Protein kinase C signaling and oxidative stress

Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C

1992 • 4,480 citations

Prooxidant States and Tumor Promotion

1985 • 2,541 citations

Requirement for Generation of H ₂ O ₂ for Platelet-Derived Growth Factor Signal Transduction

1995 • 2,505 citations

Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. A randomized controlled trial. Nutritional Prevention of Cancer Study Group

1996 • 2,404 citations

Redox Regulation of Fos and Jun DNA-Binding Activity in Vitro

1990 • 1,592 citations

Okadaic acid: a new probe for the study of cellular regulation

1990 • 1,396 citations

Oxidants as Stimulators of Signal Transduction

1997 • 1,380 citations

Epidermal Growth Factor (EGF)-induced Generation of Hydrogen Peroxide

1997 • 1,208 citations

Superoxide and hydrogen peroxide in relation to mammalian cell proliferation

1995 • 1,185 citations

Oxidants in Cigarette Smoke Radicals, Hydrogen Peroxide, Peroxynitrate, and Peroxynitritea

1993 • 1,142 citations

DNA damage and mutation in human cells exposed to nitric oxide in vitro.

1992 • 980 citations

Protein kinase C

1991 • 914 citations

The physiological role of zinc as an antioxidant

1990 • 887 citations

Redox Regulation of NF-kappa B Activation

1997 • 852 citations

ROLE OF REVERSIBLE OXIDATION-REDUCTION OF ENZYME THIOLS-DISULFIDES IN METABOLIC REGULATION

1985 • 840 citations

Thiordoxin regulates the DNA binding activity of NF-χB by reduction of a disulphid bond involving cysteine 62

1992 • 825 citations

Molecular and Cellular Aspects of Thiol–Disulfide Exchange

1990 • 763 citations

Redox regulation of transcriptional activators

1996 • 690 citations

Modulation of transcription factor NF-kappa B binding activity by oxidation-reduction in vitro.

1991 • 649 citations

Crystal structure of the Cys2 activator-binding domain of protein kinase Cδ in complex with phorbol ester

1995 • 643 citations

Activation of protein kinase C by tyrosine phosphorylation in response to H ₂ O ₂

1997 • 610 citations

Protein Kinase C δ Activates the MEK-ERK Pathway in a Manner Independent of Ras and Dependent on Raf

1996 • 570 citations

Lipid activation of protein kinase C.

1991 • 566 citations

Thiolate ligands in metallothionein confer redox activity on zinc clusters

1998 • 566 citations

Inhibition of cell proliferation by alpha-tocopherol. Role of protein kinase C.

1991 • 510 citations

Skin Tumor-Promoting Activity of Benzoyl Peroxide, a Widely Used Free Radical-Generating Compound

1981 • 510 citations

Selenocysteine, identified as the penultimate C-terminal residue in human T-cell thioredoxin reductase, corresponds to TGA in the human placental gene.

1996 • 471 citations

Phagocytes as Carcinogens: Malignant Transformation Produced by Human Neutrophils

1985 • 443 citations

Ca2+- and phospholipid-independent activation of protein kinase C by selective oxidative modification of the regulatory domain.

1989 • 409 citations

p21 as a Common Signaling Target of Reactive Free Radicals and Cellular Redox Stress

1995 • 409 citations

Identification of candidate cancer chemopreventive agents and their evaluation in animal models and human clinical trials: a review.

1990 • 402 citations

Separation of oxidant-initiated and redox-regulated steps in the NF-kappa B signal transduction pathway.

1994 • 389 citations

An overview of the relationship between oxidative stress and chemical carcinogenesis

1991 • 378 citations

Rationale and strategies for chemoprevention of cancer in humans.

1987 • 366 citations

Mitogen-Activated Protein Kinase Cascades as Regulators of Stress Responses

1998 • 331 citations

Regulation of Selenoproteins

1993 • 314 citations

Nitric oxide and nitric oxide-generating agents induce a reversible inactivation of protein kinase C activity and phorbol ester binding.

1993 • 302 citations

The glutathione redox couple modulates zinc transfer from metallothionein to zinc-depleted sorbitol dehydrogenase

1998 • 291 citations

Role of Mitogen-activated Protein Kinase Phosphatase during the Cellular Response to Genotoxic Stress

1995 • 284 citations

Protein kinase C binding partners

2000 • 264 citations

Oxidative Stress Triggers STAT3 Tyrosine Phosphorylation and Nuclear Translocation in Human Lymphocytes

1999 • 256 citations

Inhibitory effects of curcumin on protein kinase C activity induced by 12-O-tetradecanoyl-phorbol-13-acetate in NIH 3T3 cells

1993 • 252 citations

Tyrosine phosphorylation in T cells is regulated by phosphatase activity: studies with phenylarsine oxide.

