Interferon gamma signals via a high-affinity multisubunit receptor complex that contains two types of polypeptide chain.

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

1994 • 5,932 citations

Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product.

1985 • 2,456 citations

Structural design and molecular evolution of a cytokine receptor superfamily.

1990 • 2,104 citations

Cytokine signal transduction

1994 • 1,358 citations

The Molecular Cell Biology of Interferon-gamma and its Receptor

1993 • 1,323 citations

Isolation of Monoclonal Antibodies Specific for Human c-myc Proto-Oncogene Product

1985 • 788 citations

The protein tyrosine kinase JAK1 complements defects in interferon-α/β and -γ signal transduction

1993 • 766 citations

The human interferon $alpha;/$beta; receptor: Characterization and molecular cloning

1994 • 658 citations

Genetic transfer of a functional human interferon α receptor into mouse cells: Cloning and expression of its c-DNA

1990 • 582 citations

Complementation by the protein tyrosine kinase JAK2 of a mutant cell line defective in the interferon-& gamma; signal transduction pathway

1993 • 548 citations

Blocking of HIV-1 Infectivity by a Soluble, Secreted Form of the CD4 Antigen

1987 • 485 citations

Molecular cloning and expression of the human interferon-γ receptor

1988 • 481 citations

Ligand-induced IFN gamma receptor tyrosine phosphorylation couples the receptor to its signal transduction system (p91).

1994 • 453 citations

Three-dimensional structure of recombinant human interferon-gamma

1991 • 420 citations

Molecular cloning of the cDNA for tissue factor, the cellular receptor for the initiation of the coagulation protease cascade

1987 • 318 citations

Protection against endotoxic shock by a tumor necrosis factor receptor immunoadhesin.

1991 • 279 citations

Identification and sequence of an accessory factor required for activation of the human interferon γ receptor

1994 • 266 citations

A receptor for interleukin 10 is related to interferon receptors.

1993 • 233 citations

Interferon-gamma induces tyrosine phosphorylation of interferon-gamma receptor and regulated association of protein tyrosine kinases, Jak1 and Jak2, with its receptor.

1994 • 213 citations

A novel member of the interferon receptor family complements functionality of the murine interferon γ receptor in human cells

1994 • 205 citations

Interferon gamma-induced transcription of the high-affinity Fc receptor for IgG requires assembly of a complex that includes the 91-kDa subunit of transcription factor ISGF3.

1993 • 193 citations

The gene for the human immune interferon receptor is located on chromosome 6.

1986 • 127 citations

Interferon gamma rapidly induces in human monocytes a DNA-binding factor that recognizes the gamma response region within the promoter of the gene for the high-affinity Fc gamma receptor.

1992 • 114 citations

Engineering subtilisin BPN′ for site‐specific proteolysis

1989 • 110 citations

Interferon-gamma induces receptor dimerization in solution and on cells.

1993 • 102 citations

A New Member of the Cytokine Receptor Gene Family Maps on Chromosome 21 at Less Than 35 kb from IFNAR

1993 • 86 citations

Tumor necrosis factor receptor p75 mediates cell-specific activation of nuclear factor kappa B and induction of human cytomegalovirus enhancer.

1994 • 85 citations

Stoichiometry of interaction between interferon γ and its receptor

1992 • 76 citations

Chimeric interferon-gamma receptors demonstrate that an accessory factor required for activity interacts with the extracellular domain.

1992 • 75 citations

The Extracellular Domain of the Human Interferon Gamma Receptor Interacts with a Species-Specific Signal Transducer

1991 • 52 citations

Inhibition of cellular responsiveness to interferon-gamma (IFN gamma) induced by overexpression of inactive forms of the IFN gamma receptor

1993 • 51 citations

Functional characterization of a hybrid human-mouse interferon gamma receptor: evidence for species-specific interaction of the extracellular receptor domain with a putative signal transducer.

1992 • 50 citations

Immunoadhesins

1993 • 41 citations

Construction, purification, and characterization of new interferon gamma (IFN gamma) inhibitor proteins. Three IFN gamma receptor-immunoglobulin hybrid molecules.

1992 • 31 citations

Inhibition of interferon-gamma by an interferon-gamma receptor immunoadhesin.

1993 • 17 citations

Generation of soluble interleukin-1 receptor from an immunoadhesin by specific cleavage

1994 • 16 citations

The interferon-gamma receptor extracellular domain. Non-identical requirements for ligand binding and signaling.

1994 • 11 citations