Characterization of the azidopine and vinblastine binding site of P-glycoprotein.

Identification of the Cystic Fibrosis Gene: Cloning and Characterization of Complementary DNA

1989 • 7,327 citations

THE BIOCHEMISTRY OF P-GLYCOPROTEIN-MEDIATED MULTIDRUG RESISTANCE

1989 • 2,060 citations

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells

1986 • 1,903 citations

Structural model of ATP-binding proteing associated with cystic fibrosis, multidrug resistance and bacterial transport

1990 • 1,149 citations

Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine.

1987 • 1,080 citations

Mammalian multidrug resistance gene: Complete cDNA sequence indicates strong homology to bacterial transport proteins

1986 • 1,058 citations

Isolation and expression of a complementary DNA that confers multidrug resistance

1986 • 808 citations

The multidrug transporter, a double-edged sword.

1988 • 763 citations

A family of related ATP-binding subunits coupled to many distinct biological processes in bacteria

1986 • 753 citations

Homology between P-glycoprotein and a bacterial haemolysin transport protein suggests a model for multidrug resistance

1986 • 680 citations

The yeast STE6 gene encodes a homologue of the mammalian multidrug resistance P-glycoprotein

1989 • 604 citations

Amplification of the multidrug resistance gene in some chloroquine-resistant isolates of P. falciparum

1989 • 570 citations

Certain calcium channel blockers bind specifically to multidrug-resistant human KB carcinoma membrane vesicles and inhibit drug binding to P-glycoprotein.

1987 • 538 citations

Isolation and genetic characterization of human KB cell lines resistant to multiple drugs

1985 • 517 citations

A retrovirus carrying an MDR1 cDNA confers multidrug resistance and polarized expression of P-glycoprotein in MDCK cells.

1988 • 489 citations

ATP-dependent transport of vinblastine in vesicles from human multidrug-resistant cells.

1988 • 480 citations

Multiple drug-resistant human KB carcinoma cells independently selected for high-level resistance to colchicine, adriamycin, or vinblastine show changes in expression of specific proteins.

1986 • 461 citations

Saccharomyces cerevisiae STE6 gene product: a novel pathway for protein export in eukaryotic cells.

1989 • 443 citations

Reduced drug accumulation in multiply drug-resistant human KB carcinoma cell lines.

1985 • 441 citations

Amplification of a Gene Related to Mammalian mdr Genes in Drug-Resistant Plasmodium falciparum

1989 • 439 citations

Transport Protein Genes in the Murine MHC: Possible Implications for Antigen Processing

1990 • 438 citations

An altered pattern of cross-resistance in multidrug-resistant human cells results from spontaneous mutations in the mdr1 (P-glycoprotein) gene

1988 • 430 citations

Photosensitized labeling of a functional multidrug transporter in living drug-resistant tumor cells.

1990 • 386 citations

Detection of P-glycoprotein isoforms by gene-specific monoclonal antibodies.

1990 • 386 citations

Membrane vesicles from multidrug-resistant human cancer cells contain a specific 150- to 170-kDa protein detected by photoaffinity labeling.

1986 • 342 citations

Single cell analysis of daunomycin uptake and efflux in multidrug-resistant and -sensitive KB cells: effects of verapamil and other drugs.

1986 • 312 citations

Vinblastine photoaffinity labeling of a high molecular weight surface membrane glycoprotein specific for multidrug-resistant cells.

1986 • 290 citations

Nucleotide binding by membrane components of bacterial periplasmic binding protein-dependent transport systems.

1985 • 219 citations

Most drugs that reverse multidrug resistance also inhibit photoaffinity labeling of P-glycoprotein by a vinblastine analog.

1988 • 211 citations

ATP‐binding properties of P glycoprotein from multidrug‐resistant KB cells

1987 • 207 citations

Photoaffinity labeling of the multidrug-resistance-related P-glycoprotein with photoactive analogs of verapamil.

1988 • 205 citations

Two different regions of Phosphoglycoprotein are photoaffinity-labeled by azidopine

1989 • 196 citations

Transepithelial Transport of Drugs by the Multidrug Transporter in Cultured Madin-Darby Canine Kidney Cell Epithelia

1989 • 191 citations

P-Glycoprotein gene (MDR1) cDNA from human adrenal: Normal P-glycoprotein carries Gly185 with an altered pattern of multidrug resistance

1989 • 179 citations

Azidopine noncompetitively interacts with vinblastine and cyclosporin A binding to P-glycoprotein in multidrug resistant cells.

1991 • 178 citations

Molecular basis of preferential resistance to colchicine in multidrug-resistant human cells conferred by Gly-185----Val-185 substitution in P-glycoprotein.

1990 • 143 citations

Cytoplasmic Orientation and Two-domain Structure of the Multidrug Transporter, P-glycoprotein, Demonstrated with Sequence-specific Antibodies

1989 • 135 citations

Genetic basis of multidrug resistance of tumor cells

1990 • 124 citations

Cellular and biochemical characterization of thioxanthenes for reversal of multidrug resistance in human and murine cell lines.

1990 • 123 citations

Domain mapping of the photoaffinity drug-binding sites in P-glycoprotein encoded by mouse mdr1b.

1991 • 113 citations

Photoaffinity probes for the alpha 1-adrenergic receptor and the calcium channel bind to a common domain in P-glycoprotein.

1990 • 108 citations

Photoaffinity labelling of Ca²⁺ channels with [³H]azidopine

1984 • 90 citations

Azidopine photoaffinity labeling of multidrug resistance-associated glycoproteins

1988 • 86 citations

Agents which reverse multidrug-resistance are inhibitors of [3H]vinblastine transport by isolated vesicles

1991 • 85 citations

Genetics of multidrug resistance: relationship of a cloned gene to the complete multidrug resistant phenotype.

1987 • 81 citations

Use of recombinant P-glycoprotein fragments to produce antibodies to the multidrug transporter

1990 • 54 citations

Subunit composition of skeletal muscle transverse tubule calcium channels evaluated with the 1,4-dihydropyridine photoaffinity probe, [3H]azidopine.

1985 • 42 citations

Pseudomonas exotoxin fusion proteins are potent immunogens for raising antibodies against P-glycoprotein.

1991 • 36 citations

The α1-adrenergic photoaffinity probe [125I]arylazidoprazosin binds to a specific peptide of P-glycoprotein in multidrug-resistant cells

1990 • 30 citations

Functional expression of murine multidrug resistance in Xenopus laevis oocytes.

1990 • 25 citations