1990 • 246 citations

Sensitivity of the Essential Zinc-Thiolate Moiety of Yeast Alcohol Dehydrogenase to Hypochlorite and Peroxynitrite

1995 • 246 citations

Activation of phospholipase D by protein kinase C. Evidence for a phosphorylation-independent mechanism.

1992 • 237 citations

Mechanism of c-fos induction by active oxygen.

1992 • 224 citations

UV Irradiation and Heat Shock Mediate JNK Activation via Alternate Pathways

1995 • 223 citations

Activity of methylated forms of selenium in cancer prevention.

1990 • 214 citations

Activation of endothelial cell phospholipase D by hydrogen peroxide and fatty acid hydroperoxide.

1993 • 213 citations

Activation of the mitogen-activated protein kinase signaling pathway in neutrophils. Role of oxidants.

1994 • 212 citations

Phospholiphase A2 dependent release of fatty acids from peroxidized membranes

1985 • 203 citations

Redox regulation of a src family protein tyrosine kinase p56lck in T cells.

1993 • 201 citations

Inhibitors of both nuclear factor-kappaB and activator protein-1 activation block the neoplastic transformation response.

1997 • 198 citations

Effects of tocopherol (vitamin E) acid succinate on morphological alterations and growth inhibition in melanoma cells in culture.

1982 • 196 citations

H2O2 Is an Important Mediator of UVB-Induced EGF-Receptor Phosphorylation in Cultured Keratinocytes

1998 • 191 citations

A Redox-triggered Ras-Effector Interaction

1998 • 182 citations

Sublethal Levels of Oxidant Stress Stimulate Multiple Serine/Threonine Kinases and Suppress Protein Phosphatases in Jurkat T Cells

1995 • 181 citations

Effects of Peroxides on Rodent Skin: Epidermal Hyperplasia and Tumor Promotion

1982 • 178 citations

Involvement of Tyrosine Phosphorylation and Protein Kinase C in the Activation of Phospholipase D by H2O2 in Swiss 3T3 Fibroblasts

1998 • 171 citations

Induction of Oxidative Stress by Okadaic Acid Is Required for Activation of Transcription Factor NF-κB

1995 • 170 citations

p72syk tyrosine kinase is activated by oxidizing conditions that induce lymphocyte tyrosine phosphorylation and Ca2+ signals

1993 • 167 citations

Tamoxifen Modulates Protein Kinase C via Oxidative Stress in Estrogen Receptor-negative Breast Cancer Cells

1996 • 165 citations

Reaction of chromium(VI) with glutathione or with hydrogen peroxide: identification of reactive intermediates and their role in chromium(VI)-induced DNA damage.

1991 • 158 citations

Inhibition of NF-κB DNA binding and nitric oxide induction in human T cells and lung adenocarcinoma cells by selenite treatment

1997 • 157 citations

Smoking Abstinence and Small Cell Lung Cancer Survival

1980 • 154 citations

Residues in the Second Cysteine-rich Region of Protein Kinase C δ Relevant to Phorbol Ester Binding as Revealed by Site-directed Mutagenesis

1995 • 149 citations

The Evolutionarily Conserved Zinc Finger Motif in the Largest Subunit of Human Replication Protein A Is Required for DNA Replication and Mismatch Repair but Not for Nucleotide Excision Repair

1998 • 146 citations

Activation of hepatocyte protein kinase C by redox-cycling quinones

1989 • 136 citations

Translocation and enhancement of phosphotransferase activity of protein kinase C following exposure in mouse epidermal cells to oxidants.

1989 • 132 citations

Complexities of the Protein Kinase C Pathway

1991 • 131 citations

The common structure and activities of four subspecies of rat brain protein kinase C family

1987 • 129 citations

The regulatory domain of protein kinase C coordinates four atoms of zinc.

1992 • 129 citations

Activation pattern of mitogen‐activated protein kinases elicited by peroxynitrite: attenuation by selenite supplementation

1999 • 126 citations

Selenotrisulfides. II. Cross-linking of reduced pancreatic ribonuclease with selenium

1969 • 125 citations

Hydrogen peroxide stimulates transcription of c-jun in vascular smooth muscle cells: role of arachidonic acid.

