Fatty acids inhibit growth-factor-induced diacylglycerol kinase α activation in vascular smooth-muscle cells

Protein kinase C activation and the development of diabetic complications.

1998 • 1,328 citations

Quantitative measurement of sn-1,2-diacylglycerols present in platelets, hepatocytes, and ras- and sis-transformed normal rat kidney cells.

1986 • 999 citations

Measurement of Plasma Glucose, Free Fatty Acid, Lactate, and Insulin for 24 h in Patients With NIDDM

1988 • 713 citations

Human thrombins. Production, evaluation, and properties of alpha-thrombin.

1977 • 587 citations

A Rapid and Simple Method for the Determination of Esterified Fatty Acids and for Total Fatty Acids in Blood

1953 • 568 citations

Mammalian Diacylglycerol Kinases, a Family of Lipid Kinases with Signaling Functions

1999 • 284 citations

Activation of protein kinase C in glomerular cells in diabetes. Mechanisms and potential links to the pathogenesis of diabetic glomerulopathy

1994 • 273 citations

Protein kinase C regulates the nuclear localization of diacylglycerol kinase-ζ

1998 • 256 citations

Properties and functions of diacylglycerol kinases

2000 • 245 citations

Families of phosphoinositide-specific phospholipase C: structure and function

1998 • 222 citations

Prevention of glomerular dysfunction in diabetic rats by treatment with d-alpha-tocopherol.

1997 • 218 citations

Polymorphonuclear Leukocytes in Non-Insulin-dependent Diabetes Mellitus: Abnormalities in Metabolism and Function

1995 • 210 citations

Fatty acids and cell signal transduction.

1994 • 206 citations

High Glucose Concentrations Increase Endothelial Cell Permeability via Activation of Protein Kinase Cα

1997 • 206 citations

Molecular Cloning of a Novel Human Diacylglycerol Kinase Highly Selective for Arachidonate-containing Substrates

1996 • 205 citations

Diacylglycerol accumulation and microvascular abnormalities induced by elevated glucose levels.

1991 • 191 citations

Measurement of plasma glucose, free fatty acid, lactate, and insulin for 24 h in patients with NIDDM

1988 • 184 citations

Diacylglycerol – when is it an intracellular messenger?

1998 • 176 citations

sn-1,2-Diacylglycerol kinase of Escherichia coli. Mixed micellar analysis of the phospholipid cofactor requirement and divalent cation dependence.

1986 • 148 citations

Mechanisms of Glucose-Enhanced Extracellular Matrix Accumulation in Rat Glomerular Mesangial Cells

1994 • 127 citations

Phosphatidic Acid Generation through Interleukin 2 (IL-2)-induced α-Diacylglycerol Kinase Activation Is an Essential Step in IL-2-mediated Lymphocyte Proliferation

1996 • 118 citations

Selectivity of the diacylglycerol kinase inhibitor 3-{2-(4-[bis-(4-fluorophenyl)methylene]-1-piperidinyl)ethyl}-2,3-dihydro-2-thioxo-4(1H)quinazolinone (R59949) among diacylglycerol kinase subtypes

2000 • 118 citations

Diacylglycerol Kinase θ Binds to and Is Negatively Regulated by Active RhoA

1999 • 89 citations

Regulation of diacylglycerol kinase reaction in Swiss 3T3 cells. Increased phosphorylation of endogenous diacylglycerol and decreased phosphorylation of didecanoylglycerol in response to platelet-derived growth factor.

1988 • 89 citations

Specific retinal diacylglycerol and protein kinase C beta isoform modulation mimics abnormal retinal hemodynamics in diabetic rats.

1997 • 88 citations

Subtype-specific Translocation of Diacylglycerol Kinase α and γ and Its Correlation with Protein Kinase C

2000 • 85 citations

Diacylglycerol kinase

1997 • 81 citations

Arachidonoyl-diacylglycerol kinase from bovine testis. Purification and properties.

1994 • 79 citations

Diacylglycerol kinase is phosphorylated in vivo upon stimulation of the epidermal growth factor receptor and serine/threonine kinases, including protein kinase C-ε

1993 • 70 citations

Immunological characterization of sn-1,2-diacylglycerol and sn-2-monoacylglycerol kinase from pig brain.

