69‐kDa and 100‐kDa Isoforms of Interferon‐Induced (2′‐5′)Oligoadenylate Synthetase Exhibit Differential Catalytic Parameters

Biochemistry of Interferons and Their Actions

1982 • 868 citations

pppA2'p5'A2'p5'A: an inhibitor of protein synthesis synthesized with an enzyme fraction from interferon-treated cells.

1978 • 787 citations

Antiviral actions of interferon interferon-regulated cellular proteins and their surprisingly selective antiviral activities

1991 • 600 citations

Expression cloning of 2-5A-dependent RNAase: A uniquely regulated mediator of interferon action

1993 • 509 citations

Inhibition of cell-free protein synthesis by pppA2′ p5′ A2′ p5′ A: a novel oligonucleotide synthesized by interferon-treated L cell extracts

1978 • 435 citations

Synthesis of low molecular weight inhibitor of protein synthesis with enzyme from interferon-treated cells

1977 • 367 citations

Constitutive expression of (2′–5′) oligo A synthetase confers resistance to picornavirus infection

1987 • 277 citations

A dominant negative mutant of 2-5A-dependent RNase suppresses antiproliferative and antiviral effects of interferon.

1993 • 273 citations

2-5A synthetase: assay, distribution and variation with growth or hormone status

1979 • 260 citations

Natural occurrence of 2-5A in interferon-treated EMC virus-infected L cells

1979 • 245 citations

Four different forms of interferon-induced 2',5'-oligo(A) synthetase identified by immunoblotting in human cells.

1987 • 229 citations

Structure of two forms of the interferon-induced (2′-5′) oligo A synthetase of human cells based on cDNAs and gene sequences.

1985 • 201 citations

Nature of inhibitor of cell-free protein synthesis formed in response to interferon and double-stranded RNA

1977 • 198 citations

An interferon-induced phosphodiesterase degrading (2'-5') oligoisoadenylate and the C-C-A terminus of tRNA.

1979 • 183 citations

Inhibition of protein synthesis by 2′–5′ linked adenine oligonucleotides in intact cells

1978 • 182 citations

Interferon-Induced and Double-Stranded RNA-Activated Enzymes: A Specific Protein Kinase and 2′,5′-Oligoadenylate Synthetases

1991 • 170 citations

Anticellular and antiviral effects of pppA(2′p5′A)n

1980 • 164 citations

Intrinsic molecular activities of the interferon-induced 2-5A-dependent RNase.

1994 • 156 citations

Increased nuclease activity in cells treated with pppA2'p5'A2'p5' A.

1979 • 155 citations

Activation of interferon-regulated, dsRNA-dependent enzymes by human immunodeficiency virus-1 leader RNA

1989 • 135 citations

Constitutive Expression of a 2′,5′-Oligoadenylate Synthetase cDNA Results in Increased Antiviral Activity and Growth Suppression

1989 • 133 citations

Anti‐mitogenic Function of Interferon‐Induced (2′‐5′)Oligo(adenylate) and Growth‐Related Variations in Enzymes that Synthesize and Degrade This Oligonucleotide

1981 • 122 citations

Identification of 69-kd and 100-kd forms of 2-5A synthetase in interferon-treated human cells by specific monoclonal antibodies.

1987 • 112 citations

Human 2-5A synthetase: characterization of a novel cDNA and corresponding gene structure.

1985 • 98 citations

A full-length murine 2-5A synthetase cDNA transfected in NIH-3T3 cells impairs EMCV but not VSV replication

1990 • 96 citations

The 69-kDa 2-5A synthetase is composed of two homologous and adjacent functional domains.

1992 • 95 citations

Interferon, double-stranded RNA, and RNA degradation. Isolation of homogeneous pppA(2'p5'A)n-1 synthetase from Ehrlich ascites tumor cells.

1980 • 86 citations

Differential expression and distinct structure of 69- and 100-kDa forms of 2-5A synthetase in human cells treated with interferon.

