The cellular 68,000-Mr protein kinase is highly autophosphorylated and activated yet significantly degraded during poliovirus infection: implications for translational regulation

Internal initiation of translation of eukaryotic mRNA directed by a sequence derived from poliovirus RNA

1988 • 1,884 citations

A segment of the 5' nontranslated region of encephalomyocarditis virus RNA directs internal entry of ribosomes during in vitro translation

1988 • 1,325 citations

Inhibition of HeLa cell protein synthesis following poliovirus infection correlates with the proteolysis of a 220,000-dalton polypeptide associated with eucaryotic initiation factor 3 and a cap binding protein complex.

1982 • 580 citations

Purification and properties of the replicative intermediate of the RNA bacteriophage R17.

1966 • 497 citations

Translational Control of Protein Synthesis

1976 • 456 citations

Adenovirus VAI RNA is required for efficient translation of viral mRNAs at late times after infection

1982 • 395 citations

Poliovirus proteinase 2A induces cleavage of eucaryotic initiation factor 4F polypeptide p220

1987 • 329 citations

Autophosphorylation of the protein kinase dependent on double-stranded RNA.

1987 • 301 citations

Heat shock-induced translational alterations in HeLa cells. Initiation factor modifications and the inhibition of translation.

1984 • 282 citations

Cap-independent translation of poliovirus mRNA is conferred by sequence elements within the 5' noncoding region.

1988 • 273 citations

The Regulation of Initiation of Mammalian Protein Synthesis

1981 • 266 citations

Studies on the interaction of the human c-myc protein with cell nuclei: p62c-myc as a member of a discrete subset of nuclear proteins

1985 • 265 citations

Mechanism of interferon action: Phosphorylation of protein synthesis initiation factor eIF-2 in interferon-treated human cells by a ribosome-associated kinase processing site specificity similar to hemin-regulated rabbit reticulocyte kinase

1979 • 263 citations

Phosphorylation of eukaryotic initiation factor 2 during physiological stresses which affect protein synthesis.

1987 • 257 citations

A mechanism for the control of protein synthesis by adenovirus VA RNAI

1986 • 256 citations

mRNA cap binding proteins: essential factors for initiating translation

1985 • 242 citations

Interferon action: two distinct pathways for inhibition of protein synthesis by double-stranded RNA.

1978 • 216 citations

Patterns of Macromolecular Synthesis in Normal and Virus-infected Mammalian Cells

1962 • 208 citations

Regulation of protein synthesis: Activation by double-stranded RNA of a protein kinase that phosphorylates eukaryotic initiation factor 2

1978 • 206 citations

The Replication of Picornaviruses

1979 • 204 citations

Double-Stranded Poliovirus RNA Inhibits Initiation of Protein Synthesis by Reticulocyte Lysates

1971 • 204 citations

Purification of the eukaryotic initiation factor 2-eukaryotic initiation factor 2B complex and characterization of its guanine nucleotide exchange activity during protein synthesis initiation.

1983 • 203 citations

Inhibition of translation by poliovirus: inactivation of a specific initiation factor.

1978 • 201 citations

Adenovirus VAI RNA complexes with the 68 000 Mr protein kinase to regulate its autophosphorylation and activity.

1987 • 181 citations

A GDP/GTP exchange factor essential for eukaryotic initiation factor 2 cycling in Ehrlich ascites tumor cells and its regulation by eukaryotic initiation factor 2 phosphorylation.

1983 • 177 citations

Regulation of Protein Synthesis in Virus-Infected Animal Cells

1986 • 177 citations

2B or not 2B: Regulation of the catalytic utilization of elF-2

1983 • 172 citations

Poliovirus mutant that does not selectively inhibit host cell protein synthesis.

1985 • 163 citations

Adenovirus VAI RNA prevents phosphorylation of the eukaryotic initiation factor 2 alpha subunit subsequent to infection.

