 39 citations

Growth suppression of acute promyelocytic leukemia cells having increased expression of the non-rearranged alleles: RAR alpha or PML.

1995 • 36 citations

Recombinant human interferon alpha enhancement of retinoic-acid-induced differentiation of HL-60 cells.

1987 • 21 citations

Synergistic anticellular effect of a combination of beta-interferon and retinoic acid against U937 cells.

1985 • 20 citations