Membrane Topology of P-Glycoprotein As Determined by Epitope Insertion: Transmembrane Organization of the N-Terminal Domain of mdr3

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

A simple method for displaying the hydropathic character of a protein

1982 • 22,471 citations

Identification of the Cystic Fibrosis Gene: Cloning and Characterization of Complementary DNA

1989 • 7,327 citations

ABC Transporters: From Microorganisms to Man

1992 • 3,956 citations

BIOCHEMISTRY OF MULTIDRUG RESISTANCE MEDIATED BY THE MULTIDRUG TRANSPORTER

1993 • 3,515 citations

Structure of the protein subunits in the photosynthetic reaction centre of Rhodopseudomonas viridis at 3Å resolution

1985 • 3,049 citations

Model for the structure of bacteriorhodopsin based on high-resolution electron cryo-microscopy

1990 • 2,969 citations

Three-dimensional model of purple membrane obtained by electron microscopy

1975 • 2,259 citations

Analysis of membrane and surface protein sequences with the hydrophobic moment plot

1984 • 2,234 citations

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells

1986 • 1,903 citations

Crystal structures explain functional properties of two E. coli porins

1992 • 1,493 citations

Mammalian multidrug resistance gene: Complete cDNA sequence indicates strong homology to bacterial transport proteins

1986 • 1,058 citations

Detection of P-glycoprotein in multidrug-resistant cell lines by monoclonal antibodies

1985 • 927 citations

The multidrug transporter, a double-edged sword.

1988 • 763 citations

Sequences encoded in the class II region of the MHC related to the 'ABC' superfamily of transporters

1990 • 717 citations

Molecular Architecture and Electrostatic Properties of a Bacterial Porin

1991 • 700 citations

A gene in the human major histocompatibility complex class II region controlling the class I antigen presentation pathway

1990 • 644 citations

The yeast STE6 gene encodes a homologue of the mammalian multidrug resistance P-glycoprotein

1989 • 604 citations

Nucleotide sequence of an Escherichia coli chromosomal hemolysin

1985 • 572 citations

Amplification of the multidrug resistance gene in some chloroquine-resistant isolates of P. falciparum

1989 • 570 citations

Volume-regulated chloride channels associated with the human multidrug-resistance P-glycoprotein

1992 • 567 citations

Transmembrane Protein Structure: Spin Labeling of Bacteriorhodopsin Mutants

1990 • 465 citations

Two members of the mouse mdr gene family confer multidrug resistance with overlapping but distinct drug specificities.

1990 • 420 citations

The spectrum of cystic fibrosis mutations

1992 • 413 citations

Generation of protein-reactive antibodies by short peptides is an event of high frequency: implications for the structural basis of immune recognition.

1983 • 378 citations

The multidrug resistance (mdr1) gene product functions as an ATP channel.

1993 • 372 citations

Membrane vesicles from multidrug-resistant human cancer cells contain a specific 150- to 170-kDa protein detected by photoaffinity labeling.

1986 • 342 citations

Nucleotide sequence of the structural genes for an anion pump. The plasmid-encoded arsenical resistance operon.

1986 • 324 citations

The structure of porin from Rhodobacter capsulatus at 1.8 Å resolution

1991 • 303 citations

Vinblastine photoaffinity labeling of a high molecular weight surface membrane glycoprotein specific for multidrug-resistant cells.

1986 • 290 citations

Cloning and characterization of a second member of the mouse mdr gene family.

1988 • 268 citations

lac permease of Escherichia coli: topology and sequence elements promoting membrane insertion.

1990 • 248 citations

ATPase activity of purified and reconstituted P-glycoprotein from Chinese hamster ovary cells.

1994 • 235 citations

Phosphate-specific transport system of Escherichia coli: nucleotide sequence and gene-polypeptide relationships

1985 • 219 citations

Functional consequences of proline mutations in the predicted transmembrane domain of P-glycoprotein.