1993 • 123 citations

Effects of H2O2 on protein tyrosine phosphatase activity in HER14 cells

1994 • 121 citations

Modulation of Activator Protein‐1 (AP‐1) Transcription Factor and Protein Kinase C by Hydrogen Peroxide and <scp>d</scp>‐α‐Tocopherol in Vascular Smooth Muscle Cells

1994 • 116 citations

Reactive oxygen species mediate phorbol ester-regulated tyrosine phosphorylation and phospholipase A2 activation: potentiation by vanadate

1993 • 115 citations

Effect of curcumin on 12-O-tetradecanoylphorbol-13-acetate- and ultraviolet B light-induced expression of c-Jun and c-Fos in JB6 cells and in mouse epidermis

1994 • 115 citations

Protein kinase C delta involvement in mammary tumor cell metastasis.

1999 • 115 citations

Tobacco smoke tumor promoters, catechol and hydroquinone, induce oxidative regulation of protein kinase C and influence invasion and metastasis of lung carcinoma cells.

1994 • 114 citations

Hydroperoxide-Induced Diacylglycerol Formation and Protein Kinase C Activation in Vascular Endothelial Cells

1993 • 109 citations

Tumor promoter-induced membrane-bound protein kinase C regulates hematogenous metastasis.

1988 • 107 citations

Increased protein kinase Cδ in mammary tumor cells: relationship to transformation and metastatic progression

1999 • 104 citations

AP‐1 DNA‐binding activity is inhibited by selenite and selenodiglutathione

1995 • 99 citations

Hydrogen peroxide formation and DNA base modification by tumor promoter-activated polymorphonuclear leukocytes

1987 • 97 citations

Oxidative Stress, Cell Activation and Viral Infection

1994 • 91 citations

The biochemistry of selenoproteins

1984 • 89 citations

Irreversible Inactivation of Protein Kinase C by Glutathione

1998 • 89 citations

Modulation of protein kinase C activity and [3H]phorbol 12,13-dibutyrate binding by various tumor promoters in mouse brain cytosol.

1985 • 88 citations

Increased lymph node metastases at mastectomy for breast cancer associated with host obesity, cigarette smoking, age, and large tumor size

1988 • 88 citations

Reversible oxidative activation and inactivation of protein kinase C by the mitogen/tumor promoter periodate

1991 • 87 citations

Cancer-Preventive Selenocompounds Induce a Specific Redox Modification of Cysteine-Rich Regions in Ca2+- Dependent Isoenzymes of Protein Kinase C

1997 • 87 citations

Selenocompounds Induce a Redox Modulation of Protein Kinase C in the Cell, Compartmentally Independent from Cytosolic Glutathione: Its Role in Inhibition of Tumor Promotion

1997 • 84 citations

Finger-loops, oncogenes, and metals. Claude Passmore Brown memorial lecture.

1988 • 83 citations

Activation of rat brain protein kinase C by lipid oxidation products

1988 • 83 citations

Selenium-mediated inhibition of 7,12-dimethylbenz[a]anthracene-induced mouse mammary tumorigenesis

1981 • 82 citations

Inhibitory effect of curcumin on xanthine dehydrogenase/oxidase induced by phorbol-12-myristate-13-acetate in NJH3T3 cells

1994 • 82 citations

Urea-associated oxidative stress and Gadd153/CHOP induction

1999 • 78 citations

Oxidation-induced persistent activation of protein kinase C in hippocampal homogenates

1992 • 76 citations

Oxidant-Induced Activation of Protein Kinase C in Uc11mg Cells

1995 • 74 citations

Protein kinase C and tumor promoters

1990 • 69 citations

Role of asbestos and active oxygen species in activation and expression of ornithine decarboxylase in hamster tracheal epithelial cells.

1991 • 66 citations

Events associated with mouse skin tumor promotion with respect to arachidonic acid metabolism: a comparison between SENCAR and NMRI mice.

1987 • 61 citations

Possible involvement of Ca2+ mobilization and protein kinase C activation in the induction of spontaneous metastasis by mouse mammary adenocarcinoma cells.