1986 • 70 citations

Exploring the allowed sequence space of a membrane protein

1996 • 63 citations

d-α-Tocopherol prevents the hyperglycemia induced activation of diacylglycerol (DAG)-protein kinase C (PKC) pathway in vascular smooth muscle cell by an increase of DAG kinase activity

1999 • 60 citations

Vitamin E suppresses diacylglycerol (DAG) level in thrombin-stimulated endothelial cells through an increase of DAG kinase activity

1994 • 60 citations

A myo-inositol pool utilized for phosphatidylinositol synthesis is depleted in sciatic nerve from rats with streptozotocin-induced diabetes.

1990 • 59 citations

Activation of Human Neutrophil NADPH Oxidase by Phosphatidic Acid or Diacylglycerol in a Cell-free System

1999 • 59 citations

Diacylglycerol kinase in receptor-stimulated cells converts its substrate in a topologically restricted manner.

1994 • 57 citations

Translocation of diacylglycerol kinase in response to chemotactic peptide and phorbol ester in neutrophils

1987 • 54 citations

Phosphorylation of diacylglycerol kinase in vitro by protein kinase C

1989 • 53 citations

Distribution of distinct arachidonoyl-specific and non-specific isoenzymes of diacylglycerol kinase in baboon (Papio cynocephalus) tissues

1990 • 51 citations

Phorbol ester-induced translocation of diacylglycerol kinase from the cytosol to the membrane in Swiss 3T3 fibroblasts

1989 • 50 citations

Signal Transmission in Exocrine Cells Is Associated with Rapid Activity Changes of Acyltransferases and Diacylglycerol Kinase Due to Reversible Protein Phosphorylation

1989 • 49 citations

Sphingosine activates cellular diacylglycerol kinase in intact Jurkat cells, a human T-cell line

1993 • 47 citations

A Domain with Homology to Neuronal Calcium Sensors Is Required for Calcium-dependent Activation of Diacylglycerol Kinase α

2000 • 47 citations

Escherichia coli Diacylglycerol Kinase Is an α-Helical Polytopic Membrane Protein and Can Spontaneously Insert into Preformed Lipid Vesicles

1996 • 47 citations

Inhibition of storen-dependent capacitative Ca2+ influx by unsaturated fatty acids

1997 • 46 citations

[17] Diacylglycerol kinase from escherichia coli

1992 • 36 citations

Translocation of diacylglycerol kinase α to the nuclear matrix of rat thymocytes and peripheral T‐lymphocytes

1996 • 33 citations

The different effects of sphingosine on diacylglycerol kinase isozymes in Jurkat cells, a human T-cell line

1993 • 29 citations

Membrane-associated diacylglycerol kinase activity is increased by noradrenaline, but not by angiotensin II, in arterial smooth muscle

1994 • 27 citations

Role of elevated cytosolic calcium in the pathogenesis of complications in diabetes mellitus.

1997 • 27 citations

Activation of Protein Kinase C in Glomerular Cells in Diabetes: Mechanisms and Potential Links to the Pathogenesis of Diabetic Glomerulopathy

1994 • 21 citations

Fatty acids modulate protein kinase C activation in porcine vascular smooth muscle cells independently of their effect on de novo diacylglycerol synthesis

2000 • 20 citations

Alternations of Diacylglycerol Kinase in Streptozotocin-Induced Diabetic Rats

1998 • 20 citations

Diacylglycerol Kinase Is Stimulated by Arachidonic Acid in Neural Membranes

1994 • 19 citations

Activation of diacylglycerol kinase by carbachol in guinea pig taenia coli

1994 • 15 citations

cis-FFA do not alter membrane depolarization but block Ca2+ influx and GH secretion in KCl-stimulated somatotroph cells.

1997 • 14 citations

Participation of Diacylglycerol Kinase in Mitogenic Signal Transduction Induced by Platelet-Derived Growth Factor in Vascular Smooth Muscle Cells

1994 • 12 citations

Receptor-mediated diacylglycerol kinase translocation dependent on both transient increase in the intracellular calcium concentration and modification by protein kinase C

1997 • 10 citations

Effects of free fatty acids and acyl‐coenzyme a on diacylglycerol kinase in rat brain

1989 • 10 citations

Epidermal Growth Factor Receptor Stimulation of Diacylglycerol Kinase

1997 • 9 citations

Lipid metabolism in fibroblast growth factor-stimulated L6 myoblasts: a receptor mutation (Y766F) abrogates phospholipase D and diacylglycerol kinase activities

1998 • 8 citations