Physical association between STAT1 and the interferon-inducible protein kinase PKR and implications for interferon and double-stranded RNA signaling pathways

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1995 • 1,826 citations

Targeted Disruption of the Stat1 Gene in Mice Reveals Unexpected Physiologic Specificity in the JAK–STAT Signaling Pathway

1996 • 1,648 citations

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1996 • 1,560 citations

Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions

1994 • 813 citations

A Single Phosphotyrosine Residue of Stat91 Required for Gene Activation by Interferon-γ

1993 • 797 citations

Cell Growth Arrest and Induction of Cyclin-Dependent Kinase Inhibitor p21 ^WAF1/CIP1 Mediated by STAT1

1996 • 796 citations

Activation of Transcription by IFN-γ: Tyrosine Phosphorylation of a 91-kD DNA Binding Protein

1992 • 772 citations

Proteins of transcription factor ISGF-3: one gene encodes the 91-and 84-kDa ISGF-3 proteins that are activated by interferon alpha.

1992 • 661 citations

Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase.

1995 • 640 citations

Requirement of Serine Phosphorylation for Formation of STAT-Promoter Complexes

1995 • 578 citations

Double-stranded RNA-dependent protein kinase activates transcription factor NF-kappa B by phosphorylating I kappa B.

1994 • 569 citations

Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinase

1992 • 543 citations

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1992 • 530 citations

Tumor suppressor function of the interferon-induced double-stranded RNA-activated protein kinase.

1993 • 436 citations

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1992 • 387 citations

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1991 • 378 citations

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1995 • 346 citations

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1990 • 332 citations

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1990 • 321 citations

Protein Phosphorylation Controls Translation Rates

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1993 • 285 citations

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1993 • 252 citations

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1996 • 247 citations

Two RNA-binding motifs in the double-stranded RNA-activated protein kinase, DAI.

1992 • 243 citations

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1992 • 238 citations

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1995 • 223 citations

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1994 • 217 citations

Functional expression and RNA binding analysis of the interferon-induced, double-stranded RNA-activated, 68,000-Mr protein kinase in a cell-free system.

1991 • 207 citations

Kinase-negative mutants of JAK1 can sustain interferon-gamma-inducible gene expression but not an antiviral state.

1996 • 188 citations

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1995 • 176 citations

Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein.

1996 • 172 citations

Function of Stat2 Protein in Transcriptional Activation by Alpha Interferon

1996 • 169 citations

Double-stranded-RNA-dependent protein kinase and TAR RNA-binding protein form homo- and heterodimers in vivo.

1995 • 165 citations

The SH2 domains of Stat1 and Stat2 mediate multiple interactions in the transduction of IFN-alpha signals.

1996 • 156 citations

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1996 • 153 citations

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1996 • 152 citations

Combinatorial association and abundance of components of interferon-stimulated gene factor 3 dictate the selectivity of interferon responses.

1995 • 150 citations

The interferon-inducible double-stranded RNA-activated protein kinase self-associates in vitro and in vivo.

1995 • 147 citations

Interferon regulatory factor 1 (IRF-1) mediates cell growth inhibition by transactivation of downstream target genes

1993 • 140 citations

Mutants of the RNA-Dependent Protein Kinase (PKR) Lacking Double-Stranded RNA Binding Domain I Can Act as Transdominant Inhibitors and Induce Malignant Transformation

1995 • 139 citations

Transcriptional Induction by Double-stranded RNA Is Mediated by Interferon-stimulated Response Elements without Activation of Interferon-stimulated Gene Factor 3

1995 • 139 citations

ISGF3γ p48, a specificity switch for interferon activated transcription factors

1996 • 131 citations

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1995 • 129 citations

Participation of JAK and STAT Proteins in Growth Hormone-induced Signaling

1996 • 124 citations

Subunit of an Alpha-Interferon-Responsive Transcription Factor Is Related to Interferon Regulatory Factor and Myb Families of DNA-Binding Proteins

1992 • 122 citations

Purification and Cloning of Interferon-Stimulated Gene Factor 2 (ISGF2): ISGF2 (IRF-1) Can Bind to the Promoters of Both Beta Interferon- and Interferon-Stimulated Genes but Is Not a Primary Transcriptional Activator of Either

1990 • 110 citations

IRF-1 induced cell growth inhibition and interferon induction requires the activity of the protein kinase PKR.

1995 • 109 citations

Double-stranded RNA activates novel factors that bind to the interferon-stimulated response element.

1993 • 105 citations

Differentiation-Regulated Serine Phosphorylation of STAT1 Promotes GAF Activation in Macrophages

1995 • 101 citations

In vitro activation of the transcription factor ISGF3 by interferon alpha involves a membrane-associated tyrosine phosphatase and tyrosine kinase.

1993 • 99 citations

Roles of Protein-tyrosine Phosphatases in Stat1α-mediated Cell Signaling

1995 • 98 citations

In vitro activation of a transcription factor by gamma interferon requires a membrane-associated tyrosine kinase and is mimicked by vanadate.

1993 • 92 citations

Characterization of Specific DNA-binding Factors Activated by Double-stranded RNA as Positive Regulators of Interferon α/β-stimulated Genes

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Platelet-derived Growth Factor Signal Transduction through the Interferon-inducible Kinase PKR

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Differential binding of interferon-induced factors to an oligonucleotide that mediates transcriptional activation

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1988 • 74 citations

The gene encoding IFP 53/tryptophanyl-tRNA synthetase is regulated by the gamma-interferon activation factor

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1993 • 67 citations

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1991 • 56 citations

Characterization of promoter elements of an interferon-inducible Ly-6E/A differentiation antigen, which is expressed on activated T cells and hematopoietic stem cells.

1990 • 51 citations

Signal transduction and activation of gene transcription by interferons.

1995 • 47 citations

The Interferon-inducible Protein Kinase PKR Modulates the Transcriptional Activation of Immunoglobulin κ Gene

1995 • 44 citations

CD4 and Signal Transduction

1996 • 36 citations

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1993 • 27 citations

Double-Stranded RNA and Interferon-α Induce Transcription Through Different Molecular Mechanisms

1992 • 17 citations

Effect of Interferon on Protein Translation during Growth Stages of 3T3 Cells

1996 • 16 citations

The CD4 Molecule

1996 • 11 citations