STAM, Signal Transducing Adaptor Molecule, Is Associated with Janus Kinases and Involved in Signaling for Cell Growth and c-myc Induction

Efficient selection for high-expression transfectants with a novel eukaryotic vector

1991 • 5,120 citations

Signal transduction by lymphocyte antigen receptors

1994 • 2,145 citations

Identification of a Ten-Amino Acid Proline-Rich SH3 Binding Site

1993 • 1,205 citations

Interleukin-2 Receptor γ Chain: a Functional Component of the Interleukin-7 Receptor

1993 • 1,128 citations

ZAP-70: A 70 kd protein-tyrosine kinase that associates with the TCR ζ chain

1992 • 1,037 citations

Utilization of the beta and gamma chains of the IL-2 receptor by the novel cytokine IL-15.

1994 • 1,008 citations

Choice of STATs and Other Substrates Specified by Modular Tyrosine-Based Motifs in Cytokine Receptors

1995 • 992 citations

Cloning of the γ Chain of the Human IL-2 Receptor

1992 • 835 citations

Sharing of the Interleukin-2 (IL-2) Receptor γ Chain Between Receptors for IL-2 and IL-4

1993 • 734 citations

Cytokine Signaling Through Nonreceptor Protein Tyrosine Kinases

1995 • 713 citations

Sequential Interactions of the TCR with Two Distinct Cytoplasmic Tyrosine Kinases

1994 • 711 citations

Control of c-myc Regulation in Normal and Neoplastic Cells

1991 • 632 citations

Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells

1994 • 618 citations

Signaling Through the Hematopoietic Cytokine Receptors

1995 • 617 citations

Cytokine Receptors and Signal Transduction

1992 • 607 citations

Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2

1994 • 598 citations

Interleukin-2 Receptor γ Chain: a Functional Component of the Interleukin-4 Receptor

1993 • 593 citations

Functional Activation of Jak1 and Jak3 by Selective Association with IL-2 Receptor Subunits

1994 • 581 citations

Interaction of the IL-2 Receptor with thesrc-Family Kinase p56^lck: Identification of Novel Intermolecular Association

1991 • 576 citations

Structure of the murine Jak2 protein-tyrosine kinase and its role in interleukin 3 signal transduction.

1993 • 516 citations

JAK2 associates with the beta c chain of the receptor for granulocyte-macrophage colony-stimulating factor, and its activation requires the membrane-proximal region.

1994 • 506 citations

Polypeptide signalling to the nucleus through tyrosine phosphorylation of Jak and Stat proteins

1993 • 504 citations

Suppression of interleukin-3-induced gene expression by a C-terminal truncated Stat5: role of Stat5 in proliferation.

1996 • 414 citations

Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15.

1995 • 397 citations

Critical cytoplasmic domains of the common beta subunit of the human GM-CSF, IL-3 and IL-5 receptors for growth signal transduction and tyrosine phosphorylation.

1992 • 365 citations

Functional Participation of the IL-2 Receptor γ Chain in IL-7 Receptor Complexes

1994 • 342 citations

Association of the 72-kDa protein-tyrosine kinase PTK72 with the B cell antigen receptor.

1992 • 298 citations

Cytokine Receptors and Signal Transduction

1997 • 259 citations

Platelet-Derived Growth Factor Induces Phosphorylation of Multiple JAK Family Kinases and STAT Proteins

1996 • 247 citations

Interleukin 2 and erythropoietin activate STAT5/MGF via distinct pathways.

1995 • 224 citations

Different interleukin 2 receptor beta-chain tyrosines couple to at least two signaling pathways and synergistically mediate interleukin 2-induced proliferation.

1996 • 202 citations

Activation of Stat5 by interleukin 2 requires a carboxyl-terminal region of the interleukin 2 receptor beta chain but is not essential for the proliferative signal transmission.

1995 • 190 citations

Sharing of the IL-2 receptor γ chain with the functional IL-9 receptor complex

1995 • 189 citations

The Common γ-Chain for Multiple Cytokine Receptors

1995 • 168 citations

Protein tyrosine kinase syk is associated with and activated by the il-2 receptor: Possible link with the c-myc induction pathway

1995 • 164 citations

Functional coupling of the src-family protein tyrosine kinases p59fyn and p53/56lyn with the interleukin 2 receptor: implications for redundancy and pleiotropism in cytokine signal transduction.

1993 • 138 citations

JAK2 Is Essential for Activation of c-fos and c-myc Promoters and Cell Proliferation through the Human Granulocyte-Macrophage Colony-stimulating Factor Receptor in BA/F3 Cells

1996 • 133 citations

Association of p56lck with IL-2 receptor beta chain is critical for the IL-2-induced activation of p56lck.

1993 • 132 citations

An associated molecule, p64, with IL-2 receptor beta chain. Its possible involvement in the formation of the functional intermediate-affinity IL-2 receptor complex.

1992 • 128 citations

Reconstitution of functional interleukin 2 receptor complexes on fibroblastoid cells: involvement of the cytoplasmic domain of the gamma chain in two distinct signaling pathways.

1993 • 114 citations

Critical role of the interleukin 2 (IL-2) receptor gamma-chain-associated Jak3 in the IL-2-induced c-fos and c-myc, but not bcl-2, gene induction.

1995 • 108 citations

Interleukin 2 regulates the activity of the lyn protein-tyrosine kinase in a B-cell line.

1992 • 103 citations

Activation of Stat5 by interleukin 2 requires a carboxy-terminal region β chain but is not exxential for the proliferative signal transdution.

1995 • 87 citations

Cloning of a Novel Signal-Transducing Adaptor Molecule Containing an SH3 Domain and ITAM

1996 • 73 citations

Physical association of JAK1 and JAK2 tyrosine kinases with the interleukin 2 receptor beta and gamma chains.

1994 • 68 citations

Identification of interleukin-2 receptor-associated tyrosine kinase p116 as novel leukocyte-specific Janus kinase.

1994 • 55 citations

Interleukin 2‐induced activation of JAK3: Possible involvement in signal transduction for c‐myc induction and cell proliferation

1994 • 55 citations

Activation of Stat5 by interleukin 2 requires a carboxyl-terminal region of the interlekin 2 receptor βchain but is not essential for the proliferative signal transmission.

1995 • 48 citations

Dispensability of Jak1 tyrosine kinase for interleukin‐2‐induced cell growth signaling in a human T cell line

1996 • 45 citations

Differences in the interleukin‐2 (IL‐2) receptor system in human and mouse: α chain is required for formation of the functional mouse IL‐2 receptor

1995 • 37 citations

Transcription from the P2 promoter of human protooncogene myc is suppressed by retinoic acid through an interaction between the E2F element and its binding proteins.

1994 • 18 citations

Association of p56lck with IL-2 receptor βchain is critical for the IL-2-induced activation of p56lck

1994 • 15 citations