1989 • 60 citations

Intracellular targeting of protein kinase C isoenzymes: functional implications

1995 • 58 citations

Protein sulfhydryls are protected from irreversible oxidation by conversion to mixed disulfides

1992 • 56 citations

Differential Regulation of Extracellular Signal-Regulated Kinase and Nuclear Factor-κB Signal Transduction Pathways by Hydrogen Peroxide and Tumor Necrosis Factor

1998 • 56 citations

Anti-inflammatory actions of benzoyl peroxide: effects on the generation of reactive oxygen species by leucocytes and the activity of protein kinase C and calmodulin

1994 • 56 citations

Growth‐inhibitory effects of vitamin E succinate on retrovirus‐transformed tumor cellsin vitro

1990 • 54 citations

Nutritional and hormonal regulation of glutathione homeostasis

1996 • 54 citations

Role of Protein Kinase C in Basal and Hydrogen Peroxide-Stimulated NF-κB Activation in the Murine Macrophage J774A.1 Cell Line

1998 • 53 citations

Covalent crosslinking of the heme prosthetic group to myoglobin by H2O2: Toxicological implications

1996 • 50 citations

Tumor promoters and cocarcinogens in tobacco carcinogenesis.

1983 • 50 citations

Accelerated decomposition of benzoyl peroxide in the presence of sulfides and disulfides

1972 • 47 citations

Protein‐kinase‐C inhibitor calphostin C reduces B16 amelanotic melanoma cell adhesion to endothelium and lung colonization

1992 • 46 citations

Hepatic tyrosine-phosphorylated proteins identified and localized following in vivo inhibition of protein tyrosine phosphatases: effects of H2O2 and vanadate administration into rat livers

1993 • 46 citations

Biochemical and morphological effects of cigarette smoke condensate and its fractions on normal human bronchial epithelial cells in vitro.

1987 • 40 citations

Regulation of Nitric Oxide Synthase Induction by Iron and Glutathione in Asbestos-Treated Human Lung Epithelial Cells

1998 • 37 citations

Zinc replenishment reduces esophageal cell proliferation and N- nitrosomethylbenzylamine (NMBA)-induced esophageal tumor incidence in zinc-deficient rats

1998 • 36 citations

Oxidative Stress Can Activate the Epidermal Platelet-Activating Factor Receptor

1999 • 34 citations

Redox Control of Gene Expression by Eukaryotic Transcription Factors NF-κB, AP-1 and SRF/TCF

1994 • 33 citations

Malignant transformation of immortalized human bronchial epithelial cells by asbestos fibers.

1997 • 33 citations

Effect of Linoleic Acid Hydroperoxide on Endothelial Cell Calcium Homeostasis and Phospholipid Hydrolysis

1995 • 33 citations

Protein kinase C isozymes in progressively transformed rat embryo fibroblasts.

1994 • 33 citations

Benzoyl peroxide promotion of transformation of JB6 mouse epidermal cells: inhibition by ganglioside G^T but not retinoic acid

1985 • 32 citations

Physiological and Pathologic Effects of Oxidants in Mouse Epidermal Cells ^a

1988 • 31 citations

Benzoyl peroxide activation of protein kinase C activity in epidermal cell membranes

1987 • 31 citations

Copper ion-mediated modification of bases in DNA in vitro by benzoyl peroxide

1993 • 24 citations

Reaction of Chromium(VI) with Glutathione or with Hydrogen Peroxide: Identification of Reactive Intermediates and Their Role in Chromium(VI)-Induced DNA Damage

1991 • 21 citations

Vitamin E Succinate Inhibits Protein Kinase C: Correlation with its Unique Inhibitory Effects on Cell Growth and Transformation

1995 • 21 citations

Smoking abstinence and small cell lung cancer survival. An association

1980 • 21 citations

Preferential oxidation of cell surface sialic acid by periodate leads to promotion of transformation in JB6 cells

1984 • 19 citations

Tumor Promoter Benzoyl Peroxide Induces Sulfhydryl Oxidation in Protein Kinase C: Its Reversibility Is Related to the Cellular Resistance to Peroxide-Induced Cytotoxicity

1999 • 18 citations

Covalent Modification of Protein Kinase C Isozymes by the Inactivating Peptide Substrate Analog N-Biotinyl-Arg-Arg-Arg-Cys-Leu-Arg-Arg-Leu

1996 • 12 citations

Tumor Promoters and Cocarcinogens in Tobacco Carcinogenesis

1983 • 10 citations

Malignant Transformation of Immortalized Human Bronchial Epithelial Cells by Asbestos Fibers

1997 • 8 citations

Effect of Benzoyl Peroxide on Protein Kinase C in Cultured Human Epidermal Keratinocytes

1995 • 7 citations

Inhibition of Mouse Skin Protein Kinase C by Benzoyl Peroxide

1991 • 7 citations

Deleted Work

1955 • 0 citations