1985 • 155 citations

c-myc and c-myb protein degradation: effect of metabolic inhibitors and heat shock.

1988 • 154 citations

Regulation of initiation factors during translational repression caused by serum depletion. Covalent modification.

1985 • 153 citations

Regulation of Translation by Poliovirus

1987 • 152 citations

Monoclonal antibodies to an interferon-induced Mr 68,000 protein and their use for the detection of double-stranded RNA-dependent protein kinase in human cells.

1985 • 138 citations

Virus-Specific Double-Stranded RNA in Poliovirus-Infected Cells

1964 • 134 citations

Cap-Independent Translation of Poliovirus mRNA is Conferred by Sequence Elements within the 5′ Noncoding Region

1988 • 129 citations

Regulation of Protein Synthesis in HeLa Cells

1971 • 119 citations

Translational control by adenovirus: lack of virus-associated RNAI during adenovirus infection results in phosphorylation of initiation factor eIF-2 and inhibition of protein synthesis.

1985 • 117 citations

Characterization of the double-stranded RNA implicated in the inhibition of protein synthesis in cells infected with a mutant adenovirus defective for VA RNA

1988 • 116 citations

The double‐stranded RNA‐dependent protein kinase is also activated by heparin

1987 • 116 citations

Proteolysis of the p220 component of the cap-binding protein complex is not sufficient for complete inhibition of host cell protein synthesis after poliovirus infection

1987 • 114 citations

Characterization of a specific kinase inhibitory factor produced by vaccinia virus which inhibits the interferon-induced protein kinase

1984 • 114 citations

Influenza virus regulates protein synthesis during infection by repressing autophosphorylation and activity of the cellular 68,000-Mr protein kinase

1988 • 108 citations

Interferon-mediated, double-stranded RNA-dependent protein kinase is inhibited in extracts from vaccinia virus-infected cells

1984 • 101 citations

Poliovirus Mutant That Does Not Selectively Inhibit Host Cell Protein Synthesis

1985 • 94 citations

Translational control by influenza virus: suppression of the kinase that phosphorylates the alpha subunit of initiation factor eIF-2 and selective translation of influenza viral mRNAs.

1986 • 92 citations

Poliovirus-induced inhibition of host-cell protein synthesis

1982 • 84 citations

Two interferon-induced proteins are involved in the protein kinase complex dependent on double-stranded RNA

1985 • 78 citations

Nuclear-cytoplasmic transport and VAI RNA-independent translation of influenza viral messenger RNAs in late adenovirus-infected cells

1984 • 59 citations

The host protein required for in vitro replication of poliovirus is a protein kinase that phosphorylates eukaryotic initiation factor-2

1985 • 58 citations

Characterization of ribonuclease-resistant RNA from poliovirus-infected HeLa cells.

1965 • 48 citations

Effect of Poliovirus Double-Stranded RNA on Viral and Host-Cell Protein Synthesis

1974 • 46 citations

Rapid decrease in the levels of the double-stranded RNA-dependent protein kinase during virus infections

1987 • 40 citations

c-myc and c-myb Protein Degradation: Effect of Metabolic Inhibitors and Heat Shock

1988 • 33 citations

Translational Control by Influenza Virus: Suppression of the Kinase That Phosphorylates the Alpha Subunit of Initiation Factor eIF-2 and Selective Translation of Influenza Viral mRNAs

1986 • 30 citations

A heat-sensitive inhibitor in poliovirus-infected cells which selectively blocks phosphorylation of the alpha subunit of eucaryotic initiation factor 2 by the double-stranded RNA-activated protein kinase

1988 • 20 citations

Activation of double-stranded RNA-activated protein kinase in HeLa cells after poliovirus infection does not result in increased phosphorylation of eucaryotic initiation factor-2

1987 • 17 citations

Interferons: direct effects upon viral replication

1985 • 8 citations

Deleted Work

1955 • 0 citations