1990 • 79 citations

Regulation of ppp(A2'p)nA-dependent RNase levels during interferon treatment and cell differentiation

1985 • 79 citations

3′ End structure of the human (2′–5′) oligo A synthetase gene: prediction of two distinct proteins with cell type-specific expression

1985 • 77 citations

Inhibition of protein synthesis in reovirus-infected HeLa cells with elevated levels of interferon-induced protein kinase activity.

1982 • 76 citations

Characterization of 69- and 100-kDa forms of 2-5A-synthetase from interferon-treated human cells.

1988 • 73 citations

Antimitogenic effects of interferon and (2′–5′)‐oligoadenylate in synchronized 3T3 fibroblasts

1981 • 70 citations

Elongation mechanism and substrate specificity of 2',5'-oligoadenylate synthetase.

1980 • 69 citations

Synthesis of (2'-5')(A)n from ATP. Characteristics of the reaction catalyzed by (2'-5')(A)n synthetase purified from mouse Ehrlich ascites tumor cells treated with interferon.

1980 • 64 citations

Interferons, double-stranded RNA, and RNA degradation. Isolation and characterization of homogeneous human (2'-5')(a)n synthetase.

1981 • 54 citations

Synthesis, Characterisation and Biological Significance of (2′‐5′)Oiigoadenylate Derivatives of NAD⁺, ADP‐Ribose and Adenosine(5′)Tetraphosph0(5′)Adenosine

1982 • 53 citations

p67K kinase in different tissues and plasma of control and interferon-treated mice

1982 • 52 citations

Modified subcellular localization of interferon-induced p68 kinase during encephalomyocarditis virus infection

1990 • 43 citations

The 2-5A System: A Personal View

1987 • 42 citations

Possible involvement of (2'5')oligoadenylate synthetase activity in pre-mRNA splicing.

1991 • 40 citations

Isoforms p69 and p100 of 2′,5′-Oligoadenylate Synthetase Induced Differentially by InterferonsIn VivoandIn Vitro

1993 • 39 citations

Immunological evidence for the in vivo occurrence of (2'-5')adenylyladenosine oligonucleotides in eukaryotes and prokaryotes.

1984 • 37 citations

Assay and the levels of 2-5A-synthetase in lymphocytes of patients with viral, bacterial and autoimmune diseases

1983 • 32 citations

Preparation and characterization of polyclonal antibodies specific for the 69 and 100 K-dalton forms of human 2–5A synthetase

1989 • 27 citations

2′,5′-01igoadenylates Inhibit Relaxation of Supercoiled DNA by Calf Thymus DNA Topoisomerase I

1991 • 25 citations

Induction of (2′–5′) oligoadenylate synthetase activity during granulocyte and monocyte differentiation

1985 • 21 citations

Polyclonal antibodies against RNase L. Subcellular localization of this enzyme in mouse cells.

1991 • 20 citations

Production of Two Human 2′,5′-Oligoadenylate Synthetase Enzymes inEscherichia coli

1989 • 20 citations

Fractionation and Characterization of 2',5'-O1igoadenylates by Polyaecrylamide Gel Electrophoresis: An Alternative Method for Assaying 2',5'-O1igoadenylate Synthetase

1991 • 19 citations

The Binding of the 69- and 100-kD Forms of 2′,5′-Oligoadenylate Synthetase to Different Polynucleotides

1990 • 18 citations

Comparison of the effects of rabies virus infection and of combined interferon and poly(I) · poly(C) treatment on the levels of 2′,5′-adenyladenosine oligonucleotides in different organs of mice

1985 • 15 citations

INDUCTION, PURIFICATION, AND PROPERTIES OF 2′5′-OLIGOADENYLATE SYNTHETASE

1979 • 13 citations

The interferon-induced enzyme 2–5A synthetase adenylates tRNA

1985 • 10 citations

Tissue-Related and Species-Specific Differences in the 2-5A Oligomer Size Requirement for Activation of 2-5A-Dependent RNase

1993 • 6 citations