1993 • 218 citations

Characterization of the human MDR3 P-glycoprotein and its recognition by P-glycoprotein-specific monoclonal antibodies.

1991 • 212 citations

N-glycosylation and deletion mutants of the human MDR1 P-glycoprotein.

1993 • 209 citations

Two different regions of Phosphoglycoprotein are photoaffinity-labeled by azidopine

1989 • 196 citations

A single amino acid substitution strongly modulates the activity and substrate specificity of the mouse mdr1 and mdr3 drug efflux pumps.

1991 • 187 citations

Membrane topology of the ArsB protein, the membrane subunit of an anion-translocating ATPase.

1992 • 146 citations

Amino acid substitutions in the sixth transmembrane domain of P-glycoprotein alter multidrug resistance.

1992 • 140 citations

Evidence for an alternate model of human P-glycoprotein structure and biogenesis.

1993 • 138 citations

Cytoplasmic Orientation and Two-domain Structure of the Multidrug Transporter, P-glycoprotein, Demonstrated with Sequence-specific Antibodies

1989 • 135 citations

Functional expression of P-glycoproteins in secretory vesicles.

1994 • 134 citations

Mapping of cystic fibrosis transmembrane conductance regulator membrane topology by glycosylation site insertion

1994 • 134 citations

Analysis of the membrane organization of an Escherichia coli protein translocator, HlyB, a member of a large family of prokaryote and eukaryote surface transport proteins

1991 • 132 citations

Study of membrane orientation and glycosylated extracellular loops of mouse P-glycoprotein by in vitro translation.

1991 • 132 citations

Lower electrical membrane potential and altered pHi homeostasis in multidrug-resistant (MDR) cells: Further characterization of a series of MDR cell lines expressing different levels of P-glycoprotein

1993 • 131 citations

Topology of P-glycoprotein as determined by epitope mapping of MRK-16 monoclonal antibody.

1993 • 125 citations

Topology of the hydrophobic membrane-bound components of the histidine periplasmic permease. Comparison with other members of the family.

1992 • 110 citations

The topological analysis of integral cytoplasmic membrane proteins

1993 • 106 citations

Characterization of cell lines showing growth control isolated from both the wild type and a leucyl‐tRNA synthetase mutant of chinese hamster ovary cells

1979 • 100 citations

Characterization of the multidrug resistance protein expressed in cell clones stably transfected with the mouse mdr1 cDNA.

1989 • 97 citations

Properties and purification of an active biotinylated lactose permease from Escherichia coli.

1993 • 89 citations

Topological and functional studies on HlyB of Escherichia coli

1992 • 86 citations

Amino-terminal assembly of human P-glycoprotein at the endoplasmic reticulum is directed by cooperative actions of two internal sequences.

1993 • 86 citations

Membrane topology of the N-terminal half of the hamster P-glycoprotein molecule

1993 • 82 citations

The ATP-binding component of a prokaryotic traffic ATPase is exposed to the periplasmic (external) surface.

1993 • 69 citations

Membrane topology of multidrug resistance protein expressed in Escherichia coli. N-terminal domain.

1994 • 67 citations

Membrane topology of the integral membrane components, OppB and OppC, of the oligopeptide permease of Salmonella typhimurium

1992 • 64 citations

Transmembrane organization of the sodium-potassium-ATPase determined by epitope addition

1993 • 62 citations

The nitrogen of the acetamido group of colchicine modulates P-glycoprotein-mediated multidrug resistance

1993 • 59 citations

Photoaffinity Labeling of P-Glycoprotein in Multidrug-Resistant Cells

1993 • 53 citations

Transmembrane orientation and topogenesis of the third and fourth membrane-spanning regions of human P-glycoprotein (MDR1).

1994 • 49 citations

[33] Preparation of monoclonal antibodies and site-directed polyclonal antibodies against the lac permease of Escherichia coli

1986 • 22 citations